PL1745052T3 - Inhibitory integrazy HIV: Cykliczne związki pirymidynonowe - Google Patents

Inhibitory integrazy HIV: Cykliczne związki pirymidynonowe

Info

Publication number
PL1745052T3
PL1745052T3 PL05738619T PL05738619T PL1745052T3 PL 1745052 T3 PL1745052 T3 PL 1745052T3 PL 05738619 T PL05738619 T PL 05738619T PL 05738619 T PL05738619 T PL 05738619T PL 1745052 T3 PL1745052 T3 PL 1745052T3
Authority
PL
Poland
Prior art keywords
hiv integrase
integrase inhibitors
pyrimidinone compounds
cyclic
cyclic pyrimidinone
Prior art date
Application number
PL05738619T
Other languages
English (en)
Inventor
B Narasimhulu Naidu
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PL1745052T3 publication Critical patent/PL1745052T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL05738619T 2004-05-12 2005-04-22 Inhibitory integrazy HIV: Cykliczne związki pirymidynonowe PL1745052T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57034804P 2004-05-12 2004-05-12
PCT/US2005/013911 WO2005113562A1 (en) 2004-05-12 2005-04-22 Hiv integrase inhibitors: cyclic pyrimidinone compounds
EP05738619A EP1745052B9 (en) 2004-05-12 2005-04-22 Hiv integrase inhibitors: cyclic pyrimidinone compounds

Publications (1)

Publication Number Publication Date
PL1745052T3 true PL1745052T3 (pl) 2009-01-30

Family

ID=34967012

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05738619T PL1745052T3 (pl) 2004-05-12 2005-04-22 Inhibitory integrazy HIV: Cykliczne związki pirymidynonowe

Country Status (26)

Country Link
US (2) US7273859B2 (pl)
EP (1) EP1745052B9 (pl)
JP (1) JP2007537251A (pl)
KR (1) KR20070014173A (pl)
CN (1) CN1984917A (pl)
AR (1) AR049498A1 (pl)
AT (1) ATE405570T1 (pl)
AU (1) AU2005245789A1 (pl)
BR (1) BRPI0511078A (pl)
CA (1) CA2566755A1 (pl)
DE (1) DE602005009172D1 (pl)
DK (1) DK1745052T3 (pl)
ES (1) ES2310823T3 (pl)
HR (1) HRP20080531T3 (pl)
IL (1) IL179161A0 (pl)
MX (1) MXPA06013023A (pl)
NO (1) NO20065443L (pl)
NZ (1) NZ550698A (pl)
PE (1) PE20060238A1 (pl)
PL (1) PL1745052T3 (pl)
PT (1) PT1745052E (pl)
RU (1) RU2006143683A (pl)
SI (1) SI1745052T1 (pl)
TW (1) TW200540173A (pl)
WO (1) WO2005113562A1 (pl)
ZA (1) ZA200609181B (pl)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115601B2 (en) 2004-05-18 2006-10-03 Bristol-Myers Squibb Company HIV integrase inhibitors
AU2006228278C1 (en) * 2005-03-31 2011-06-23 Msd Italia S.R.L. HIV integrase inhibitors
US7494984B2 (en) * 2005-08-31 2009-02-24 Bristol-Myers Squibb Company Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors
WO2007058646A1 (en) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Hiv integrase inhibitors: cyclic pyrimidinone compounds
US7897592B2 (en) * 2005-11-15 2011-03-01 Bristol-Myers Squibb Company HIV integrase inhibitors
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2007064502A1 (en) * 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Forms of n-[(4-fluorophenyl)methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide
US7897593B2 (en) * 2006-05-30 2011-03-01 Bristol-Myers Squibb Company HIV integrase inhibitors
US7893055B2 (en) * 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
US7763630B2 (en) * 2007-06-06 2010-07-27 Bristol-Myers Squibb Company HIV integrase inhibitors
US8129398B2 (en) * 2008-03-19 2012-03-06 Bristol-Myers Squibb Company HIV integrase inhibitors
BRPI0913934A2 (pt) * 2008-07-02 2015-10-20 Avexa Ltd compostos tendo propriedades antivirais
EP2291377B1 (en) * 2008-07-02 2015-02-18 Avexa Limited Imidazopyrimidinones and uses thereof
AU2009302663B2 (en) * 2008-10-06 2012-11-08 Merck Sharp & Dohme Corp. HIV integrase inhibitors
EP2391212A4 (en) * 2009-01-28 2012-08-08 BROKEN COMPOUNDS AS HIV INTEGRASE INHIBITORS
US8143244B2 (en) * 2009-02-26 2012-03-27 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US20120220571A1 (en) * 2009-08-26 2012-08-30 Wai John S Hiv integrase inhibitors
US8383639B2 (en) 2009-10-15 2013-02-26 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2011075747A1 (en) * 2009-12-18 2011-06-23 Glaxosmithkline Llc Therapeutic compounds
WO2012151567A1 (en) * 2011-05-05 2012-11-08 St. Jude Children's Research Hospital Pyrimidinone compounds and methods for preventing and treating influenza
US10699038B2 (en) 2012-03-30 2020-06-30 Litmus Blue Technology LLC Configurable representation of domain models
WO2014008636A1 (en) * 2012-07-11 2014-01-16 Merck Sharp & Dohme Corp. Macrocyclic compounds as hiv integrase inhibitors
WO2014099586A1 (en) 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. 4-pyridinonetriazine derivatives as hiv integrase inhibitors
CA2893843C (en) 2012-12-21 2018-09-04 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
HK1214817A1 (en) 2012-12-27 2016-08-05 Japan Tobacco Inc. Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as hiv integrase inhibitor
WO2014172188A2 (en) 2013-04-16 2014-10-23 Merck Sharp & Dohme Corp. 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors
PT2997033T (pt) 2013-05-17 2018-01-25 Merck Sharp & Dohme Compostos heterocíclicos tricíclicos fundidos como inibidores de vih integrase
WO2014200880A1 (en) 2013-06-13 2014-12-18 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
DK3019503T3 (da) 2013-07-12 2017-11-20 Gilead Sciences Inc Polycykliske-carbamoylpyridon-forbindelser og anvendelse deraf til behandling af hiv-infektioner
NO2865735T3 (pl) 2013-07-12 2018-07-21
MX367057B (es) 2013-09-27 2019-08-02 Merck Sharp & Dohme Derivados de quinolizina sustituidos utiles como inhibidores de integrasa del vih.
WO2015096651A1 (en) 2013-12-23 2015-07-02 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as pde2 inhibitors
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
NO2717902T3 (pl) 2014-06-20 2018-06-23
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TWI738321B (zh) 2014-12-23 2021-09-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
WO2016154081A1 (en) 2015-03-26 2016-09-29 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
TR201905009T4 (tr) 2015-04-02 2019-05-21 Gilead Sciences Inc Polisiklik-karbamoilpiridon bileşikleri ve bunların farmasötik kullanımları.
WO2016187788A1 (en) 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds useful for treating hiv infection
US10647727B2 (en) 2015-06-25 2020-05-12 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
WO2017000277A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
WO2017087257A1 (en) 2015-11-17 2017-05-26 Merck Sharp & Dohme Corp. Amido-substituted pyridotriazine derivatives useful as hiv integrase inhibitors
WO2017106071A1 (en) 2015-12-15 2017-06-22 Merck Sharp & Dohme Corp. Spirocyclic quinolizine derivatives useful as hiv integrase inhibitors
WO2017113288A1 (en) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
AU2017367714B2 (en) 2016-12-02 2020-11-12 Merck Sharp & Dohme Corp. Tricyclic heterocycle compounds useful as HIV integrase inhibitors
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
WO2018140368A1 (en) 2017-01-26 2018-08-02 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9201803D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
SI1441734T1 (sl) 2001-10-26 2007-08-31 Angeletti P Ist Richerche Bio Dihidropirimidin karboksamidni inhibitorji HIV-integraze
DE60209381T2 (de) 2001-10-26 2006-10-05 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. N-substituierte hydroxypyrimidinoncarboxamid-hemmer der hiv-integrase
US7094783B2 (en) 2002-06-26 2006-08-22 Bristol-Myers Squibb Company Bicyclic pyrimidinones as coagulation cascade inhibitors
BR0317749A (pt) 2002-12-27 2005-11-22 Angeletti P Ist Richerche Bio Composto, composição farmacêutica, e, uso de um composto
AR046938A1 (es) 2003-12-12 2006-01-04 Merck & Co Inc Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
CN1934093A (zh) 2004-01-12 2007-03-21 吉里德科学公司 嘧啶基膦酸酯抗病毒化合物和使用方法
US7173022B2 (en) * 2004-05-28 2007-02-06 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
AU2006228278C1 (en) * 2005-03-31 2011-06-23 Msd Italia S.R.L. HIV integrase inhibitors
PT1874117E (pt) * 2005-04-28 2013-10-17 Shionogi & Co Derivado policíclico de carbamoílpiridona possuindo actividade inibidora de hiv-integrasse

Also Published As

Publication number Publication date
EP1745052A1 (en) 2007-01-24
RU2006143683A (ru) 2008-06-20
MXPA06013023A (es) 2006-12-20
DK1745052T3 (da) 2009-01-05
US7273859B2 (en) 2007-09-25
US20060106007A1 (en) 2006-05-18
ZA200609181B (en) 2008-06-25
HRP20080531T3 (en) 2009-03-31
BRPI0511078A (pt) 2007-12-26
ATE405570T1 (de) 2008-09-15
US7419969B2 (en) 2008-09-02
ES2310823T3 (es) 2009-01-16
NO20065443L (no) 2006-11-27
DE602005009172D1 (de) 2008-10-02
PE20060238A1 (es) 2006-03-31
WO2005113562A1 (en) 2005-12-01
CA2566755A1 (en) 2005-12-01
KR20070014173A (ko) 2007-01-31
NZ550698A (en) 2009-05-31
IL179161A0 (en) 2007-03-08
SI1745052T1 (sl) 2009-04-30
AR049498A1 (es) 2006-08-09
US20050256109A1 (en) 2005-11-17
EP1745052B1 (en) 2008-08-20
TW200540173A (en) 2005-12-16
PT1745052E (pt) 2008-11-14
AU2005245789A1 (en) 2005-12-01
CN1984917A (zh) 2007-06-20
EP1745052B9 (en) 2009-10-28
JP2007537251A (ja) 2007-12-20

Similar Documents

Publication Publication Date Title
IL179161A0 (en) Hiv integrase inhibitors: cyclic pyrimidinone compounds
EP1756069A4 (en) HIV INTEGRASE INHIBITORS
IL177189A0 (en) Hiv integrase inhibitors
IL177858A0 (en) Hiv integrase inhibitors
TWI366567B (en) Bicyclic heterocycles as hiv integrase inhibitors
SI1948666T1 (sl) Hiv integrazni inhibitorji
EP1753767A4 (en) BICYCLIC HETEROCYCLES AS HIV INTEGRASE INHIBITORS
ZA200704130B (en) Protassium salt of an HIV integrase inhibitor
IL180959A0 (en) Hiv inhibiting 5-heterocyclyl pyrimidines
IL180963A0 (en) Hiv inhibiting bicyclic pyrimidine derivatives
AU2003248872A8 (en) Hiv integrase inhibitors
IL180760A0 (en) Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines
IL192208A0 (en) Methods for improving the pharmacokinetics of hiv integrase inhibitors
AP2005003451A0 (en) HIV integrase inhibitors.
EP1910363A4 (en) INHIBITORS OF HIV INTEGRASE
EP1778252A4 (en) NON-CARDIOTOXIC PHARMACEUTICAL COMPOUNDS
IL189939A0 (en) Inhibitors of the hiv integrase enzyme
EP1910356A4 (en) HIV integrase
HK1094450A (en) Hiv integrase inhibitors: cyclic pyrimidinone compounds
EP1910355A4 (en) HIV integrase
EP1909578A4 (en) INHIBITORS OF HIV INTEGRASE
ZA200804845B (en) Bubbling brick
ZA200606956B (en) HIV integrase inhibitors
ZA200609935B (en) Bicyclic heterocycles as HIV integrase inhibitors
ZA200806222B (en) Methods for improving the pharmacokinetics of HIV integrase inhibitors