BRPI0510269A - composições de dalbavancina para o tratamento de infecções bacterianas - Google Patents

composições de dalbavancina para o tratamento de infecções bacterianas

Info

Publication number
BRPI0510269A
BRPI0510269A BRPI0510269-3A BRPI0510269A BRPI0510269A BR PI0510269 A BRPI0510269 A BR PI0510269A BR PI0510269 A BRPI0510269 A BR PI0510269A BR PI0510269 A BRPI0510269 A BR PI0510269A
Authority
BR
Brazil
Prior art keywords
treatment
dalbavancin
bacterial infections
compositions
infection
Prior art date
Application number
BRPI0510269-3A
Other languages
English (en)
Inventor
Martin Stogniew
Luigi Colombo
Romeo Ciabatti
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of BRPI0510269A publication Critical patent/BRPI0510269A/pt
Publication of BRPI0510269B1 publication Critical patent/BRPI0510269B1/pt
Publication of BRPI0510269B8 publication Critical patent/BRPI0510269B8/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K9/00Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

COMPOSIçõES DE DALBAVANCINA PARA O TRATAMENTO DE INFECçõES BACTERIANAS A invenção proporciona métodos e composições para o tratamento de infecções bacterianas. A composição pode ser uma combinação de fatores, os quais incluem A~ 0~, A~ 1~, B~ 1~, B~ 2~, C~ 0~, C~ 1~, isoB~ 0~, e MAG, na presença de solvente em baixo nível. Os métodos da invenção incluem a administração de formulações de dalbavancina para o tratamento de uma infecção bacteriana, em particular uma infecção por bactérias Gram-positivas da pele e do tecido mole, Os regimes de dosagem incluem a administração de doses múltiplas de dalbavancina, a qual freqüentemente permanece em níveis terapêuticos na corrente sanguínea por pelo menos uma semana, proporcionando ação terapêutica prolongada contra una infecção bacteriana. Os regimes de dosagem para pacientes renais estão também incluídos.
BRPI0510269A 2004-04-27 2005-04-26 composições de dalbavancina para o tratamento de infecções bacterianas BRPI0510269B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/834.395 2004-04-27
US10/834,395 US7119061B2 (en) 2002-11-18 2004-04-27 Dalbavancin compositions for treatment of bacterial infections
PCT/US2005/014355 WO2006078277A2 (en) 2004-04-27 2005-04-26 Dalbavancin compositions for treatment of bacterial infections

Publications (3)

Publication Number Publication Date
BRPI0510269A true BRPI0510269A (pt) 2007-10-30
BRPI0510269B1 BRPI0510269B1 (pt) 2019-08-06
BRPI0510269B8 BRPI0510269B8 (pt) 2021-05-25

Family

ID=36692659

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510269A BRPI0510269B8 (pt) 2004-04-27 2005-04-26 composições de dalbavancina para o tratamento de infecções bacterianas

Country Status (16)

Country Link
US (2) US7119061B2 (pt)
EP (1) EP1748786A4 (pt)
JP (2) JP5207734B2 (pt)
KR (2) KR20070015179A (pt)
CN (1) CN1964736B (pt)
AU (2) AU2005325261B2 (pt)
BR (1) BRPI0510269B8 (pt)
CA (1) CA2564112C (pt)
IL (1) IL178207A (pt)
MX (1) MXPA06012301A (pt)
NO (1) NO345529B1 (pt)
NZ (2) NZ588109A (pt)
RU (2) RU2352353C2 (pt)
SG (1) SG152274A1 (pt)
WO (1) WO2006078277A2 (pt)
ZA (2) ZA200607889B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119061B2 (en) 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
US20060074014A1 (en) * 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
MXPA05005338A (es) * 2002-11-18 2005-12-14 Vicuron Pharm Inc Metodos para administrar dalbavancin para el tratamiento de infecciones bacterianas.
KR102083046B1 (ko) 2012-06-07 2020-02-28 칠드런'스 하스피틀 로스 앤젤레스 레티노이드 작용제를 이용하여 호중구감소증을 치료하기 위한 방법
CN103087918B (zh) * 2013-02-20 2015-04-22 广州市微生物研究所 一种好氧反硝化菌剂及其制备与应用
KR102237887B1 (ko) 2013-03-15 2021-04-07 멜린타 서브시디어리 코프. 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
MX2016010699A (es) 2014-02-18 2017-10-11 Children's Hospital Los Angeles Composiciones y metodos para tratar neutropenia.
EP3169345B1 (en) 2014-07-17 2025-01-29 Melinta Therapeutics, LLC High purity oritavancin and method of producing same
US20200171124A1 (en) 2016-04-15 2020-06-04 Lupin Limited Topical compositions for ophthalmic and otic use
KR20190005940A (ko) * 2016-05-09 2019-01-16 셀리아 파마슈티칼즈 에이피에스 안정화된 글리코펩티드 항생제 제형
RU2019119405A (ru) * 2016-11-23 2020-12-25 Гуфик Байосайенсиз Лимитед Лиофилизированные фармацевтические композиции далбаванцина
CN109946398B (zh) * 2019-03-28 2022-05-24 丽珠集团新北江制药股份有限公司 一种检测达巴万星及其杂质的方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN113666987A (zh) * 2020-05-14 2021-11-19 博瑞生物医药泰兴市有限公司 一种达巴万星的纯化方法
CN111686240B (zh) * 2020-06-14 2021-04-09 中国科学院昆明动物研究所 达巴万星在制备抑制SARS-CoV-2与ACE2结合的药物中的应用
CN115219626A (zh) * 2022-07-18 2022-10-21 丽珠集团福州福兴医药有限公司 达巴万星合成反应的分析方法
AU2023359653A1 (en) * 2022-10-12 2025-05-29 Hikma Pharmaceuticals Usa Inc. Liquid dalbavancin composition
CN116355056A (zh) * 2023-05-12 2023-06-30 丽珠集团福州福兴医药有限公司 一种适合大规模生产的达巴万星制备方法
WO2025158262A1 (en) 2024-01-23 2025-07-31 Lupin Limited Stable pharmaceutical compositions of dalbavancin as ready-to-dilute formulation
GB202405997D0 (en) 2024-04-29 2024-06-12 Arecor Ltd Novel compositions
GB202405996D0 (en) 2024-04-29 2024-06-12 Arecor Ltd Novel compositions
CN119157832B (zh) * 2024-07-26 2025-09-12 健进制药有限公司 丙二醇的水溶液在抑制盐酸达巴万星降解中的应用、达巴万星注射液制剂、制备方法及应用

