ATE323110T1 - Verfahren zur herstellung von einem cyclodextrin - Google Patents
Verfahren zur herstellung von einem cyclodextrinInfo
- Publication number
- ATE323110T1 ATE323110T1 AT98304785T AT98304785T ATE323110T1 AT E323110 T1 ATE323110 T1 AT E323110T1 AT 98304785 T AT98304785 T AT 98304785T AT 98304785 T AT98304785 T AT 98304785T AT E323110 T1 ATE323110 T1 AT E323110T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclodextrin
- base
- residual
- alkyl sultone
- added
- Prior art date
Links
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 Sulfoalkyl ether Chemical compound 0.000 abstract 4
- 239000007858 starting material Substances 0.000 abstract 2
- 229940097362 cyclodextrins Drugs 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5149797P | 1997-07-01 | 1997-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323110T1 true ATE323110T1 (de) | 2006-04-15 |
Family
ID=21971666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98304785T ATE323110T1 (de) | 1997-07-01 | 1998-06-17 | Verfahren zur herstellung von einem cyclodextrin |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6153746A (de) |
| EP (1) | EP0889056B1 (de) |
| JP (1) | JP3272669B2 (de) |
| AT (1) | ATE323110T1 (de) |
| BR (1) | BR9802331A (de) |
| CA (1) | CA2241774C (de) |
| DE (1) | DE69834154T2 (de) |
| DK (1) | DK0889056T3 (de) |
| ES (1) | ES2257795T3 (de) |
| PT (1) | PT889056E (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6479467B1 (en) * | 1999-12-16 | 2002-11-12 | Eastman Chemical Company | Cyclodextrin ethers |
| EP1278549B1 (de) * | 2000-05-02 | 2008-12-10 | Theravance, Inc. | Zusammensetzung die eine zyklodextrin und ein glykopeptid-antibiotikum enthält |
| US20030028014A1 (en) * | 2001-04-26 | 2003-02-06 | Chris Sikorski | Agglomerated modified cyclodextrin and process for making same |
| UA75135C2 (en) * | 2001-05-01 | 2006-03-15 | Pfizer Prod Inc | Dry granulation method for manufacturing pharmaceutical composition containing tetrahydronaphthalene-2-ol derivative and low dosage tablet compositions |
| CN101039682A (zh) * | 2003-10-31 | 2007-09-19 | 堪萨斯大学 | 磺基烷基醚－烷基醚环糊精衍生物 |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| CA2552641A1 (en) | 2003-12-31 | 2005-07-21 | Cydex, Inc. | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid prepared from a unit dose suspension |
| HUE058227T2 (hu) | 2004-04-23 | 2022-07-28 | Cydex Pharmaceuticals Inc | DPI készítmény, amely szulfoalkil-éter-ciklodextrint tartalmaz |
| US20100204178A1 (en) | 2006-10-02 | 2010-08-12 | James Cloyd | Novel parenteral carbamazepine formulation |
| MX348982B (es) | 2005-10-26 | 2017-07-06 | Cydex Pharmaceuticals Inc | Composiciones de eter sulfoalquilico-ciclodextrina y metodos de preparacion de las mismas. |
| CN102327617B (zh) * | 2005-10-26 | 2014-08-20 | 锡德克斯药物公司 | 磺基烷基醚环糊精组合物和其制备方法 |
| RU2417103C2 (ru) * | 2005-10-26 | 2011-04-27 | Сайдекс Фармасьютикалз, Инк. | Композиции простого сульфоалкилового эфира циклодекстрина и способы их получения |
| AU2011204957B2 (en) * | 2005-10-26 | 2013-12-05 | Cydex Pharmaceuticals, Inc | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| US7629331B2 (en) * | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| US20090239942A1 (en) | 2006-09-15 | 2009-09-24 | Cloyd James C | Topiramate Compositions and Methods of Making and Using the Same |
| WO2008065142A1 (en) * | 2006-11-29 | 2008-06-05 | N.V. Organon | Stabilized solution of rocuronium comprising a sulfoalkyl-ether-beta-cyclodextrin derivative |
| MX2009011619A (es) | 2007-04-27 | 2010-01-18 | Cydex Pharmaceuticals Inc | Formulaciones que contienen clopidogrel y eter sulfoalquilico-ciclodextrina y metodos de uso. |
| ES2493641T3 (es) * | 2007-06-28 | 2014-09-12 | Cydex Pharmaceuticals, Inc. | Administración nasal de soluciones acuosas de corticosteroides |
| US12370352B2 (en) | 2007-06-28 | 2025-07-29 | Cydex Pharmaceuticals, Inc. | Nasal and ophthalmic delivery of aqueous corticosteroid solutions |
| US7635773B2 (en) * | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| EA024364B1 (ru) | 2008-10-21 | 2016-09-30 | Оникс Терапьютикс, Инк. | Способ лечения множественной миеломы |
| US10463677B2 (en) | 2008-11-07 | 2019-11-05 | Cydex Pharmaceuticals, Inc. | Composition containing sulfoalkyl ether cyclodextrin and latanoprost |
