BRPI0510075A - benzoxazocinas e seu uso terapêutico como inibidores de reabsorção de monoamina - Google Patents
benzoxazocinas e seu uso terapêutico como inibidores de reabsorção de monoaminaInfo
- Publication number
- BRPI0510075A BRPI0510075A BRPI0510075-5A BRPI0510075A BRPI0510075A BR PI0510075 A BRPI0510075 A BR PI0510075A BR PI0510075 A BRPI0510075 A BR PI0510075A BR PI0510075 A BRPI0510075 A BR PI0510075A
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- alkyl
- unsubstituted
- cycloalkyl
- alkenyl
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- SFVYUAJWNYVQDB-UHFFFAOYSA-N 2h-1,2-benzoxazocine Chemical class O1NC=CC=CC2=CC=CC=C21 SFVYUAJWNYVQDB-UHFFFAOYSA-N 0.000 title 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
BENZOXAZOCINAS E SEU USO TERAPêUTICO COMO INIBIDORES DE REABSORçãO DE MONOAMINA Compostos tendo utilidade terapêutica são da fórmula geral (1) onde R~ 1~ é H, alquila C~ 1~-C~ 6~ opcionalmente substituída por F ou cicloalquila C~ 3~- C~ 6~ ou alquenila C~ 2~-C~ 4~; A é O, CH~ 2~ ou S (O)~ n~ onde n é 0-2; Um entre W, X, Y e Z é N, CH ou CR~ 3~ e os outros são CH; R~ 2~ é heteroarila C~ 5~-C~ 6~, Cicloalquila C~ 5~-C~ 10~ ou cicloalquenila opcionalmente contendo um ou mais heteroátomos selecionados entre O, N e S(O)~ n~ onde n é 0-2, e opcionalmente substituido por R~ 3~; ou um grupo fenila opcionalmente substituído em uma ou mais posições com um ou mais substituintes independentemente selecionados entre halogênio, CN, CF~ 3~, alquila C~ 1~-C~ 6~ e OR~ 1~, ou o grupo fenila é fundido com um anel de cinco ou seis membros que pode ser carbocíclico, heterocíclico (contendo 1-2 heteroátomos selecionados entre O, N e S), aromático ou heteroaromático (contendo 1-2 heteroátomos selecionados de O e N); R~ 3~ é selecionado dentre halogênio; CF~ 3~; CN; OR~ 5~; SO~ 2~N (R~ 5~)~ 2~; COR~ 5~; CO~ 2~R~ 5~; CON(R~ 5~)~ 2~; NR~ 1~COR~ 4~; NR~ 1~SO~ 2~R~ 4~; NR~ 1CO~ 2~R~ 4~; NR~ 1~CON(R~ 5~)~ 2~; alquila OC~ 1~-C~ 6~ substituída com R~ 3~; alquila C~ 1~-C~ 6~ opcionalmente substituída com R~ 3~ não substituído; cicloalquila C~ 3~-C~ 5~ opcionalmente substituída com R~ 3~ não substituído; alquenila C~ 2~-C~ 6~ opcionalmente substituído com R~ 3~ não substituído; alquinila C~ 2~-C~ 6~ opcionalmente substituído com R~ 3~ não substituído; arila opcionalmente substituída com R~ 3~ não substituído; e heterociclos aromáticos com cinco ou seis membros contendo 1-4 heteroátomos selecionados entre N e O; R~ 4~ é alquila C~ 1~-C~ 6~, alquenila C~ 2~-C~ 6~, alquinila C~ 2~-C~ 6~, cicloalquila C~ 3~-C~ 6~, arila e heteroarila; e R~ 5~ é H, alquila C~ 1~-C~ 6~, alquenila C~ 2~-C~ 6~, alquinila C~ 2~-C~ 6~, cicloalquila C~ 3~-C~ 6~, arila ou heteroarila e é igual ou diferente de outro R~ 5~; ou um sal farmacêuticamente aceitável do mesmo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0408862A GB0408862D0 (en) | 2004-04-21 | 2004-04-21 | Novel benzoxazocines |
| GB0408863A GB0408863D0 (en) | 2004-04-21 | 2004-04-21 | Novel benzoxazocines |
| PCT/GB2005/001519 WO2005103019A1 (en) | 2004-04-21 | 2005-04-21 | Benzoxazocines and their therapeutic use as monoamine reuptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0510075A true BRPI0510075A (pt) | 2007-10-16 |
Family
ID=34965745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0510075-5A BRPI0510075A (pt) | 2004-04-21 | 2005-04-21 | benzoxazocinas e seu uso terapêutico como inibidores de reabsorção de monoamina |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1740558A1 (pt) |
| JP (1) | JP2007533718A (pt) |
| AU (1) | AU2005235786A1 (pt) |
| BR (1) | BRPI0510075A (pt) |
| CA (1) | CA2558741A1 (pt) |
| IL (1) | IL177750A0 (pt) |
| NO (1) | NO20065057L (pt) |
| WO (1) | WO2005103019A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0504960D0 (en) * | 2005-03-10 | 2005-04-20 | Arakis Ltd | Benzoxazocines |
| GB0506835D0 (en) * | 2005-04-04 | 2005-05-11 | Arakis Ltd | Therapeutic use of nefopam |
| US8957107B2 (en) | 2009-12-15 | 2015-02-17 | The Hospital For Sick Children | Method of treating scars and β-catenin-mediated disorders using Nefopam compounds |
| ES2603032T3 (es) | 2010-07-15 | 2017-02-23 | Bayer Intellectual Property Gmbh | Compuestos de 3-piridil-heteroarilcarboxamida como pesticidas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3830803A (en) * | 1965-05-10 | 1974-08-20 | Riker Laboratories Inc | 5-loweralkyl-1-phenyl-1,3,4,6-tetrahydro-5h-benz(f)-2,5-oxazocines and 4-ones |
| US3978085A (en) * | 1975-03-07 | 1976-08-31 | Riker Laboratories, Inc. | Process for benz[f]-2,5-oxazocines |
| JPS5913770A (ja) * | 1982-07-13 | 1984-01-24 | Sanwa Kagaku Kenkyusho:Kk | 新規の１−フエニル−２，５−ベンゾチアゾシン誘導体及びその製法 |
| JPS5913760A (ja) * | 1982-07-13 | 1984-01-24 | Sanwa Kagaku Kenkyusho:Kk | 新規の２−ベンズアゾシン誘導体及びその製法 |
| KR100885986B1 (ko) * | 1999-11-03 | 2009-03-03 | 에이엠알 테크놀로지, 인크. | 노르에피네프린, 도파민 및 세로토닌의 재흡수를 방지하기위한 아릴 및 헤테로아릴 치환된테트라하이드로이소퀴놀린 및 이들의 용도 |
| BR0317467A (pt) * | 2002-12-20 | 2005-11-16 | Arakis Ltd | Benzoxazocinas e seu uso como inibidores de reassimilação de monoaminas |
-
2005
- 2005-04-21 CA CA002558741A patent/CA2558741A1/en not_active Abandoned
- 2005-04-21 EP EP05736028A patent/EP1740558A1/en not_active Withdrawn
- 2005-04-21 WO PCT/GB2005/001519 patent/WO2005103019A1/en not_active Ceased
- 2005-04-21 BR BRPI0510075-5A patent/BRPI0510075A/pt not_active IP Right Cessation
- 2005-04-21 AU AU2005235786A patent/AU2005235786A1/en not_active Abandoned
- 2005-04-21 JP JP2007508968A patent/JP2007533718A/ja not_active Withdrawn
-
2006
- 2006-08-29 IL IL177750A patent/IL177750A0/en unknown
- 2006-11-02 NO NO20065057A patent/NO20065057L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005235786A1 (en) | 2005-11-03 |
| WO2005103019A1 (en) | 2005-11-03 |
| IL177750A0 (en) | 2006-12-31 |
| NO20065057L (no) | 2006-11-21 |
| JP2007533718A (ja) | 2007-11-22 |
| EP1740558A1 (en) | 2007-01-10 |
| CA2558741A1 (en) | 2005-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |