BRPI0507463A - uso de glufosfamide e gemcitabine , produto, e, combinação de glufosfamide e gemcitabine - Google Patents

uso de glufosfamide e gemcitabine , produto, e, combinação de glufosfamide e gemcitabine

Info

Publication number
BRPI0507463A
BRPI0507463A BRPI0507463-0A BRPI0507463A BRPI0507463A BR PI0507463 A BRPI0507463 A BR PI0507463A BR PI0507463 A BRPI0507463 A BR PI0507463A BR PI0507463 A BRPI0507463 A BR PI0507463A
Authority
BR
Brazil
Prior art keywords
glufosfamide
gemcitabine
combination
product
methods
Prior art date
Application number
BRPI0507463-0A
Other languages
English (en)
Inventor
George Tidmarsh
Original Assignee
Threshold Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Threshold Pharmaceuticals Inc filed Critical Threshold Pharmaceuticals Inc
Publication of BRPI0507463A publication Critical patent/BRPI0507463A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

USO DE GLUFOSFAMIDE E GEMCITABINE, PRODUTO, E, COMBINAçãO DE GLUFOSFAMIDE E GEMCITABINE São descritos métodos para o tratamento de câncer. Em particular, são expostos métodos para o tratamento de câncer que compreedem a administração de glufosfamide isoladamente ou em combinação com um outro agente anti-cãncer.
BRPI0507463-0A 2004-02-06 2005-02-04 uso de glufosfamide e gemcitabine , produto, e, combinação de glufosfamide e gemcitabine BRPI0507463A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54249404P 2004-02-06 2004-02-06
PCT/US2005/003370 WO2005076888A2 (en) 2004-02-06 2005-02-04 Anti-cancer therapies

Publications (1)

Publication Number Publication Date
BRPI0507463A true BRPI0507463A (pt) 2007-07-10

Family

ID=34860311

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507463-0A BRPI0507463A (pt) 2004-02-06 2005-02-04 uso de glufosfamide e gemcitabine , produto, e, combinação de glufosfamide e gemcitabine

Country Status (16)

Country Link
US (3) US8318683B2 (pt)
EP (1) EP1711188B1 (pt)
JP (4) JP5235304B2 (pt)
KR (2) KR20120117943A (pt)
CN (1) CN1917885A (pt)
AU (1) AU2005213372B2 (pt)
BR (1) BRPI0507463A (pt)
CA (1) CA2554463C (pt)
DK (1) DK1711188T3 (pt)
ES (1) ES2389809T3 (pt)
IL (1) IL177136A (pt)
NO (1) NO336884B1 (pt)
NZ (1) NZ549605A (pt)
RU (1) RU2006132069A (pt)
WO (1) WO2005076888A2 (pt)
ZA (1) ZA200606456B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200507752B (en) 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
NZ549605A (en) * 2004-02-06 2010-01-29 Threshold Pharmaceuticals Inc Use of glufosfamide to treat chemotherapy-refractory pancreatic cancer
WO2006071955A2 (en) * 2004-12-23 2006-07-06 Threshold Pharmaceuticals, Inc. Glufosfamide combination therapy
EP1896040B1 (en) 2005-06-29 2012-08-01 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
ATE479432T1 (de) * 2006-11-03 2010-09-15 Nerviano Medical Sciences Srl Verfahren zur verabreichung einer antitumoralen verbindung
ES2884044T3 (es) 2006-12-26 2021-12-10 Immunogenesis Inc Profármaco alquilante de fosforamidato para el tratamiento del cáncer
US8765690B2 (en) 2007-04-05 2014-07-01 Threshold Pharmaceuticals, Inc. Treatment of cancer with glufosfamide in patients not receiving insulin therapy
US20110207680A1 (en) * 2008-08-13 2011-08-25 Curd John G Administration of Glufosfamide For The Treatment of Cancer
TWI448295B (zh) 2011-11-15 2014-08-11 Univ Kaohsiung Medical 抗人類泌尿上皮癌之香桂超臨界萃取物、製備方法及用途
EP3430170B1 (en) * 2016-03-16 2023-08-16 Dana-Farber Cancer Institute, Inc. Methods for genome characterization
CN116392497A (zh) * 2017-11-28 2023-07-07 深圳艾欣达伟医药科技有限公司 葡磷酰胺的抗癌医药用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489302A (en) * 1979-09-24 1984-12-18 Eventoff Franklin Neal Electronic pressure sensitive force transducer
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
EP0184365B1 (en) * 1984-12-04 1993-08-04 Eli Lilly And Company Improvements in the treatment of tumors in mammals
DE3835772A1 (de) * 1988-10-20 1990-04-26 Deutsches Krebsforsch Tumorhemmende saccharid-konjugate
DE19524515A1 (de) * 1995-07-05 1997-01-09 Deutsches Krebsforsch Saccharid-Konjugate
US7452538B2 (en) * 1997-01-28 2008-11-18 Human Genome Sciences, Inc. Death domain containing receptor 4 antibodies and methods
WO2003082301A1 (en) * 2002-03-29 2003-10-09 Threshold Pharmaceuticals, Inc. Compositions and methods for treating cancer
WO2004062604A2 (en) * 2003-01-10 2004-07-29 Threshold Pharmaceuticals, Inc. Treatment of cancer with 2-deoxyglucose
CN1771334A (zh) 2003-03-07 2006-05-10 施瑞修德制药公司 用于确定肿瘤对抗肿瘤药剂的治疗的敏感性的方法
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
NZ549605A (en) 2004-02-06 2010-01-29 Threshold Pharmaceuticals Inc Use of glufosfamide to treat chemotherapy-refractory pancreatic cancer
WO2006071955A2 (en) 2004-12-23 2006-07-06 Threshold Pharmaceuticals, Inc. Glufosfamide combination therapy
EP1883298A1 (en) 2005-05-11 2008-02-06 Threshold Pharmaceuticals, Inc. Glufosfamide combination therapy
JP2009509974A (ja) 2005-09-23 2009-03-12 スレッシュオールド ファーマシューティカルズ， インコーポレイテッド 抗癌治療

Also Published As

Publication number Publication date
WO2005076888A2 (en) 2005-08-25
AU2005213372B2 (en) 2011-03-24
IL177136A0 (en) 2006-12-10
US20170157161A1 (en) 2017-06-08
US20130045944A1 (en) 2013-02-21
JP5235304B2 (ja) 2013-07-10
EP1711188A2 (en) 2006-10-18
JP2007520562A (ja) 2007-07-26
ZA200606456B (en) 2008-01-08
JP2013064002A (ja) 2013-04-11
US8318683B2 (en) 2012-11-27
JP2018177808A (ja) 2018-11-15
ES2389809T3 (es) 2012-10-31
NO20063987L (no) 2006-09-06
WO2005076888A3 (en) 2005-10-27
CA2554463C (en) 2013-06-11
RU2006132069A (ru) 2008-03-20
KR101226631B1 (ko) 2013-01-28
NO336884B1 (no) 2015-11-23
AU2005213372A1 (en) 2005-08-25
EP1711188B1 (en) 2012-06-06
IL177136A (en) 2010-11-30
US9205098B2 (en) 2015-12-08
JP2017071625A (ja) 2017-04-13
CA2554463A1 (en) 2005-08-25
KR20060131869A (ko) 2006-12-20
CN1917885A (zh) 2007-02-21
KR20120117943A (ko) 2012-10-24
NZ549605A (en) 2010-01-29
US20090247480A1 (en) 2009-10-01
DK1711188T3 (da) 2012-09-10

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]