| KR101743591B1 (ko) | 2009-05-13 | 2017-06-20 | 사이덱스 파마슈티칼스, 인크. | 프라수그렐 및 사이클로덱스트린 유도체를 포함하는 약학 조성물 및 그의 제조 및 사용 방법 |
| CN106389307A (zh) | 2009-05-29 | 2017-02-15 | 锡德克斯药物公司 | 包含环糊精衍生物的可注射美法仑组合物及其制备和使用方法 |
| US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
| US8492538B1 (en) | 2009-06-04 | 2013-07-23 | Jose R. Matos | Cyclodextrin derivative salts |
| TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物 |
| TW201336527A (zh) | 2012-02-10 | 2013-09-16 | Alcon Res Ltd | 具增強的穩定性之水性藥學組成物 |
| WO2013123254A1 (en) | 2012-02-15 | 2013-08-22 | Cydex Pharmaceuticals, Inc. | Manufacturing process for cyclodextrin derivatives |
| US9493582B2 (en) * | 2012-02-28 | 2016-11-15 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| JP6081572B2 (ja) * | 2012-03-30 | 2017-02-15 | ザピオテック・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＳＡＰＩＯＴＥＣ ＧｍｂＨ | アントシアニジン複合体 |
| MX364393B (es) | 2012-05-08 | 2019-04-24 | Onyx Therapeutics Inc | Procedimientos para la formacion de complejos de ciclodextrina para formular inhibidores del proteasoma peptidico. |
| HK1213585A1 (zh) * | 2012-10-22 | 2016-07-08 | Cydex Pharmaceuticals, Inc. | 烷基化环糊精组合物及其制备和使用方法 |
| GB201312737D0 (en) * | 2013-07-17 | 2013-08-28 | Univ Greenwich | Cyclodextrin |
| CN103694376B (zh) | 2014-01-10 | 2016-04-13 | 凯莱英医药集团（天津）股份有限公司 | 一种制备磺丁基醚-β-环糊精的方法 |
| EP3183295B1 (de) * | 2014-08-22 | 2023-08-02 | CyDex Pharmaceuticals, Inc. | Fraktionierte alkylierte cyclodextrinzusammensetzungen und verfahren zur herstellung und verwendung davon |
| EP3270941B1 (de) | 2015-03-19 | 2021-05-26 | Cydex Pharmaceuticals, Inc. | Zusammensetzungen mit silymarin und sulfoalkylethercyclodextrin und verfahren zur verwendung davon |
| CN104892797B (zh) * | 2015-05-28 | 2017-03-22 | 天津大学 | 特定平均取代度磺丁基醚‑β‑环糊精的合成方法 |
| CN106749770A (zh) * | 2015-11-20 | 2017-05-31 | 天津市通航科技有限公司 | 一种微波辐射/碱耦合制备不同取代度磺丁基醚-β-环糊精的方法 |
| WO2018146698A1 (en) | 2017-02-07 | 2018-08-16 | Biophore India Pharmaceuticals Pvt. Ltd. | Improved method for the preparation of sulfobutylether beta cyclodextrin sodium |
| CN110831588B (zh) | 2017-05-03 | 2023-06-27 | 锡德克斯药物公司 | 包含环糊精和白消安的组合物 |
| JP7336657B2 (ja) | 2018-10-15 | 2023-09-01 | 国立大学法人大阪大学 | 環状オリゴ糖及びその製造方法 |
| BR112022009506A2 (pt) * | 2019-11-18 | 2022-08-16 | Cydex Pharmaceuticals Inc | Composições de ciclodextrina alquilada e processos para preparação e uso das mesmas |
| CA3198795A1 (en) | 2020-11-18 | 2022-05-27 | Jeffrey Becker | Complexing agent salt formulations of pharmaceutical compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3426011A (en) * | 1967-02-13 | 1969-02-04 | Corn Products Co | Cyclodextrins with anionic properties |
| US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5681828A (en) | 1995-12-19 | 1997-10-28 | Pitha; Josef | Selective alkylations of cyclodextrins leading to derivatives which have a rigidly extended cavity |
-
1998
- 1998-06-17 EP EP98304785A patent/EP0889056B1/de not_active Expired - Lifetime
- 1998-06-17 PT PT98304785T patent/PT889056E/pt unknown
- 1998-06-17 DK DK98304785T patent/DK0889056T3/da active
- 1998-06-17 ES ES98304785T patent/ES2257795T3/es not_active Expired - Lifetime
- 1998-06-17 DE DE69834154T patent/DE69834154T2/de not_active Expired - Lifetime
- 1998-06-17 AT AT98304785T patent/ATE323110T1/de active
- 1998-06-25 JP JP17883198A patent/JP3272669B2/ja not_active Expired - Lifetime
- 1998-06-29 CA CA002241774A patent/CA2241774C/en not_active Expired - Lifetime
- 1998-06-29 US US09/106,983 patent/US6153746A/en not_active Expired - Lifetime
- 1998-07-01 BR BR9802331-4A patent/BR9802331A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0889056A2 (de) | 1999-01-07 |
| DE69834154T2 (de) | 2007-01-25 |
| CA2241774C (en) | 2002-06-25 |
| US6153746A (en) | 2000-11-28 |
| JP3272669B2 (ja) | 2002-04-08 |
| EP0889056B1 (de) | 2006-04-12 |
| ES2257795T3 (es) | 2006-08-01 |
| JPH1160610A (ja) | 1999-03-02 |
| DK0889056T3 (da) | 2006-07-17 |
| BR9802331A (pt) | 2000-09-05 |
| DE69834154D1 (de) | 2006-05-24 |
| CA2241774A1 (en) | 1999-01-01 |
| PT889056E (pt) | 2006-07-31 |
| EP0889056A3 (de) | 1999-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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