ATE308558T1 - Hiv-1- und hiv-2-peptide zur hemmung von mit membranfusionen in zusammenhang stehenden phänomenen, einschliesslich der übertragung von hiv - Google Patents

Hiv-1- und hiv-2-peptide zur hemmung von mit membranfusionen in zusammenhang stehenden phänomenen, einschliesslich der übertragung von hiv

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Publication number
ATE308558T1
ATE308558T1 AT95943483T AT95943483T ATE308558T1 AT E308558 T1 ATE308558 T1 AT E308558T1 AT 95943483 T AT95943483 T AT 95943483T AT 95943483 T AT95943483 T AT 95943483T AT E308558 T1 ATE308558 T1 AT E308558T1
Authority
AT
Austria
Prior art keywords
hiv
peptides
including transmission
membrane fusion
related phenomena
Prior art date
Application number
AT95943483T
Other languages
English (en)
Inventor
Dani P Bolognesi
Thomas J Matthews
Cart T Wild
Shawn O'lin Barney
Dennis M Lambert
Stephen R Petteway Jr
Alphonse J Langlois
Original Assignee
Univ Duke
Trimeris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27000760&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE308558(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/360,107 external-priority patent/US6017536A/en
Application filed by Univ Duke, Trimeris Inc filed Critical Univ Duke
Application granted granted Critical
Publication of ATE308558T1 publication Critical patent/ATE308558T1/de

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AT95943483T 1994-12-20 1995-12-20 Hiv-1- und hiv-2-peptide zur hemmung von mit membranfusionen in zusammenhang stehenden phänomenen, einschliesslich der übertragung von hiv ATE308558T1 (de)

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US08/360,107 US6017536A (en) 1993-06-07 1994-12-20 Simian immunodeficiency virus peptides with antifusogenic and antiviral activities
US08/470,896 US6479055B1 (en) 1993-06-07 1995-06-06 Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
PCT/US1995/016733 WO1996019495A1 (en) 1994-12-20 1995-12-20 Methods and compositions for inhibition of membrane fusion-associated events, including hiv transmission

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US (17) US6479055B1 (de)
EP (2) EP1714974A3 (de)
JP (3) JP2001523082A (de)
KR (1) KR100558087B1 (de)
AT (1) ATE308558T1 (de)
CA (1) CA2208420C (de)
DE (1) DE69534569T2 (de)
ES (1) ES2252747T3 (de)
NZ (1) NZ300002A (de)
WO (1) WO1996019495A1 (de)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US20070202127A1 (en) * 1993-06-07 2007-08-30 Duke University Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids
US6475491B1 (en) * 1995-06-07 2002-11-05 Trimeris, Inc. Treatment of HIV and other viral infections using combinatorial therapy
US6271198B1 (en) 1996-11-06 2001-08-07 Genentech, Inc. Constrained helical peptides and methods of making same
FR2771011B1 (fr) * 1997-11-17 2000-01-28 Hippocampe Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale
BR9909018A (pt) * 1998-03-23 2001-10-16 Trimeris Inc Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US20070026021A1 (en) * 1998-05-01 2007-02-01 Chiron S.R.I. Neisseria meningitidis antigens and compositions
EP2261347A3 (de) 1998-05-01 2012-01-11 Novartis Vaccines and Diagnostics, Inc. Antigene und Zusammensetzungen gegen Neisseria meningitidis
US6258782B1 (en) 1998-05-20 2001-07-10 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
US6656906B1 (en) 1998-05-20 2003-12-02 Trimeris, Inc. Hybrid polypeptides with enhanced pharmacokinetic properties
US6797462B1 (en) 1998-06-23 2004-09-28 Uab Research Foundation Cell-based assay for immunodeficiency virus infectivity and sensitivity
FR2786773B1 (fr) * 1998-12-03 2002-03-08 Univ Paris Curie Proteines d'enveloppe, methodes et utilisations
WO2000045833A1 (en) * 1999-02-02 2000-08-10 Uab Research Foundation, The Hiv drug resistance system
