BRPI0416215A - forma de ministração individualmente dosada, não comprimida, processo para produzir uma forma de ministração individualmente dosada, não comprimida e uso de pelo menos um agente de estabilização - Google Patents
forma de ministração individualmente dosada, não comprimida, processo para produzir uma forma de ministração individualmente dosada, não comprimida e uso de pelo menos um agente de estabilizaçãoInfo
- Publication number
- BRPI0416215A BRPI0416215A BRPI0416215-3A BRPI0416215A BRPI0416215A BR PI0416215 A BRPI0416215 A BR PI0416215A BR PI0416215 A BRPI0416215 A BR PI0416215A BR PI0416215 A BRPI0416215 A BR PI0416215A
- Authority
- BR
- Brazil
- Prior art keywords
- uncompressed
- individually dosed
- stabilizing agent
- delivery form
- composition
- Prior art date
Links
- 239000003381 stabilizer Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- -1 fatty acid esters Chemical class 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 239000004033 plastic Substances 0.000 abstract 1
- 229920003023 plastic Polymers 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"FORMA DE MINISTRAçãO INDIVIDUALMENTE DOSADA, NãO COMPRIMIDA, PROCESSO PARA PRODUZIR UMA FORMA DE MINISTRAçãO INDIVIDUALMENTE DOSADA, NãO COMPRIMIDA E USO DE PELO MENOS UM AGENTE DE ESTABILIZAçãO". A presente invenção refere-se a formas de ministração individualmente dosadas, não comprimidas, compreendendo uma composição de pelo menos uma substância farmaceuticamente ativa dissolvida ou dispersa dentro de um material de matriz compreendendo uma mistura de pelo menos 0.2% em peso de uma gelatina, pelo menos um agente de estabilização, e pelo menos um álcool solúvel em água e/ou água como um solvente, a qual composição é plástica em temperatura elevada, na qual: a) o agente de estabilização é selecionado a partir do grupo consistindo de (i) ésteres de glicerina e de ácidos grassos; (ii) produtos resultantes a partir da reação da alcoólise/esterificação de tais ésteres de glicerina e de ácidos grassos com polietilenoglicóis; e b) o agente de estabilização tem um ponto de fusão na faixa de 42 <198>C a 63 <198>C; c) a água está presente em uma quantidade não maior do que 46% em peso da composição.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200302612A ES2235626B1 (es) | 2003-11-10 | 2003-11-10 | Formas de administracion masticables, no comprimidas dosificadas individualmente. |
| PCT/EP2004/012658 WO2005048974A2 (en) | 2003-11-10 | 2004-11-09 | Non-tabletted, chewable, individually dosed administration forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0416215A true BRPI0416215A (pt) | 2006-12-26 |
Family
ID=34610359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416215-3A BRPI0416215A (pt) | 2003-11-10 | 2004-11-09 | forma de ministração individualmente dosada, não comprimida, processo para produzir uma forma de ministração individualmente dosada, não comprimida e uso de pelo menos um agente de estabilização |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20070134318A1 (pt) |
| EP (1) | EP1682097B1 (pt) |
| JP (1) | JP4879021B2 (pt) |
| KR (1) | KR20060116821A (pt) |
| CN (1) | CN1878542A (pt) |
| AR (1) | AR048050A1 (pt) |
| AT (1) | ATE492270T1 (pt) |
| AU (1) | AU2004290517B2 (pt) |
| BR (1) | BRPI0416215A (pt) |
| CA (1) | CA2548615A1 (pt) |
| CO (1) | CO5690531A2 (pt) |
| DE (1) | DE602004030706D1 (pt) |
| EC (1) | ECSP066553A (pt) |
| ES (2) | ES2235626B1 (pt) |
| IL (1) | IL175285A (pt) |
| MY (1) | MY143793A (pt) |
| NO (1) | NO20062723L (pt) |
| NZ (1) | NZ546375A (pt) |
| PE (1) | PE20050488A1 (pt) |
| RU (1) | RU2369379C2 (pt) |
| TW (1) | TW200526266A (pt) |
