BRPI0418332A - adjuvantes vacinais, formulação vacinal, uso da formulação vacinal e esquema de imunização - Google Patents
adjuvantes vacinais, formulação vacinal, uso da formulação vacinal e esquema de imunizaçãoInfo
- Publication number
- BRPI0418332A BRPI0418332A BRPI0418332-0A BRPI0418332A BRPI0418332A BR PI0418332 A BRPI0418332 A BR PI0418332A BR PI0418332 A BRPI0418332 A BR PI0418332A BR PI0418332 A BRPI0418332 A BR PI0418332A
- Authority
- BR
- Brazil
- Prior art keywords
- vaccine
- formulation
- derivatives
- adjuvants
- vacinal
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 238000009472 formulation Methods 0.000 title abstract 6
- 229960005486 vaccine Drugs 0.000 title abstract 4
- 238000002649 immunization Methods 0.000 title abstract 2
- 230000003053 immunization Effects 0.000 title abstract 2
- 239000012646 vaccine adjuvant Substances 0.000 title abstract 2
- 229940124931 vaccine adjuvant Drugs 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 108010030416 proteoliposomes Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 1
- 230000007402 cytotoxic response Effects 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 229940021993 prophylactic vaccine Drugs 0.000 abstract 1
- 239000003725 proteoliposome Substances 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
- 229940021747 therapeutic vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
ADJUVANTES VACINAIS, FORMULAçãO VACINAL, USO DA FORMULAçãO VACINAL E ESQUEMA DE IMUNIZAçãO A presente invenção se relaciona com o campo das composições vacinais para o tratamento efetivo ou prevenção de infecções fúngicas, virais, protozoárias ou bacterianas (preferivelmente intracelulares) e câncer. O objetivo técnico que se persegue é obter adjuvantes para uso em vacinas profiláticas ou terapêuticas utilizando proteolipossomas bacterianos e derivados destes, que ao serem aplicados junto a antígenos inseridos em sua estrutura, conjugados o mesclados a estes induzam uma resposta de linfócitos T citotóxica contra dito antígeno. Desta forma obtém-se formulações múltiplas do proteolipossoma ou seus derivados com antígenos heterológos, que ao serem aplicados por via parenteral ou mucosal (preferentemente nasal) induzem respostas citotóxicas. Este novo uso dos proteolipossomas e seus derivados e as formulações antigênicas resultantes são aplicáveis á obtenção de novas vacinas na indústria farmacêutica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20030312A CU23420A1 (es) | 2003-12-30 | 2003-12-30 | Proteoliposomas y sus derivados como adyuvantes inductores de respuesta citotóxica y las formulaciones resultantes |
| PCT/CU2004/000017 WO2005063287A1 (es) | 2003-12-30 | 2004-12-28 | Proteoliposomas y sus derivados como adyuvantes inductores de respuesta citotóxica y las formulaciones resultantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0418332A true BRPI0418332A (pt) | 2008-02-06 |
Family
ID=34716104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0418332-0A BRPI0418332A (pt) | 2003-12-30 | 2004-12-28 | adjuvantes vacinais, formulação vacinal, uso da formulação vacinal e esquema de imunização |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1716866A1 (pt) |
| KR (1) | KR20070036020A (pt) |
| AR (1) | AR051059A1 (pt) |
| AU (1) | AU2004308553A1 (pt) |
| BR (1) | BRPI0418332A (pt) |
| CA (1) | CA2552271A1 (pt) |
| CU (1) | CU23420A1 (pt) |
| ES (1) | ES2301418B1 (pt) |
| UY (1) | UY28706A1 (pt) |
| WO (1) | WO2005063287A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU20080215A7 (es) | 2008-11-19 | 2012-06-21 | Inst Finlay | Vacunas unitemporales |
| CU20100083A7 (es) | 2010-05-05 | 2012-06-21 | Inst Finlay | Tolerogenos adyuvados como vacuna de malaria |
| CU20110202A7 (es) | 2011-11-02 | 2013-12-27 | Inst Finlay Ct De Investigación Producción De Sueros Y Vacunas | Composición inmunogénica de polisacáridos planos adyuvados y las formulaciones resultantes |
| EP2689775A1 (en) | 2012-07-25 | 2014-01-29 | Instituto Finlay, Centro de Investigacion-Produccion de vacunas y sueros | Cochleate with only one mamp |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01125328A (ja) * | 1987-07-30 | 1989-05-17 | Centro Natl De Biopreparados | 髄膜炎菌ワクチン |
| GB2282379A (en) * | 1993-09-30 | 1995-04-05 | Merck & Co Inc | Conjugates of epitopes of HIV with a protein complex from Neisseria |
| ATE489968T1 (de) * | 2001-03-09 | 2010-12-15 | Id Biomedical Corp Quebec | Proteosom-liposaccharid-vakzine-adjuvans |
| CU22983A1 (es) * | 2002-05-08 | 2004-09-09 | Inst Finlay | Composición vacunal contra las alergias y método para su obtención y empleo en el tratamiento de las mismas |
-
2003
- 2003-12-30 CU CU20030312A patent/CU23420A1/es unknown
-
2004
- 2004-12-28 EP EP04802609A patent/EP1716866A1/en not_active Ceased
- 2004-12-28 BR BRPI0418332-0A patent/BRPI0418332A/pt not_active Application Discontinuation
- 2004-12-28 WO PCT/CU2004/000017 patent/WO2005063287A1/es not_active Ceased
- 2004-12-28 ES ES200650046A patent/ES2301418B1/es not_active Expired - Fee Related
- 2004-12-28 CA CA002552271A patent/CA2552271A1/en not_active Abandoned
- 2004-12-28 AU AU2004308553A patent/AU2004308553A1/en not_active Abandoned
- 2004-12-28 KR KR1020067014392A patent/KR20070036020A/ko not_active Ceased
- 2004-12-29 AR ARP040104938A patent/AR051059A1/es unknown
- 2004-12-30 UY UY28706A patent/UY28706A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2301418B1 (es) | 2009-05-01 |
| AR051059A1 (es) | 2006-12-20 |
| UY28706A1 (es) | 2005-08-31 |
| WO2005063287A1 (es) | 2005-07-14 |
| AU2004308553A1 (en) | 2005-07-14 |
| CU23420A1 (es) | 2009-09-08 |
| EP1716866A1 (en) | 2006-11-02 |
| CA2552271A1 (en) | 2005-07-14 |
| ES2301418A1 (es) | 2008-06-16 |
| KR20070036020A (ko) | 2007-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |