BRPI0501091A - comprimido de domperidona rapidamente dispersìvel em água - Google Patents
comprimido de domperidona rapidamente dispersìvel em águaInfo
- Publication number
- BRPI0501091A BRPI0501091A BRPI0501091-8A BRPI0501091A BRPI0501091A BR PI0501091 A BRPI0501091 A BR PI0501091A BR PI0501091 A BRPI0501091 A BR PI0501091A BR PI0501091 A BRPI0501091 A BR PI0501091A
- Authority
- BR
- Brazil
- Prior art keywords
- water
- domperidone
- minutes
- dispersion
- fast
- Prior art date
Links
- FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001253 domperidone Drugs 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 2
- 239000006185 dispersion Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000008187 granular material Substances 0.000 abstract 2
- 239000003826 tablet Substances 0.000 abstract 2
- 229920002261 Corn starch Polymers 0.000 abstract 1
- 235000019759 Maize starch Nutrition 0.000 abstract 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
- 239000008108 microcrystalline cellulose Substances 0.000 abstract 1
- 229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 239000004565 water dispersible tablet Substances 0.000 abstract 1
- 238000005550 wet granulation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Cephalosporin Compounds (AREA)
Abstract
"COMPRIMIDO DE DOMPERIDONA RAPIDAMENTE DISPERSìVEL EM áGUA". A presente invenção relaciona-se com comprimidos contendo domperidona rapidamente dispersíveis em água para administração oral. As formulações compreendem domperidona ou os seus sais farmaceuticamente aceitáveis, cerca de 60 80 % de granulado 'auxiliar' (p/p) e cerca de 10 - 30 % de celulose microcristalina (p/p), expressos em relação ao peso total dos comprimidos, um edulcorante, um agente aromatizante e um lubrificante. O granulado 'auxiliar' é obtido por granulação a húmido de D-manitol e goma de amido de milho num granulador rápido, facilita o escoamento e a compressibilidade da mistura e, devido à sua elevada solubilidade em água, contribui para a rápida dispersão do comprimido. As formulações têm uma integridade estrutural melhorada tendo, por exemplo, uma friabilidade inferior a 1,0 % e valores de dureza entre 3 and 6 Kp, e são capazes de dispersar-se em água em 3 minutos, preferencialmente em 2 minutos e mais preferencialmente em 1 minuto, para originar uma dispersão que passa através de um tamis com 710 gm de diâmetro de malha e que apresenta um sabor agradável e ausência de grânulos perceptíveis na boca. Esta invenção refere-se também ao processo de preparação das referidas formulações.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04398007A EP1634586B1 (en) | 2004-09-09 | 2004-09-09 | Fast water-dispersible domperidone tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0501091A true BRPI0501091A (pt) | 2006-04-18 |
Family
ID=34932031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0501091-8A BRPI0501091A (pt) | 2004-09-09 | 2005-01-31 | comprimido de domperidona rapidamente dispersìvel em água |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7494668B2 (pt) |
| EP (1) | EP1634586B1 (pt) |
| AT (1) | ATE353635T1 (pt) |
| BR (1) | BRPI0501091A (pt) |
| DE (1) | DE602004004782T2 (pt) |
| ES (1) | ES2282831T3 (pt) |
| MA (1) | MA27816A1 (pt) |
| PL (1) | PL1634586T3 (pt) |
| PT (1) | PT1634586E (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050244492A1 (en) * | 2004-04-30 | 2005-11-03 | Mehra Dev K | Rapidly disintegrating tablets comprising titanium dioxide |
| US8617597B2 (en) | 2006-07-06 | 2013-12-31 | Bayer Intellectual Property Gmbh | Pharmaceutical composition containing a tetrahydrofolic acid |
| FR2909877B1 (fr) * | 2006-12-13 | 2009-07-10 | Galenix Dev Soc Par Actions Si | Composition pharmaceutique contenat de la 5-chloro-1-[1-[3- (2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)propyl] piperidin-4-yl]-1,3-dihydro-2h-benzimidazol-2-one et son procede de preparation |
| AU2008245580A1 (en) * | 2007-04-26 | 2008-11-06 | Craig A. Aronchick | Compositions and methods for transmucosal delivery of domperidone |
| TWI349410B (en) * | 2008-01-08 | 2011-09-21 | Novatek Microelectronics Corp | Change pump circuit |
| US20110027374A1 (en) * | 2008-12-16 | 2011-02-03 | Maria Oksana Bachynsky | Capecitabine rapidly disintegrating tablets |
| MX364947B (es) | 2009-10-01 | 2019-05-15 | Adare Pharmaceuticals Inc | Composiciones de corticosteroides administradas oralmente. |
| WO2015034678A2 (en) * | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
| CN104127390B (zh) * | 2014-08-05 | 2016-05-11 | 孙丽华 | 一种多潘立酮片及其制备工艺 |
| TWI728172B (zh) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
| JP2019529343A (ja) * | 2017-07-05 | 2019-10-17 | ノバルティス アーゲー | 新規な医薬組成物 |
| CN115462495A (zh) * | 2022-09-06 | 2022-12-13 | 江苏艾兰得营养品有限公司 | 一种微泡腾片及其制备方法 |
| CN117598387A (zh) * | 2023-12-06 | 2024-02-27 | 浙江贝灵生物医药有限公司 | 一种闪释型润喉组合物及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020071864A1 (en) * | 1999-03-25 | 2002-06-13 | Yuhan Corporation | Rapidly disintegrable tablet for oral administration |
| DE19931708A1 (de) * | 1999-07-08 | 2001-01-18 | Bayer Ag | Verfahren zur Herstellung schnell zerfallender, fester pharmazeutischer Zubereitungen |
| US20030185886A1 (en) * | 2000-05-26 | 2003-10-02 | Hanmi Pharm. Co., Ltd. | Process for the preparation of rapidly disintegrating tablet |
| CA2449731A1 (en) * | 2001-06-07 | 2002-12-19 | Tanabe Seiyaku Co., Ltd. | Functional grain-containing preparations quickly disintegrated in the oral cavity |
| AU2003238670A1 (en) * | 2002-04-05 | 2003-10-27 | Cadila Healthcare Limited | Fast disintegrating oral dosage forms |
-
2004
- 2004-09-09 EP EP04398007A patent/EP1634586B1/en not_active Expired - Lifetime
- 2004-09-09 ES ES04398007T patent/ES2282831T3/es not_active Expired - Lifetime
- 2004-09-09 PL PL04398007T patent/PL1634586T3/pl unknown
- 2004-09-09 AT AT04398007T patent/ATE353635T1/de not_active IP Right Cessation
- 2004-09-09 PT PT04398007T patent/PT1634586E/pt unknown
- 2004-09-09 DE DE602004004782T patent/DE602004004782T2/de not_active Expired - Lifetime
-
2005
- 2005-01-31 BR BRPI0501091-8A patent/BRPI0501091A/pt not_active IP Right Cessation
- 2005-02-16 US US11/058,234 patent/US7494668B2/en not_active Expired - Fee Related
- 2005-06-24 MA MA28359A patent/MA27816A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE353635T1 (de) | 2007-03-15 |
| US20060051414A1 (en) | 2006-03-09 |
| US7494668B2 (en) | 2009-02-24 |
| EP1634586B1 (en) | 2007-02-14 |
| ES2282831T3 (es) | 2007-10-16 |
| PL1634586T3 (pl) | 2007-07-31 |
| EP1634586A1 (en) | 2006-03-15 |
| DE602004004782T2 (de) | 2007-10-31 |
| MA27816A1 (fr) | 2006-04-03 |
| PT1634586E (pt) | 2007-04-30 |
| HK1087948A1 (en) | 2006-10-27 |
| DE602004004782D1 (de) | 2007-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A E 6A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2086 DE 28/12/2010. |