US20080318890A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318889A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7314926B1 (en) 1999-04-08 2008-01-01 Antisoma Research Limited Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
JP4520441B2 (ja) * 1999-05-13 2010-08-04 独立行政法人科学技術振興機構 インテグラーゼｎ−末端領域を標的としたウイルス感染阻害剤
BR0010757A (pt) * 1999-05-17 2002-02-19 Conjuchem Inc Inibidores de peptìdeo de fusão de longa duração de infecção viral
US6469136B1 (en) 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
US6541020B1 (en) 1999-07-09 2003-04-01 Trimeris, Inc. Methods and compositions for administration of therapeutic reagents
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
US6706892B1 (en) 1999-09-07 2004-03-16 Conjuchem, Inc. Pulmonary delivery for bioconjugation
US7090851B1 (en) 1999-09-10 2006-08-15 Conjuchem Inc. Long lasting fusion peptide inhibitors of viral infection
AU784551B2 (en) * 1999-10-06 2006-05-04 Trustees Of The University Of Pennsylvania, The Cell targeting compositions and methods of using the same
EP1264177A2 (de) 2000-02-10 2002-12-11 Panacos Pharmaceuticals, Inc. Verfahren zur detektion von viralen fusionsinhibitoren
US6623741B1 (en) * 2000-02-29 2003-09-23 Trimeris, Inc. Methods and compositions for inhibition of membrane fusion-associated events including RSV transmission
US6528308B1 (en) 2000-03-16 2003-03-04 Duke University Suppressor of HIV replication and transcription
WO2002033128A2 (en) * 2000-10-18 2002-04-25 Pharmasset Limited Multiplex quantification of nucleic acids in diseased cells
US6821731B2 (en) * 2000-11-28 2004-11-23 Wyeth Expression analysis of FKBP nucleic acids and polypeptides useful in the diagnosis of prostate cancer
WO2002044419A2 (en) * 2000-11-28 2002-06-06 Wyeth Expression analysis of kiaa nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
HUP0303899A3 (en) * 2000-11-28 2007-05-02 Wyeth Corp Expression analysis of smarc nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
DK1479691T3 (da) * 2001-05-31 2007-03-12 John Erickson Langvarigt aktive fuionspeptidinhibitorer for HIV infektion
CA2450548C (en) 2001-06-15 2012-05-01 F. Hoffmann-La Roche Ag Method for the recombinant production of peptidic antiviral fusion inhibitors, and acetylation of gb41 fragments
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US20050227933A1 (en) * 2001-11-29 2005-10-13 Benkovic Stephen J Treatment of bacterial induced diseases using DNA methyl transferase inhibitors
EP2258712A3 (de) 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Zusammensetzungen und Verfahren zur Einleitung bzw. Verstärkung von Antikörper- und Haupthistokompatibilität-Klasse-I- oder-Klasse-II-beschränkten T-Zell-Reaktionen unter Anwendung von Immunmodulierenden, nicht-codierenden RNA-Motiven
US20040132011A1 (en) * 2002-10-16 2004-07-08 Panacos Pharmaceuticals, Inc. Method for detecting viral inactivating agents
CA2443365C (en) * 2002-11-19 2010-01-12 F. Hoffmann-La Roche Ag Methods for the recombinant production of antifusogenic peptides
NZ543122A (en) * 2003-03-24 2008-07-31 Sequoia Pharmaceuticals Inc An HIV fusion inhibitor peptide covalently linked to a blood protein
JP2006522806A (ja) * 2003-03-26 2006-10-05 マルチセル・イミュノセラピューティクス，インコーポレイテッド 細胞死及び／又はアポトーシスを誘導するための、選択されたｒｎａモチーフ
WO2004108885A2 (en) * 2003-05-06 2004-12-16 Syntonix Pharmaceuticals, Inc. Fc chimeric proteins with anti-hiv drugs
US7348004B2 (en) 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
AU2004238263A1 (en) * 2003-05-06 2004-11-25 Syntonix Pharmaceuticals, Inc. Inhibition of drug binding to serum albumin
ES2333598T5 (es) * 2003-05-06 2013-09-04 Biogen Idec Hemophilia Inc Proteinas quimericas del factor de coagulacion fc para tratar la hemofilia.
