BRPI0417259A - métodos para tratar uma doença associada com adamts-5 em um paciente, para identificar um agente potencial útil para o tratamento de uma doença associada com adamts-5 e para modular a atividade de adamts-5 - Google Patents

métodos para tratar uma doença associada com adamts-5 em um paciente, para identificar um agente potencial útil para o tratamento de uma doença associada com adamts-5 e para modular a atividade de adamts-5

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Publication number
BRPI0417259A
BRPI0417259A BRPI0417259-0A BRPI0417259A BRPI0417259A BR PI0417259 A BRPI0417259 A BR PI0417259A BR PI0417259 A BRPI0417259 A BR PI0417259A BR PI0417259 A BRPI0417259 A BR PI0417259A
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BR
Brazil
Prior art keywords
adamts
activity
treating
animals
osteoarthritis
Prior art date
Application number
BRPI0417259-0A
Other languages
English (en)
Inventor
Elisabeth A Morris
Sonya S Glasson
Jason Shaoyun Xiang
Original Assignee
Wyeth Corp
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Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0417259A publication Critical patent/BRPI0417259A/pt

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Abstract

"MéTODOS PARA TRATAR UMA DOENçA ASSOCIADA COM ADAMTS-5 EM UM PACIENTE, PARA IDENTIFICAR UM AGENTE POTENCIAL úTIL PARA O TRATAMENTO DE UMA DOENçA ASSOCIADA COM ADAMTS-5 E PARA MODULAR A ATIVIDADE DE ADAMTS-5". A presente invenção diz respeito a métodos de tratar doenças associadas com ADAMTS-5 e particularmente osteoartrite que compreende administrar um agente capaz de modular a atividade de ADAMTS-5 a um paciente afligido pela doença. O agente é preferivelmente um composto de biaril sulfonamida. A invenção está fundamentada, em parte, na descoberta que os animais trangênicos que nao expressam ADAMTS-5 funcional apresentam uma redução no grau de osteoartrite após a indução de osteoartrite em comparação com animais WT. Além disso, os animais transgênicos com ADAMTS-5 tem atividade de agrecanase reduzida no tecido articular em comparação com animais WT. Estes animais são bons modelos para doenças associadas com ADAMTS-5 e para a avaliação de medicamentos úteis no tratamento e/ou prevenção destas doenças. Não existem outros modelos animais em que a anulação da atividade de um único gene seja capaz de anular o curso da osteoartrite. Conseqüentemente, estes animais também mostram que a osteoartrite pode ser evitada e/ou tratada pela administração, a um paciente de um agente inibidor de ADAMTS-5 e particularmente um agente capaz de inibir a atividade de agrecanase de ADAMTS -5.
BRPI0417259-0A 2003-12-04 2004-11-08 métodos para tratar uma doença associada com adamts-5 em um paciente, para identificar um agente potencial útil para o tratamento de uma doença associada com adamts-5 e para modular a atividade de adamts-5 BRPI0417259A (pt)

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PCT/US2004/037169 WO2005060456A2 (en) 2003-12-04 2004-11-08 Method for treating adamts-5-associate disease

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BRPI0417259-0A BRPI0417259A (pt) 2003-12-04 2004-11-08 métodos para tratar uma doença associada com adamts-5 em um paciente, para identificar um agente potencial útil para o tratamento de uma doença associada com adamts-5 e para modular a atividade de adamts-5

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Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1692124B1 (en) * 2003-12-04 2008-10-15 Wyeth Biaryl sulfonamides as mmp inhibitors
CA2548513A1 (en) * 2003-12-04 2005-07-07 Wyeth Biaryl sulfonamides and methods for using same
US20080119513A1 (en) * 2004-09-06 2008-05-22 Fumihiko Watanabe Sulfonamide Derivative Selectively Inhibiting Mmp-13
KR20080031379A (ko) 2005-07-11 2008-04-08 와이어쓰 글루타메이트 아그레카나제 저해제
CN101300345A (zh) * 2005-08-25 2008-11-05 惠氏公司 聚集蛋白聚糖酶结构
US7615363B2 (en) * 2005-08-25 2009-11-10 Wyeth Aggrecanase structure
KR20080058436A (ko) 2005-10-13 2008-06-25 와이어쓰 글루탐산 유도체의 제조 방법
WO2007102392A1 (ja) 2006-03-03 2007-09-13 Shionogi & Co., Ltd. Ｍｍｐ－１３選択的阻害剤
KR20090060333A (ko) * 2006-09-08 2009-06-11 노파르티스 아게 림프구 상호작용에 의해 매개되는 질환의 치료에 유용한 ｎ-바이아릴 (헤테로)아릴술폰아미드 유도체
US8106070B2 (en) * 2006-10-20 2012-01-31 Merck Sharp & Dohme Corp. Substituted imidazoles as bombesin receptor subtype-3 modulators
CA2667003A1 (en) * 2006-10-20 2008-05-02 Merck & Co., Inc. Substituted imidazoles as bombesin receptor subtype-3 modulators
CA2666310C (en) * 2006-10-20 2012-07-31 Merck & Co., Inc. Substituted imidazoles as bombesin receptor subtype-3 modulators
WO2008053913A1 (en) 2006-11-02 2008-05-08 Shionogi & Co., Ltd. Sulfonylurea derivative capable of selectively inhibiting mmp-13
EP2102244A2 (en) * 2006-12-19 2009-09-23 Ablynx N.V. Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders
EP2147684A1 (en) * 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
AU2013203591B2 (en) * 2009-05-01 2017-01-19 University Court Of The University Of Dundee Treatment or prophylaxis of proliferative conditions
AU2010266272A1 (en) * 2009-07-02 2012-01-19 Glaxo Group Limited Polypeptides and method of treatment
US20130336989A1 (en) * 2011-02-24 2013-12-19 Glaxo Group Limited Methods of identifying a patient population
HUE031089T2 (en) 2012-04-13 2017-06-28 Rottapharm Biotech Srl Anti-ADAMTS-5 antibody, derivatives and uses
GB201312311D0 (en) 2013-07-09 2013-08-21 Uni I Oslo Uses of enzyme inhibitors
EP3209794A1 (en) * 2014-10-22 2017-08-30 Katholieke Universiteit Leuven KU Leuven Research & Development Modulating adipose tissue and adipogenesis
US10377818B2 (en) 2015-01-30 2019-08-13 The Board Of Trustees Of The Leland Stanford Junior University Method of treating glioma
TW202417517A (zh) 2017-06-02 2024-05-01 德商麥克專利有限公司 與ｍｍｐ１３結合之免疫球蛋白
JP7249961B2 (ja) 2017-06-02 2023-03-31 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ａｄａｍｔｓ５、ｍｍｐ１３およびアグリカンに結合するポリペプチド
CN118894939A (zh) * 2017-06-02 2024-11-05 默克专利股份有限公司 结合adamts的免疫球蛋白
AU2019216531A1 (en) 2018-02-02 2020-09-24 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
CN111187289B (zh) * 2020-02-26 2021-03-23 湖南中大检测技术集团有限公司 一种过氧化氢荧光探针及其制备方法和应用
US12043672B2 (en) 2022-09-07 2024-07-23 Synoa Therapeutics, Llc Compositions comprising bispecific antibodies to human ADAMTS5 and nerve growth factor

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9707010B1 (pt) * 1996-01-23 2009-05-05 compostos, composição farmacêutica e composições para inibir metaloproteinase e colagenase do tipo iv.
CN1077885C (zh) * 1996-05-17 2002-01-16 沃尼尔·朗伯公司 联苯基磺酰胺基质金属蛋白酶抑制剂
EP0998572A2 (en) * 1997-07-25 2000-05-10 Du Pont Pharmaceuticals Company Aggrecan degrading metallo proteases
IL138725A0 (en) * 1998-04-03 2001-10-31 Sankyo Co Sulfonamide derivatives and pharmaceutical compositions containing the same
MXPA01008857A (es) * 1999-03-03 2002-07-02 Procter & Gamble Inhibidores de metaloproteasa dihetero sustituidos.
EP1165500A1 (en) * 1999-04-02 2002-01-02 Du Pont Pharmaceuticals Company Amide derivatives as inhibitors of matrix metalloproteinases,tnf-alpha,and aggrecanase
US6391610B1 (en) * 1999-08-06 2002-05-21 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
WO2001027084A1 (en) 1999-10-14 2001-04-19 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
KR100819680B1 (ko) * 2000-08-15 2008-04-04 아크조 노벨 엔.브이. 트리옥세판 화합물
CN1568306A (zh) * 2001-07-09 2005-01-19 酶系统产品公司/(Icn－生物医学公司) 抑制聚集蛋白聚糖酶活性的异羟肟酸血小板凝血酶敏感蛋白肽类似物
AU2003215070A1 (en) * 2002-02-05 2003-09-02 Wyeth Truncated aggrecanase molecules
EP1692124B1 (en) 2003-12-04 2008-10-15 Wyeth Biaryl sulfonamides as mmp inhibitors
CA2548513A1 (en) * 2003-12-04 2005-07-07 Wyeth Biaryl sulfonamides and methods for using same

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