BRPI0509683A - vìrus de estomatite vesicular geneticamente modificado, vetor de vìrus da estomatite vesicular geneticamente modificado, composição imunogênica, e, métodos para imunizar um hospedeiro mamìfero contra infecção bacteriana e contra infecção viral - Google Patents

vìrus de estomatite vesicular geneticamente modificado, vetor de vìrus da estomatite vesicular geneticamente modificado, composição imunogênica, e, métodos para imunizar um hospedeiro mamìfero contra infecção bacteriana e contra infecção viral

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Publication number
BRPI0509683A
BRPI0509683A BRPI0509683-9A BRPI0509683A BRPI0509683A BR PI0509683 A BRPI0509683 A BR PI0509683A BR PI0509683 A BRPI0509683 A BR PI0509683A BR PI0509683 A BRPI0509683 A BR PI0509683A
Authority
BR
Brazil
Prior art keywords
genetically modified
stomatitis virus
vesicular stomatitis
modified vesicular
methods
Prior art date
Application number
BRPI0509683-9A
Other languages
English (en)
Inventor
David Kirkwood Clarke
Roger Michael Hendry
Stephen A Udem
Christopher Lee Parks
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0509683A publication Critical patent/BRPI0509683A/pt
Publication of BRPI0509683A8 publication Critical patent/BRPI0509683A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20241—Use of virus, viral particle or viral elements as a vector
    • C12N2760/20243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20261—Methods of inactivation or attenuation
    • C12N2760/20264—Methods of inactivation or attenuation by serial passage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • AIDS & HIV (AREA)
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Abstract

VìRUS DA ESTOMATITE VESICULAR GENETICAMENTE MODIFICADO, VETOR DE VìRUS DA ESTOMATITE VESICULAR GENETICAMENTE MODIFICADO, COMPOSIçãO IMUNOGêNICA, E, MéTODOS PARA IMUNIZAR UM HOSPEDEIRO MAMìFERO CONTRA INFECçãO BACTERIANA E CONTRA INFECçãO VIRAL. A presente invenção refere-se amplamente à atenuação sinérgica do vírus da estomatite vesicular (VSV). Mais particularmente, a invenção refere-se à identificação de classes de mutação combinadas que atenuam sinergicamente a patogenicidade dos vetores de VSV em mamíferos e às suas composições imunogênicas.
BRPI0509683A 2004-04-09 2005-04-05 Vírus de estomatite vesicular geneticamente modificado, vetor de vírus da estomatite vesicular geneticamente modificado, composição imunogênica, e, métodos para imunizar um hospedeiro mamífero contra infecção bacteriana e contra infecção viral BRPI0509683A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56121404P 2004-04-09 2004-04-09
US64490205P 2005-01-19 2005-01-19
PCT/US2005/011499 WO2005098009A2 (en) 2004-04-09 2005-04-05 Synergistic attenutation of vesicular stomatitis virus, vectors thereof and immunogenic compositions thereof

Publications (2)

Publication Number Publication Date
BRPI0509683A true BRPI0509683A (pt) 2007-10-30
BRPI0509683A8 BRPI0509683A8 (pt) 2015-12-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509683A BRPI0509683A8 (pt) 2004-04-09 2005-04-05 Vírus de estomatite vesicular geneticamente modificado, vetor de vírus da estomatite vesicular geneticamente modificado, composição imunogênica, e, métodos para imunizar um hospedeiro mamífero contra infecção bacteriana e contra infecção viral

Country Status (15)

Country Link
US (2) US8287878B2 (pt)
EP (1) EP1756287B1 (pt)
JP (3) JP2007535918A (pt)
KR (1) KR101255016B1 (pt)
AR (1) AR048596A1 (pt)
AU (1) AU2005230687B8 (pt)
BR (1) BRPI0509683A8 (pt)
CA (1) CA2561245C (pt)
DK (1) DK1756287T3 (pt)
ES (1) ES2535310T3 (pt)
IL (2) IL178395A (pt)
MX (1) MX343109B (pt)
NZ (1) NZ550150A (pt)
TW (1) TW200602495A (pt)
WO (1) WO2005098009A2 (pt)

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JP5081329B1 (ja) * 2012-06-06 2012-11-28 有限会社ユニバーサルライフ ガードル

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MX343109B (es) 2016-10-25
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KR20070004822A (ko) 2007-01-09
EP1756287A2 (en) 2007-02-28
IL178395A0 (en) 2007-02-11
US20070218078A1 (en) 2007-09-20
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CA2561245A1 (en) 2005-10-20
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AU2005230687B2 (en) 2011-07-21
WO2005098009A2 (en) 2005-10-20
ES2535310T3 (es) 2015-05-07
AU2005230687A1 (en) 2005-10-20
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US20130023032A1 (en) 2013-01-24
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IL224774A (en) 2014-07-31
US8647638B2 (en) 2014-02-11
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JP2007535918A (ja) 2007-12-13
AR048596A1 (es) 2006-05-10
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