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1496386A (en) 1975-03-05 1977-12-30 Lepetit Spa Antibiotics
US4195079A (en) 1979-01-31 1980-03-25 Pfizer Inc. New polycyclic ether antibiotic
CA1183789A (en) 1981-08-04 1985-03-12 Kiyoshi Isono Antibiotic 76-11, process for the production thereof, anticoccidiosis agent and domestic animals growth accelerator comprising the same as an effective ingredient
US4578271A (en) 1982-05-24 1986-03-25 Fujisawa Pharmaceutical Co., Ltd. Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions
FI73697C (fi) 1982-06-08 1987-11-09 Lepetit Spa Foerfarande foer framstaellning av individuella faktorer 1, 2, 3, 4 och 5 av teikomysin a2.
FR2548021B1 (fr) 1983-06-29 1986-02-28 Dick P R Compositions pharmaceutiques dermiques a action prolongee et continue a base d'acides gras essentiels
GB8415092D0 (en) 1984-06-13 1984-07-18 Lepetit Spa Ester derivatives
GB8425685D0 (en) 1984-10-11 1984-11-14 Lepetit Spa Antibiotic a 40926 complex
GB8428619D0 (en) 1984-11-13 1984-12-19 Lepetit Spa Derivatives of antibiotic l 17046
US4914187A (en) 1984-11-13 1990-04-03 Gruppo Lepetit S.P.A Ester derivatives of antibiotic L 17046
GB8512795D0 (en) 1985-05-21 1985-06-26 Lepetit Spa Increasing ratio of components of teicoplanin a2 complex
GB8531846D0 (en) 1985-12-30 1986-02-05 Lepetit Spa Antibiotic a 40926 mannosyl aglycon
GB8608809D0 (en) 1986-04-11 1986-05-14 Lepetit Spa Antibiotic
GB8621911D0 (en) 1986-09-11 1986-10-15 Lepetit Spa Increasing ratio of components of anti-biotic complex
GB8621912D0 (en) 1986-09-11 1986-10-15 Lepetit Spa Increasing ratio of components of anti-biotic complex
GR871488B (en) 1986-10-10 1987-11-12 Lepetit Spa New antibiotics
GB8715735D0 (en) 1987-07-03 1987-08-12 Lepetit Spa De-mannosyl teicoplanin derivatives
US4882313A (en) 1987-07-31 1989-11-21 Smithkline Beckman Corporation Carboxamide derivatives of glycopeptides
GB8726859D0 (en) 1987-11-17 1987-12-23 Lepetit Spa 22-dechlorotei-coplanins
EP0376041B1 (en) 1988-12-27 1996-02-28 GRUPPO LEPETIT S.p.A. C63-Amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanins
IE64155B1 (en) 1989-03-29 1995-07-12 Lepetit Spa New substituted alkylamide derivatives of teicoplanin
JPH03193735A (ja) * 1989-12-22 1991-08-23 Shionogi & Co Ltd グリコペプチド系抗生物質の安定化組成物
US5030619A (en) 1990-04-16 1991-07-09 Miles Inc. Synergistic fungicidal composition
US5606036A (en) 1991-03-27 1997-02-25 Gruppo Lepetit Spa Antibiotic A 40926 ester derivatives
EP0596929B1 (en) * 1991-07-29 1995-07-26 GRUPPO LEPETIT S.p.A. Amide derivatives of antibiotic a 40926
US5750509A (en) 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5882900A (en) 1992-09-10 1999-03-16 Gruppo Lepetit S.P.A. Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
CN1036654C (zh) * 1993-01-01 1997-12-10 格鲁波莱佩蒂特公司 抗菌素a40926的酰氨衍生物及其制备方法
WO1996024608A1 (en) 1995-02-07 1996-08-15 Biosearch Italia S.P.A. Basic oxazoline-amide derivatives of ge 2270 and ge 2270-like antibiotics
DE69600244T2 (de) 1995-02-07 1998-10-01 Biosearch Italia Spa Basische prolinamid derivate von ge2270 und ge2270-ahnlichten antibiotika
ES2186866T3 (es) 1996-02-14 2003-05-16 Biosearch Italia Spa Derivados de factores del antibiotico ge2270.
AU2441697A (en) 1996-04-12 1997-11-07 Eli Lilly And Company Covalently-linked glycopeptide dimers
EP0912604B1 (en) 1996-04-23 2001-11-14 Biosearch Italia S.p.A. Improved chemical process for preparing amide derivatives of antibiotic A 40926
US5935238A (en) 1997-06-19 1999-08-10 Sun Microsystems, Inc. Selection from multiple fetch addresses generated concurrently including predicted and actual target by control-flow instructions in current and previous instruction bundles
CA2255140A1 (en) 1997-12-23 1999-06-23 Eli Lilly And Company Echinocandin binding domain of 1,3-.beta.-glucan synthase
US6417180B1 (en) * 1998-10-07 2002-07-09 University Of Massachusetts Zinc finger-reactive antimicrobial compounds
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
JP4931282B2 (ja) * 2000-10-02 2012-05-16 日本ケミカルリサーチ株式会社 生理活性ペプチド含有粉末
EP1343518B1 (en) * 2000-11-07 2009-07-22 Novartis Vaccines and Diagnostics, Inc. Stabilized interferon compositions
US7119061B2 (en) 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
MXPA05005338A (es) 2002-11-18 2005-12-14 Vicuron Pharm Inc Metodos para administrar dalbavancin para el tratamiento de infecciones bacterianas.

Also Published As

Publication number Publication date
SG152274A1 (en) 2009-05-29
AU2005325261B2 (en) 2010-11-11
AU2011200423B2 (en) 2012-11-29
US7119061B2 (en) 2006-10-10
NZ550053A (en) 2011-01-28
US20050004050A1 (en) 2005-01-06
JP2007534768A (ja) 2007-11-29
HK1103639A1 (en) 2007-12-28
BRPI0510269B1 (pt) 2019-08-06
NO20064287L (no) 2006-10-24
RU2008142899A (ru) 2010-05-10
BRPI0510269B8 (pt) 2021-05-25
CA2564112C (en) 2014-08-05
WO2006078277A3 (en) 2006-10-19
ZA200607888B (en) 2008-03-26
EP1748786A4 (en) 2009-07-15
CN1964736A (zh) 2007-05-16
ZA200607889B (en) 2007-12-27
NZ588109A (en) 2012-05-25
KR20070015179A (ko) 2007-02-01
CA2564112A1 (en) 2006-07-27
WO2006078277A2 (en) 2006-07-27
EP1748786A2 (en) 2007-02-07
IL178207A (en) 2014-05-28
IL178207A0 (en) 2007-07-04
JP5207734B2 (ja) 2013-06-12
AU2011200423A1 (en) 2011-02-24
JP2013014613A (ja) 2013-01-24
KR20080048093A (ko) 2008-05-30
US20050004051A1 (en) 2005-01-06
CN1964736B (zh) 2012-07-04
NO345529B1 (no) 2021-03-29
KR100930982B1 (ko) 2009-12-10
RU2006136736A (ru) 2008-06-10
AU2005325261A1 (en) 2006-07-27
MXPA06012301A (es) 2007-03-15
RU2352353C2 (ru) 2009-04-20

Similar Documents

Publication Publication Date Title
BRPI0510269A (pt) composições de dalbavancina para o tratamento de infecções bacterianas
MXPA05005338A (es) Metodos para administrar dalbavancin para el tratamiento de infecciones bacterianas.
CY1116215T1 (el) Θεραπεια συνδυασμου για τη θεραπευτικη αγωγη διαταραχων ανεπαρκειας πρωτεϊνης
CU23423B7 (es) Oxazolidinonas sustituidas y su uso en el campo de la coagulación sanguínea
Zhadan et al. Surgical site irrigation in plastic surgery
BRPI0406667A (pt) Método para o tratamento de câncer, e, formulação terapeuticamente aceitável de 2-dg
BR0000003A (pt) Azalidas e métodos de preparação das mesmas
AR082803A1 (es) Metodos y formulaciones para el tratamiento de la trombosis con betrixaban y un inhibidor de la glicoproteina p
MX2024010591A (es) Compuestos y metodos para el tratamiento de infecciones virales.
WO2005089738A3 (en) Use and administration of bacterial efflux pump inhibitors
BR0315573A (pt) Método para tratar, prevenir, controlar e/ou modificar dor em um paciente e composição farmacêutica
ATE528311T1 (de) Glycomimetische inhibitoren des pa-il-lectins, pa-iil-lectins oder beider lectine aus pseudomonas
AR048324A1 (es) Metodos para tratar infecciones por vih
EA200501821A1 (ru) Фармацевтическая комбинация, содержащая модафинил и другой лекарственный препарат
BR0110382A (pt) Utilização de composições antibióticas azalida para o tratamento ou prevenção de uma infecção causada por bactérias ou protozoários em mamìferos
Poeppl et al. Daptomycin, fosfomycin, or both for treatment of methicillin-resistant Staphylococcus aureus osteomyelitis in an experimental rat model
BR112021018815A2 (pt) Gepotidacina para uso no tratamento de infecções bacterianas do trato urinário
Eskandarinezhad et al. The comparison of calcium hydroxide, curcumin, and Aloe vera antibacterial effects on 6-week-old Enterococcus faecalis biofilm as an intracanal medicament: An: in vitro: study
CL2024001520A1 (es) Nueva composición farmacéutica oral y régimen de dosificación para la terapia de enfermedades pulmonares intersticiales
MX2009003912A (es) Metodos y composiciones usando compuestos inmunomoduladores para el tratamiento y manejo de enfermedades bacterianas por espiroquetas y otras bacterias intracelulares obligadas.
Scheinfeld Extensive hidradenitis suppurativa (HS) Hurly stage III disease treated with intravenous (IV) linezolid and meropenem with rapid remission
BRPI0414518A (pt) composições farmacêuticas e métodos compreendendo combinações de derivados de 2-alquilideno-19-nor-vitamina d e hormÈnio paratireoidiano
MX2008008556A (es) Derivados de triterpenoquinonas y triterpenofenoles y su aplicacion para el tratamiento de tumores y enfermedades parasitarias.
BR0309878A (pt) Heterotriciclil-6-alquilideno-penemas como inibidores de beta-lactamase
AR057876A1 (es) Tratamiento de pacientes con enfermedad renal cronica (erc) utilizando compuestos de la invencion

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: PAGAR RESTAURACAO.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI 2260 DE 29/04/2014

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/08/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/08/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/04/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF