BRPI0417706A - métodos para aumentar o fluxo metabólico através da via pentose fosfato em um microorganismo, e para produzir um produto quimico fino, e microorganismo recombinante - Google Patents
métodos para aumentar o fluxo metabólico através da via pentose fosfato em um microorganismo, e para produzir um produto quimico fino, e microorganismo recombinanteInfo
- Publication number
- BRPI0417706A BRPI0417706A BRPI0417706-1A BRPI0417706A BRPI0417706A BR PI0417706 A BRPI0417706 A BR PI0417706A BR PI0417706 A BRPI0417706 A BR PI0417706A BR PI0417706 A BRPI0417706 A BR PI0417706A
- Authority
- BR
- Brazil
- Prior art keywords
- microorganism
- methods
- fine chemical
- increasing
- lysine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 244000005700 microbiome Species 0.000 title abstract 5
- 239000012847 fine chemical Substances 0.000 title abstract 3
- 230000002503 metabolic effect Effects 0.000 title abstract 2
- 230000004108 pentose phosphate pathway Effects 0.000 title 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 4
- 239000004472 Lysine Substances 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 102000057621 Glycerol kinases Human genes 0.000 abstract 2
- 108700016170 Glycerol kinases Proteins 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 abstract 2
- 241000186216 Corynebacterium Species 0.000 abstract 1
- 241000186226 Corynebacterium glutamicum Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229930091371 Fructose Natural products 0.000 abstract 1
- 239000005715 Fructose Substances 0.000 abstract 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- QVLTXCYWHPZMCA-UHFFFAOYSA-N po4-po4 Chemical compound OP(O)(O)=O.OP(O)(O)=O QVLTXCYWHPZMCA-UHFFFAOYSA-N 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"MéTODOS PARA AUMENTAR O FLUXO METABóLICO ATRAVéS DA VIA PENTOSE FOSFATO EM UM MICROORGANISMO, E PARA PRODUZIR UM PRODUTO QUIMICO FINO, E MICROORGANISMO RECOMBINANTE". A presente invenção refere-se a métodos de aumento da produção de um produto químico fino, por exemplo lisina, a partir de um microorganismo, por exemplo Corynebacterium, por meio de des-regulação de um gene codificando enzima, isto é, glicerol quinase. Em uma forma de realização preferida, a invenção provê métodos de aumento da produção de lisina em Corynebacterium glutamicum por meio de aumento da expressão de atividade de glicerol quinase. A invenção também provê um novo processo para a produção de lisina por meio de regulação de fluxo de carbono para oxaloacetato (OAA). Em uma forma de realização preferida, a invenção provê métodos para a produção de lisina por meio de utilização de frutose ou sacarose como uma fonte de carbono.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB0306464 | 2003-12-18 | ||
| PCT/IB2004/004463 WO2005121349A2 (en) | 2003-12-18 | 2004-12-17 | Methods for the preparation of a fine chemical by fermentation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0417706A true BRPI0417706A (pt) | 2007-03-20 |
Family
ID=34957140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0417706-1A BRPI0417706A (pt) | 2003-12-18 | 2004-12-17 | métodos para aumentar o fluxo metabólico através da via pentose fosfato em um microorganismo, e para produzir um produto quimico fino, e microorganismo recombinante |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080038787A1 (pt) |
| EP (1) | EP1704241A2 (pt) |
| JP (1) | JP2007514439A (pt) |
| KR (1) | KR20070026354A (pt) |
| AR (1) | AR047058A1 (pt) |
| AU (1) | AU2004320598A1 (pt) |
| BR (1) | BRPI0417706A (pt) |
| CA (1) | CA2546847A1 (pt) |
| MX (1) | MXPA06006859A (pt) |
| NO (1) | NO20062447L (pt) |
| RU (1) | RU2006125498A (pt) |
| TW (1) | TW200532023A (pt) |
| WO (1) | WO2005121349A2 (pt) |
| ZA (1) | ZA200605865B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005047596A1 (de) * | 2005-10-05 | 2007-04-12 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| EP1873246A1 (en) * | 2006-06-26 | 2008-01-02 | DSMIP Assets B.V. | Biological process using a transaldolase |
| US9109242B2 (en) | 2006-09-15 | 2015-08-18 | Cj Cheiljedang Corporation | Corynebacteria having enhanced L-lysine productivity and a method of producing L-lysine using the same |
| KR100838035B1 (ko) | 2006-12-29 | 2008-06-12 | 씨제이제일제당 (주) | Ｌ-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용한 ｌ-라이신 생산 방법 |
| KR100838038B1 (ko) | 2006-12-29 | 2008-06-12 | 씨제이제일제당 (주) | Ｌ-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용한 ｌ-라이신 생산 방법 |
| KR100830826B1 (ko) | 2007-01-24 | 2008-05-19 | 씨제이제일제당 (주) | 코리네박테리아를 이용하여 글리세롤을 포함한탄소원으로부터 발효산물을 생산하는 방법 |
| KR100924904B1 (ko) * | 2007-11-20 | 2009-11-02 | 씨제이제일제당 (주) | 글리세롤을 포함한 탄소원을 이용할 수 있는코리네박테리아 및 이를 이용하여 발효산물을 생산하는방법 |
| KR101126041B1 (ko) | 2008-04-10 | 2012-03-19 | 씨제이제일제당 (주) | 트랜스포존을 이용한 형질전환용 벡터, 상기 벡터로형질전환된 미생물 및 이를 이용한 ｌ-라이신 생산방법 |
| US8932861B2 (en) | 2008-04-10 | 2015-01-13 | Cj Cheiljedang Corporation | Transformation vector comprising transposon, microorganisms transformed with the vector, and method for producing L-lysine using the microorganism |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| KR102115497B1 (ko) | 2009-04-30 | 2020-05-26 | 게노마티카 인코포레이티드 | 1,3-부탄다이올 생산 유기체 |
| US8143036B2 (en) * | 2009-05-11 | 2012-03-27 | Industrial Technology Research Institute | Genetically modified microorganisms for producing itaconic acid with high yields |
| CA2783096A1 (en) * | 2009-12-10 | 2011-06-16 | Genomatica, Inc. | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol |
| WO2013059218A1 (en) | 2011-10-17 | 2013-04-25 | William Marsh Rice University | Bacteria and method for synthesizing fatty acids |
| WO2013164834A1 (en) * | 2012-05-04 | 2013-11-07 | Phyto Biotech Pvt. Ltd. | Cost-effective process for commercial production of paclitaxel |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US20220162655A1 (en) * | 2019-03-26 | 2022-05-26 | Zymergen Inc. | Engineered biosynthetic pathways for production of l-homocysteine by fermentation |
| CN116286571A (zh) * | 2022-12-30 | 2023-06-23 | 青岛康小鹿生物科技有限公司 | 一种产l-赖氨酸的重组基因工程菌及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK18872001A3 (sk) * | 1999-06-25 | 2002-12-03 | Basf Aktiengesellschaft | Gény Corynebacterium glutamicum kódujúce proteíny zapojené do metabolizmu uhlíka a produkcie energie |
| WO2001007626A2 (en) * | 1999-07-23 | 2001-02-01 | Archer-Daniels-Midland Company | Methods for producing l-amino acids by increasing cellular nadph |
| ATE513036T1 (de) * | 2001-04-04 | 2011-07-15 | Danisco Us Inc | Entkoppelte anabole und katabole stoffwechselwege in wirtszellen |
| CN101126075B (zh) * | 2001-08-06 | 2012-05-09 | 赢创德固赛有限公司 | 生产化合物ⅱ的棒状细菌 |
-
2004
- 2004-12-17 CA CA002546847A patent/CA2546847A1/en not_active Abandoned
- 2004-12-17 US US10/579,693 patent/US20080038787A1/en not_active Abandoned
- 2004-12-17 KR KR1020067014060A patent/KR20070026354A/ko not_active Ceased
- 2004-12-17 WO PCT/IB2004/004463 patent/WO2005121349A2/en not_active Ceased
- 2004-12-17 JP JP2006544606A patent/JP2007514439A/ja not_active Withdrawn
- 2004-12-17 EP EP04822067A patent/EP1704241A2/en not_active Withdrawn
- 2004-12-17 MX MXPA06006859A patent/MXPA06006859A/es not_active Application Discontinuation
- 2004-12-17 BR BRPI0417706-1A patent/BRPI0417706A/pt not_active IP Right Cessation
- 2004-12-17 TW TW093139530A patent/TW200532023A/zh unknown
- 2004-12-17 AU AU2004320598A patent/AU2004320598A1/en not_active Abandoned
- 2004-12-17 RU RU2006125498/13A patent/RU2006125498A/ru not_active Application Discontinuation
- 2004-12-17 AR ARP040104742A patent/AR047058A1/es not_active Application Discontinuation
-
2006
- 2006-05-30 NO NO20062447A patent/NO20062447L/no not_active Application Discontinuation
- 2006-07-17 ZA ZA200605865A patent/ZA200605865B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004320598A1 (en) | 2005-12-22 |
| US20080038787A1 (en) | 2008-02-14 |
| AR047058A1 (es) | 2006-01-04 |
| NO20062447L (no) | 2006-09-14 |
| ZA200605865B (en) | 2008-07-30 |
| RU2006125498A (ru) | 2008-01-27 |
| KR20070026354A (ko) | 2007-03-08 |
| TW200532023A (en) | 2005-10-01 |
| WO2005121349A3 (en) | 2006-04-13 |
| EP1704241A2 (en) | 2006-09-27 |
| MXPA06006859A (es) | 2007-01-26 |
| CA2546847A1 (en) | 2005-12-22 |
| JP2007514439A (ja) | 2007-06-07 |
| WO2005121349A2 (en) | 2005-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A E 6A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011. |