BRPI0506793A - métodos de tratamento de obesidade ou diabetes com o uso de nt-4/5 - Google Patents
métodos de tratamento de obesidade ou diabetes com o uso de nt-4/5Info
- Publication number
- BRPI0506793A BRPI0506793A BRPI0506793-6A BRPI0506793A BRPI0506793A BR PI0506793 A BRPI0506793 A BR PI0506793A BR PI0506793 A BRPI0506793 A BR PI0506793A BR PI0506793 A BRPI0506793 A BR PI0506793A
- Authority
- BR
- Brazil
- Prior art keywords
- obesity
- treatment methods
- diabetes treatment
- polypeptide
- relates
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title abstract 3
- 235000020824 obesity Nutrition 0.000 title abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
MéTODOS DE TRATAMENTO DA OBESIDADE OU DIABETES COM O USO DE NT-4/5. invenção refere-se a métodos para tratamento da obesidade, diabetes melito não insulino-dependente, síndrome metabólica e outras doenças relacionadas, por administração de um polipeptídeo NT-4/5. A invenção também se refere a composições farmacêuticas e kits compreendendo um polipeptídeo NT-4/5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54639004P | 2004-02-20 | 2004-02-20 | |
| PCT/US2005/005881 WO2005082401A1 (en) | 2004-02-20 | 2005-02-22 | Methods of treating obesity or diabetes using nt-4/5 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0506793A true BRPI0506793A (pt) | 2007-05-22 |
Family
ID=34910771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0506793-6A BRPI0506793A (pt) | 2004-02-20 | 2005-02-22 | métodos de tratamento de obesidade ou diabetes com o uso de nt-4/5 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20050209148A1 (pt) |
| EP (1) | EP1720564A1 (pt) |
| JP (1) | JP2007523196A (pt) |
| BR (1) | BRPI0506793A (pt) |
| CA (1) | CA2556923A1 (pt) |
| WO (1) | WO2005082401A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007210862A1 (en) | 2006-02-02 | 2007-08-09 | Rinat Neuroscience Corp. | Methods for treating unwanted weight loss or eating disorders by administering a trkB agonist |
| JP2009525319A (ja) * | 2006-02-02 | 2009-07-09 | ライナット ニューロサイエンス コーポレイション | trkBアンタゴニストを投与することにより肥満を治療する方法 |
| WO2007095716A1 (en) * | 2006-02-23 | 2007-08-30 | Iomedix Sleep International Srl | Compositions and methods for the induction and maintenance of quality sleep |
| WO2010086828A2 (en) * | 2009-02-02 | 2010-08-05 | Rinat Neuroscience Corporation | Agonist anti-trkb monoclonal antibodies |
| WO2011127304A2 (en) * | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
| US12205686B2 (en) * | 2020-02-27 | 2025-01-21 | The Cleveland Clinic Foundation | Identifying patients for intensive hyperglycemia management |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4777127A (en) * | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
| US5219740A (en) * | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US5364768A (en) * | 1987-07-07 | 1994-11-15 | Farmitalia Carlo Erba S.R.L. | Process for the preparation of penems |
| US5422120A (en) * | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
| US5686579A (en) * | 1988-06-21 | 1997-11-11 | Hybrisens, Ltd. | Use of antibody/antigen interactions to protect biologically active proteins and peptides |
| US6673776B1 (en) * | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| JPH03133378A (ja) * | 1989-07-19 | 1991-06-06 | Modrovich Ivan E | 被験体を安定化させて液体中でのその生物学的活性を保存する方法 |
| US6566091B1 (en) * | 1990-09-25 | 2003-05-20 | Genentech, Inc. | Neurotrophic factor |
| US6506728B2 (en) * | 1990-09-25 | 2003-01-14 | Genentech, Inc. | Methods using a novel neurotrophic factor, NT-4 |
| CA2092567C (en) * | 1990-09-25 | 2007-07-03 | Arnon Rosenthal | Nt-4 neurotrophic factor |
| ES2148144T3 (es) * | 1990-11-20 | 2000-10-16 | Dade Behring Marburg Gmbh | Procedimiento para la estabilizacion de conjugados de enzima. |
| EP0666756B1 (en) * | 1992-09-14 | 1999-11-24 | Regeneron Pharmaceuticals, Inc. | Method of producing analgesia using neurotrophins |
| US6015686A (en) * | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| US20030191061A1 (en) * | 1994-03-31 | 2003-10-09 | Brewitt Barbara A. | Treatment methods using homeopathic preparations of growth factors |
