BRPI0508874A - derivados de epotilona - Google Patents

derivados de epotilona

Info

Publication number
BRPI0508874A
BRPI0508874A BRPI0508874-7A BRPI0508874A BRPI0508874A BR PI0508874 A BRPI0508874 A BR PI0508874A BR PI0508874 A BRPI0508874 A BR PI0508874A BR PI0508874 A BRPI0508874 A BR PI0508874A
Authority
BR
Brazil
Prior art keywords
epothilone derivatives
derivatives
epothilone
epotilone
formula
Prior art date
Application number
BRPI0508874-7A
Other languages
English (en)
Inventor
Karl-Heinz Altmann
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0508874A publication Critical patent/BRPI0508874A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE EPOTILONA A presente invenção refere-se a derivados de epotilona da fór-mula (I) e seu uso como um produto farmacêutico.
BRPI0508874-7A 2004-03-16 2005-03-15 derivados de epotilona BRPI0508874A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0405898.8A GB0405898D0 (en) 2004-03-16 2004-03-16 Organic compounds
PCT/EP2005/002756 WO2005090335A1 (en) 2004-03-16 2005-03-15 Epothilone derivatives

Publications (1)

Publication Number Publication Date
BRPI0508874A true BRPI0508874A (pt) 2007-09-04

Family

ID=32117793

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508874-7A BRPI0508874A (pt) 2004-03-16 2005-03-15 derivados de epotilona

Country Status (11)

Country Link
US (2) US7825141B2 (pt)
EP (3) EP2301940A1 (pt)
JP (1) JP2007529455A (pt)
KR (1) KR20070006773A (pt)
CN (2) CN1926133B (pt)
AU (1) AU2005223325B2 (pt)
BR (1) BRPI0508874A (pt)
CA (1) CA2556915A1 (pt)
GB (1) GB0405898D0 (pt)
RU (1) RU2006136089A (pt)
WO (1) WO2005090335A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007016046A1 (de) * 2007-03-30 2008-10-23 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von Epothilonderivaten durch selektive katalytische Epoxidierung

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59609305D1 (de) 1995-11-17 2002-07-11 Biotechnolog Forschung Gmbh Epothilon-Derivate und deren Herstellung
DE19751027A1 (de) 1996-11-20 1998-05-28 Degussa Arylsubstituierte aminoacylierte Phosphonsäuren und deren Halbester
US6380394B1 (en) * 1996-12-13 2002-04-30 The Scripps Research Institute Epothilone analogs
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
AU738576B2 (en) 1997-12-04 2001-09-20 Bristol-Myers Squibb Company A process for the reduction of oxiranyl epothilones to olefinic epothilones
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
DE19856128A1 (de) 1998-12-04 2000-06-15 Volkswagen Ag Verfahren und Einrichtung zum Lesen von Navigationsdaten
BR9916833A (pt) * 1998-12-22 2001-09-25 Novartis Ag Derivados de epotilona e seu uso como agentes antitumor
EE04852B1 (et) 1999-02-22 2007-06-15 Gesellschaft Fuer Biotechnologische Forschung Mbh C-21 modifitseeritud epotioloonid, nende valmistamise meetod ning kasutamine ja ravimkoostise kasutamine vähkkasvajate või teiste proliferatiivsete haiguste ravimisel
ES2315399T3 (es) 2001-08-23 2009-04-01 Novartis Ag Analogos de epotilona ciclobutilo y ciclopropilo.
AU2003218110A1 (en) 2002-03-12 2003-09-29 Bristol-Myers Squibb Company C3-cyano epothilone derivatives
ES2297189T3 (es) 2002-08-02 2008-05-01 Novartis Ag Derivados de epotilona.

Also Published As

Publication number Publication date
WO2005090335A1 (en) 2005-09-29
AU2005223325A1 (en) 2005-09-29
KR20070006773A (ko) 2007-01-11
EP2213670A3 (en) 2010-11-24
US7825141B2 (en) 2010-11-02
GB0405898D0 (en) 2004-04-21
EP1730138A1 (en) 2006-12-13
AU2005223325B2 (en) 2009-09-10
CN1926133B (zh) 2010-06-23
RU2006136089A (ru) 2008-04-27
JP2007529455A (ja) 2007-10-25
CN1926133A (zh) 2007-03-07
EP2213670A2 (en) 2010-08-04
CA2556915A1 (en) 2005-09-29
EP2301940A1 (en) 2011-03-30
US20110009459A1 (en) 2011-01-13
CN101805328A (zh) 2010-08-18
US20080114040A1 (en) 2008-05-15

Similar Documents

Publication Publication Date Title
BRPI0408347A (pt) derivados de pirimidina
BRPI0512797A (pt) derivados de quinazolinona como inibidores de parp
UY27714A1 (es) 2 - heteroaril - pirimidinas inhibidoras de cdk, su preparación y su uso como medicamentos.
ECSP099177A (es) Derivados de quinazolinona e isoquinolinona
CR20110016A (es) Compuestos quimicos 251
UY30206A1 (es) Derivados de diamina, composiciones farmacéuticas conteniéndolos, procesos de preparacion y aplicaciones
ECSP088152A (es) 7-aza-indazoles sustituidos, composiciones que los contienen, procedimiento de fabricación y utilización
UY29112A1 (es) Derivados de pirazol condensado, su preparacion y su aplicacion terapeutica
BRPI0513901A (pt) derivados de uréia cìclicos substituìdos, preparação dos mesmos e uso farmacêutico dos mesmos como inibidores de cinase
ECSP088252A (es) 7-aza-indazoles sustituidos, composiciones que los contienen, procedimiento de fabricación y utilización
BRPI0514731A (pt) derivados de pirimidina
UY27419A1 (es) Formulaciones en combinación de derivados de 1,4-benzotiepina-1,1-dioxido con otras sustancias activas, y su utilización.
BRPI0511874A (pt) derivados da pirrolopiridina
NI200700176A (es) Compuestos peptídicos
BR0317693A (pt) Derivados de epotilona
BR0113581A (pt) Derivados de aril-piperazinas e seu uso como psicofármacos
UY29768A1 (es) Derivados de benzotiazolonas, procesos para su preparación, composiciones farmacéuticas que los contienen y aplicaciones
UY28917A1 (es) Derivados de tetrahidroisoquinolilsulfonamidas composiciones farmaceuticas y su uso terapeutico
DOP2006000024A (es) Tiazolidinonas, su preparación y su uso como medicamento
UY29394A1 (es) Derivados sustituidos de n-(5-(2-propilamino.1.hidroxietil)-2-hdroxifenil) metano sulfonamida, composiciones farmacéuticas que lo contienen y aplicaciónes.
UY29892A1 (es) Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
BRPI0416739A (pt) derivados de indano substituìdo heterocìclico e compostos afins para o tratamento de esquizofrenia
PT1183247E (pt) Sistemas tiazole policiclicos e sua utilizacao como anorecticos
UY27628A1 (es) "2'-halo -3',5'-dialcoxi-fen-1'il-2-imidazolidinas y su uso como un fármaco"
SV2006002238A (es) Inhibidores de la adenilato ciclasa soluble ref. p-sv-78. 959/gh

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.