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
CN1829524A (zh) * 2003-05-08 2006-09-06 波特·W·安德森 基于gp160和人cd4蛋白共有的保守氨基酸序列的抗hiv－1化合物
CA2533878A1 (en) * 2003-07-29 2005-09-22 Immunomedics, Inc. Fluorinated carbohydrate conjugates
US20110104196A1 (en) * 2003-10-23 2011-05-05 Karp Nelson M Immunogenic composition and method of developing a vaccine based on fusion protein
US7556814B2 (en) * 2003-10-23 2009-07-07 Karp Nelson M Immunogenic compositions comprising UV-irradiated, psoralen-inactivated, desialated human immunodeficiency virus (HIV) devoid of CD55 and CD59 in the viral membrane
CA2544848C (en) * 2003-11-04 2015-12-29 The Administrators Of The Tulane Educational Fund Method of preventing virus: cell fusion by inhibiting the function of the fusion initiation region in rna viruses having class i membrane fusogenic envelope proteins
US20080096809A1 (en) * 2003-12-22 2008-04-24 Yeda Research & Development Co. Ltd. Diastereomeric Peptides Useful as Inhibitors of Membrane Protein Assembly
WO2005063282A1 (en) 2003-12-23 2005-07-14 Centocor, Inc. Anti-retroviral agents, compositions, methods and uses
ES2387215T3 (es) * 2003-12-23 2012-09-18 Nationwide Children's Hospital, Inc. Pili de tipo IV de la Haemophilus influenzae
ATE376556T1 (de) * 2003-12-31 2007-11-15 Hoffmann La Roche Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel
WO2005063793A1 (en) * 2003-12-31 2005-07-14 F. Hoffmann-La Roche Ag Process and systems for recovery of peptides
EP1701976A2 (de) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptidsynthese und entschützung mit cosolvenz
EP1701971A2 (de) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptidsynthese unter anwendung eines dekantierungsfilters
EP1701970A2 (de) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Verfahren zur wiedergewinnung eines gespaltenen peptides von einem träger
JP2007517522A (ja) * 2004-01-07 2007-07-05 トリメリス，インコーポレーテッド ＨＩＶｇｐ４１ＨＲ２由来の合成ペプチド、およびヒト免疫不全ウイルスの伝播を阻止する治療におけるその使用
US20080027006A1 (en) * 2004-02-12 2008-01-31 The Regents Of The University Of Colorado Compositions And Methods For Modification And Prevention Of Sars Coronavirus Infectivity
CA2565658A1 (en) * 2004-05-06 2005-11-17 Conjuchem Biotechnologies Inc. Compounds for specific viral target
GB0422439D0 (en) * 2004-10-08 2004-11-10 European Molecular Biology Lab Embl Inhibitors of infection
WO2006060737A2 (en) * 2004-12-03 2006-06-08 Takeda San Diego, Inc. Mitotic kinesin inhibitors
CN101133076B (zh) * 2004-12-30 2011-07-13 弗·哈夫曼-拉罗切有限公司 使用肽中间片段合成肽t-1249
EP1833843B1 (de) * 2004-12-30 2009-10-14 F. Hoffmann-La Roche Ag Synthese des peptides t-20 aus peptidfragmenten als zwischenprodukte
US20090270312A1 (en) * 2005-01-24 2009-10-29 Yechiel Shai Hiv-i gp41 fusion peptides for immunomodulaltion
WO2007022477A2 (en) * 2005-08-17 2007-02-22 Multicell Immunotherapeutics, Inc. Methods and compositions to generate and control the effector profile of t cells
US20070185025A1 (en) * 2005-09-11 2007-08-09 The Trustees Of Columbia University In The City Of New York Filoviral immunosuppressive peptides and uses thereof
EP1989220B1 (de) 2006-02-02 2011-12-14 Trimeris, Inc. Hiv-fusionshemmerpeptide mit verbesserten biologischen eigenschaften
US8216592B2 (en) * 2006-04-19 2012-07-10 The Reed Institute Infection model for developing chemotherapeutic agents
US8222204B2 (en) * 2006-05-03 2012-07-17 The Administrators of the Tulane Educational Fund and Autoimmune Technologies, LLC Influenza inhibiting compositions and methods
CN101088557A (zh) 2006-06-12 2007-12-19 天津市扶素生物技术有限公司 用于预防或治疗hiv感染的药用组合物及其应用
WO2008001627A1 (fr) 2006-06-27 2008-01-03 Nec Corporation système de communication, émetteur, récepteur et procédé d'accès multiple
CA2658484A1 (en) * 2006-07-20 2008-01-24 Vical Incorporated Compositions and methods for vaccinating against hsv-2
TW200817438A (en) * 2006-08-17 2008-04-16 Hoffmann La Roche A conjugate of an antibody against CCR5 and an antifusogenic peptide
KR101105610B1 (ko) 2006-08-17 2012-01-18 에프. 호프만-라 로슈 아게 Ｃｃｒ５ 에 대한 항체 및 항푸소제닉 펩타이드의 컨쥬게이트
ES2535358T3 (es) 2006-12-12 2015-05-08 Biorexis Pharmaceutical Corporation Bibliotecas de proteínas de fusión de transferrina
US20090088378A1 (en) * 2007-01-12 2009-04-02 Omar Quraishi Long lasting inhibitors of viral infection
CL2008000707A1 (es) * 2007-03-13 2008-09-22 Hoffmann La Roche Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion.
