BRPI0717845A2 - Uso de compostos, composições farmacêuticas e métodos para o tratamento e/ou profilaxia de enfermidades que podem ser tratadas com agentes de elevação de colesterol-hdl e compostos - Google Patents

Uso de compostos, composições farmacêuticas e métodos para o tratamento e/ou profilaxia de enfermidades que podem ser tratadas com agentes de elevação de colesterol-hdl e compostos

Info

Publication number: BRPI0717845A2
Authority: BR; Brazil
Prior art keywords: compounds; hdl; prophylaxis; diseases; treated
Prior art date: 2006-10-04

Application number

BRPI0717845-0A

Other languages

English (en)

Inventor

Mirjana Andjelkovic

Agnès Bénardeau

Evelyne Chaput

Paul Hebeisen

Matthias Nettekoven

Ulrike Obst Sander

Constantinos G Panousis

Stephan Roever

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-04

Filing date

2007-09-24

Publication date

2015-06-16

2007-09-24 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2015-06-16 Publication of BRPI0717845A2 publication Critical patent/BRPI0717845A2/pt

Links

150000001875 compounds Chemical class 0.000 title 2
108010023302 HDL Cholesterol Proteins 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000003028 elevating effect Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
238000011321 prophylaxis Methods 0.000 title 1
238000011282 treatment Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0717845-0A 2006-10-04 2007-09-24 Uso de compostos, composições farmacêuticas e métodos para o tratamento e/ou profilaxia de enfermidades que podem ser tratadas com agentes de elevação de colesterol-hdl e compostos BRPI0717845A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06121755		2006-10-04
PCT/EP2007/060094 WO2008040651A1 (en)	2006-10-04	2007-09-24	3-pyridinecarboxamide and 2-pyrazinecarboxamide derivatives as hdl-cholesterol raising agents

Publications (1)

Publication Number	Publication Date
BRPI0717845A2 true BRPI0717845A2 (pt)	2015-06-16

Family

ID=38740266

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0717845-0A BRPI0717845A2 (pt)	2006-10-04	2007-09-24	Uso de compostos, composições farmacêuticas e métodos para o tratamento e/ou profilaxia de enfermidades que podem ser tratadas com agentes de elevação de colesterol-hdl e compostos

Country Status (14)

Country	Link
US (3)	US20080085906A1 (pt)
EP (2)	EP2074096B1 (pt)
JP (1)	JP2010505789A (pt)
KR (1)	KR101107896B1 (pt)
CN (1)	CN101522626A (pt)
AU (1)	AU2007304365A1 (pt)
BR (1)	BRPI0717845A2 (pt)
CA (1)	CA2664119A1 (pt)
IL (1)	IL197577A0 (pt)
MX (1)	MX2009003222A (pt)
NO (1)	NO20091045L (pt)
RU (1)	RU2454405C2 (pt)
WO (1)	WO2008040651A1 (pt)
ZA (1)	ZA200902353B (pt)

