BRPI0417773A - métodos para aumentar o fluxo metabólico através da via de pentose fosfato em um microorganismo e para produzir uma substáncia quìmica fina, e, microorganismo recombinante - Google Patents
métodos para aumentar o fluxo metabólico através da via de pentose fosfato em um microorganismo e para produzir uma substáncia quìmica fina, e, microorganismo recombinanteInfo
- Publication number
- BRPI0417773A BRPI0417773A BRPI0417773-8A BRPI0417773A BRPI0417773A BR PI0417773 A BRPI0417773 A BR PI0417773A BR PI0417773 A BRPI0417773 A BR PI0417773A BR PI0417773 A BRPI0417773 A BR PI0417773A
- Authority
- BR
- Brazil
- Prior art keywords
- microorganism
- methods
- lysine
- production
- increasing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 244000005700 microbiome Species 0.000 title abstract 5
- 239000012847 fine chemical Substances 0.000 title abstract 2
- 230000002503 metabolic effect Effects 0.000 title abstract 2
- 230000004108 pentose phosphate pathway Effects 0.000 title 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 4
- 239000004472 Lysine Substances 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 102000003855 L-lactate dehydrogenase Human genes 0.000 abstract 2
- 108700023483 L-lactate dehydrogenases Proteins 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 abstract 2
- 241000186216 Corynebacterium Species 0.000 abstract 1
- 241000186226 Corynebacterium glutamicum Species 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 239000005715 Fructose Substances 0.000 abstract 1
- 229930091371 Fructose Natural products 0.000 abstract 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"MéTODOS PARA AUMENTAR O FLUXO METABóLICO ATRAVéS DA VIA DE PENTOSE FOSFATO EM UM MICROORGANISMO E PARA PRODUZIR UMA SUBSTáNCIA QUìMICA FINA, E, MICROORGANISMO RECOMBINANTE". A presente invenção caracteriza os métodos de aumentar a produção de uma substância química fina, por exemplo, lisina de um microorganismo, por exemplo, Corynebacterium a fim de desregular um gene que codifica enzima, isto é, a lactato desidrogenase. Em uma forma de realização preferida, a invenção fornece métodos de aumentar a produção de lisina em Corynebacterium glutamicum a fim de aumentar a expressão da atividade da lactato desidrogenase. A invenção também fornece um novo processo para a produção de lisina a fim de regular o fluxo de carbono sobre o oxaloacetato (OAA). Em uma forma de realização preferida, a invenção fornece métodos para a produção de lisina a fim de utilizar frutose ou sacarose como uma fonte de carbono.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB0306435 | 2003-12-18 | ||
| PCT/IB2004/004426 WO2005059154A2 (en) | 2003-12-18 | 2004-12-17 | Methods for the preparation of a fine chemical by fermentation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0417773A true BRPI0417773A (pt) | 2007-03-20 |
Family
ID=34685564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0417773-8A BRPI0417773A (pt) | 2003-12-18 | 2004-12-17 | métodos para aumentar o fluxo metabólico através da via de pentose fosfato em um microorganismo e para produzir uma substáncia quìmica fina, e, microorganismo recombinante |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20070134768A1 (pt) |
| EP (1) | EP1697532A2 (pt) |
| JP (1) | JP2007514436A (pt) |
| KR (1) | KR20070026355A (pt) |
| AU (1) | AU2004299728A1 (pt) |
| BR (1) | BRPI0417773A (pt) |
| CA (1) | CA2548125A1 (pt) |
| MX (1) | MXPA06006758A (pt) |
| NO (1) | NO20062685L (pt) |
| RU (1) | RU2006125503A (pt) |
| TW (1) | TW200602486A (pt) |