| US6024734A (en) * | 1994-03-31 | 2000-02-15 | Brewitt; Barbara A. | Treatment methods using homeopathic preparations of growth factors |
| US6436908B1 (en) * | 1995-05-30 | 2002-08-20 | Duke University | Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function |
| WO1995031183A1 (en) * | 1994-05-16 | 1995-11-23 | Washington University | Cell membrane fusion composition and method |
| MX9606598A (es) * | 1994-06-24 | 1997-05-31 | Behringwerke Ag | Procedimiento para la estabilizacion de moleculas, o partes de moleculas, sensibles a la hidrolisis. |
| US5770577A (en) * | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
| US6143718A (en) * | 1995-06-07 | 2000-11-07 | Amylin Pharmaceuticals, Inc. | Treatment of Type II diabetes mellutis with amylin agonists |
| NZ333650A (en) * | 1996-07-19 | 2000-02-28 | Amgen Inc | Analogs of cationic proteins like NT-3 (neurotrophin-3) and BDNF (brain derived neurotrophic factor) that are circulated more readily due to a lower isoelectric point and a lower protein charge relative to the native protein |
| AU729459B2 (en) * | 1996-11-15 | 2001-02-01 | Genentech Inc. | Purification of neurotrophins |
| US6391312B1 (en) * | 1997-01-23 | 2002-05-21 | Sumitomo Pharmaceuticals Co., Limited | Remedies for diabetes |
| US20030105057A1 (en) * | 1997-03-19 | 2003-06-05 | Yale University | Methods and compositions for stimulating apoptosis and cell death or for inhibiting cell growth and cell attachment |
| US8173127B2 (en) * | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
| US6753165B1 (en) * | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| CA2300134A1 (en) * | 1997-08-29 | 1999-03-04 | Vertex Pharmaceuticals Incorporated | Compounds possessing neuronal activity |
| WO1999018792A1 (en) * | 1997-10-10 | 1999-04-22 | Johns Hopkins University | Gene delivery compositions and methods |
| US6565874B1 (en) * | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
| EP1172113A4 (en) * | 1999-04-16 | 2004-06-30 | Sumitomo Pharma | MEDICINE FOR AUTONOMOUS NEUROPATHIES |
| JP5249482B2 (ja) * | 1999-06-16 | 2013-07-31 | ボストン・バイオメデイカル・リサーチ・インステイテユート | インビボのβ−アミロイドレベルの免疫学的制御 |
| WO2001002376A1 (en) * | 1999-07-06 | 2001-01-11 | Vertex Pharmaceuticals Incorporated | Amino-alkyl derivatives |
| EP1200440A1 (en) * | 1999-07-06 | 2002-05-02 | Vertex Pharmaceuticals Incorporated | Quinuclidine derivatives for treatment of neurological disorders |
| JP2003503476A (ja) * | 1999-07-06 | 2003-01-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | 環化アミド誘導体 |
| JP2004510684A (ja) * | 1999-07-06 | 2004-04-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | 神経学的疾患の治療のためのアゾアミノ酸誘導体 |
| WO2001002372A1 (en) * | 1999-07-06 | 2001-01-11 | Vertex Pharmaceuticals Incorporated | Cyclized amino acid derivatives |
| EP1207882A4 (en) * | 1999-07-30 | 2003-03-19 | Vertex Pharma | DERIVATIVES OF ACYCLIC AND CYCLIC AMINES |
| DE60002496T2 (de) * | 1999-10-29 | 2004-03-25 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Verwendung von gdnf für behandlung von hornhautdefekten |
| US20030022840A1 (en) * | 2000-02-18 | 2003-01-30 | Michiko Kishino | Drugs for ameliorating impaired glucose tolerance |
| EP1262189A1 (en) * | 2000-03-06 | 2002-12-04 | Sumitomo Pharmaceuticals Company, Limited | Leptin-resistance ameliorating agents |
| CN1529599A (zh) * | 2001-06-14 | 2004-09-15 | ��̩��˹ҩ��ɷ�����˾ | 可用于治疗神经元损伤的无环哌嗪和哌啶衍生物 |
| US6818613B2 (en) * | 2001-11-07 | 2004-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Aqueous sustained-release formulations of proteins |
| US6712086B1 (en) * | 2002-12-20 | 2004-03-30 | Sidney T. Fails | Above ground meter box |
| AU2007210862A1 (en) * | 2006-02-02 | 2007-08-09 | Rinat Neuroscience Corp. | Methods for treating unwanted weight loss or eating disorders by administering a trkB agonist |
-
2005
- 2005-02-22 BR BRPI0506793-6A patent/BRPI0506793A/pt not_active IP Right Cessation
- 2005-02-22 US US11/064,309 patent/US20050209148A1/en not_active Abandoned
- 2005-02-22 CA CA002556923A patent/CA2556923A1/en not_active Abandoned
