ES2186866T3 - Derivados de factores del antibiotico ge2270. - Google Patents

Derivados de factores del antibiotico ge2270.

Info

Publication number
ES2186866T3
ES2186866T3 ES97903258T ES97903258T ES2186866T3 ES 2186866 T3 ES2186866 T3 ES 2186866T3 ES 97903258 T ES97903258 T ES 97903258T ES 97903258 T ES97903258 T ES 97903258T ES 2186866 T3 ES2186866 T3 ES 2186866T3
Authority
ES
Spain
Prior art keywords
derivatives
unit
formula
pirrolidinilo
aminocarbonil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97903258T
Other languages
English (en)
Inventor
Sergio Lociuro
Paolo Tavecchia
Romeo Ciabatti
Ermenegildo Restelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosearch Italia SpA
Original Assignee
Biosearch Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosearch Italia SpA filed Critical Biosearch Italia SpA
Application granted granted Critical
Publication of ES2186866T3 publication Critical patent/ES2186866T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

DERIVADOS MONO - O DI - SUSTITUIDOS DE LOS FACTORES C SUB,2A , D 2 Y E DE GE2270 DE LA FORMULA GENERAL (I), EN LA QUE W REPRESENTA UNA UNIDAD DE LA FORMULA (A), (B) O (C), R SUP,1 Y R 2 REPRESENTAN UNA VARIEDAD DE SUSTITUYENTES, X S UP,1 ES METILO, X 2 ES UNA UNIDAD - CH 2 - W 1 Y X 3 ES METILAMINO O AMINO, O X 1 ES UNA UNIDAD - CH 2 W 1 , X 2 ES METOXIMETILENO Y X 3 ES ME TILAMINO, CON LA CONDICION DE QUE CUANDO X 3 SEA AMINO, W SEA 2 (AMINOCARBONIL) - PIRROLIDINILO; Y CON LA CONDICION ADEMAS DE QUE CUANDO W SEA 2 - (AMINOCARBONIL) - PIRROLIDINILO, W SUP,1 NO SEA HIDROXI; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. LOS DERIVADOS MONO - O DI - SUSTITUIDOS DEL ANTIBIOTICO GE2270 DE LA FORMULA (I) SON AGENTES ANTIMICROBIANOS ACTIVOS SOBRE TODO CONTRA LAS BACTERIAS GRAM POSITIVAS.
ES97903258T 1996-02-14 1997-02-12 Derivados de factores del antibiotico ge2270. Expired - Lifetime ES2186866T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96102145 1996-02-14

Publications (1)

Publication Number Publication Date
ES2186866T3 true ES2186866T3 (es) 2003-05-16

Family

ID=8222478

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97903258T Expired - Lifetime ES2186866T3 (es) 1996-02-14 1997-02-12 Derivados de factores del antibiotico ge2270.

Country Status (13)

Country Link
US (1) US6008225A (es)
EP (1) EP0880541B1 (es)
JP (1) JP2000505438A (es)
KR (1) KR19990082541A (es)
AT (1) ATE231163T1 (es)
AU (1) AU714958B2 (es)
CA (1) CA2242067A1 (es)
DE (1) DE69718442T2 (es)
DK (1) DK0880541T3 (es)
ES (1) ES2186866T3 (es)
HU (1) HUP9901007A3 (es)
IL (1) IL125107A (es)
WO (1) WO1997030078A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2071143T3 (es) * 1990-03-08 1995-06-16 Lepetit Spa Factores b1, b2, c1, c2, d1, d2, e y t del antibiotico ge 2270.
US5882900A (en) * 1992-09-10 1999-03-16 Gruppo Lepetit S.P.A. Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
DE69600244T2 (de) * 1995-02-07 1998-10-01 Biosearch Italia Spa Basische prolinamid derivate von ge2270 und ge2270-ahnlichten antibiotika
WO1996024608A1 (en) * 1995-02-07 1996-08-15 Biosearch Italia S.P.A. Basic oxazoline-amide derivatives of ge 2270 and ge 2270-like antibiotics
KR20050026401A (ko) * 2002-06-17 2005-03-15 비큐론 파마세티컬스 인코포레이티드 여드름 치료를 위한 ｇｅ 2270 인자 ａ3의 아미드유도체의 용도
US20060074014A1 (en) * 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
US7119061B2 (en) * 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
MXPA05005338A (es) * 2002-11-18 2005-12-14 Vicuron Pharm Inc Metodos para administrar dalbavancin para el tratamiento de infecciones bacterianas.
AR060977A1 (es) * 2006-05-31 2008-07-23 Novartis Ag Aminotiazoles y sus usos
BRPI0720542A2 (pt) * 2006-12-20 2014-01-21 Novartis Ag Compostos antibacterianos e processos para a sua produção
CN101772506B (zh) * 2007-06-04 2014-02-12 诺华股份有限公司 大环化合物及其用途
EP2229386B1 (en) 2007-12-12 2015-06-03 Novartis AG An aminothiazole derivative as antibacterial agent
WO2024136758A1 (en) * 2022-12-21 2024-06-27 Agency For Science, Technology And Research Thiopeptide compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202241A (en) * 1988-09-09 1993-04-13 Gruppo Lepetit S.P.A. Antibiotic GE 2270
DE69016284T2 (de) * 1989-07-04 1995-05-24 Lepetit Spa Antibiotikum GE 22270, Faktoren A1,A2,A3 und H.
ES2071143T3 (es) * 1990-03-08 1995-06-16 Lepetit Spa Factores b1, b2, c1, c2, d1, d2, e y t del antibiotico ge 2270.
IL100572A (en) * 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
DK0529410T3 (da) * 1991-08-30 1998-05-11 Biosearch Italia Spa Antibiotikum GE 2270 faktor C2a
JP3458355B2 (ja) * 1992-09-10 2003-10-20 バイオサーチ・イタリア・ソチエタ・ペル・アチオニ 抗生物質ｇｅ２２７０因子ａの生産を選択的に増加させる方法
JPH10508476A (ja) * 1994-11-08 1998-08-25 グルポ・レペチツト・エス・ピー・エイ 抗生物質ｇｅ２２７０因子ｄ▲下２▼を得るための微生物変換法
WO1996024608A1 (en) * 1995-02-07 1996-08-15 Biosearch Italia S.P.A. Basic oxazoline-amide derivatives of ge 2270 and ge 2270-like antibiotics
DE69600244T2 (de) * 1995-02-07 1998-10-01 Biosearch Italia Spa Basische prolinamid derivate von ge2270 und ge2270-ahnlichten antibiotika

Also Published As

Publication number Publication date
EP0880541B1 (en) 2003-01-15
DE69718442T2 (de) 2003-04-30
US6008225A (en) 1999-12-28
EP0880541A1 (en) 1998-12-02
DE69718442D1 (de) 2003-02-20
WO1997030078A1 (en) 1997-08-21
ATE231163T1 (de) 2003-02-15
IL125107A0 (en) 1999-01-26
KR19990082541A (ko) 1999-11-25
DK0880541T3 (da) 2003-05-05
JP2000505438A (ja) 2000-05-09
AU714958B2 (en) 2000-01-13
HUP9901007A2 (hu) 1999-07-28
IL125107A (en) 2002-12-01
CA2242067A1 (en) 1997-08-21
AU1768797A (en) 1997-09-02
HUP9901007A3 (en) 1999-11-29

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