BRPI0809995A2 (pt) * 2007-04-03 2015-07-21 Trimeris Inc Composição, e, métodos para a liberação prolongada de um peptídeo em um paciente e para melhorar um sintoma associado com uma infecção por hiv
BRPI0811864A2 (pt) * 2007-05-16 2014-11-18 Conjuchem Biotechnologies Inc Derivados de ácido cistéico de peptídeos antivirais
US20090022720A1 (en) * 2007-07-20 2009-01-22 Stephan Fischer Conjugate of an antibody against CD4 and antifusogenic peptides
BRPI0817697A2 (pt) * 2007-09-25 2015-04-07 Trimeris Inc Método de síntese de um peptídeo, conjunto de fragmentos de peptídeo, e, peptídeo
US20090131351A1 (en) * 2007-11-16 2009-05-21 Antisoma Research Limited Methods, compositions, and kits for modulating tumor cell proliferation
US7892562B2 (en) * 2008-10-08 2011-02-22 Karp Nelson M Methods of inducing TH-1 immune responses to HIV-1 by administering UV/psoralen-treated desialated inactiviated HIV-1 virions deficient in CD55 and CD59
EP3698811A1 (de) 2009-06-18 2020-08-26 Dana Farber Cancer Institute, Inc. Strukturierte viralpeptidzusammensetzungen und verwendungsverfahren dafür
WO2011094363A2 (en) 2010-01-26 2011-08-04 The Regents Of The University Of Colorado Influenza virus compositions and methods for universal vaccines
US9782454B2 (en) 2010-04-22 2017-10-10 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
JP5757639B2 (ja) 2010-09-14 2015-07-29 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ セルピンフィンガー融合ポリペプチド
EP2447277A1 (de) 2010-10-28 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Impfstoffzusammensetzungen auf Basis von modifizierten gp41-Immunogenen
ES2744840T3 (es) 2011-04-01 2020-02-26 Univ Yale Anticuerpos anti-ADN que penetran en las células y usos de los mismos para inhibir la reparación del ADN
WO2013023362A1 (zh) * 2011-08-16 2013-02-21 深圳市卫武光明生物制品有限公司 静注巨细胞病毒人免疫球蛋白及其制备方法
WO2013049389A1 (en) 2011-09-27 2013-04-04 Yale University Compositions and methods for transient expression of recombinant rna
US8771698B2 (en) * 2011-10-27 2014-07-08 Institut National De La Recherche Scientifique Modulation of UL24 interactions with protein targets and uses thereof for inhibition of herpesvirus infection
EP2834264A1 (de) 2012-04-04 2015-02-11 Yeda Research and Development Co. Ltd. Lipopeptidkonjugate mit sphingolipid und aus hiv gp41 gewonnenen peptiden
HK1205138A1 (en) 2012-07-27 2015-12-11 Institut National De La Santé Et De La Recherche Médicale (Inserm) Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia
WO2014041505A1 (en) * 2012-09-13 2014-03-20 Universite De Geneve Cell penetrating peptides
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US9649375B2 (en) * 2013-03-14 2017-05-16 The Administrators Of The Tulane Educational Fund Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith
WO2014145718A2 (en) 2013-03-15 2014-09-18 Longevity Biotech, Inc. Peptides comprising non-natural amino acids and methods of making and using the same
TWI828269B (zh) 2013-03-15 2024-01-01 美商百歐維拉提夫治療公司 因子ix多肽調配物
US9341391B2 (en) * 2013-12-31 2016-05-17 Bollente Companies, Inc. Automatically controlled flow-through water heater system
WO2015134607A1 (en) 2014-03-04 2015-09-11 Yale University Cell penetrating anti-guanosine antibody based therapy for cancers with ras mutations
US10238742B2 (en) 2014-06-25 2019-03-26 Yale University Cell penetrating nucleolytic antibody based cancer therapy
EP3169702A4 (de) * 2014-07-14 2018-04-18 The Regents of The University of California Proteinmarkierungssystem für in-vivo-einzelmolekül-bildgebung und steuerung der gentranskription
CN105989283B (zh) 2015-02-06 2019-08-09 阿里巴巴集团控股有限公司 一种识别病毒变种的方法及装置
WO2016146143A1 (en) 2015-03-16 2016-09-22 Amal Therapeutics Sa Cell penetrating peptides and complexes comprising the same
PT3429618T (pt) * 2016-03-16 2024-04-02 Amal Therapeutics Sa Combinação de um modulador de ponto de controlo imunitário e um complexo que compreende um péptido de penetração celular, uma carga e um agonistra peptídico de tlr para utilização em medicina
WO2017218825A1 (en) 2016-06-15 2017-12-21 Yale University Antibody-mediated autocatalytic, targeted delivery of nanocarriers to tumors
US12486318B2 (en) 2016-06-15 2025-12-02 Yale University Anti-guanosine antibody as a molecular delivery vehicle
IL265479B (en) 2016-09-21 2022-09-01 Amal Therapeutics Sa A fusion containing a cell-penetrating peptide, a multiple epitope, and a peptide tlr agonist for cancer therapy
WO2018059214A1 (zh) * 2016-09-29 2018-04-05 广州君赫生物科技有限公司 影响saicar合成的化合物及应用
EP3613731A4 (de) 2017-04-20 2021-01-13 Geneheal Biotechnology Co., Ltd. Anwendungen von spermidin und dessen derivaten
EP3539562A1 (de) 2018-03-12 2019-09-18 Eberhard Karls Universität Tübingen Medizinische Fakultät Immuntherapeutische peptide
CN109207504B (zh) * 2018-09-26 2022-03-18 四川大学 一种有效免疫ib与nd的唾液乳酸杆菌的制备方法
JP7333538B2 (ja) * 2018-10-09 2023-08-25 東亞合成株式会社 抗ウイルス性ペプチドおよびその利用
CN109320594B (zh) * 2018-11-13 2021-09-28 四川大学 一种禽传染性支气管炎和新城疫的病毒样颗粒、制备方法及应用
CN112029735B (zh) * 2020-08-31 2022-04-12 中国农业科学院兰州兽医研究所 一种口蹄疫病毒非结构蛋白3b优势表位缺失标记毒株及其制备方法和应用
CN112410351A (zh) * 2020-11-12 2021-02-26 山东农业大学 兼抗黄瓜花叶病毒和马铃薯x病毒的双联弱毒疫苗及其应用
CN112410312A (zh) * 2020-11-27 2021-02-26 江南大学 一种环己酮单加氧酶及其应用
CN114385906B (zh) * 2021-10-29 2024-10-25 北京达佳互联信息技术有限公司 一种预测方法、推荐方法、装置、设备以及存储介质

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4659669A (en) 1981-03-02 1987-04-21 Regents Of The Univ. Of California Microbial expression of human influenza hemagglutinin proteins
US4609546A (en) 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
US4859765A (en) * 1983-10-17 1989-08-22 Syntex (U.S.A.) Inc. Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture
US5843638A (en) 1983-12-05 1998-12-01 Institut Pasteur And Centre National De La Recherche Scientifique Nucleic acids and pepties of human immunodeficiency virus type-1 (HIV-1).
US4707358A (en) 1984-01-30 1987-11-17 The University Of Chicago Vaccine against Epstein-Barr Virus
US5116725A (en) 1984-08-08 1992-05-26 Scripps Clinic And Research Foundation Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides
IL76082A (en) 1984-08-22 1991-07-18 Us Health Molecular clones of the genome of htlv-iii and a process for the preparation thereof
US6610476B1 (en) 1984-08-22 2003-08-26 The United States Of America As Represented By The Department Of Health And Human Services Detection of HIV-1 DNA
WO1986002383A1 (en) 1984-10-18 1986-04-24 Institut Pasteur Envelope antigens of lymphadenopathy associated virus and their applications
US5705612A (en) 1984-10-18 1998-01-06 Institut Pasteur And Centre National De La Recherche Scientifique NEF peptide encoded by human immunodefiency virus type 1 (HIV-1)
GB8501473D0 (en) 1985-01-21 1985-02-20 Pasteur Institut Cloned dna sequences
CA1341423C (en) 1984-10-31 2003-03-04 Paul A. Luciw Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome
US5853978A (en) 1985-12-04 1998-12-29 Genentech, Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and methods of use
AU600658B2 (en) 1984-12-24 1990-08-23 Genentech Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use
KR910002374B1 (ko) 1985-04-29 1991-04-20 제네틱 시스템즈 코포레이션 Aids 관련질병의 검출을 위한 합성항원
US4761470A (en) * 1985-12-16 1988-08-02 Merck & Co., Inc. Immunogenic synthetic peptide capable of eliciting herpes simplex virus neutralizing antibody
US5075211A (en) * 1986-03-26 1991-12-24 Genetic Systems Corporation Synthetic antigen for the detection of AIDS-related disease
WO1988005051A1 (en) 1986-12-30 1988-07-14 United States Of America, Represented By The Unite Synthetic peptides which induce cellular immunity of the aids virus and aids viral proteins
ES2104556T3 (es) 1987-01-16 1997-10-16 Pasteur Institut Peptidos que tienen propiedades inmunologicas de hiv-2.
