BRPI0506494A - compostos de silinano como inibidores de cisteìna protease - Google Patents

compostos de silinano como inibidores de cisteìna protease

Info

Publication number
BRPI0506494A
BRPI0506494A BRPI0506494-5A BRPI0506494A BRPI0506494A BR PI0506494 A BRPI0506494 A BR PI0506494A BR PI0506494 A BRPI0506494 A BR PI0506494A BR PI0506494 A BRPI0506494 A BR PI0506494A
Authority
BR
Brazil
Prior art keywords
compounds
protease inhibitors
cysteine protease
silinane
present
Prior art date
Application number
BRPI0506494-5A
Other languages
English (en)
Inventor
John O Link
Michael Graupe
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BRPI0506494A publication Critical patent/BRPI0506494A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSTOS DE SILINANO COMO INIBIDORES DE CISTEìNA PROTEASE". A presente invenção refere-se aos compostos que são inibidores de cisteína proteases, em particular, catepsinas B, K, L, F e S e são portanto úteis no tratamento de doenças mediadas por estas proteases. A presente invenção é da mesma forma direcionada às composições farmacêuticas compreendendo estes compostos e processos para prepará-las. A presente invenção é da mesma forma direcionada ao uso destes inibidores em combinação com uma terapia que causa uma resposta imune prejudicial em pacientes que recebem a terapia.
BRPI0506494-5A 2004-01-30 2005-01-31 compostos de silinano como inibidores de cisteìna protease BRPI0506494A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54058104P 2004-01-30 2004-01-30
US54749804P 2004-02-24 2004-02-24
PCT/US2005/002773 WO2005074904A2 (en) 2004-01-30 2005-01-31 Silinane compounds as cysteine protease inhibitors

Publications (1)

Publication Number Publication Date
BRPI0506494A true BRPI0506494A (pt) 2007-02-13

Family

ID=34841106

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506494-5A BRPI0506494A (pt) 2004-01-30 2005-01-31 compostos de silinano como inibidores de cisteìna protease

Country Status (13)

Country Link
US (1) US20070088001A1 (pt)
EP (1) EP1716158A2 (pt)
JP (1) JP2007519744A (pt)
KR (1) KR20060129416A (pt)
AU (1) AU2005210631A1 (pt)
BR (1) BRPI0506494A (pt)
CA (1) CA2554626A1 (pt)
CR (1) CR8574A (pt)
EC (1) ECSP066805A (pt)
IL (1) IL177055A0 (pt)
NO (1) NO20063842L (pt)
RU (1) RU2006131043A (pt)
WO (1) WO2005074904A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0410979A (pt) 2003-09-18 2006-07-04 Axys Pharm Inc composto, composição farmacêutica, e, métodos para tratar uma doença em um animal mediada pela catepsina s e para tratar um paciente submetido a uma terapia
WO2006060810A1 (en) 2004-12-02 2006-06-08 Schering Aktiengesellschaft Sulfonamide compounds as cysteine protease inhibitors
WO2006102243A2 (en) 2005-03-21 2006-09-28 Applera Corporation Alpha ketoamide compounds as cysteine protease inhibitors
EP1866277B1 (en) 2005-03-22 2014-06-25 Virobay, Inc. Sulfonyl containing compounds as cysteine protease inhibitors
US7893112B2 (en) 2006-10-04 2011-02-22 Virobay, Inc. Di-fluoro containing compounds as cysteine protease inhibitors
ZA200902477B (en) 2006-10-04 2010-08-25 Virobay Inc Di-fluoro containing compounds as cysteine protease inhibitors
MY162041A (en) 2007-02-28 2017-05-31 Sanofi Aventis Imaging probes
US8324417B2 (en) 2009-08-19 2012-12-04 Virobay, Inc. Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof
WO2017036357A1 (zh) 2015-08-29 2017-03-09 广东东阳光药业有限公司 组织蛋白酶k抑制剂及其用途
WO2017222914A1 (en) 2016-06-21 2017-12-28 Inception 4, Inc. Carbocyclic prolinamide derivatives
EP4257191A3 (en) 2016-06-21 2023-11-22 Orion Ophthalmology LLC Heterocyclic prolinamide derivatives
AU2020250933A1 (en) 2019-04-05 2021-10-28 Centre Hospitalier Régional Et Universitaire De Brest Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0912601T4 (da) * 1996-04-22 2009-03-09 Massachusetts Inst Technology Suppression af immunrespons ved inhibering af cathepsin S
EP1516877A1 (en) * 1999-03-15 2005-03-23 Axys Pharmaceuticals, Inc. Amine derivatives as protease inhibitors
TW200404789A (en) * 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
AU2003256305A1 (en) * 2002-06-24 2004-01-06 Axys Pharmaceuticals, Inc. Peptidic compounds as cysteine protease inhibitors
BRPI0410979A (pt) * 2003-09-18 2006-07-04 Axys Pharm Inc composto, composição farmacêutica, e, métodos para tratar uma doença em um animal mediada pela catepsina s e para tratar um paciente submetido a uma terapia

Also Published As

Publication number Publication date
RU2006131043A (ru) 2008-03-10
AU2005210631A1 (en) 2005-08-18
KR20060129416A (ko) 2006-12-15
ECSP066805A (es) 2006-11-16
WO2005074904A3 (en) 2005-09-29
NO20063842L (no) 2006-10-20
CR8574A (es) 2007-02-05
US20070088001A1 (en) 2007-04-19
WO2005074904A2 (en) 2005-08-18
JP2007519744A (ja) 2007-07-19
IL177055A0 (en) 2006-12-10
EP1716158A2 (en) 2006-11-02
CA2554626A1 (en) 2005-08-18

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Legal Events

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]