BRPI0417334A - proteìna nmb0928 e uso da mesma em formulações farmacêuticas - Google Patents

proteìna nmb0928 e uso da mesma em formulações farmacêuticas

Info

Publication number
BRPI0417334A
BRPI0417334A BRPI0417334-1A BRPI0417334A BRPI0417334A BR PI0417334 A BRPI0417334 A BR PI0417334A BR PI0417334 A BRPI0417334 A BR PI0417334A BR PI0417334 A BRPI0417334 A BR PI0417334A
Authority
BR
Brazil
Prior art keywords
formulations
nmb0928
protein
diseases
nmb0928 protein
Prior art date
Application number
BRPI0417334-1A
Other languages
English (en)
Inventor
Rolando Pajon Feyt
Gerardo Enrique Guillem Nieto
Gretel Sardi As Garcia
Lazaro Hiram Betancourt Nu Ez
Lila Rosa Castellanos Serra
Yasser Perera Negrin
Darien Garcia Diaz
Olivia Niebla Perez
Evelin Caballero Menendez
Sonia Gonzalez Blanco
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Publication of BRPI0417334A publication Critical patent/BRPI0417334A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"PROTEìNA NMB0928 E USO DA MESMA EM FORMULAçõES FARMACêUTICAS". A presente invenção refere-se ao uso de um novo antígeno para vacina aplicado como uma medida preventiva ou terapêutica contra doenças em geral, sendo essas doenças de origem bacteriana, viral, câncer correlato, ou outras origens. O objetivo técnico que esta invenção prossegue é o desenvolvimento de formulações com a capacidade de aumentar o espectro protetor de vacinas existentes e, portanto, expandindo-o contra diferentes patógenos. A fim de atingir esse objetivo a proteína NMB0928 foi isolada e identificada como um componente de preparações de membranas externas de Nelsseria meningitidis capaz de induzir atividade bactericida. Adicionalmente, o gene que codifica a proteína NMB0928 foi clonado e expresso, e o polipeptídeo foi purificado e sua imunogenicidade avaliada em modelos animais. Os dados de seqüência de genes homólogos mostraram, devido ao alto grau de conservação, seu alto valor como um antígeno alvo de uma resposta reativa de forma cruzada quando ele é apresentado por vias diferentes. Formulações resultantes desta invenção são de uso na indústria farmacêutica como formulações de vacina para uso humano.
BRPI0417334-1A 2003-12-03 2004-12-02 proteìna nmb0928 e uso da mesma em formulações farmacêuticas BRPI0417334A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU2002008620030286A CU23236A1 (es) 2003-12-03 2003-12-03 PROTEINA NMB0928 Y SU USO EN FORMULACIONES FARMACéUTICAS P
PCT/CU2004/000016 WO2005054282A1 (es) 2003-12-03 2004-12-02 Proteína nmb0928 y su uso en formulaciones farmaceuticas

Publications (1)

Publication Number Publication Date
BRPI0417334A true BRPI0417334A (pt) 2007-03-27

Family

ID=40091627

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417334-1A BRPI0417334A (pt) 2003-12-03 2004-12-02 proteìna nmb0928 e uso da mesma em formulações farmacêuticas

Country Status (16)

Country Link
US (1) US20070128230A1 (pt)
EP (1) EP1693379B1 (pt)
KR (1) KR20060124625A (pt)
CN (1) CN100549027C (pt)
AR (1) AR046937A1 (pt)
AT (1) ATE456573T1 (pt)
AU (1) AU2004294377A1 (pt)
BR (1) BRPI0417334A (pt)
CA (1) CA2547537A1 (pt)
CU (1) CU23236A1 (pt)
DE (1) DE602004025377D1 (pt)
NO (1) NO20063017L (pt)
NZ (1) NZ547521A (pt)
RU (1) RU2335505C2 (pt)
WO (1) WO2005054282A1 (pt)
ZA (1) ZA200604492B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU23549A1 (es) * 2005-12-29 2010-07-20 Ct Ingenieria Genetica Biotech Composiciones farmacéuticas que contienen la proteína nma0939
CU23575A1 (es) * 2006-03-31 2010-09-30 Ct Ingenieria Genetica Biotech Composición farmacéutica que comprende la proteína nmb0606
CU23572A1 (es) * 2006-03-31 2010-09-30 Ct Ingenieria Genetica Biotech Composición farmacéutica que comprende la proteína nmb0938
RS65362B1 (sr) 2016-09-02 2024-04-30 Sanofi Pasteur Inc Vakcina protiv neisseria meningitidis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4219821A1 (de) * 1992-06-17 1993-12-23 Boehringer Mannheim Gmbh Spezifischer Nachweis von Neisseria Gonorrhoeae
CU22559A1 (es) * 1996-01-17 1999-05-03 Ct Ingenieria Genetica Biotech Sistema de expresión de antígenos heterologos en e. coli como proteínas de fusión
EP2261347A3 (en) * 1998-05-01 2012-01-11 Novartis Vaccines and Diagnostics, Inc. Neisseria meningitidis antigens and compositions
GB9911683D0 (en) * 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9911692D0 (en) * 1999-05-19 1999-07-21 Chiron Spa Antigenic combinations
EP1226253A2 (en) * 1999-10-29 2002-07-31 Chiron S.P.A. Neisserial antigenic peptides
GB9928196D0 (en) * 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens

Also Published As

Publication number Publication date
AU2004294377A1 (en) 2005-06-16
CN100549027C (zh) 2009-10-14
CN1890261A (zh) 2007-01-03
KR20060124625A (ko) 2006-12-05
AR046937A1 (es) 2006-01-04
ZA200604492B (en) 2007-05-30
NO20063017L (no) 2006-09-01
DE602004025377D1 (de) 2010-03-18
NZ547521A (en) 2009-07-31
RU2335505C2 (ru) 2008-10-10
EP1693379A1 (en) 2006-08-23
CA2547537A1 (en) 2005-06-16
CU23236A1 (es) 2007-09-26
WO2005054282A1 (es) 2005-06-16
US20070128230A1 (en) 2007-06-07
EP1693379B1 (en) 2010-01-27
ATE456573T1 (de) 2010-02-15
RU2006123414A (ru) 2008-01-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.