BRPI0415755A - antagonistas do receptor b1 de bradiquinina - Google Patents

antagonistas do receptor b1 de bradiquinina

Info

Publication number
BRPI0415755A
BRPI0415755A BRPI0415755-9A BRPI0415755A BRPI0415755A BR PI0415755 A BRPI0415755 A BR PI0415755A BR PI0415755 A BRPI0415755 A BR PI0415755A BR PI0415755 A BRPI0415755 A BR PI0415755A
Authority
BR
Brazil
Prior art keywords
receptor antagonists
present
bradykinin
peptides
conjugated peptides
Prior art date
Application number
BRPI0415755-9A
Other languages
English (en)
Inventor
Gordon Ng
Yue-Sheng Li
Colin V Gegg
Benny C Askew
Thomas Storz
Yulie Lu
Derin C D Amico
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BRPI0415755A publication Critical patent/BRPI0415755A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/043—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A—HUMAN NECESSITIES
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)

Abstract

"ANTAGONISTAS DO RECEPTOR B1 DE BRADIQUININA". A presente invenção refere-se a determinados peptídeos biologicamente ativos e peptídeos conjugados os quais podem ser usados como produtos terapêuticos ou profiláticos contra doenças ou condições relacionadas ao B1 como o agente causador. Em uma modalidade preferida da invenção, peptídeos PEG-conjugados biologicamente ativos são proporcionados. Em um aspecto da presente invenção, peptídeos PEG-conjugados farmacologicamente ativos da presente invenção são úteis para tratar inflamação ou dor.
BRPI0415755-9A 2003-10-22 2004-10-22 antagonistas do receptor b1 de bradiquinina BRPI0415755A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51391303P 2003-10-22 2003-10-22
US53892904P 2004-01-24 2004-01-24
US10/972,236 US7605120B2 (en) 2003-10-22 2004-10-21 Antagonists of the brandykinin B1 receptor
PCT/US2004/034976 WO2005042027A2 (en) 2003-10-22 2004-10-22 Antagonists of the bradykinin b1 receptor

Publications (1)

Publication Number Publication Date
BRPI0415755A true BRPI0415755A (pt) 2006-12-19

Family

ID=34990807

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415755-9A BRPI0415755A (pt) 2003-10-22 2004-10-22 antagonistas do receptor b1 de bradiquinina

Country Status (15)

Country Link
US (4) US7605120B2 (pt)
EP (1) EP1677830B1 (pt)
JP (1) JP4896728B2 (pt)
KR (2) KR100860654B1 (pt)
AU (1) AU2004285467A1 (pt)
BR (1) BRPI0415755A (pt)
CA (1) CA2545499A1 (pt)
EA (1) EA009294B1 (pt)
EC (1) ECSP066575A (pt)
ES (1) ES2395546T3 (pt)
IL (1) IL175084A0 (pt)
MA (1) MA28160A1 (pt)
NO (1) NO20062198L (pt)
SG (1) SG149872A1 (pt)
WO (1) WO2005042027A2 (pt)

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Also Published As

Publication number Publication date
US20050215470A1 (en) 2005-09-29
US8278280B2 (en) 2012-10-02
NO20062198L (no) 2006-07-18
IL175084A0 (en) 2006-08-20
JP4896728B2 (ja) 2012-03-14
MA28160A1 (fr) 2006-09-01
ECSP066575A (es) 2006-10-17
KR100860654B1 (ko) 2008-09-26
EP1677830B1 (en) 2012-10-17
KR20080015054A (ko) 2008-02-15
AU2004285467A1 (en) 2005-05-12
EA009294B1 (ru) 2007-12-28
US7605120B2 (en) 2009-10-20
US20090137452A1 (en) 2009-05-28
US20090048149A1 (en) 2009-02-19
WO2005042027A2 (en) 2005-05-12
WO2005042027A3 (en) 2006-02-09
US20090137483A1 (en) 2009-05-28
US8288351B2 (en) 2012-10-16
JP2007526240A (ja) 2007-09-13
AU2004285467A2 (en) 2005-05-12
EP1677830A2 (en) 2006-07-12
SG149872A1 (en) 2009-02-27
EA200600817A1 (ru) 2006-12-29
CA2545499A1 (en) 2005-05-12
ES2395546T3 (es) 2013-02-13
KR20060105757A (ko) 2006-10-11

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