BRPI0507540A - processo para a produção de conjugados de polissacarìdeos e polinucleotìdeos - Google Patents

processo para a produção de conjugados de polissacarìdeos e polinucleotìdeos

Info

Publication number
BRPI0507540A
BRPI0507540A BRPI0507540-8A BRPI0507540A BRPI0507540A BR PI0507540 A BRPI0507540 A BR PI0507540A BR PI0507540 A BRPI0507540 A BR PI0507540A BR PI0507540 A BRPI0507540 A BR PI0507540A
Authority
BR
Brazil
Prior art keywords
aldonic acid
polynucleotide
polysaccharide
derivative
production
Prior art date
Application number
BRPI0507540-8A
Other languages
English (en)
Inventor
Klaus Sommermeyer
Original Assignee
Supramol Parenteral Colloids
Noxxon Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supramol Parenteral Colloids, Noxxon Pharma Ag filed Critical Supramol Parenteral Colloids
Publication of BRPI0507540A publication Critical patent/BRPI0507540A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCESSO PARA A PRODUçãO DE CONJUGADOS DE POLISSACARìDEOS E POLINUCLEOTìDEOS. A presente invenção refere-se a um processo para a produção de um conjugado de um polissacarídeo e de um polinucleotídeo compreendendo as etapas: (a) provisão de um ácido aldónico do polissacarídeo ou de um derivado deste; (b) reação do ácido aldónico com um derivado de álcool, preferivelmente um derivado de carbonato de um álcool, com um éster de ácido aldónico, preferivelmente com um éster de ácido aldónico ativado; e (c) reação do éster de ácido aldónico com o polinucleotídeo, onde o polinucleotídeo exibe um grupo de amino funcional, onde a reação do ácido aldónico com o derivado de álcool na etapa (b) ocorre em um solvente polar aprótico seco.
BRPI0507540-8A 2004-02-09 2005-02-08 processo para a produção de conjugados de polissacarìdeos e polinucleotìdeos BRPI0507540A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004006249 2004-02-09
PCT/EP2005/001252 WO2005074993A2 (de) 2004-02-09 2005-02-08 Verfahren zur herstellung von konjugaten aus polysacchariden und polynukleotiden

Publications (1)

Publication Number Publication Date
BRPI0507540A true BRPI0507540A (pt) 2007-07-03

Family

ID=34832566

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507540-8A BRPI0507540A (pt) 2004-02-09 2005-02-08 processo para a produção de conjugados de polissacarìdeos e polinucleotìdeos

Country Status (9)

Country Link
US (1) US20090281296A1 (pt)
EP (1) EP1713509A2 (pt)
JP (2) JP5193468B2 (pt)
KR (1) KR101189555B1 (pt)
CN (1) CN1917905B (pt)
AU (1) AU2005210142A1 (pt)
BR (1) BRPI0507540A (pt)
CA (1) CA2555467C (pt)
WO (1) WO2005074993A2 (pt)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
US7538092B2 (en) 2002-10-08 2009-05-26 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
ES2390885T3 (es) * 2004-03-11 2012-11-19 Fresenius Kabi Deutschland Gmbh Conjugados de hidroxialquilalmidón y una proteína
DK2135949T3 (da) 2006-02-14 2013-02-04 Noxxon Pharma Ag MCP-1-bindende nukleinsyrer
WO2008052774A2 (en) 2006-10-31 2008-05-08 Noxxon Pharma Ag Methods for detection of a single- or double-stranded nucleic acid molecule
EP2562256A3 (en) 2007-09-24 2013-06-19 Noxxon Pharma AG C5a binding nucleic acids
WO2010108657A2 (en) 2009-03-23 2010-09-30 Noxxon Pharma Ag C5a binding nucleic acids and the use thereof
EP2561079A1 (en) 2010-04-21 2013-02-27 Noxxon Pharma AG Lipid binding nucleic acids
WO2012025251A1 (en) 2010-08-27 2012-03-01 Noxxon Pharma Ag Nucleic acids for treatment of chronic complications of diabetes
JP2014503187A (ja) 2010-10-29 2014-02-13 ノクソン ファーマ エージー 身体からヘプシジンを除去するためのヘプシジン結合核酸の使用
US9976145B2 (en) 2011-01-10 2018-05-22 Noxxon Pharma Ag Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
JP2014533098A (ja) 2011-10-21 2014-12-11 ノクソン・ファルマ・アクチエンゲゼルシャフト グルカゴン結合核酸
BR112014016939A2 (pt) 2012-01-10 2019-09-24 Noxxon Pharma Ag ácidos nucleicos que se ligam especificamente a cgrp
KR102034203B1 (ko) 2012-01-10 2019-10-18 아프타리온 바이오테크 아게 새로운 C5a 결합 핵산
WO2013113503A1 (en) 2012-01-31 2013-08-08 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and an oligonucleotide
EP3228715B1 (en) 2012-02-09 2019-08-14 Life Technologies Corporation Conjugated polymeric particle and method of making same
WO2013170963A2 (en) 2012-05-16 2013-11-21 Noxxon Pharma Ag Enzymatic synthesis of l-nucleic acids
EP3065744B1 (en) 2013-11-04 2021-04-21 Noxxon Pharma AG A ccl2 antagonist for use in treating proteinuria
CN107922974B (zh) 2015-07-02 2021-11-09 生命技术公司 羧基官能亲水微珠的偶合
EP3320115B1 (en) 2015-07-06 2020-09-02 Life Technologies Corporation Substrates and methods useful in sequencing
EP3443095A1 (en) 2016-04-15 2019-02-20 Noxxon Pharma AG Method of modulating the number and the distribution of tumor-infiltrating leukocytes in tumors
EP4306640A1 (en) 2022-06-21 2024-01-17 TME Pharma AG Method for treating a tumor in a subject
KR20250025627A (ko) 2022-06-21 2025-02-24 티엠이 파마 아게 대상체의 종양을 치료하는 방법
EP4620474A1 (en) 2024-03-20 2025-09-24 APTARION biotech AG Method of treating a disorder with a c5a inhibitor
WO2025196240A1 (en) 2024-03-20 2025-09-25 Aptarion Biotech Ag Method of treating a disorder with a c5a inhibitor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3720663A (en) * 1971-06-24 1973-03-13 Nat Starch Chem Corp Preparation of starch esters
US6172208B1 (en) * 1992-07-06 2001-01-09 Genzyme Corporation Oligonucleotides modified with conjugate groups
US5981507A (en) * 1995-12-14 1999-11-09 Advanced Magnetics, Inc. Polymeric carriers linked to nucleotide analogues via a phosphoramide bond
FR2809112B1 (fr) * 2000-05-16 2004-05-07 Centre Nat Rech Scient Materiaux a base de polymeres biodegradables et son procede de preparation
EP1283855B1 (de) * 2000-05-23 2005-11-02 Dyomics GmbH Stabile nir-marker-farbstoffe auf der basis von benzopyrylium-polymethinen
DE10112825A1 (de) * 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
ATE469164T1 (de) * 2001-10-26 2010-06-15 Noxxon Pharma Ag Modifizierte l-nukleinsäure
DE10207072A1 (de) * 2002-02-20 2003-08-28 Supramol Parenteral Colloids Stärkederivate, ihre Konjugate und Verfahren zur Herstellung derselben
DE10209821A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
DE10254745A1 (de) * 2002-11-23 2004-06-03 Supramol Parenteral Colloids Gmbh Imidazolide von Polysaccharid Aldonsäuren, Verfahren zu ihrer Herstellung und Verwendung zur Kopplung an pharmazeutische Wirkstoffe
DE10256558A1 (de) * 2002-12-04 2004-09-16 Supramol Parenteral Colloids Gmbh Ester von Polysaccharid Aldonsäuren, Verfahren zu ihrer Herstellung und Verwendung zur Kopplung an pharmazeutische Wirkstoffe
DE10302520A1 (de) * 2003-01-23 2004-08-05 Supramol Parenteral Colloids Gmbh Kohlensäurediester von Stärkefraktionen und deren Derivate, Verfahren zu ihrer Herstellung und Verwendung zur Kopplung an pharmazeutische Wirkstoffe

Also Published As

Publication number Publication date
EP1713509A2 (de) 2006-10-25
AU2005210142A1 (en) 2005-08-18
WO2005074993A2 (de) 2005-08-18
WO2005074993A3 (de) 2006-04-20
CN1917905A (zh) 2007-02-21
KR20060132906A (ko) 2006-12-22
CA2555467A1 (en) 2005-08-18
CA2555467C (en) 2012-10-09
KR101189555B1 (ko) 2012-10-16
JP5193468B2 (ja) 2013-05-08
JP2007522164A (ja) 2007-08-09
US20090281296A1 (en) 2009-11-12
JP2013056889A (ja) 2013-03-28
CN1917905B (zh) 2012-01-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2308 DE 31/03/2015.

B15K Others concerning applications: alteration of classification

Ipc: A61K 47/61 (2017.01)