BRPI0509153A - composto, composição farmacêutica, uso de um composto, e, métodos de contracepção, e de tratamento de um distúrbio ginecológico - Google Patents
composto, composição farmacêutica, uso de um composto, e, métodos de contracepção, e de tratamento de um distúrbio ginecológicoInfo
- Publication number
- BRPI0509153A BRPI0509153A BRPI0509153-5A BRPI0509153A BRPI0509153A BR PI0509153 A BRPI0509153 A BR PI0509153A BR PI0509153 A BRPI0509153 A BR PI0509153A BR PI0509153 A BRPI0509153 A BR PI0509153A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- compound
- optionally substituted
- halogen
- contraception
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
- 125000004011 3 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000001845 4 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000000298 cyclopropenyl group Chemical group [H]C1=C([H])C1([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/001—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class spiro-linked
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, E, MéTODOS DE CONTRACEPçãO, E DE TRATAMENTO DE UM DISTúRBIO GINECOLóGICO. A invenção do assunto fornece um composto de acordo com a Fórmula I, em que a Fórmula (I) é O, NOH, NO(l -4C)alquila, NO(1-4c)acila; A1-A5 são C, substituído por RI, ou N, desde que pelo menos um e não mais do que três de A1-A5 sejam N; ou um ou dois de A1, A2 e A5 sejam N e os outros sejam C, substituídos por R1, e A3 e A4 juntos representem um anel benzo fundido ou um anel aromático contendo nitrogênio de cinco ou seis membros fundidos, ambos opcionalmente substituídos por um ou mais halogênio e/ou (1-4C)alquila; RI é H, halogênio, (1-4C)alquila, (1-4C)alcóxi; R2 é H, (1-4C)alquila ou (1-6C)aquenila, ambos opcionalmente substituídos por um grupo (6-10)arila, que é opcionalmente substituído por um ou mais halogênio e/ou (1-4C)alquila; e R3 é H ou (1-4C)alquila, opcionalmente substituída por um ou mais átomos de halogênio; e R4 é ciclopropila ou ciclopropenila, ambos opcionalmente substituídos por um ou mais halogênio e/ou (1-4C)alquila; ou R2, junto com R3, forma um anel carbocíclico de 3, 4, 5 ou 6 membros e R4 é ciclopropila ou ciclopenila, ambos opcionalmente substituídos por um ou mais halogênios e/ou (l-4C)alquila; ou R2 é H ou (1-4C)alquila; e R3, junto com R4, forma um anel carbocíclico saturado ou insaturado de 5, 6 ou 7 membros; R5 é H ou (1-4C)alquila; ou um seu sal e/ou forma de hidrato e/ou pró-droga farmaceuticamente aceitável.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55621004P | 2004-03-25 | 2004-03-25 | |
| EP04101241 | 2004-03-25 | ||
| PCT/EP2005/051265 WO2005092912A1 (en) | 2004-03-25 | 2005-03-18 | Progesterone receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0509153A true BRPI0509153A (pt) | 2007-11-20 |
Family
ID=34928929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0509153-5A BRPI0509153A (pt) | 2004-03-25 | 2005-03-18 | composto, composição farmacêutica, uso de um composto, e, métodos de contracepção, e de tratamento de um distúrbio ginecológico |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7691836B2 (pt) |
| EP (1) | EP1735330B1 (pt) |
| JP (1) | JP4922918B2 (pt) |
| KR (1) | KR20070028355A (pt) |
| CN (1) | CN100549023C (pt) |
| AR (1) | AR048330A1 (pt) |
| AU (1) | AU2005225560B2 (pt) |
| BR (1) | BRPI0509153A (pt) |
| CA (1) | CA2560694C (pt) |
| CY (1) | CY1107132T1 (pt) |
| DE (1) | DE602005003564T2 (pt) |
| DK (1) | DK1735330T3 (pt) |
| EC (1) | ECSP066881A (pt) |
| ES (1) | ES2297699T3 (pt) |
| IL (1) | IL178010A0 (pt) |
| LV (1) | LV13527B (pt) |
| MX (1) | MXPA06010906A (pt) |
| MY (1) | MY143074A (pt) |
| NO (1) | NO20064822L (pt) |
| NZ (1) | NZ549862A (pt) |
| PE (1) | PE20060094A1 (pt) |
| PL (1) | PL1735330T3 (pt) |
| PT (1) | PT1735330E (pt) |
| RU (1) | RU2381232C2 (pt) |
| SI (1) | SI1735330T1 (pt) |
| TW (1) | TW200531977A (pt) |
| UA (1) | UA88782C2 (pt) |
| WO (1) | WO2005092912A1 (pt) |
| ZA (1) | ZA200607801B (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016090139A1 (en) * | 2014-12-03 | 2016-06-09 | Evestra, Inc. | Combination of estrogens plus antiprogestins with significant partial agonistic effect as an effective treatment of menopausal symptoms and for prevention of the occurrence of breast cancer |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE290198C (pt) | ||||
