BRPI0500235A - Compostos de benzotiadiazina fluorada, um processo para sua preparação e composições farmacêuticas contendo os mesmos - Google Patents

Compostos de benzotiadiazina fluorada, um processo para sua preparação e composições farmacêuticas contendo os mesmos

Info

Publication number
BRPI0500235A
BRPI0500235A BR0500235-4A BRPI0500235A BRPI0500235A BR PI0500235 A BRPI0500235 A BR PI0500235A BR PI0500235 A BRPI0500235 A BR PI0500235A BR PI0500235 A BRPI0500235 A BR PI0500235A
Authority
BR
Brazil
Prior art keywords
optionally substituted
preparation
pharmaceutical compositions
compositions containing
alkyl
Prior art date
Application number
BR0500235-4A
Other languages
English (en)
Inventor
Pierre Francotte
Pierre Fraikin
Pascal De Tullio
Bernard Pirotte
Pierre Lestage
Laurence Danober
Daniel Henri Caignard
Pierre Renard
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0500235A publication Critical patent/BRPI0500235A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A62—LIFE-SAVING; FIRE-FIGHTING
    • A62C—FIRE-FIGHTING
    • A62C13/00—Portable extinguishers which are permanently pressurised or pressurised immediately before use
    • A62C13/76—Details or accessories
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Emergency Management (AREA)
  • Business, Economics & Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSTOS DE BENZOTIADIAZINA FLUORADA, UM PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS". Compostos de fórmula (I) na qual: R~ F~ representa um grupo alquila monoflúor ou poliflúor ou cicloalquilalquila monoflúor ou poliflúor, R~ 1~ representa um átomo de hidrogênio ou um grupo selecionado de alquilaminocarbonila e alquila opcionalmente substituída, R~ 2~ representa um átomo de hidrogênio ou de halogênio ou um grupo selecionado de cicloalquila e alquila opcionalmente substituída, R~ 3~ a R~ 6~, que podem ser iguais ou diferentes, cada um representa um átomo ou grupo selecionado de átomos de hidrogênio e halogênio e dos grupos nitro, ciano, alquilsulfonila, hidróxi, alcóxi, alquila opcionalmente substituída e amino opcionalmente substituído, e também seus sais de adição com um ácido ou base farmaceuticamente aceitável e seus isómeros óticos quando estes existirem. A invenção refere-se também a medicamentos.
BR0500235-4A 2004-01-26 2005-01-26 Compostos de benzotiadiazina fluorada, um processo para sua preparação e composições farmacêuticas contendo os mesmos BRPI0500235A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0400689A FR2865474B1 (fr) 2004-01-26 2004-01-26 Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BRPI0500235A true BRPI0500235A (pt) 2005-09-06

Family

ID=34630671

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0500235-4A BRPI0500235A (pt) 2004-01-26 2005-01-26 Compostos de benzotiadiazina fluorada, um processo para sua preparação e composições farmacêuticas contendo os mesmos

Country Status (19)

Country Link
US (1) US7268129B2 (pt)
EP (1) EP1557412A1 (pt)
JP (1) JP4291786B2 (pt)
KR (1) KR100668195B1 (pt)
CN (1) CN1308317C (pt)
AR (1) AR047455A1 (pt)
AU (1) AU2005200311A1 (pt)
BR (1) BRPI0500235A (pt)
CA (1) CA2492161C (pt)
EA (1) EA009698B1 (pt)
FR (1) FR2865474B1 (pt)
GE (1) GEP20063960B (pt)
MA (1) MA27545A1 (pt)
MX (1) MXPA05001019A (pt)
NO (1) NO20050391L (pt)
NZ (1) NZ537877A (pt)
SG (1) SG113569A1 (pt)
UA (1) UA86574C2 (pt)
ZA (1) ZA200500774B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2879201B1 (fr) * 2004-12-10 2007-02-16 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US9150591B2 (en) 2010-08-10 2015-10-06 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
CN102977054A (zh) * 2012-12-12 2013-03-20 中国药科大学 一类选择性α2A受体激动剂的治疗阿尔茨海默病用途
CR20220160A (es) 2019-09-16 2022-06-16 Takeda Pharmaceuticals Co Derivados de piridazin-3(2h)-ona fusionados con azol
CN114230471B (zh) * 2021-11-09 2024-01-26 河北科技大学 一种3,4-二氯-2-氟苯胺的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488049A (en) * 1993-12-10 1996-01-30 Fidia - Georgetown Institute For The Neuro-Sciences Method of treating learning and memory disorders using benzothiadiazide derivatives as nootropic agents
US6083947A (en) * 1996-01-29 2000-07-04 The Regents Of The University Of California Method for treating sexual dysfunctions
AU4345297A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor
CN1293665A (zh) * 1998-02-18 2001-05-02 神经研究公司 新化合物及其用作阳性ampa受体调节剂
FR2801587B1 (fr) * 1999-11-30 2002-01-11 Adir Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2003005978A1 (en) * 2001-07-10 2003-01-23 Sven Jarby Remedy against skin diseases
FR2833950B1 (fr) * 2001-12-21 2005-12-16 Servier Lab Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2856064B1 (fr) * 2003-06-13 2005-08-19 Servier Lab Nouveaux derives de benzothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
MA27545A1 (fr) 2005-10-03
JP4291786B2 (ja) 2009-07-08
UA86574C2 (ru) 2009-05-12
HK1079778A1 (en) 2006-04-13
FR2865474A1 (fr) 2005-07-29
NO20050391L (no) 2005-07-27
SG113569A1 (en) 2005-08-29
CN1680343A (zh) 2005-10-12
KR100668195B1 (ko) 2007-01-11
CA2492161C (fr) 2010-06-22
NO20050391D0 (no) 2005-01-25
AR047455A1 (es) 2006-01-18
JP2005232166A (ja) 2005-09-02
KR20050077028A (ko) 2005-07-29
ZA200500774B (en) 2005-08-10
US20050165008A1 (en) 2005-07-28
GEP20063960B (en) 2006-11-10
EP1557412A1 (fr) 2005-07-27
US7268129B2 (en) 2007-09-11
CN1308317C (zh) 2007-04-04
MXPA05001019A (es) 2007-11-14
FR2865474B1 (fr) 2008-06-13
CA2492161A1 (fr) 2005-07-26
NZ537877A (en) 2005-10-28
EA200500072A1 (ru) 2005-08-25
AU2005200311A1 (en) 2005-08-11
EA009698B1 (ru) 2008-02-28

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.