BRPI0416945A - biomarcadores para a eficácia do tratamento com hormÈnio paratiróide e calcitonina - Google Patents

biomarcadores para a eficácia do tratamento com hormÈnio paratiróide e calcitonina

Info

Publication number
BRPI0416945A
BRPI0416945A BRPI0416945-0A BRPI0416945A BRPI0416945A BR PI0416945 A BRPI0416945 A BR PI0416945A BR PI0416945 A BRPI0416945 A BR PI0416945A BR PI0416945 A BRPI0416945 A BR PI0416945A
Authority
BR
Brazil
Prior art keywords
biomarkers
efficacy
treatment
hormone
parathyroid hormone
Prior art date
Application number
BRPI0416945-0A
Other languages
English (en)
Inventor
Maria Bobadilla
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0416945A publication Critical patent/BRPI0416945A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"BIOMARCADORES PARA A EFICáCIA DO TRATAMENTO COM HORMÈNIO PARATIRóIDE E CALCITONINA". A presente invenção refere-se a análise do perfil genético de múltiplos órgãos dos resultados de uma administração, a um indivíduo, de calcitonina do salmão ou um análogo de hormónio paratiróide que proporciona biomarcadores da eficácia do tratamento com calcitonina e da eficácia do tratamento com hormónio paratiróide ou análogo de hormónio paratiróide. Entre os biomarcadores estão os perfis de expressão dos genes para proteína de ligação Y-box, BMP~ S~, FGF~ S~, IGF~ S~, VEGF, glicoproteína <244>-2-HS (AHSG), OSF, receptores nucleares (família esteróide/tiroidiano) e outros. Os resultados obtidos corroboram o efeito anabólico da calcitonina do salmão sobre o metabolismo ósseo.
BRPI0416945-0A 2003-11-25 2004-11-24 biomarcadores para a eficácia do tratamento com hormÈnio paratiróide e calcitonina BRPI0416945A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52502503P 2003-11-25 2003-11-25
PCT/EP2004/013347 WO2005053731A1 (en) 2003-11-25 2004-11-24 Biomarkers for the efficacy of calcitonin and parathyroid hormone treatment

Publications (1)

Publication Number Publication Date
BRPI0416945A true BRPI0416945A (pt) 2007-02-13

Family

ID=34652293

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416945-0A BRPI0416945A (pt) 2003-11-25 2004-11-24 biomarcadores para a eficácia do tratamento com hormÈnio paratiróide e calcitonina

Country Status (12)

Country Link
US (1) US20070099828A1 (pt)
EP (1) EP1689427A1 (pt)
JP (1) JP2007522100A (pt)
KR (1) KR20060110304A (pt)
CN (1) CN1905894A (pt)
AU (1) AU2004294268A1 (pt)
BR (1) BRPI0416945A (pt)
CA (1) CA2546111A1 (pt)
IL (1) IL175575A0 (pt)
MX (1) MXPA06005950A (pt)
RU (1) RU2006122632A (pt)
WO (1) WO2005053731A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010043393A1 (en) * 2008-10-17 2010-04-22 Roche Diagnostics Gmbh Use of biglycan in the assessment of heart failure
WO2011057078A2 (en) 2009-11-05 2011-05-12 University Of Virginia Patent Foundation Compositions and methods for detecting plectin-1 as a biomarker for cancer
WO2012125914A1 (en) * 2011-03-16 2012-09-20 University Of Delaware Injectable delivery system for heparan sulfate binding growth factors
CN112748241B (zh) * 2019-10-16 2024-05-31 浙江中医药大学附属第二医院 一种用于检测i型骨质疏松症的蛋白芯片及其制作方法与应用
CN112574991B (zh) * 2020-12-17 2023-03-17 安徽师范大学 一种寡核苷酸、载体及制备方法和应用
CN116173187B (zh) * 2023-03-14 2024-05-10 哈尔滨医科大学 降钙素在制备防治支架内再狭窄药物中的应用、药物涂层支架及制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59175437A (ja) * 1983-03-25 1984-10-04 Teikoku Hormone Mfg Co Ltd 高コレステロ−ル血症改善剤
US4692433A (en) * 1983-10-12 1987-09-08 The Regents Of The University Of California Method and composition for regulating serum calcium levels of mammals
US5514365A (en) * 1988-10-11 1996-05-07 Schiapparelli Salute S.P.A. Pharmaceutical compositions comprising calcitonin for intranasal administration
JPH02229119A (ja) * 1989-02-28 1990-09-11 Toyo Jozo Co Ltd 動脈硬化予防および治療剤
US20030091973A1 (en) * 2000-09-19 2003-05-15 Horesovsky Gregory J. Method of identifying osteoregenerative agents using differential gene expression
WO2002092854A2 (en) * 2001-05-16 2002-11-21 Novartis Ag Genes expressed in breast cancer as prognostic and therapeutic targets
US7384736B2 (en) * 2001-09-06 2008-06-10 Decode Genetics Ehf. Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
JP2005507261A (ja) * 2001-10-31 2005-03-17 ノバルティス アクチエンゲゼルシャフト Ｔｃｆ１遺伝子における多型に基づく糖尿病および関連状態の治療方法

Also Published As

Publication number Publication date
KR20060110304A (ko) 2006-10-24
EP1689427A1 (en) 2006-08-16
MXPA06005950A (es) 2006-07-06
AU2004294268A1 (en) 2005-06-16
CA2546111A1 (en) 2005-06-16
WO2005053731A1 (en) 2005-06-16
RU2006122632A (ru) 2008-02-10
CN1905894A (zh) 2007-01-31
US20070099828A1 (en) 2007-05-03
JP2007522100A (ja) 2007-08-09
IL175575A0 (en) 2006-09-05

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.