BRPI0511078A - compostos de pirimidinona cìclicos, composição compreendendo os mesmos, método de inibição e uso - Google Patents

compostos de pirimidinona cìclicos, composição compreendendo os mesmos, método de inibição e uso

Info

Publication number
BRPI0511078A
BRPI0511078A BRPI0511078-5A BRPI0511078A BRPI0511078A BR PI0511078 A BRPI0511078 A BR PI0511078A BR PI0511078 A BRPI0511078 A BR PI0511078A BR PI0511078 A BRPI0511078 A BR PI0511078A
Authority
BR
Brazil
Prior art keywords
compounds
composition
inhibition
pyrimidinone compounds
cyclic
Prior art date
Application number
BRPI0511078-5A
Other languages
English (en)
Inventor
B Narasimhulu Naidu
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BRPI0511078A publication Critical patent/BRPI0511078A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTOS DE PIRIMIDINONA CìCLICOS, COMPOSIçãO COMPREENDENDO OS MESMOS, MéTODO DE INIBIçãO E USO. A presente invenção refere-se a uma série de compostos de pirimidinona que inibem integrase de HIV e desse modo prevenindo integração viral em DNA humano. Esta ação toma os compostos úteis para o tratamento de infecção por HIV e AIDS. A invenção também inclui intermediários úteis para a produção dos compostos de pirimidona. Adicionalmente, são incluídos métodos e composições farmacêuticas para o tratamento destes infectados com HIV. Fórmula (I).
BRPI0511078-5A 2004-05-12 2005-04-22 compostos de pirimidinona cìclicos, composição compreendendo os mesmos, método de inibição e uso BRPI0511078A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57034804P 2004-05-12 2004-05-12
PCT/US2005/013911 WO2005113562A1 (en) 2004-05-12 2005-04-22 Hiv integrase inhibitors: cyclic pyrimidinone compounds

Publications (1)

Publication Number Publication Date
BRPI0511078A true BRPI0511078A (pt) 2007-12-26

Family

ID=34967012

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511078-5A BRPI0511078A (pt) 2004-05-12 2005-04-22 compostos de pirimidinona cìclicos, composição compreendendo os mesmos, método de inibição e uso

Country Status (26)

Country Link
US (2) US7273859B2 (pt)
EP (1) EP1745052B9 (pt)
JP (1) JP2007537251A (pt)
KR (1) KR20070014173A (pt)
CN (1) CN1984917A (pt)
AR (1) AR049498A1 (pt)
AT (1) ATE405570T1 (pt)
AU (1) AU2005245789A1 (pt)
BR (1) BRPI0511078A (pt)
CA (1) CA2566755A1 (pt)
DE (1) DE602005009172D1 (pt)
DK (1) DK1745052T3 (pt)
ES (1) ES2310823T3 (pt)
HR (1) HRP20080531T3 (pt)
IL (1) IL179161A0 (pt)
MX (1) MXPA06013023A (pt)
NO (1) NO20065443L (pt)
NZ (1) NZ550698A (pt)
PE (1) PE20060238A1 (pt)
PL (1) PL1745052T3 (pt)
PT (1) PT1745052E (pt)
RU (1) RU2006143683A (pt)
SI (1) SI1745052T1 (pt)
TW (1) TW200540173A (pt)
WO (1) WO2005113562A1 (pt)
ZA (1) ZA200609181B (pt)

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US7494984B2 (en) * 2005-08-31 2009-02-24 Bristol-Myers Squibb Company Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors
US7897592B2 (en) * 2005-11-15 2011-03-01 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2007058646A1 (en) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Hiv integrase inhibitors: cyclic pyrimidinone compounds
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2007064502A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Forms of n-[(4-fluorophenyl)methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide
WO2007143446A1 (en) * 2006-05-30 2007-12-13 Bristol-Myers Squibb Company Spiro-condensed heterotricyclic compounds as hiv integrase inhibitors
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WO2014172188A2 (en) 2013-04-16 2014-10-23 Merck Sharp & Dohme Corp. 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors
HUE036384T2 (hu) 2013-05-17 2018-07-30 Merck Sharp & Dohme Fúzionált triciklusos heterociklikus vegyületek mint HIV integráz inhibitorok
EP3008044B1 (en) 2013-06-13 2018-11-21 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
PT3019503T (pt) 2013-07-12 2017-11-27 Gilead Sciences Inc Compostos carbamoílpiridona- policíclicos e seu uso para o tratamento de infecções por hiv
NO2865735T3 (pt) 2013-07-12 2018-07-21
AU2014324829B2 (en) 2013-09-27 2017-09-07 Merck Sharp & Dohme Corp. Substituted Quinolizine Derivatives useful as HIV integrase inhibitors
EP3087060B1 (en) 2013-12-23 2020-05-13 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as pde2 inhibitors
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
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Also Published As

Publication number Publication date
PT1745052E (pt) 2008-11-14
NO20065443L (no) 2006-11-27
RU2006143683A (ru) 2008-06-20
TW200540173A (en) 2005-12-16
US7273859B2 (en) 2007-09-25
JP2007537251A (ja) 2007-12-20
WO2005113562A1 (en) 2005-12-01
EP1745052B9 (en) 2009-10-28
ES2310823T3 (es) 2009-01-16
AR049498A1 (es) 2006-08-09
ATE405570T1 (de) 2008-09-15
AU2005245789A1 (en) 2005-12-01
CA2566755A1 (en) 2005-12-01
US7419969B2 (en) 2008-09-02
CN1984917A (zh) 2007-06-20
ZA200609181B (en) 2008-06-25
EP1745052B1 (en) 2008-08-20
PE20060238A1 (es) 2006-03-31
KR20070014173A (ko) 2007-01-31
US20050256109A1 (en) 2005-11-17
MXPA06013023A (es) 2006-12-20
SI1745052T1 (sl) 2009-04-30
US20060106007A1 (en) 2006-05-18
NZ550698A (en) 2009-05-31
DK1745052T3 (da) 2009-01-05
IL179161A0 (en) 2007-03-08
EP1745052A1 (en) 2007-01-24
HRP20080531T3 (en) 2009-03-31
PL1745052T3 (pl) 2009-01-30
DE602005009172D1 (de) 2008-10-02

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.