BRPI0417542A - uso de chp como um inibidor de glutationa s-transferases e colágeno iv - Google Patents
uso de chp como um inibidor de glutationa s-transferases e colágeno ivInfo
- Publication number
- BRPI0417542A BRPI0417542A BRPI0417542-5A BRPI0417542A BRPI0417542A BR PI0417542 A BRPI0417542 A BR PI0417542A BR PI0417542 A BRPI0417542 A BR PI0417542A BR PI0417542 A BRPI0417542 A BR PI0417542A
- Authority
- BR
- Brazil
- Prior art keywords
- collagen
- glutathione
- chp
- transferases
- inhibitor
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title abstract 5
- 108010035532 Collagen Proteins 0.000 title abstract 5
- 102000005720 Glutathione transferase Human genes 0.000 title abstract 5
- 108010070675 Glutathione transferase Proteins 0.000 title abstract 5
- 229920001436 collagen Polymers 0.000 title abstract 5
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000003367 anti-collagen effect Effects 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- PMMYEEVYMWASQN-IMJSIDKUSA-N cis-4-Hydroxy-L-proline Chemical compound O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyrrole Compounds (AREA)
Abstract
"USO DE CHP COMO UM INIBIDOR DE GLUTATIONA S-TRANSFERASES E COLáGENO IV". A invenção se refere ao uso de cis hidroxiprolina para a inibição de glutationa s-transferases e colágeno IV, bem como a um processo, que é usado para reduzir a concentração de glutationa s-transferase e/ou colágeno IV in vitro ou in vivo, como também a redutores de anticolágeno IV/ colágeno IV ou a redutores de agentes de glutationa s-transferase/ glutationa s-transferase.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10359829A DE10359829A1 (de) | 2003-12-12 | 2003-12-12 | Verwendung von CHP als Inhibitor von Glutathion-S-Transferasen und Kollagen IV |
| PCT/DE2004/002762 WO2005056006A1 (de) | 2003-12-12 | 2004-12-13 | Verwendung von chp als inhibitor von glutathion-s-transferasen und kollagen iv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0417542A true BRPI0417542A (pt) | 2007-03-27 |
Family
ID=34672935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0417542-5A BRPI0417542A (pt) | 2003-12-12 | 2004-12-13 | uso de chp como um inibidor de glutationa s-transferases e colágeno iv |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20070099982A1 (pt) |
| EP (1) | EP1701720A1 (pt) |
| JP (1) | JP2007513895A (pt) |
| CN (1) | CN1889945A (pt) |
| AU (1) | AU2004296131A1 (pt) |
| BR (1) | BRPI0417542A (pt) |
| CA (1) | CA2548443A1 (pt) |
| DE (1) | DE10359829A1 (pt) |
| RU (1) | RU2006124794A (pt) |
| WO (1) | WO2005056006A1 (pt) |
| ZA (1) | ZA200605706B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110110286A (ko) * | 2009-01-30 | 2011-10-06 | 토야마 케미칼 컴퍼니 리미티드 | Ｎ-아실 안트라닐산 유도체 또는 그 염 |
| US10328051B2 (en) * | 2014-09-22 | 2019-06-25 | Zoser B. Salama | Proline or proline derivatives for the treatment of dementia |
| EP4304643A1 (en) * | 2021-03-11 | 2024-01-17 | Lapix Therapeutics, Inc. | Compositions and methods for reducing immune intolerance |
| JP7804370B2 (ja) | 2021-08-13 | 2026-01-22 | ラピックス セラピューティクス， インコーポレイテッド | 免疫不寛容を軽減し、自己免疫障害を治療するための組成物及び方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6153643A (en) * | 1984-11-05 | 2000-11-28 | Hoerrmann; Wilhelm | Anti-cancer-substance |
| CA1281288C (en) * | 1984-11-05 | 1991-03-12 | Wilhelm Hoerrmann | Tumor therapy |
| DE3518078A1 (de) * | 1985-05-20 | 1986-11-20 | Wilhelm Dr. 8127 Iffeldorf Hoerrmann | Arzneimittel, die derivate des prolin oder hydroxyprolin enthalten |
| US5665371A (en) * | 1985-05-20 | 1997-09-09 | Hoerrmann; Wilhelm | Medicines which contain derivatives of proline or hydroxyproline |
| JPS6388136A (ja) * | 1986-09-30 | 1988-04-19 | Advance Co Ltd | 発癌予防剤 |
| US5091171B2 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
| US5372807A (en) * | 1990-05-14 | 1994-12-13 | University Of Medicine And Dentistry Of New Jersey | Polymers containing antifibrotic agents, compositions containing such polymers, and methods of preparation and use |
| ES2152664T3 (es) * | 1996-03-11 | 2001-02-01 | Hoerrmann Wilhelm | Combinacion de cis-4-hidroxi-l-prolina y n-metil-cis-4-hidroxi-l-prolina para aplicacion como agente terapeutico, especialmente para el tratamiento contra el cancer. |
| US6420378B1 (en) * | 1999-10-15 | 2002-07-16 | Supergen, Inc. | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same |
-
2003
- 2003-12-12 DE DE10359829A patent/DE10359829A1/de not_active Withdrawn
-
2004
- 2004-12-13 RU RU2006124794/15A patent/RU2006124794A/ru not_active Application Discontinuation
- 2004-12-13 ZA ZA200605706A patent/ZA200605706B/en unknown
- 2004-12-13 WO PCT/DE2004/002762 patent/WO2005056006A1/de not_active Ceased
- 2004-12-13 JP JP2006543365A patent/JP2007513895A/ja not_active Withdrawn
- 2004-12-13 US US10/596,410 patent/US20070099982A1/en not_active Abandoned
- 2004-12-13 BR BRPI0417542-5A patent/BRPI0417542A/pt not_active IP Right Cessation
- 2004-12-13 AU AU2004296131A patent/AU2004296131A1/en not_active Abandoned
- 2004-12-13 CA CA002548443A patent/CA2548443A1/en not_active Abandoned
- 2004-12-13 EP EP04816271A patent/EP1701720A1/de not_active Withdrawn
- 2004-12-13 CN CNA2004800367053A patent/CN1889945A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200605706B (en) | 2008-03-26 |
| CN1889945A (zh) | 2007-01-03 |
| WO2005056006A1 (de) | 2005-06-23 |
| JP2007513895A (ja) | 2007-05-31 |
| DE10359829A1 (de) | 2005-07-21 |
| EP1701720A1 (de) | 2006-09-20 |
| US20070099982A1 (en) | 2007-05-03 |
| CA2548443A1 (en) | 2005-06-23 |
| RU2006124794A (ru) | 2008-01-20 |
| AU2004296131A1 (en) | 2005-06-23 |
| AU2004296131A2 (en) | 2005-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 8A, 9A, 10A, 11A E 12A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |