BRPI0418194A - compostos peptìdeos liberadores de gastrina aperfeiçoados - Google Patents
compostos peptìdeos liberadores de gastrina aperfeiçoadosInfo
- Publication number
- BRPI0418194A BRPI0418194A BRPI0418194-8A BRPI0418194A BRPI0418194A BR PI0418194 A BRPI0418194 A BR PI0418194A BR PI0418194 A BRPI0418194 A BR PI0418194A BR PI0418194 A BRPI0418194 A BR PI0418194A
- Authority
- BR
- Brazil
- Prior art keywords
- releasing peptide
- compounds
- peptide compounds
- improved
- patient
- Prior art date
Links
- PUBCCFNQJQKCNC-XKNFJVFFSA-N gastrin-releasingpeptide Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)C1=CNC=N1 PUBCCFNQJQKCNC-XKNFJVFFSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000003384 imaging method Methods 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 239000002738 chelating agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 238000001126 phototherapy Methods 0.000 abstract 1
- 230000003439 radiotherapeutic effect Effects 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0493—Steroids, e.g. cholesterol, testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57572—Gastrin releasing peptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
"COMPOSTOS PEPTìDEOS LIBERADORES DE GASTRINA APERFEIçOADOS". A presente invenção se refere a novos compostos aperfeiçoados para uso no diagnóstico de imagem ou terapia que tem a fórmula M-N-O-P-G, na qual M é uma etiqueta ótica ou um quelator do metal (na forma complexada com um radionuclídeo metal ou não), N-O-P são ligantes e G é o peptídeo alvo receptor GRP. Os métodos para obter a imagem de um paciente e/ou fornecer radioterapia ou fototerapia a um paciente que usa os compostos da invenção são também fornecidos. Os métodos e kits para preparar um agente radioterapêutico são adicionalmente fornecidos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2003/041328 WO2004065407A2 (en) | 2003-01-13 | 2003-12-24 | Improved gastrin releasing peptide compounds |
| US10/828,925 US7611692B2 (en) | 2003-01-13 | 2004-04-20 | Gastrin releasing peptide compounds |
| PCT/US2004/022115 WO2005067983A1 (en) | 2003-12-24 | 2004-07-12 | Improved gastrin releasing peptide compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0418194A true BRPI0418194A (pt) | 2007-04-27 |
Family
ID=36928823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0418194-8A BRPI0418194A (pt) | 2003-12-24 | 2004-07-12 | compostos peptìdeos liberadores de gastrina aperfeiçoados |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1706154A4 (pt) |
| JP (1) | JP2008501627A (pt) |
| KR (1) | KR20060121244A (pt) |
| AU (1) | AU2004314112A1 (pt) |
| BR (1) | BRPI0418194A (pt) |
| CA (1) | CA2549318A1 (pt) |
| IL (1) | IL175785A0 (pt) |
| RU (1) | RU2006126637A (pt) |
| WO (1) | WO2005067983A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3153267A1 (en) * | 2019-12-19 | 2021-06-24 | Hans-Jurgen Wester | Modified grpr antagonist peptides for imaging and therapy of cancer |
| KR102456989B1 (ko) * | 2020-06-12 | 2022-10-21 | (주)케어젠 | 항비만 활성을 가지는 디옥시콜산-펩타이드 결합체 및 이의 용도 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX174467B (es) * | 1986-01-23 | 1994-05-17 | Squibb & Sons Inc | 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos |
| US5723578A (en) * | 1987-09-24 | 1998-03-03 | The Administrators Of Tulane Educational Fund | Peptide analogs of bombesin |
| US5877277A (en) * | 1987-09-24 | 1999-03-02 | Biomeasure, Inc. | Octapeptide bombesin analogs |
| US6875864B2 (en) * | 1991-08-01 | 2005-04-05 | Bracco International B.V. | Aminocarboxylate ligands having substituted aromatic amide moieties |
| IT1269839B (it) * | 1994-05-26 | 1997-04-15 | Bracco Spa | Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi |
| CA2346154A1 (en) * | 2001-05-02 | 2002-11-02 | University Of Missouri | Gastrin receptor-avid peptide conjugates |
| IT1304501B1 (it) * | 1998-12-23 | 2001-03-19 | Bracco Spa | Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza |
| WO2001062777A1 (en) * | 2000-02-24 | 2001-08-30 | Dabur Research Foundation | Bombesin analogs for treatment of cancer |
| AU2003303714B2 (en) * | 2003-01-13 | 2009-02-19 | Bracco Imaging S.P.A. | Improved linkers for radiopharmaceutical compounds |
| US7226577B2 (en) * | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
-
2004
- 2004-07-12 BR BRPI0418194-8A patent/BRPI0418194A/pt not_active IP Right Cessation
- 2004-07-12 WO PCT/US2004/022115 patent/WO2005067983A1/en not_active Ceased
- 2004-07-12 AU AU2004314112A patent/AU2004314112A1/en not_active Withdrawn
- 2004-07-12 CA CA002549318A patent/CA2549318A1/en not_active Abandoned
- 2004-07-12 RU RU2006126637/04A patent/RU2006126637A/ru not_active Application Discontinuation
- 2004-07-12 KR KR1020067012647A patent/KR20060121244A/ko not_active Ceased
- 2004-07-12 EP EP04777906A patent/EP1706154A4/en not_active Withdrawn
- 2004-07-12 JP JP2006546954A patent/JP2008501627A/ja not_active Withdrawn
-
2006
- 2006-05-21 IL IL175785A patent/IL175785A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004314112A1 (en) | 2005-07-28 |
| KR20060121244A (ko) | 2006-11-28 |
| EP1706154A4 (en) | 2008-11-26 |
| RU2006126637A (ru) | 2008-01-27 |
| WO2005067983A1 (en) | 2005-07-28 |
| IL175785A0 (en) | 2006-10-05 |
| JP2008501627A (ja) | 2008-01-24 |
| EP1706154A1 (en) | 2006-10-04 |
| CA2549318A1 (en) | 2005-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2143 DE 31/01/2012. |