BRPI0418582A - opioid delivery system - Google Patents

opioid delivery system

Info

Publication number
BRPI0418582A
BRPI0418582A BRPI0418582-0A BRPI0418582A BRPI0418582A BR PI0418582 A BRPI0418582 A BR PI0418582A BR PI0418582 A BRPI0418582 A BR PI0418582A BR PI0418582 A BRPI0418582 A BR PI0418582A
Authority
BR
Brazil
Prior art keywords
opioid
administration
formulation
pulmonary
delivery system
Prior art date
Application number
BRPI0418582-0A
Other languages
Portuguese (pt)
Inventor
Orlando Ricardo Hung
Steven Louis Shafer
Diana Helen Pliura
Original Assignee
Delex Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2004/000303 external-priority patent/WO2004075879A1/en
Application filed by Delex Therapeutics Inc filed Critical Delex Therapeutics Inc
Priority claimed from PCT/CA2004/001578 external-priority patent/WO2005082369A1/en
Publication of BRPI0418582A publication Critical patent/BRPI0418582A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

SISTEMA DE ADMINISTRAçãO DE OPIóIDES Uma formulação de opióide para administração pulmonar no tratamento ou gerenciamento de dor, que contém um dispositivo de administração de fármaco pulmonar, método de administração, que contém um kit e usos da mesma. A formulação contém pelo menos um opióide de início rápido e preferivelmente também contém um opióide de efeito prolongado para reduzir a freqüêcia de administração. A invenção emprega os efeitos colaterais da formulação de opióide para permitir que os pacientes autolimitem a ingestão de fámaco e, com evite a toxicidade enquanto se atinge analgesia. Emprega-se um modelo farmacocinético e farmacodinâmico para determinar as formulações de fármaco ideais e os parâmetros ideais para administração.OPIOID ADMINISTRATION SYSTEM An opioid formulation for pulmonary administration in the treatment or management of pain, which contains a pulmonary drug delivery device, method of administration, which contains a kit and uses thereof. The formulation contains at least one rapid onset opioid and preferably also contains a long acting opioid to reduce the frequency of administration. The invention employs the side effects of the opioid formulation to allow patients to self-limit drug intake and to avoid toxicity while achieving analgesia. A pharmacokinetic and pharmacodynamic model is employed to determine the ideal drug formulations and the optimal parameters for administration.

BRPI0418582-0A 2003-02-28 2004-08-27 opioid delivery system BRPI0418582A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45033303P 2003-02-28 2003-02-28
PCT/CA2004/000303 WO2004075879A1 (en) 2003-02-28 2004-03-01 Opioid delivery system
PCT/CA2004/001578 WO2005082369A1 (en) 2003-02-28 2004-08-27 Opioid delivery system

Publications (1)

Publication Number Publication Date
BRPI0418582A true BRPI0418582A (en) 2007-06-19

Family

ID=40635740

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418582-0A BRPI0418582A (en) 2003-02-28 2004-08-27 opioid delivery system

Country Status (1)

Country Link
BR (1) BRPI0418582A (en)

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: YM BIOSCIENCES INC. (CA)

Free format text: TRANSFERIDO DE: DELEX THERAPEUTICS INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.