| UA (1) | UA90253C2 (pt) |
| UY (1) | UY28586A1 (pt) |
| WO (2) | WO2005048975A1 (pt) |
| ZA (1) | ZA200602416B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7799832B2 (en) | 2003-10-23 | 2010-09-21 | Valeant Pharmaceuticals North America | Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US8993593B2 (en) | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US8293911B2 (en) | 2006-08-23 | 2012-10-23 | Valeant Pharmaceuticals International | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| WO2008066900A1 (en) | 2006-11-28 | 2008-06-05 | Valeant Pharmaceuticals International | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators |
| US8367684B2 (en) | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| EP2170282A4 (en) * | 2007-06-27 | 2014-11-05 | Hanmi Pharm Ind Co Ltd | METHOD FOR PRODUCING A QUICKLY CRUSHING FORMULATION FOR ORAL ADMINISTRATION AND DEVICE FOR PREPARING AND PACKAGING THE FORMULATION |
| IL187159A0 (en) | 2007-07-03 | 2009-02-11 | Gur Megiddo | Use of metadoxine in relief of alcohol intoxication |
| US7786146B2 (en) | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| EP2323735A1 (en) | 2008-07-29 | 2011-05-25 | Alcobra Ltd. | Substituted pyridoxine-lactam carboxylate salts |
| EP2238976B1 (en) * | 2009-04-03 | 2012-06-27 | Hexal AG | Oral films comprising 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro- 1H-quinolin-2-one base or salts or hydrates thereof |
| JP5770173B2 (ja) | 2009-06-25 | 2015-08-26 | アルコブラ、リミテッドＡｌｃｏｂｒａ Ｌｔｄ． | 認知疾患、障害または病態の治療、症状緩和、軽減、改善および予防方法 |
| EA021368B1 (ru) * | 2011-06-21 | 2015-06-30 | Общество С Ограниченной Ответственностью "Консорциум-Пик" | Препарат кардиопротекторного действия |
| CN105911057B (zh) * | 2016-06-22 | 2018-10-19 | 扬州一洋制药有限公司 | 一种铝镁加混悬液的质量控制方法 |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| CA3155812A1 (en) | 2019-11-08 | 2021-05-14 | Cynthia Louise HARDEN | Methods of treating depressive disorders |
| CN116847843A (zh) | 2021-02-09 | 2023-10-03 | 泽农医药公司 | 用于治疗快感缺乏的电压门控的钾通道开放剂 |
| CN113425694A (zh) * | 2021-07-02 | 2021-09-24 | 杭州蚕宝生物技术有限公司 | 一种石斛生物碱口腔崩解片剂及其制备方法 |
| US12053484B2 (en) | 2021-10-29 | 2024-08-06 | Medicated Chews, Llc | Simethicone chewable composition |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5645411A (en) * | 1979-09-20 | 1981-04-25 | Taiho Yakuhin Kogyo Kk | Poultice |
| FR2515035A1 (fr) * | 1981-10-26 | 1983-04-29 | Rhone Poulenc Sante | Nouvelle forme galenique solide pour administration par voie orale et son procede de fabrication |
| EP0409432A3 (en) * | 1989-07-20 | 1991-12-11 | Warner-Lambert Company | Confectionery delivery system |
| US5433951A (en) * | 1993-10-13 | 1995-07-18 | Bristol-Myers Squibb Company | Sustained release formulation containing captopril and method |
| JPH08319232A (ja) * | 1995-03-22 | 1996-12-03 | Takeda Chem Ind Ltd | 粉粒状組成物 |
| JPH0912463A (ja) * | 1995-06-23 | 1997-01-14 | Fujisawa Pharmaceut Co Ltd | 口中咀嚼用製剤 |
| US20030216303A1 (en) * | 1998-03-06 | 2003-11-20 | Michael Ambuhl | Emulsion preconcentrates containing cyclosporin or a macrolide |
| US6171615B1 (en) * | 1998-07-06 | 2001-01-09 | Gattefoss{acute over (e)} | Sustained release theophylline formulations, excipient systems and methods of production |
| US6060078A (en) * | 1998-09-28 | 2000-05-09 | Sae Han Pharm Co., Ltd. | Chewable tablet and process for preparation thereof |
| US6652880B1 (en) * | 1999-04-01 | 2003-11-25 | R.P. Scherer Technologies, Inc. | Oral pharmaceutical compositions containing long-chain triglycerides and liphophilic surfactants |
| CA2438097C (en) * | 2001-02-14 | 2006-04-25 | Gw Pharma Limited | Cannabinoids pharmaceutical formulations |
| US6692771B2 (en) * | 2001-02-23 | 2004-02-17 | Cima Labs Inc. | Emulsions as solid dosage forms for oral administration |
| RU2197094C1 (ru) * | 2001-12-26 | 2003-01-27 | Ставрулов Игорь Анатольевич | Жевательная резинка |
-
2003
- 2003-11-10 ES ES200302612A patent/ES2235626B1/es not_active Expired - Fee Related
-
2004
- 2004-03-11 WO PCT/EP2004/002513 patent/WO2005048975A1/en not_active Ceased
- 2004-10-28 UY UY28586A patent/UY28586A1/es not_active Application Discontinuation
- 2004-11-05 PE PE2004001080A patent/PE20050488A1/es not_active Application Discontinuation
- 2004-11-08 AR ARP040104105A patent/AR048050A1/es not_active Application Discontinuation
- 2004-11-08 MY MYPI20044643A patent/MY143793A/en unknown
- 2004-11-09 KR KR1020067009596A patent/KR20060116821A/ko not_active Ceased
- 2004-11-09 BR BRPI0416215-3A patent/BRPI0416215A/pt not_active IP Right Cessation
- 2004-11-09 NZ NZ546375A patent/NZ546375A/en unknown
- 2004-11-09 CA CA002548615A patent/CA2548615A1/en not_active Abandoned
- 2004-11-09 WO PCT/EP2004/012658 patent/WO2005048974A2/en not_active Ceased
- 2004-11-09 US US10/578,515 patent/US20070134318A1/en not_active Abandoned
- 2004-11-09 DE DE602004030706T patent/DE602004030706D1/de not_active Expired - Lifetime
- 2004-11-09 UA UAA200606335A patent/UA90253C2/ru unknown
- 2004-11-09 JP JP2006538767A patent/JP4879021B2/ja not_active Expired - Fee Related
- 2004-11-09 AT AT04797734T patent/ATE492270T1/de not_active IP Right Cessation
- 2004-11-09 AU AU2004290517A patent/AU2004290517B2/en not_active Ceased
- 2004-11-09 RU RU2006120087/15A patent/RU2369379C2/ru not_active IP Right Cessation
- 2004-11-09 CN CNA2004800330379A patent/CN1878542A/zh active Pending
- 2004-11-09 ES ES04797734T patent/ES2358332T3/es not_active Expired - Lifetime
- 2004-11-09 EP EP04797734A patent/EP1682097B1/en not_active Expired - Lifetime
- 2004-11-10 TW TW093134361A patent/TW200526266A/zh unknown
-
2006
- 2006-03-24 ZA ZA200602416A patent/ZA200602416B/xx unknown
- 2006-04-27 IL IL175285A patent/IL175285A/en not_active IP Right Cessation
- 2006-05-08 EC EC2006006553A patent/ECSP066553A/es unknown
- 2006-05-09 CO CO06043842A patent/CO5690531A2/es not_active Application Discontinuation
- 2006-06-12 NO NO20062723A patent/NO20062723L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005048974A3 (en) | 2006-02-23 |
| IL175285A (en) | 2011-04-28 |
| CN1878542A (zh) | 2006-12-13 |
| PE20050488A1 (es) | 2005-08-24 |
| AU2004290517A1 (en) | 2005-06-02 |
| MY143793A (en) | 2011-07-15 |
| ES2235626A1 (es) | 2005-07-01 |
| RU2369379C2 (ru) | 2009-10-10 |
| RU2006120087A (ru) | 2007-12-27 |
| ATE492270T1 (de) | 2011-01-15 |
| DE602004030706D1 (de) | 2011-02-03 |
| KR20060116821A (ko) | 2006-11-15 |
| NZ546375A (en) | 2009-11-27 |
| UY28586A1 (es) | 2005-05-31 |
| WO2005048975A1 (en) | 2005-06-02 |
| ECSP066553A (es) | 2006-12-20 |
| EP1682097B1 (en) | 2010-12-22 |
| AR048050A1 (es) | 2006-03-29 |
| NO20062723L (no) | 2006-06-12 |
| CO5690531A2 (es) | 2006-10-31 |
| EP1682097A2 (en) | 2006-07-26 |
| UA90253C2 (ru) | 2010-04-26 |
| US20070134318A1 (en) | 2007-06-14 |
| TW200526266A (en) | 2005-08-16 |
| JP4879021B2 (ja) | 2012-02-15 |
| JP2007510690A (ja) | 2007-04-26 |
| ES2358332T3 (es) | 2011-05-09 |
| CA2548615A1 (en) | 2005-06-02 |
| WO2005048974A2 (en) | 2005-06-02 |
| ES2235626B1 (es) | 2006-11-01 |
| AU2004290517B2 (en) | 2010-05-27 |
| IL175285A0 (en) | 2006-09-05 |
| ZA200602416B (en) | 2009-06-24 |
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| Date | Code | Title | Description |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |