ATE398125T1 - Chinazolin-derivate als tgf-beta-inhibitoren - Google Patents

Chinazolin-derivate als tgf-beta-inhibitoren

Info

Publication number: ATE398125T1
Authority: AT; Austria
Prior art keywords: tgf beta; quinazoline derivatives; beta inhibitors; mediated disease; tgf
Prior art date: 2003-03-12

Application number

AT04718542T

Other languages

English (en)

Inventor

Robert Scarborough

Anjali Pandey

Meenakshi Venkatraman

Original Assignee

Millennium Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-12

Filing date

2004-03-08

Publication date

2008-07-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32990876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE398125(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-03-08 Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE398125T1 publication Critical patent/ATE398125T1/de

Links

239000003112 inhibitor Substances 0.000 title 1
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
230000001404 mediated effect Effects 0.000 abstract 2
125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

AT04718542T 2003-03-12 2004-03-08 Chinazolin-derivate als tgf-beta-inhibitoren ATE398125T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US45416403P	2003-03-12	2003-03-12

Publications (1)

Publication Number	Publication Date
ATE398125T1 true ATE398125T1 (de)	2008-07-15

Family

ID=32990876

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04718542T ATE398125T1 (de)	2003-03-12	2004-03-08	Chinazolin-derivate als tgf-beta-inhibitoren

Country Status (6)

Country	Link
US (2)	US7189733B2 (de)
EP (1)	EP1603908B1 (de)
AT (1)	ATE398125T1 (de)
DE (1)	DE602004014347D1 (de)
ES (1)	ES2305744T3 (de)
WO (1)	WO2004081009A1 (de)

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WO2006127329A1 (en)	2005-05-20	2006-11-30	Vertex Pharmaceuticals Incorporated	Quinoline derivatives useful as modulators of ion channels
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JP2011521969A (ja) *	2008-05-30	2011-07-28	スムマヘルスシステムズエルエルシー	眼疾患を治療するためのＴＧＦ−β受容体阻害剤又はアクチビン様キナーゼ（ＡＬＫ）５阻害剤、Ａ−８３−０１及びＳＢ−４３１５４２の使用方法及び創傷治療条件
WO2010121162A1 (en) *	2009-04-17	2010-10-21	Summa Health Systems Llc	Use of transforming growth factor-b receptor inhibitors to suppress ocular scarring
CN102596200A (zh) *	2009-11-07	2012-07-18	默克专利有限公司	作为TGF-β受体激酶抑制剂的杂芳基氨基喹啉类
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JP5826261B2 (ja)	2010-06-28	2015-12-02	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	癌に対する使用のためのキナーゼ阻害剤としての２，４−ジアリール置換［１，８］ナフチリジン
MX2013010163A (es) *	2011-03-09	2013-10-30	Merck Patent Gmbh	Derivados de pirido[2,3-b] pirazina y sus usos terapeuticos.
WO2014058317A1 (en)	2012-10-10	2014-04-17	Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis	Methods and means for predicting resistance to anti-cancer treatment
LT2970890T (lt)	2013-03-14	2020-07-10	The Brigham And Women`S Hospital, Inc.	Kompozicijos ir būdai, skirti epitelinių kamieninių ląstelių padauginimui ir kultivavimui
KR101658111B1 (ko) *	2013-05-13	2016-09-20	제일모직 주식회사	유기광전자소자용 화합물, 이를 포함하는 유기발광소자 및 상기 유기발광소자를 포함하는 표시장치
CN103570632B (zh) *	2013-07-22	2015-09-30	成都理工大学	无催化剂的4(3h)-喹唑啉酮的合成方法
HRP20201384T1 (hr)	2014-01-01	2020-11-27	Medivation Technologies Llc	Spojevi i postupci njihove upotrebe
WO2016037016A1 (en)	2014-09-03	2016-03-10	The Brigham And Women's Hospital, Inc.	Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
CN107427506A (zh)	2014-10-14	2017-12-01	拉霍拉敏感及免疫学研究所	低分子量蛋白酪氨酸磷酸酶的抑制剂及其用途
US10669528B2 (en)	2015-06-25	2020-06-02	Children's Medical Center Corporation	Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
CN108137597A (zh) *	2015-07-28	2018-06-08	百时美施贵宝公司	TGFβ受体拮抗剂
CN108779437A (zh)	2016-01-08	2018-11-09	麻省理工学院	分化的肠内分泌细胞和胰岛素产生细胞的制备
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2004
- 2004-03-08 ES ES04718542T patent/ES2305744T3/es not_active Expired - Lifetime
- 2004-03-08 DE DE602004014347T patent/DE602004014347D1/de not_active Expired - Lifetime
- 2004-03-08 WO PCT/US2004/007090 patent/WO2004081009A1/en not_active Ceased
- 2004-03-08 EP EP04718542A patent/EP1603908B1/de not_active Expired - Lifetime
- 2004-03-08 AT AT04718542T patent/ATE398125T1/de not_active IP Right Cessation
- 2004-03-08 US US10/795,538 patent/US7189733B2/en not_active Expired - Fee Related
2007
- 2007-01-16 US US11/653,679 patent/US8268857B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20070142408A1 (en)	2007-06-21
EP1603908A1 (de)	2005-12-14
US8268857B2 (en)	2012-09-18
EP1603908B1 (de)	2008-06-11
WO2004081009A1 (en)	2004-09-23
US7189733B2 (en)	2007-03-13
ES2305744T3 (es)	2008-11-01
DE602004014347D1 (de)	2008-07-24
US20040204431A1 (en)	2004-10-14

Legal Events

Date	Code	Title	Description
2008-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE398125T1 (de)	2008-07-15	Chinazolin-derivate als tgf-beta-inhibitoren
UA87153C2 (ru)	2009-06-25	Энантиомерно чистые аминогетероарильные соединения как ингибиторы протеинкиназы
DK1767535T3 (da)	2010-04-12	Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse
ATE433447T1 (de)	2009-06-15	Pyrimiidinverbindungen
EA200600317A1 (ru)	2006-06-30	Производные омега-карбоксиарилдифенилмочевины (варианты), фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с их использованием (варианты)
CY1109998T1 (el)	2014-09-10	Ενδυναμωτες υποδοχεων γλουταμινικου
CY1119077T1 (el)	2018-01-10	Παραγωγα πυραζολυλαμινοπυριδινης χρησιμα ως αναστολεις κινασων
NO20032801L (no)	2003-08-04	Tiazolderivater for behandling av PPAR-relaterte forstyrrelser
SE0301373D0 (sv)	2003-05-09	Novel compounds
NO20063479L (no)	2006-10-02	Fosfonater, monofosfonamidater og bis-fosfonamidater for behandling av virussykdommer
EA200700188A1 (ru)	2007-06-29	Производные замещенного 2-алкилхиназолинона как ингибиторы parp
ATE302775T1 (de)	2005-09-15	Carbolinderivate
CY1107403T1 (el)	2012-12-19	Μια μεθοδος δια την παρασκευη υπερινδοπριλης,των αναλογων ενωσεων αυτης και των αλατων αυτων με χρησιμοποιηση ενδιαμεσων ενωσεων 2,5-διοξο-οξαζολιδινης
NO20044526L (no)	2004-12-21	Hemisterlinderivater og anvendelser derav
EA200700202A1 (ru)	2007-10-26	Гетероарильные соединения в качестве бетамиметиков для лечения заболеваний дыхательных путей
MA32956B1 (fr)	2012-01-02	Derives de 5-amino-2-(1-hydroxyethyl)-tetrahydropyrane
NO20043016L (no)	2004-07-15	6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
EA200501584A1 (ru)	2006-06-30	Бета-карболины, применяемые для лечения воспалительных заболеваний
ATE399168T1 (de)	2008-07-15	Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren
HRP20080057T3 (en)	2008-02-29	9,10-alpha,alpha-oh-taxane analogs and methods for production thereof
ATE441630T1 (de)	2009-09-15	Substituierte cyclopenten-verbindungen
ECSP045396A (es)	2005-01-03	Proceso para preparar derivados de 6-alquiliden penem
ATE543803T1 (de)	2012-02-15	3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren
DE602005011267D1 (de)	2009-01-08	Benzofuran- und benzothiophenderivate, die sich für die behandlung von herzkreislauferkrankungen eignen
ATE403655T1 (de)	2008-08-15	Imidazopyridinderivate als induzierbare no- synthaseinhibitoren