| WO (1) | WO2005059154A2 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7326546B2 (en) * | 2005-03-10 | 2008-02-05 | Ajinomoto Co., Inc. | Purine-derived substance-producing bacterium and a method for producing purine-derived substance |
| US8048649B2 (en) * | 2007-09-26 | 2011-11-01 | Archer Daniels Midland Company | Production of amino acids from sucrose in Corynebacterium glutamicum |
| US20090238920A1 (en) * | 2008-03-21 | 2009-09-24 | Lewis Ted C | Process for making high grade protein product |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| TWI385596B (en) * | 2008-11-12 | 2013-02-11 | Image signal filtering device and the method therefore | |
| MY176050A (en) | 2009-04-30 | 2020-07-22 | Genomatica Inc | Organisms for the production of 1,3-butanediol |
| KR20120120493A (ko) * | 2009-12-10 | 2012-11-01 | 게노마티카 인코포레이티드 | 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체 |
| CN102250764B (zh) * | 2010-05-19 | 2013-06-26 | 华东理工大学 | 微型全息式生物传感反应器系统 |
| US9644220B2 (en) | 2011-12-22 | 2017-05-09 | Basf Se | Processes and recombinant microorganisms for the production of fine chemicals |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US12600991B2 (en) | 2019-04-12 | 2026-04-14 | Green Earth Institute Co., Ltd. | Genetically modified microorganism for production of aspartic acid and downstream metabolites from aspartic acid as target substance, and method for producing target substance using same |
| CN110791535A (zh) * | 2019-12-02 | 2020-02-14 | 齐齐哈尔龙江阜丰生物科技有限公司 | 一种生产和提取赖氨酸的工艺 |
| KR102433234B1 (ko) * | 2020-09-29 | 2022-08-18 | 대상 주식회사 | L-시트룰린 생산능이 향상된 코리네박테리움 글루타미쿰 변이주 및 이를 이용한 l-시트룰린의 생산 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4074365B2 (ja) * | 1998-01-28 | 2008-04-09 | 三菱化学株式会社 | ラクテートデヒドロゲナーゼ遺伝子及び該遺伝子破壊株 |
| KR100878336B1 (ko) * | 1999-06-25 | 2009-01-14 | 백광산업 주식회사 | 탄소 대사 및 에너지 생산과 관련된 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자 |
| CA2377693C (en) * | 1999-07-23 | 2016-11-08 | Archer-Daniels-Midland Company | Methods for producing l-amino acids |
| DE10044681A1 (de) * | 2000-09-09 | 2002-03-21 | Degussa | Neue für das lldD2-Gen kodierende Nukleotidsequenzen |
| CA2456416A1 (en) * | 2001-08-06 | 2003-02-20 | Degussa Ag | Coryneform bacteria which produce chemical compounds ii |
-
2004
- 2004-12-17 BR BRPI0417773-8A patent/BRPI0417773A/pt not_active IP Right Cessation
- 2004-12-17 EP EP04817627A patent/EP1697532A2/en not_active Withdrawn
- 2004-12-17 CA CA002548125A patent/CA2548125A1/en not_active Abandoned
- 2004-12-17 JP JP2006544603A patent/JP2007514436A/ja not_active Withdrawn
- 2004-12-17 MX MXPA06006758A patent/MXPA06006758A/es not_active Application Discontinuation
- 2004-12-17 US US10/579,648 patent/US20070134768A1/en not_active Abandoned
- 2004-12-17 RU RU2006125503/13A patent/RU2006125503A/ru not_active Application Discontinuation
- 2004-12-17 WO PCT/IB2004/004426 patent/WO2005059154A2/en not_active Ceased
- 2004-12-17 TW TW093139527A patent/TW200602486A/zh unknown
- 2004-12-17 KR KR1020067014061A patent/KR20070026355A/ko not_active Ceased
- 2004-12-17 AU AU2004299728A patent/AU2004299728A1/en not_active Abandoned
-
2006
- 2006-06-09 NO NO20062685A patent/NO20062685L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200602486A (en) | 2006-01-16 |
| AU2004299728A1 (en) | 2005-06-30 |
| WO2005059154A3 (en) | 2005-10-13 |
| KR20070026355A (ko) | 2007-03-08 |
| US20070134768A1 (en) | 2007-06-14 |
| JP2007514436A (ja) | 2007-06-07 |
| EP1697532A2 (en) | 2006-09-06 |
| MXPA06006758A (es) | 2007-01-26 |
| WO2005059154A2 (en) | 2005-06-30 |
| RU2006125503A (ru) | 2008-01-27 |
| CA2548125A1 (en) | 2005-06-30 |
| NO20062685L (no) | 2006-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A E 6A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011. |