BRPI0417077A - anticorpos de anti-mpl - Google Patents

anticorpos de anti-mpl

Info

Publication number
BRPI0417077A
BRPI0417077A BRPI0417077-6A BRPI0417077A BRPI0417077A BR PI0417077 A BRPI0417077 A BR PI0417077A BR PI0417077 A BRPI0417077 A BR PI0417077A BR PI0417077 A BRPI0417077 A BR PI0417077A
Authority
BR
Brazil
Prior art keywords
mpl
human
antibodies
purified
those
Prior art date
Application number
BRPI0417077-6A
Other languages
English (en)
Inventor
Hiroyuki Tsunoda
Kiyotaka Nakano
Tetsuro Orita
Masayuki Tsuchiya
Yuichi Hirata
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BRPI0417077A publication Critical patent/BRPI0417077A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"ANTICORPOS DE ANTI-MPL". Anticorpos de Mpl de anti-humano foram isolados e foram purificados, e então diacorpos de Mpl anti-humanos e Mpl sc(Fv)2 anti-humano foram purificados usando-se técnicas de engenheiramento genético. Além do mais, os presentes inventores são bem sucedidos na humanização de sc(Fv)2 Mpl de anti-humano. Os diacorpos e sc(Fv)2 foram ensaiados quanto a atividade agonística de tipo TPO, e demonstraram ter atividades mais altas do que aqueles de anticorpos de Mpl de anti-humano, ou atividades equivalentes a ou mais altas do que àuqelas de ligante de TPO humano de ocorrência natural.
BRPI0417077-6A 2003-12-12 2004-12-10 anticorpos de anti-mpl BRPI0417077A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2003415746 2003-12-12
JP2004071763 2004-03-12
JP2004248323 2004-08-27
PCT/JP2004/018506 WO2005056604A1 (ja) 2003-12-12 2004-12-10 抗Mpl抗体

Publications (1)

Publication Number Publication Date
BRPI0417077A true BRPI0417077A (pt) 2007-03-13

Family

ID=34681972

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417077-6A BRPI0417077A (pt) 2003-12-12 2004-12-10 anticorpos de anti-mpl

Country Status (12)

Country Link
US (2) US7993642B2 (pt)
EP (1) EP1616881A4 (pt)
JP (1) JP4708190B2 (pt)
KR (1) KR20060107572A (pt)
AU (1) AU2004297111A1 (pt)
BR (1) BRPI0417077A (pt)
CA (1) CA2548567A1 (pt)
IL (1) IL175710A0 (pt)
MX (1) MXPA06006289A (pt)
NO (1) NO20063224L (pt)
TW (1) TW200530269A (pt)
WO (1) WO2005056604A1 (pt)

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MXPA06006289A (es) 2006-08-23
CA2548567A1 (en) 2005-06-23
AU2004297111A1 (en) 2005-06-23
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IL175710A0 (en) 2006-09-05
EP1616881A4 (en) 2008-08-27
TW200530269A (en) 2005-09-16
US7993642B2 (en) 2011-08-09
JP4708190B2 (ja) 2011-06-22
US20060222643A1 (en) 2006-10-05
NO20063224L (no) 2006-07-11
EP1616881A1 (en) 2006-01-18

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