BRPI0508505A - processo para acoplamento cruzado de indóis - Google Patents

processo para acoplamento cruzado de indóis

Info

Publication number
BRPI0508505A
BRPI0508505A BRPI0508505-5A BRPI0508505A BRPI0508505A BR PI0508505 A BRPI0508505 A BR PI0508505A BR PI0508505 A BRPI0508505 A BR PI0508505A BR PI0508505 A BRPI0508505 A BR PI0508505A
Authority
BR
Brazil
Prior art keywords
cross coupling
indole
alkyl
aryl
indos
Prior art date
Application number
BRPI0508505-5A
Other languages
English (en)
Inventor
Ahmad Khodabocus
Guisheng Li
Zhi-Hui Lu
Frank Roschangar
Chris Hugh Senanayake
Ming Shen
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34962116&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0508505(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BRPI0508505A publication Critical patent/BRPI0508505A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCESSO PARA ACOPLAMENTO CRUZADO DE INDóIS. A presente invenção fornece um processo para fabricação de um composto de fórmula geral I: em que: R=H ou C~ 1~~ -~~ 8~ alquila: X=C~ 3~~ -~C~ 8~ cicloalquila, C~ 3~~ -~C~ 8~ arila ou C~ 3~~ -~C~ 8~ alquila; Y= heteroarila ou arila; Z=H, HO~ 2~C-, C~ 1~~ -~~8 ~~ alquila O~ 2~C~ -~, C~ 1~~ -~~ 6~ alquila HNC(O)-, e tal como descrito aqui.
BRPI0508505-5A 2004-03-08 2005-03-07 processo para acoplamento cruzado de indóis BRPI0508505A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55110704P 2004-03-08 2004-03-08
PCT/US2005/006919 WO2005092855A1 (en) 2004-03-08 2005-03-07 Process for cross coupling indoles

Publications (1)

Publication Number Publication Date
BRPI0508505A true BRPI0508505A (pt) 2007-07-31

Family

ID=34962116

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508505-5A BRPI0508505A (pt) 2004-03-08 2005-03-07 processo para acoplamento cruzado de indóis

Country Status (14)

Country Link
US (1) US7332614B2 (pt)
EP (1) EP1727797B1 (pt)
JP (2) JP5442949B2 (pt)
KR (1) KR20060128045A (pt)
CN (1) CN1930124A (pt)
AU (1) AU2005227289B2 (pt)
BR (1) BRPI0508505A (pt)
CA (1) CA2552980A1 (pt)
IL (1) IL177936A0 (pt)
NZ (1) NZ550177A (pt)
RU (1) RU2430916C2 (pt)
TW (1) TW200631939A (pt)
WO (1) WO2005092855A1 (pt)
ZA (1) ZA200605150B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
CN102911161A (zh) * 2004-02-20 2013-02-06 贝林格尔.英格海姆国际有限公司 病毒聚合酶抑制剂
RU2430916C2 (ru) * 2004-03-08 2011-10-10 Бёрингер Ингельхайм Фармасьютиклз, Инк. Способ кросс-сочетания индолов
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
MX2007009689A (es) * 2005-02-11 2007-09-13 Boehringer Ingelheim Int Proceso para preparar indoles disustituidos en posicion 2,3.
US8076365B2 (en) * 2005-08-12 2011-12-13 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2557111B1 (fr) * 1983-12-21 1986-04-11 Rhone Poulenc Sante Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
GB0323845D0 (en) * 2003-10-10 2003-11-12 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
RU2430916C2 (ru) * 2004-03-08 2011-10-10 Бёрингер Ингельхайм Фармасьютиклз, Инк. Способ кросс-сочетания индолов

Also Published As

Publication number Publication date
KR20060128045A (ko) 2006-12-13
JP2011241217A (ja) 2011-12-01
WO2005092855A1 (en) 2005-10-06
CN1930124A (zh) 2007-03-14
AU2005227289A1 (en) 2005-10-06
US20050234242A1 (en) 2005-10-20
US7332614B2 (en) 2008-02-19
TW200631939A (en) 2006-09-16
EP1727797B1 (en) 2012-05-30
AU2005227289B2 (en) 2012-03-08
JP2007527906A (ja) 2007-10-04
JP5442949B2 (ja) 2014-03-19
RU2430916C2 (ru) 2011-10-10
ZA200605150B (en) 2007-10-31
EP1727797A1 (en) 2006-12-06
IL177936A0 (en) 2006-12-31
RU2006135543A (ru) 2008-04-20
CA2552980A1 (en) 2005-10-06
NZ550177A (en) 2010-08-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.