| GB8513723D0 (en) | 1985-05-31 | 1985-07-03 | Erba Farmitalia | 11-beta substituted steroids |
| IE60780B1 (en) | 1987-01-23 | 1994-08-10 | Akzo Nv | New 11-aryl steroid derivatives |
| EP0289073B1 (en) | 1987-04-24 | 1991-11-27 | Akzo N.V. | Novel 11-aryloestrane and 11-arylpregnane derivatives |
| EP0303306B1 (en) | 1987-08-08 | 1993-03-10 | Akzo N.V. | Contraceptive implant |
| DE3822770A1 (de) * | 1988-07-01 | 1990-01-04 | Schering Ag | 13-alkyl-11ss-phenylgonane |
| DD290198A5 (de) * | 1989-09-18 | 1991-05-23 | Zi Fuer Mikrobiologie Und Experimentelle Therapie Jena,De | Verfahren zur herstellung von 11 beta-arylsubstituierten estra-4,9-dien-3-on-17(s)-spiro-1'-cyclohexan-2'-onen und 11 beta-arylsubstituierten estra-4,9-dien-3-on-17(s)-spiro-1'-cyclohexan-2'-olen sowie deren derivate |
| FR2658516B1 (fr) | 1990-02-22 | 1992-06-12 | Roussel Uclaf | Nouveaux produits sterouides comportant un radical spiro en position 17, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| ZA929315B (en) | 1991-12-20 | 1993-05-24 | Akzo Nv | 17-spirofuran-3'-ylidene steroids. |
| CA2100514C (en) | 1992-07-29 | 2005-03-29 | Johannes A. M. Hamersma | 17-spiromethylene steroids |
| US5696130A (en) | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Tricyclic steroid receptor modulator compounds and methods |
| NZ332894A (en) | 1996-06-25 | 1999-05-28 | Akzo Nobel Nv | A regimen containing progestogen and/or estrogen with two or more anti-progestogen dosage units |
| IL123813A0 (en) | 1997-04-11 | 1998-10-30 | Akzo Nobel Nv | Drug delivery system for two or more active substances |
| TR200001334T2 (tr) | 1997-11-14 | 2000-09-21 | Akzo Nobel N.V. | Progestojen-anti-progestojen rejimleri. |
| US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
| US6172052B1 (en) * | 1998-12-04 | 2001-01-09 | Research Triangle Institute | 17β-acyl-17α-propynyl-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
-
2005
- 2005-03-15 TW TW094107888A patent/TW200531977A/zh unknown
- 2005-03-18 US US10/594,103 patent/US7691836B2/en active Active
- 2005-03-18 RU RU2006137578/04A patent/RU2381232C2/ru not_active IP Right Cessation
- 2005-03-18 DE DE602005003564T patent/DE602005003564T2/de not_active Expired - Lifetime
- 2005-03-18 SI SI200530144T patent/SI1735330T1/sl unknown
- 2005-03-18 CA CA2560694A patent/CA2560694C/en not_active Expired - Fee Related
- 2005-03-18 MX MXPA06010906A patent/MXPA06010906A/es active IP Right Grant
- 2005-03-18 NZ NZ549862A patent/NZ549862A/en unknown
- 2005-03-18 CN CNB2005800096126A patent/CN100549023C/zh not_active Expired - Fee Related
- 2005-03-18 DK DK05733590T patent/DK1735330T3/da active
- 2005-03-18 EP EP05733590A patent/EP1735330B1/en not_active Expired - Lifetime
- 2005-03-18 JP JP2007504406A patent/JP4922918B2/ja not_active Expired - Fee Related
- 2005-03-18 BR BRPI0509153-5A patent/BRPI0509153A/pt not_active IP Right Cessation
- 2005-03-18 WO PCT/EP2005/051265 patent/WO2005092912A1/en not_active Ceased
- 2005-03-18 ES ES05733590T patent/ES2297699T3/es not_active Expired - Lifetime
- 2005-03-18 PT PT05733590T patent/PT1735330E/pt unknown
- 2005-03-18 PL PL05733590T patent/PL1735330T3/pl unknown
- 2005-03-18 KR KR1020067021801A patent/KR20070028355A/ko not_active Ceased
- 2005-03-18 UA UAA200609904A patent/UA88782C2/ru unknown
- 2005-03-18 AU AU2005225560A patent/AU2005225560B2/en not_active Ceased
- 2005-03-22 PE PE2005000328A patent/PE20060094A1/es not_active Application Discontinuation
- 2005-03-23 AR ARP050101145A patent/AR048330A1/es unknown
- 2005-03-24 MY MYPI20051276A patent/MY143074A/en unknown
-
2006
- 2006-09-11 IL IL178010A patent/IL178010A0/en unknown
- 2006-09-18 ZA ZA200607801A patent/ZA200607801B/en unknown
- 2006-09-25 EC EC2006006881A patent/ECSP066881A/es unknown
- 2006-10-24 NO NO20064822A patent/NO20064822L/no not_active Application Discontinuation
- 2006-10-24 LV LVP-06-120A patent/LV13527B/lv unknown
-
2008
- 2008-01-10 CY CY20081100031T patent/CY1107132T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2204 DE 02/04/2013. |