BRPI0900983A2 - compostos de diometina, processo para sua preparação e composições farmacêuticas contendo os mesmos - Google Patents

compostos de diometina, processo para sua preparação e composições farmacêuticas contendo os mesmos

Info

Publication number
BRPI0900983A2
BRPI0900983A2 BRPI0900983-3A BRPI0900983A BRPI0900983A2 BR PI0900983 A2 BRPI0900983 A2 BR PI0900983A2 BR PI0900983 A BRPI0900983 A BR PI0900983A BR PI0900983 A2 BRPI0900983 A2 BR PI0900983A2
Authority
BR
Brazil
Prior art keywords
compounds
same
diomethine
pharmaceutical compositions
compositions containing
Prior art date
Application number
BRPI0900983-3A
Other languages
English (en)
Inventor
Michel Wierzbicki
Marie-Francoise Boussard
Tony Verbeuren
Patricia Sansilvestri-Morel
Alain Rupin
Jerome Paysant
Francois Lefoulon
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0900983A2 publication Critical patent/BRPI0900983A2/pt
Publication of BRPI0900983B1 publication Critical patent/BRPI0900983B1/pt
Publication of BRPI0900983B8 publication Critical patent/BRPI0900983B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)

Abstract

COMPOSTOS DE DIOMETINA, PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS. Compostos de fórmula (1): em que R~ 1~, R~ 2~ e R~ 3~, que podem ser iguais ou diferentes, representam, cada um, um átomo de hidrogênio ou o grupo de fórmula (A): Medicamentos.
BRPI0900983A 2008-04-01 2009-03-31 composto de diometina, processo para a síntese do mesmo, composição farmacêutica e seu uso BRPI0900983B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0801779 2008-04-01
FR0801779A FR2929276B1 (fr) 2008-04-01 2008-04-01 Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
BRPI0900983A2 true BRPI0900983A2 (pt) 2009-11-17
BRPI0900983B1 BRPI0900983B1 (pt) 2020-01-28
BRPI0900983B8 BRPI0900983B8 (pt) 2021-05-25

Family

ID=39809617

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0900983A BRPI0900983B8 (pt) 2008-04-01 2009-03-31 composto de diometina, processo para a síntese do mesmo, composição farmacêutica e seu uso

Country Status (48)

Country Link
US (2) US8138223B2 (pt)
EP (1) EP2107055B1 (pt)
JP (1) JP5047211B2 (pt)
KR (1) KR20120049855A (pt)
CN (1) CN101550124B (pt)
AP (1) AP3024A (pt)
AR (2) AR071120A1 (pt)
AT (1) ATE502024T1 (pt)
AU (1) AU2009201068B2 (pt)
BR (1) BRPI0900983B8 (pt)
CA (1) CA2659947C (pt)
CL (1) CL2009000757A1 (pt)
CO (1) CO6150038A1 (pt)
CR (1) CR10665A (pt)
CU (1) CU23761B7 (pt)
CY (1) CY1111367T1 (pt)
DE (1) DE602009000873D1 (pt)
DK (1) DK2107055T3 (pt)
EA (1) EA015424B1 (pt)
EC (1) ECSP099216A (pt)
ES (1) ES2363196T3 (pt)
FR (1) FR2929276B1 (pt)
GE (1) GEP20115342B (pt)
GT (1) GT200900062A (pt)
HN (1) HN2009000566A (pt)
HR (1) HRP20110361T1 (pt)
IL (1) IL197638A (pt)
JO (1) JO2673B1 (pt)
MA (1) MA31413B1 (pt)
ME (1) ME00680B (pt)
MX (1) MX2009003383A (pt)
MY (1) MY144726A (pt)
NI (1) NI200900042A (pt)
NZ (1) NZ575902A (pt)
PE (1) PE20091692A1 (pt)
PL (1) PL2107055T3 (pt)
PT (1) PT2107055E (pt)
PY (1) PY09010618A (pt)
RS (1) RS51661B (pt)
SA (1) SA109300201B1 (pt)
SG (1) SG155849A1 (pt)
SI (1) SI2107055T1 (pt)
SV (1) SV2009003199A (pt)
TW (1) TWI385178B (pt)
UA (1) UA98623C2 (pt)
UY (1) UY31712A1 (pt)
WO (1) WO2009133269A1 (pt)
ZA (1) ZA200901947B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2002835A1 (en) 2007-06-04 2008-12-17 GenKyo Tex Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP2165707A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166010A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2305679A1 (en) 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
FR3002543A1 (fr) 2013-02-28 2014-08-29 Servier Lab Procede de synthese enzymatique de flavonoides, et application a la synthese de derives de diosmetine
CN106031723A (zh) * 2015-09-29 2016-10-19 西南大学 香叶木素的抗炎活性及其制剂应用
CN106822087A (zh) * 2017-01-12 2017-06-13 西南大学 香叶木素在制备治疗ⅱ型糖尿病的药物中的应用
BR112019023109A2 (pt) * 2017-05-04 2020-05-26 Glenmark Pharmaceuticals S.A. Composto, composição farmacêutica e método para tratar uma doença, distúrbio, síndrome ou afecção mediada por nadph oxidase em um indivíduo
MX2020000625A (es) * 2017-07-19 2020-09-28 Primus Pharmaceuticals Inc Metodos para tratar trastornos microvasculares autoinmunes.
CN109280067B (zh) * 2017-07-21 2022-07-05 南京正大天晴制药有限公司 香叶木苷衍生物、其制备方法以及医药用途
CN111885914B (zh) * 2017-10-27 2022-05-13 投资健康有限责任公司 使用芴衍生物制造扩增的造血干细胞的组合物和方法
EP3479843A1 (en) 2017-11-01 2019-05-08 GenKyoTex Suisse SA Use of nox inhibitors for treatment of cancer
CN109394753B (zh) * 2018-12-24 2020-10-02 武汉轻工大学 香叶木素在制备预防和/或治疗高尿酸血症肾病的药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701261B1 (fr) * 1993-02-05 1995-03-31 Adir Nouveaux composés glucuronides de la diosmétine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
FR2726273B1 (fr) * 1994-10-26 1996-12-06 Adir Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
HUP0101381A3 (en) * 1998-03-12 2002-06-28 Microbial Chem Res Found Benzofurylpyrone derivatives and pharmaceutical compositions containing them
GB9920912D0 (en) * 1999-09-03 1999-11-10 Indena Spa Novel derivatives of flavones,xanthones and coumarins
FR2882654B1 (fr) * 2005-03-01 2007-04-27 Servier Lab Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques

Also Published As

Publication number Publication date
AP3024A (en) 2014-11-30
CL2009000757A1 (es) 2010-03-26
AP2009004810A0 (en) 2009-04-30
CO6150038A1 (es) 2010-04-20
MX2009003383A (es) 2009-10-16
MEP10909A (xx) 2011-12-20
CN101550124B (zh) 2011-11-30
CN101550124A (zh) 2009-10-07
GEP20115342B (en) 2011-12-12
CR10665A (es) 2009-05-25
EA015424B1 (ru) 2011-08-30
WO2009133269A1 (fr) 2009-11-05
AU2009201068A1 (en) 2009-10-15
US8138223B2 (en) 2012-03-20
BRPI0900983B1 (pt) 2020-01-28
TW200944539A (en) 2009-11-01
AR109739A2 (es) 2019-01-16
PY09010618A (es) 2014-09-01
US20120208777A1 (en) 2012-08-16
HK1136291A1 (en) 2010-06-25
MY144726A (en) 2011-10-31
US8404742B2 (en) 2013-03-26
UY31712A1 (es) 2009-05-29
AR071120A1 (es) 2010-05-26
SV2009003199A (es) 2009-10-27
PL2107055T3 (pl) 2011-06-30
EA200900397A1 (ru) 2010-10-29
RS51661B (sr) 2011-10-31
CY1111367T1 (el) 2015-08-05
SI2107055T1 (sl) 2011-05-31
DE602009000873D1 (de) 2011-04-28
PT2107055E (pt) 2011-05-09
SG155849A1 (en) 2009-10-29
ME00680B (me) 2011-12-20
ZA200901947B (en) 2010-02-24
ECSP099216A (es) 2010-03-31
CU23761B7 (es) 2012-01-31
NI200900042A (es) 2010-03-19
TWI385178B (zh) 2013-02-11
PE20091692A1 (es) 2009-11-07
JP5047211B2 (ja) 2012-10-10
UA98623C2 (ru) 2012-06-11
IL197638A0 (en) 2009-12-24
EP2107055B1 (fr) 2011-03-16
ATE502024T1 (de) 2011-04-15
IL197638A (en) 2014-06-30
MA31413B1 (fr) 2010-06-01
ES2363196T3 (es) 2011-07-26
SA109300201B1 (ar) 2013-04-20
DK2107055T3 (da) 2011-06-27
FR2929276B1 (fr) 2010-04-23
NZ575902A (en) 2010-12-24
CA2659947A1 (fr) 2009-10-01
JO2673B1 (en) 2012-06-17
HRP20110361T1 (hr) 2011-06-30
FR2929276A1 (fr) 2009-10-02
CA2659947C (fr) 2012-05-08
HN2009000566A (es) 2011-07-11
GT200900062A (es) 2011-10-13
CU20090048A7 (es) 2011-03-21
BRPI0900983B8 (pt) 2021-05-25
JP2009263354A (ja) 2009-11-12
AU2009201068B2 (en) 2012-11-22
KR20120049855A (ko) 2012-05-17
EP2107055A1 (fr) 2009-10-07
US20090247621A1 (en) 2009-10-01

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