CR8411A - Metodo para el tratamiento de la enfermedad asociada con adamts-5 - Google Patents

Metodo para el tratamiento de la enfermedad asociada con adamts-5

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Publication number
CR8411A
CR8411A CR8411A CR8411A CR8411A CR 8411 A CR8411 A CR 8411A CR 8411 A CR8411 A CR 8411A CR 8411 A CR8411 A CR 8411A CR 8411 A CR8411 A CR 8411A
Authority
CR
Costa Rica
Prior art keywords
adamts
treatment
disease associated
agent
disease
Prior art date
Application number
CR8411A
Other languages
English (en)
Inventor
A Morris Elisabeth
S Glasson Sonya
Shaoyun Xiang Jason
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR8411A publication Critical patent/CR8411A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

El presente invento se relaciona con metodos para tratar enfermedades asociadas con ADAMTS-5, en especial la osteoartritis, que consta de la administracion de un agente capaz de modular la actividad de ADAMTS-5 a un sujeto que presenta la enfermedad. El agente es preferiblemente un compuesto biarilsulfonamidico.
CR8411A 2003-12-04 2006-05-19 Metodo para el tratamiento de la enfermedad asociada con adamts-5 CR8411A (es)

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US7615363B2 (en) * 2005-08-25 2009-11-10 Wyeth Aggrecanase structure
US7625731B2 (en) * 2005-08-25 2009-12-01 Wyeth Aggrecanase structure
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RU2009118935A (ru) * 2006-10-20 2010-11-27 Мерк энд Ко., Инк. (US) Земещенные имидазолы в качестве модуляторов подтипа 3 бомбезиновых рецепторов
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EP2147684A1 (en) * 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
AU2013203591B2 (en) * 2009-05-01 2017-01-19 University Court Of The University Of Dundee Treatment or prophylaxis of proliferative conditions
SG177288A1 (en) * 2009-07-02 2012-02-28 Glaxo Group Ltd Polypeptides and method of treatment
WO2012116260A1 (en) * 2011-02-24 2012-08-30 Glaxo Group Limited Methods of identifying a patient population
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GB201312311D0 (en) 2013-07-09 2013-08-21 Uni I Oslo Uses of enzyme inhibitors
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US10377818B2 (en) 2015-01-30 2019-08-13 The Board Of Trustees Of The Leland Stanford Junior University Method of treating glioma
CN110997001A (zh) 2017-06-02 2020-04-10 默克专利股份有限公司 Mmp13结合免疫球蛋白
US11261260B2 (en) * 2017-06-02 2022-03-01 Merck Patent Gmbh ADAMTS binding immunoglobulins
IL270951B2 (en) 2017-06-02 2025-05-01 Merck Patent Gmbh ADAMTS5, MMP13 and aggrecan-binding polypeptides
KR20200118827A (ko) 2018-02-02 2020-10-16 마베릭스 온콜로지, 잉크. 젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트
CN111187289B (zh) * 2020-02-26 2021-03-23 湖南中大检测技术集团有限公司 一种过氧化氢荧光探针及其制备方法和应用
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