- 2005-02-22 JP JP2006554325A patent/JP2007523196A/ja active Pending
- 2005-02-22 WO PCT/US2005/005881 patent/WO2005082401A1/en not_active Ceased
- 2005-02-22 EP EP05714023A patent/EP1720564A1/en not_active Withdrawn
-
2009
- 2009-03-13 US US12/404,202 patent/US20090203610A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005082401A1 (en) | 2005-09-09 |
| US20050209148A1 (en) | 2005-09-22 |
| US20090203610A1 (en) | 2009-08-13 |
| JP2007523196A (ja) | 2007-08-16 |
| EP1720564A1 (en) | 2006-11-15 |
| CA2556923A1 (en) | 2005-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2006003672A1 (es) | Compuestos derivados de pirimido-[4,5-b]-oxazinas; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de diabetes mellitus y/u obesidad. | |
| WO2008055940A8 (en) | Combination therapy with sglt-2 inhibitors and their pharmaceutical compositions | |
| WO2004110375A3 (en) | Combination therapy for the treatment of diabetes | |
| CY1112398T1 (el) | Πυρρολιδινονες υποκατασταθεισες απο κυκλοεξυλιο ως αναστολεις της 11-β-υδροξυστεροειδικης αφυδρογονασης 1 | |
| BRPI0511703A (pt) | composto, composição farmacêutica, e, métodos de tratar diabete melito tipo 2, de retardar o inìcio do diabete melito tipo 2, de tratar hiperglicemia, diabete ou resistência à insulina, obesidade, sìndrome x, um distúrbio lipìdico, aterosclerose, e uma condição | |
| CL2008002227A1 (es) | Compuestos derivados de 4-[(8r)-4-amino-5-oxo-7,8-dihidrorimido[5,4-f][1,4]oxazepin-6(5h)-il]fenilo sustituido; su composicion farmaceutica; y uso de los compuestos en el tratamiento de la diabetes de tipo 2, utiles particularmente para tratar la obesidad. | |
| BRPI0519106A2 (pt) | compostos, uso destes, processo para sua fabricaÇço, composiÇÕes farmacÊuticas, mÉtodo para o tratamento e/ou profilaxia de doenÇas que sço associadas com a dpp-iv | |
| IL219915A0 (en) | Pharmaceutical composition for the treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases | |
| NO20091700L (no) | Florizinanaloger som inhibitorer av glukose-ko-transporter 2 | |
| CL2004001069A1 (es) | Compuestos derivados de 1-benzoil-isoquinolinas sustituidos; procedimiento de preparacion, composicion farmaceutica; y uso para el tratamiento o profilaxis de diabetes tipo ii. | |
| CL2010000375A1 (es) | Compuestos mimeticos de glucocorticoides derivados de hidroxialquilo sustituidos por heterociclos; procedimiento de preparacion; composicion farmaceutica; kit farmaceutico; y uso para el tratamiento de un estado o trastorno seleccionado de diabetes tipo ii, obesidad, hipertension, entre otras (divisional de solicitud 585-03). | |
| EA200802128A1 (ru) | Новые нутрицевтические композиции | |
| BR0116370A (pt) | Composto, composição farmacêutica, uso de um composto, e, método de tratamento de uma doença ou condição mediada por hppar em um paciente. | |
| BR0210383A (pt) | compostos para o tratamento de distúrbios metabólicos | |
| SE9702457D0 (sv) | Screening | |
| DE602006009095D1 (en) | Diacylglycerol-acyltransferase-hemmer | |
| BRPI0516126A (pt) | produtos farmacêuticos de polipeptìdeos intestinais vasoativos | |
| BR0206847A (pt) | Tratamento do diabete melito | |
| BRPI0517701A8 (pt) | métodos de tratamento de diabetes mellitus | |
| CL2007002890A1 (es) | Compuestos derivados de 2-piridincarboxamida, activador de glucosinasa; composicion farmaceutica; y uso del compuesto para el tratamiento de diabetes o la obesidad. | |
| EA201170795A1 (ru) | Антагонисты ccr2 группы 4-азетидинил-1-гетероарил-циклогексанола | |
| CL2007000595A1 (es) | Compuestos derivados de piperidina; composicion farmaceutica y uso para el tratamiento y/o profilaxis de enfermedades seleccionadas entre hipertension, insuficiencia cardiaca congestiva e insuficiencia renal entre otras. | |
| AR075998A1 (es) | Tratamiento de trastornos resistentes a insulina.composicion farmaceutica. uso. kit | |
| WO2006066747A8 (en) | 4-aminopiperidine derivatives | |
| BRPI0511367A (pt) | uso de uma composição,composição, uso de vip e/ou de um fragmento ativo do mesmo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6 ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011. |