BRPI0511005A - peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv - Google Patents
peptìdeos oligoméricos e seu uso para o tratamento de infecções por hivInfo
- Publication number
- BRPI0511005A BRPI0511005A BRPI0511005-0A BRPI0511005A BRPI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A BR PI0511005 A BRPI0511005 A BR PI0511005A
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- phenylalanine
- cysteine
- alanine
- acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PEPTìDEOS OLIGOMéRICOS E SEU USO PARA O TRATAMENTO DE INFECçõES POR HIV. A invenção refere-se a peptídeos oligoméricos com atividade biológica contra infecção por HIV, tendo a seqüência de aminoácidos (Z~ 1~-LE-X~ 1~-I P-X~ 2~-X~ 3~-X~ 4~-P-X~ 5~-X~ 6~-X~ 7~-X~ 8~-X~ 9~-X~ 10~-K-X~ 11~-X~ 12~-X~ 13~-X~ 14~-X~ 15~-Z~ 2~)~ n~ onde n indica o número de cadeias peptídicas monoméricas, com o que n é 2, 3 ou 4; X~ 1~ é uma usina, alanina ou ácido aspártico; X~ 2~ é uma cisteina, metionina ou isoleucina; X~3~ é uma serina, cisteina, usina ou glicina; X~ 4~ é uma isoleucina, alanina, fenilalanina ou cisteina; X~ 5~ é uma prolina, D-prolina ou uma L-ou D-prolina substituida; X~ 6~ é uma cisteína ou ácido glutâmico; X~ 7~ é um aminoácido com cadeia lateral hidrofóbica ou aromática ou cisteína; X~ 8~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática ou cisteína; X~ 9~ é um aminoácido com uma cadeia lateral aromática; X~ 10~ é uma glicina, alanina ou asparagina; X~ 11~ é uma prolina, ácido aspártico, ácido octaidroindolil-2-carboxílico ou ácido D-,2,3,4-tetraisoquinolina-3-carboxílico; X~ 12~ é uma fenilalanina, alanina, glicina, ácido glutâmico ou ácido D-1,2,3,4-tetraisoquinolina-3-carboxílico; X~ 13~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática; X~ 14~ é um aminoácido com uma cadeia lateral hidrofóbica ou aromática; X~ 15~ é uma fenilalanina ou deleção; Z~ 1~ é NH~ 2~ ou uma seqüência de 1 a 10 resíduos de aminoácidos; Z~2~ é COOH ou uma seqüência de 1 a 10 resíduos de aminoácidos; e os peptídeos oligoméricos que são fragmentos dos mesmos e/ou derivados, especialmente os derivados amidados, alquilados, acuados, sulfatados, "peguilados", fosforilados e/ou glicosilados, e mutantes dos mesmos; e desde que (a) caso X~ 12~ seja alanina, glicina, ácido glutâmico, ou ácido 0-1,2,3,4-tetraisoquinolina-3-carboxílico, então X~ 13~, X~ 14~ e X~ 15~ são fenilalanina, valina ou fenilalanina, respectivamente; e/ou (b) caso X~ 12~ seja fenilalanina, então X~ 13~, X~ 14~ e X~ 15~ são valina, fenilalanina e uma deleção, respectivamente; e (c) há no máximo três resíduos de cisteína em um peptídeo; e (d) o peptídeo oligomérico não tem a seqüência (LEAIPCSIPPEFLFGKPFVF)~ 2~ (VIR-576); e (e) as cadeias peptídicas monoméricas não são ligadas por ligações peptídicas entre o terminal N de uma cadeia peptídica e o terminal C de outra cadeia peptídica.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58038404P | 2004-06-18 | 2004-06-18 | |
| EP04014304 | 2004-06-18 | ||
| US67586105P | 2005-04-29 | 2005-04-29 | |
| PCT/EP2005/052833 WO2005123771A2 (en) | 2004-06-18 | 2005-06-17 | Oligomeric peptides and their use for the treatment of hiv infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0511005A true BRPI0511005A (pt) | 2007-11-20 |
Family
ID=34925397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0511005-0A BRPI0511005A (pt) | 2004-06-18 | 2005-06-17 | peptìdeos oligoméricos e seu uso para o tratamento de infecções por hiv |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070123465A1 (pt) |
| EP (1) | EP1756160B1 (pt) |
| JP (1) | JP4782782B2 (pt) |
| CN (1) | CN100577686C (pt) |
| AP (1) | AP2081A (pt) |
| AU (1) | AU2005254736B2 (pt) |
| BR (1) | BRPI0511005A (pt) |
| CA (1) | CA2569807A1 (pt) |
| EA (1) | EA011037B1 (pt) |
| MX (1) | MXPA06014393A (pt) |
| NO (1) | NO20070296L (pt) |
