BRPI0413323A - processo para a preparação de vacinas conjugadas de polissacarìdeo-proteìna - Google Patents

processo para a preparação de vacinas conjugadas de polissacarìdeo-proteìna

Info

Publication number
BRPI0413323A
BRPI0413323A BRPI0413323-4A BRPI0413323A BRPI0413323A BR PI0413323 A BRPI0413323 A BR PI0413323A BR PI0413323 A BRPI0413323 A BR PI0413323A BR PI0413323 A BRPI0413323 A BR PI0413323A
Authority
BR
Brazil
Prior art keywords
preparation
polysaccharide
protein
protein conjugate
conjugate vaccines
Prior art date
Application number
BRPI0413323-4A
Other languages
English (en)
Inventor
Ellen Jessouroun
Ivna Alana Freitas Br Silveira
Renata Chagas Bastos
Carl E Frasch
Che-Hung Robert Lee
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Publication of BRPI0413323A publication Critical patent/BRPI0413323A/pt
Publication of BRPI0413323B1 publication Critical patent/BRPI0413323B1/pt
Publication of BRPI0413323B8 publication Critical patent/BRPI0413323B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE VACINAS CONJUGADAS DE POLISSACARìDEO-PROTEìNA". Métodos para a preparação de vacinas conjugadas de polissacarídeo-proteína em produção elevada, são fornecidos. Os métodos envolvem a reação de um grupo de hidrazida em um reagente com um grupo de aldeído no outro reagente. A reação prossegue rapidamente com uma eficiência elevada de conjugação. Os processos de purificação simplificados podem ser empregados para separar o produto conjugado do polissacarídeo e proteína não conjugados e outros subprodutos de molécula pequena.
BRPI0413323A 2003-08-06 2004-08-06 método para a preparação de uma vacina meningocócica conjugada ao toxóide tetânico em volumes comerciais BRPI0413323B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49338903P 2003-08-06 2003-08-06
PCT/US2004/026431 WO2005037320A2 (en) 2003-08-06 2004-08-06 Process for preparing polysaccharide-protein conjugate vaccines

Publications (3)

Publication Number Publication Date
BRPI0413323A true BRPI0413323A (pt) 2006-10-10
BRPI0413323B1 BRPI0413323B1 (pt) 2019-09-10
BRPI0413323B8 BRPI0413323B8 (pt) 2021-05-25

Family

ID=34135243

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0413323A BRPI0413323B8 (pt) 2003-08-06 2004-08-06 método para a preparação de uma vacina meningocócica conjugada ao toxóide tetânico em volumes comerciais
BRPI0413309A BRPI0413309B8 (pt) 2003-08-06 2004-08-06 método para a preparação de uma vacina conjugada de polissacarídeo-proteína

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0413309A BRPI0413309B8 (pt) 2003-08-06 2004-08-06 método para a preparação de uma vacina conjugada de polissacarídeo-proteína

Country Status (8)

Country Link
US (1) US9173931B2 (pt)
EP (4) EP1651262A2 (pt)
CN (4) CN102151331B (pt)
AU (2) AU2004263135B2 (pt)
BR (2) BRPI0413323B8 (pt)
CA (4) CA2948114C (pt)
WO (2) WO2005014037A2 (pt)
ZA (2) ZA200601689B (pt)

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GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination
NZ550533A (en) * 2004-04-30 2010-02-26 Novartis Vaccines & Diagnostic Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin
WO2005117965A1 (en) * 2004-06-04 2005-12-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for preparing immunogenic conjugates
GB0502095D0 (en) 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
US7955605B2 (en) 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US7709001B2 (en) * 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
EP3311836A1 (en) 2005-04-08 2018-04-25 Wyeth LLC Multivalent pneumococcal polysaccharide-protein conjugate composition
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BR112016015835B1 (pt) * 2014-01-21 2023-12-26 Pfizer Inc Processo de preparação de conjugados compreendendo polissacarídeos capsulares de streptococcus pneumoniae
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Also Published As

Publication number Publication date
ZA200601688B (en) 2007-05-30
CA2534870C (en) 2014-05-06
CA2948114C (en) 2019-02-26
EP1651262A2 (en) 2006-05-03
CN100423774C (zh) 2008-10-08
BRPI0413309B8 (pt) 2021-05-25
EP1651261A2 (en) 2006-05-03
HK1195512A1 (zh) 2014-11-14
WO2005037320A3 (en) 2006-01-05
WO2005014037A3 (en) 2006-01-26
EP2366403B1 (en) 2014-10-08
WO2005014037A2 (en) 2005-02-17
CA2844154A1 (en) 2005-02-17
WO2005037320A2 (en) 2005-04-28
BRPI0413309B1 (pt) 2019-10-01
AU2004281630A1 (en) 2005-04-28
CA2844154C (en) 2016-12-20
BRPI0413323B8 (pt) 2021-05-25
EP2366404B1 (en) 2014-11-19
ZA200601689B (en) 2007-12-27
EP2366404A2 (en) 2011-09-21
US20070110762A1 (en) 2007-05-17
AU2004263135A1 (en) 2005-02-17
CA2534870A1 (en) 2005-02-17
EP2366403A3 (en) 2012-03-14
AU2004263135B2 (en) 2010-11-25
CN1863554A (zh) 2006-11-15
BRPI0413323B1 (pt) 2019-09-10
CN103623405A (zh) 2014-03-12
CA2948114A1 (en) 2005-02-17
CN103623405B (zh) 2016-06-15
CA2535043A1 (en) 2005-04-28
EP2366403A2 (en) 2011-09-21
EP2366404A3 (en) 2012-03-14
CN102151331A (zh) 2011-08-17
US9173931B2 (en) 2015-11-03
CN1863553A (zh) 2006-11-15
EP1651261B1 (en) 2014-10-08
CN102151331B (zh) 2013-10-30
CN1863553B (zh) 2011-05-04
BRPI0413309A (pt) 2006-10-10

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