NO20063224L - Anti-MPL-antistoff - Google Patents

Anti-MPL-antistoff

Info

Publication number
NO20063224L
NO20063224L NO20063224A NO20063224A NO20063224L NO 20063224 L NO20063224 L NO 20063224L NO 20063224 A NO20063224 A NO 20063224A NO 20063224 A NO20063224 A NO 20063224A NO 20063224 L NO20063224 L NO 20063224L
Authority
NO
Norway
Prior art keywords
human mpl
human
mpl
diabody
purified
Prior art date
Application number
NO20063224A
Other languages
English (en)
Inventor
Kiyotaka Nakano
Hiroyuki Tsunoda
Tetsuro Orita
Masayuki Tsuchiya
Yuichi Hirata
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of NO20063224L publication Critical patent/NO20063224L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Anti-humane Mpl-antistofifer erholdes og renses. Ved anvendelse av en teknikk for genetisk modifisering renses anti-humant Mpl-diastofif og anti-humant Mpl sc(Fv)2. Videre humaniseres anti-humant Mpl sc(Fv)2 på en vellykket måte. Som resultater av evalueringen av den TPO-lignende agonistiske aktivitet av diastoffet og sc(Fv)2 firmes det at diastoffet og sc(Fv)2 viser høy agonistisk aktivitet ovenfor anti-humant Mpl-antistofif og aktiviteten er sammenlignbar med aktiviteten til humant TPO som er en naturlig ligand, eller til og med overlegen den.
NO20063224A 2003-12-12 2006-07-11 Anti-MPL-antistoff NO20063224L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2003415746 2003-12-12
JP2004071763 2004-03-12
JP2004248323 2004-08-27
PCT/JP2004/018506 WO2005056604A1 (ja) 2003-12-12 2004-12-10 抗Mpl抗体

Publications (1)

Publication Number Publication Date
NO20063224L true NO20063224L (no) 2006-07-11

Family

ID=34681972

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063224A NO20063224L (no) 2003-12-12 2006-07-11 Anti-MPL-antistoff

Country Status (12)

Country Link
US (2) US7993642B2 (no)
EP (1) EP1616881A4 (no)
JP (1) JP4708190B2 (no)
KR (1) KR20060107572A (no)
AU (1) AU2004297111A1 (no)
BR (1) BRPI0417077A (no)
CA (1) CA2548567A1 (no)
IL (1) IL175710A0 (no)
MX (1) MXPA06006289A (no)
NO (1) NO20063224L (no)
TW (1) TW200530269A (no)
WO (1) WO2005056604A1 (no)

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MXPA06006289A (es) 2006-08-23
CA2548567A1 (en) 2005-06-23
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EP1616881A4 (en) 2008-08-27
TW200530269A (en) 2005-09-16
US7993642B2 (en) 2011-08-09
JP4708190B2 (ja) 2011-06-22
US20060222643A1 (en) 2006-10-05
BRPI0417077A (pt) 2007-03-13
EP1616881A1 (en) 2006-01-18

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