US5141867A (en) * 1987-02-02 1992-08-25 E. I. Du Pont De Nemours And Company Nucleotide sequence encoding a human immunodeficiency virus antigen
NO881151L (no) 1987-03-27 1988-09-28 Syntello Ab Syntetisk hiv-1-antigen.
AU1711888A (en) 1987-04-24 1988-12-02 Biogen, Inc. Immunotherapeutic methods and compositions
US5223254A (en) 1987-09-29 1993-06-29 Praxis Biologics, Inc. Respiratory syncytial virus: vaccines
EP0323157A3 (de) 1987-12-24 1990-07-25 The University Of Melbourne Antivirale Verbindungen und Methoden
US5241047A (en) 1988-12-08 1993-08-31 Biochem Pharma Inc. Synthetic peptides and mixtures thereof for detecting HIV antibodies
AU608413B2 (en) 1988-03-30 1991-03-28 Abbott Laboratories Mouse monoclonal antibody (5-21-3) to human immunodeficiency virus gp41 protein
DE68915165T2 (de) * 1988-04-22 1994-09-08 Upjohn Co Schimärische glykoproteine enthaltende immunogenische abschnitte von menschlichem parainfluenzavirus typ 3.
EP0362909A3 (de) 1988-08-26 1990-11-14 Akzo N.V. Synthetische Polypeptide, immunochemisch aktiv mit HIV-Antikörpern
EP0362910A3 (de) 1988-08-27 1991-01-09 Akzo N.V. Synthetische Polypeptide, immunochemisch aktiv mit HIV-Antikörpern
EP0362927A3 (de) * 1988-10-06 1990-11-14 Akzo N.V. Mit HIV-Antikörpern immunochemisch reaktive synthetische Polypeptide
US5268358A (en) * 1988-12-08 1993-12-07 Cor Therapeutics, Inc. PDGF receptor blocking peptides
US5057211A (en) 1988-12-19 1991-10-15 Baummer George P Benefication apparatus and process for land and seabed mining
EP0449955B1 (de) 1988-12-20 1996-03-06 Clarity Technologies Incorporated Synthetische hiv ähnliche peptide, deren zusammensetzungen und verwendungen
US6248574B1 (en) 1989-12-13 2001-06-19 Avigdor Shaffermann Polypeptides selectively reactive with antibodies against human immunodeficiency virus and vaccines comprising the polypeptides
FR2677346B1 (fr) 1991-06-10 1993-08-27 Atochem Procede de purification d'une solution aqueuse de chlorure de metal alcalin par enlevement de l'ammonium et de l'iode.
IL102092A (en) 1991-06-11 1996-11-14 Microgenesys Inc Use of recombinant hiv envelope protein in medicament for treating hiv and therapeutic composition containing the agglomerated protein
GB9120221D0 (en) * 1991-09-23 1991-11-06 Smithkline Beecham Biolog Novel compounds
GB9200117D0 (en) 1992-01-06 1992-02-26 Connaught Lab Production of recombinant chimeric proteins for vaccine use
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5444044A (en) 1992-03-26 1995-08-22 New York Blood Center Synthetic polypeptides as inhibitors of HIV-1
AU688733B2 (en) * 1992-07-20 1998-03-19 Duke University Compounds which inhibit HIV replication
US5464933A (en) 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US6479055B1 (en) 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US6017536A (en) 1993-06-07 2000-01-25 Trimeris, Inc. Simian immunodeficiency virus peptides with antifusogenic and antiviral activities
US20070202127A1 (en) 1993-06-07 2007-08-30 Duke University Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids
DE741187T1 (de) 1995-05-05 1997-04-30 Hoffmann La Roche Rekombinante Obesitäts-(OB)-Proteine
US6475491B1 (en) * 1995-06-07 2002-11-05 Trimeris, Inc. Treatment of HIV and other viral infections using combinatorial therapy
US6156949A (en) * 1998-12-28 2000-12-05 Mobil Oil Corporation Selective pseudocumene production by xylene methylation

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