| WO (1) | WO2005123771A2 (pt) |
| ZA (1) | ZA200705769B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090088365A1 (en) * | 2005-11-02 | 2009-04-02 | Roberto Mariani | Biosynthetic Polypeptide Fusion Inhibitors |
| WO2009015384A1 (en) * | 2007-07-26 | 2009-01-29 | University Of Rochester | Nucleic acid binding compounds and methods of use |
| CN101993485B (zh) * | 2009-08-20 | 2013-04-17 | 重庆富进生物医药有限公司 | 促胰岛素分泌肽类似物同源二聚体及其用途 |
| GR1007010B (el) * | 2009-10-08 | 2010-10-07 | Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), | Ινσουλινοειδη πεπτιδια |
| US8927485B2 (en) * | 2010-02-18 | 2015-01-06 | Advanced Proteome Therapeutics Inc. | Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides |
| WO2011110049A1 (zh) * | 2010-03-12 | 2011-09-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 抗hiv的融合多肽及其用途 |
| WO2011127624A1 (zh) * | 2010-04-13 | 2011-10-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 抗hiv肽 |
| CN102180951B (zh) * | 2011-05-03 | 2012-09-26 | 中国医学科学院病原生物学研究所 | 胆固醇修饰的抗hiv多肽药物及其用途 |
| WO2013170272A2 (en) | 2012-05-11 | 2013-11-14 | Alexander Krantz | Site-specific labeling and targeted delivery of proteins for the treatment of cancer |
| WO2014198834A1 (en) * | 2013-06-12 | 2014-12-18 | Pharis Biotec Gmbh | Peptides with antagonistic activities against natural cxcr4 |
| EP3509612A4 (en) * | 2016-09-06 | 2021-07-21 | Mainline Biosciences | CXCR4 ANTAGONISTS AND METHOD OF USE |
| CN109963863A (zh) * | 2016-11-09 | 2019-07-02 | 法瑞斯生物技术有限公司 | 促转导素-C（Protransducine-C）：基因转移激活因子 |
| CN114450324B (zh) * | 2019-09-26 | 2024-02-27 | 日油株式会社 | 具有肽连接子的异双官能单分散聚乙二醇 |
| JPWO2022202785A1 (pt) * | 2021-03-22 | 2022-09-29 | ||
| WO2024197259A1 (en) * | 2023-03-23 | 2024-09-26 | Brandeis University | Transcytotic intercellular gelation enables cell spheroids |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001034640A2 (de) * | 1999-11-08 | 2001-05-17 | Ipf Pharmaceuticals Gmbh | Humanes zirkulierendes virus inhibierendes peptid (virip) und seine verwendung |
| US7655629B2 (en) * | 2002-12-19 | 2010-02-02 | Ipf Pharmaceuticals Gmbh | Peptides and their use for the treatment of HIV infections |
-
2005
- 2005-06-17 AU AU2005254736A patent/AU2005254736B2/en not_active Ceased
- 2005-06-17 BR BRPI0511005-0A patent/BRPI0511005A/pt not_active IP Right Cessation
- 2005-06-17 CN CN200580019909A patent/CN100577686C/zh not_active Expired - Fee Related
- 2005-06-17 MX MXPA06014393A patent/MXPA06014393A/es active IP Right Grant
- 2005-06-17 US US11/629,883 patent/US20070123465A1/en not_active Abandoned
- 2005-06-17 CA CA002569807A patent/CA2569807A1/en not_active Abandoned
- 2005-06-17 EA EA200700062A patent/EA011037B1/ru not_active IP Right Cessation
- 2005-06-17 WO PCT/EP2005/052833 patent/WO2005123771A2/en not_active Ceased
- 2005-06-17 EP EP05752836.6A patent/EP1756160B1/en not_active Expired - Lifetime
- 2005-06-17 ZA ZA200705769A patent/ZA200705769B/xx unknown
- 2005-06-17 AP AP2007003877A patent/AP2081A/en active
- 2005-06-17 JP JP2007515966A patent/JP4782782B2/ja not_active Expired - Fee Related
-
2007
- 2007-01-16 NO NO20070296A patent/NO20070296L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005123771A2 (en) | 2005-12-29 |
| MXPA06014393A (es) | 2007-07-04 |
| AU2005254736B2 (en) | 2011-08-18 |
| WO2005123771A3 (en) | 2006-02-09 |
| CA2569807A1 (en) | 2005-12-29 |
| CN100577686C (zh) | 2010-01-06 |
| NO20070296L (no) | 2007-02-27 |
| AP2007003877A0 (en) | 2007-02-28 |
| AP2081A (en) | 2010-01-04 |
| EP1756160B1 (en) | 2013-08-14 |
| JP4782782B2 (ja) | 2011-09-28 |
| CN1968964A (zh) | 2007-05-23 |
| EP1756160A2 (en) | 2007-02-28 |
| US20070123465A1 (en) | 2007-05-31 |
| EA011037B1 (ru) | 2008-12-30 |
| AU2005254736A1 (en) | 2005-12-29 |
| EA200700062A1 (ru) | 2007-04-27 |
| JP2008505854A (ja) | 2008-02-28 |
| ZA200705769B (en) | 2008-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |