BRPI0501093A - Processo para a sìntese de (7-metóxi-3,4-diidro-1-naftalenil)acetonitrila e sua aplicação na sìntese de agomelatina - Google Patents

Processo para a sìntese de (7-metóxi-3,4-diidro-1-naftalenil)acetonitrila e sua aplicação na sìntese de agomelatina

Info

Publication number
BRPI0501093A
BRPI0501093A BR0501093-4A BRPI0501093A BRPI0501093A BR PI0501093 A BRPI0501093 A BR PI0501093A BR PI0501093 A BRPI0501093 A BR PI0501093A BR PI0501093 A BRPI0501093 A BR PI0501093A
Authority
BR
Brazil
Prior art keywords
synthesis
application
agomelatine
naphthalenyl
dihydro
Prior art date
Application number
BR0501093-4A
Other languages
English (en)
Inventor
Jean-Claude Souvie
Isaac Gonzalez Blanco
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0501093A publication Critical patent/BRPI0501093A/pt
Publication of BRPI0501093B1 publication Critical patent/BRPI0501093B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA A SìNTESE DE (7-METóXI-3,4-DIIDRO-1-NAFTALENIL)ACETONITRILA E SUA APLICAçãO NA SìNTESE DE AGOMELATINA". Processo para a síntese industrial do composto de fórmula (1) Aplicação na síntese de agomelatina.
BRPI0501093-4A 2004-02-13 2005-02-14 Processo para a síntese de (7-metóxi-3,4-diidro-1- naftalenil)acetonitrila, tal composto e processo para a síntese de agomelatina BRPI0501093B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0401436A FR2866336B1 (fr) 2004-02-13 2004-02-13 Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine
FR0401436 2004-02-13

Publications (2)

Publication Number Publication Date
BRPI0501093A true BRPI0501093A (pt) 2005-11-16
BRPI0501093B1 BRPI0501093B1 (pt) 2018-07-10

Family

ID=34685016

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0501093-4A BRPI0501093B1 (pt) 2004-02-13 2005-02-14 Processo para a síntese de (7-metóxi-3,4-diidro-1- naftalenil)acetonitrila, tal composto e processo para a síntese de agomelatina

Country Status (32)

Country Link
US (1) US7479569B2 (pt)
EP (1) EP1564204B1 (pt)
JP (1) JP4192155B2 (pt)
KR (1) KR100682699B1 (pt)
CN (1) CN1293048C (pt)
AR (1) AR048235A1 (pt)
AT (1) ATE382603T1 (pt)
AU (1) AU2005200618B8 (pt)
BR (1) BRPI0501093B1 (pt)
CA (1) CA2495628C (pt)
CY (1) CY1107156T1 (pt)
DE (1) DE602005004044T2 (pt)
DK (1) DK1564204T3 (pt)
EA (1) EA007795B1 (pt)
ES (1) ES2298964T3 (pt)
FR (1) FR2866336B1 (pt)
GE (1) GEP20063955B (pt)
HR (1) HRP20080134T3 (pt)
MA (1) MA27515A1 (pt)
ME (1) ME01401B (pt)
MX (1) MXPA05001632A (pt)
MY (1) MY143266A (pt)
NO (1) NO333483B1 (pt)
NZ (1) NZ538194A (pt)
PL (1) PL1564204T3 (pt)
PT (1) PT1564204E (pt)
RS (1) RS50545B (pt)
SG (1) SG114704A1 (pt)
SI (1) SI1564204T1 (pt)
UA (1) UA76649C2 (pt)
WO (1) WO2005077888A1 (pt)
ZA (1) ZA200501254B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2866334B1 (fr) * 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine
FR2889521B1 (fr) * 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline iii de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2889523B1 (fr) * 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2889522B1 (fr) * 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline iv de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
WO2007079317A2 (en) * 2005-12-06 2007-07-12 Neurocrine Biosciences, Inc. Use of sedative hypnotics for treating obesity or maintaining weight loss
CN101638376B (zh) 2008-07-29 2011-04-27 江苏恩华药业股份有限公司 阿戈美拉汀的制备方法及其中间体
CN102276492B (zh) * 2010-06-08 2013-04-10 上海医药工业研究院 阿戈美拉汀中间体及其制备方法
CL2011001405A1 (es) 2010-06-10 2012-03-30 Gador S A Conicet Procedimiento para la preparacion de n-[2-(7-metoxi-1-naftil)etil]acetamida, agometalina.
CN102060733B (zh) * 2010-12-06 2014-01-29 威海迪素制药有限公司 (7-甲氧基-3,4-二氢-1-萘基)乙腈的制备方法
WO2013054273A2 (en) 2011-10-11 2013-04-18 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
US20140336380A1 (en) 2011-12-01 2014-11-13 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
WO2014001939A1 (en) * 2012-06-30 2014-01-03 Alembic Pharmaceuticals Limited Process for preparation of agomelatine and crystalline form i thereof
ITMI20121444A1 (it) 2012-08-27 2014-02-28 Procos Spa Processo per la produzione di agomelatine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US432702A (en) * 1890-07-22 Car-seat
US3931188A (en) * 1974-05-06 1976-01-06 Bristol-Myers Company 3-Hydroxy-5,6-benzomorphinan derivatives
US3992403A (en) * 1975-05-30 1976-11-16 Schering Corporation 2-Imidazolines and their use as hypoglycemic agents
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866334B1 (fr) * 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine

Also Published As

Publication number Publication date
EP1564204A1 (fr) 2005-08-17
AU2005200618B2 (en) 2011-05-19
HK1078565A1 (en) 2006-03-17
JP2005239716A (ja) 2005-09-08
US20050182268A1 (en) 2005-08-18
GEP20063955B (en) 2006-10-25
MA27515A1 (fr) 2005-09-01
PL1564204T3 (pl) 2008-03-31
KR100682699B1 (ko) 2007-02-15
AU2005200618A8 (en) 2011-06-02
ZA200501254B (en) 2005-11-30
EP1564204B1 (fr) 2008-01-02
JP4192155B2 (ja) 2008-12-03
FR2866336A1 (fr) 2005-08-19
ATE382603T1 (de) 2008-01-15
RS50545B (sr) 2010-05-07
CY1107156T1 (el) 2012-10-24
SG114704A1 (en) 2005-09-28
CA2495628A1 (fr) 2005-08-13
CA2495628C (fr) 2007-11-27
NO333483B1 (no) 2013-06-24
WO2005077888A1 (fr) 2005-08-25
AR048235A1 (es) 2006-04-12
EA007795B1 (ru) 2007-02-27
MY143266A (en) 2011-04-15
ES2298964T3 (es) 2008-05-16
CN1680295A (zh) 2005-10-12
NO20050738D0 (no) 2005-02-11
FR2866336B1 (fr) 2006-03-24
NZ538194A (en) 2006-01-27
DE602005004044T2 (de) 2009-01-15
NO20050738L (no) 2005-08-15
SI1564204T1 (sl) 2008-04-30
AU2005200618B8 (en) 2011-06-02
ME01401B (me) 2010-05-07
CN1293048C (zh) 2007-01-03
HRP20080134T3 (en) 2008-05-31
BRPI0501093B1 (pt) 2018-07-10
PT1564204E (pt) 2008-01-29
MXPA05001632A (es) 2005-08-19
US7479569B2 (en) 2009-01-20
DE602005004044D1 (de) 2008-02-14
DK1564204T3 (da) 2008-05-13
UA76649C2 (en) 2006-08-15
KR20060041904A (ko) 2006-05-12
AU2005200618A1 (en) 2005-09-01
EA200500202A1 (ru) 2005-08-25

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Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]