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PL3354650T3 (pl)	2008-12-19	2022-06-13	Vertex Pharmaceuticals Incorporated	Związki przydatne jako inhibitory kinazy atr
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US8962631B2 (en)	2010-05-12	2015-02-24	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of ATR kinase
US9096584B2 (en)	2010-05-12	2015-08-04	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of ATR kinase
WO2011143423A2 (en)	2010-05-12	2011-11-17	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of atr kinase
JP5836367B2 (ja)	2010-05-12	2015-12-24	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	Ａｔｒキナーゼ阻害剤として有用な化合物
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
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CA2832100A1 (en)	2011-04-05	2012-10-11	Vertex Pharmaceuticals Incorporated	Aminopyrazine compounds useful as inhibitors of tra kinase
JP2014522818A (ja)	2011-06-22	2014-09-08	バーテックスファーマシューティカルズインコーポレイテッド	Ａｔｒキナーゼ阻害剤として有用な化合物
WO2012178125A1 (en)	2011-06-22	2012-12-27	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of atr kinase
WO2012178123A1 (en)	2011-06-22	2012-12-27	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of atr kinase
CA2844865A1 (en) *	2011-09-12	2013-03-21	F. Hoffmann-La Roche Ag	3-pyridine carboxylic acid hydrazides as hdl-cholesterol raising agents
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CA2844834A1 (en) *	2011-09-12	2013-03-21	F.Hoffmann-La Roche Ag	5-cycloalkyl- or 5-heterocyclyl-nicotinamides
KR20140061518A (ko)	2011-09-12	2014-05-21	에프. 호프만-라 로슈 아게	N-(5-사이클로알킬- 또는 5-헤테로사이클릴-)-피리딘-3-일 카복스아마이드
US8765751B2 (en)	2011-09-30	2014-07-01	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of ATR kinase
RU2018147217A (ru)	2011-09-30	2019-01-18	Вертекс Фармасьютикалз Инкорпорейтед	Способы получения соединений, которые можно использовать в качестве ингибиторов киназы atr
IN2014KN00943A (pt)	2011-09-30	2015-08-21	Vertex Pharma
US8853217B2 (en)	2011-09-30	2014-10-07	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of ATR kinase
AU2012315384B2 (en)	2011-09-30	2017-08-10	Vertex Pharmaceuticals Incorporated	Treating pancreatic cancer and non-small cell lung cancer with ATR inhibitors
US9403808B2 (en) *	2011-10-28	2016-08-02	Hoffmann-La Roche Inc.	Pyrazine derivatives
EP2776429A1 (en)	2011-11-09	2014-09-17	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of atr kinase
WO2013071090A1 (en)	2011-11-09	2013-05-16	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of atr kinase
EP2776421A1 (en)	2011-11-09	2014-09-17	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of atr kinase
US8841449B2 (en)	2011-11-09	2014-09-23	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of ATR kinase
US8841450B2 (en)	2011-11-09	2014-09-23	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of ATR kinase
CN104582795B (zh)	2012-04-05	2018-04-20	沃泰克斯药物股份有限公司	可用作atr激酶抑制剂的化合物及其组合疗法
KR20150044952A (ko) *	2012-08-23	2015-04-27	에프. 호프만-라 로슈 아게	암의 치료를 위한 신규한 페닐-피리딘/피라진 아미드
DK2904406T3 (en)	2012-10-04	2018-06-18	Vertex Pharma	METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
US8912198B2 (en)	2012-10-16	2014-12-16	Vertex Pharmaceuticals Incorporated	Compounds useful as inhibitors of ATR kinase
LT3418281T (lt)	2012-12-07	2021-01-11	Vertex Pharmaceuticals Inc.	Pirazolo[1,5-a]pirimidinai, naudotini kaip atr kinazės inhibitoriai, skirti vėžinių ligų gydymui
AU2014241430B2 (en) *	2013-03-14	2018-04-26	Dart Neuroscience (Cayman) Ltd.	Substituted pyridine and pyrazine compounds as PDE4 inhibitors
WO2014143240A1 (en)	2013-03-15	2014-09-18	Vertex Pharmaceuticals Incorporated	Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
HUE046727T2 (hu)	2013-12-06	2020-03-30	Vertex Pharma	Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai
ES2777608T3 (es)	2014-06-05	2020-08-05	Vertex Pharma	Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útiles como inhibidores de ATR cinasa, la preparación de dicho compuesto y diferentes formas sólidas del mismo
US11179394B2 (en)	2014-06-17	2021-11-23	Vertex Pharmaceuticals Incorporated	Method for treating cancer using a combination of Chk1 and ATR inhibitors
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2007
- 2007-09-24 EP EP07820501A patent/EP2074096B1/en not_active Not-in-force
- 2007-09-24 KR KR1020097009023A patent/KR101107896B1/ko not_active Expired - Fee Related
- 2007-09-24 RU RU2009116670/04A patent/RU2454405C2/ru not_active IP Right Cessation
- 2007-09-24 WO PCT/EP2007/060094 patent/WO2008040651A1/en not_active Ceased
- 2007-09-24 AU AU2007304365A patent/AU2007304365A1/en not_active Abandoned
- 2007-09-24 MX MX2009003222A patent/MX2009003222A/es active IP Right Grant
- 2007-09-24 CA CA002664119A patent/CA2664119A1/en not_active Abandoned
- 2007-09-24 CN CNA2007800369086A patent/CN101522626A/zh active Pending
- 2007-09-24 JP JP2009530843A patent/JP2010505789A/ja active Pending
- 2007-09-24 EP EP12153000A patent/EP2450350A1/en not_active Withdrawn
- 2007-09-24 BR BRPI0717845-0A patent/BRPI0717845A2/pt not_active IP Right Cessation
- 2007-09-27 US US11/904,425 patent/US20080085906A1/en not_active Abandoned
2009
- 2009-02-06 US US12/366,692 patent/US7812028B2/en not_active Expired - Fee Related
- 2009-03-10 NO NO20091045A patent/NO20091045L/no not_active Application Discontinuation
- 2009-03-12 IL IL197577A patent/IL197577A0/en unknown
- 2009-04-03 ZA ZA200902353A patent/ZA200902353B/xx unknown
2010
- 2010-06-29 US US12/825,374 patent/US8188093B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20090143409A1 (en)	2009-06-04
WO2008040651A1 (en)	2008-04-10
AU2007304365A1 (en)	2008-04-10
JP2010505789A (ja)	2010-02-25
US7812028B2 (en)	2010-10-12
RU2454405C2 (ru)	2012-06-27
EP2074096A1 (en)	2009-07-01
RU2009116670A (ru)	2010-11-10
IL197577A0 (en)	2009-12-24
US20100267745A1 (en)	2010-10-21
NO20091045L (no)	2009-03-31
MX2009003222A (es)	2009-04-06
CN101522626A (zh)	2009-09-02
CA2664119A1 (en)	2008-04-10
EP2074096B1 (en)	2012-06-27
KR20090075852A (ko)	2009-07-09
ZA200902353B (en)	2010-04-28
US20080085906A1 (en)	2008-04-10
US8188093B2 (en)	2012-05-29
KR101107896B1 (ko)	2012-01-25
EP2450350A1 (en)	2012-05-09

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2015-12-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 7A E 8A ANUIDADES.
2016-04-05	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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