BRPI0511084A - sistema de perfusão e aparelho para registros de eletrofisiologia automatizados de multicanal utilizando configuração de célula integral ás avessas - Google Patents

sistema de perfusão e aparelho para registros de eletrofisiologia automatizados de multicanal utilizando configuração de célula integral ás avessas

Info

Publication number
BRPI0511084A
BRPI0511084A BRPI0511084-0A BRPI0511084A BRPI0511084A BR PI0511084 A BRPI0511084 A BR PI0511084A BR PI0511084 A BRPI0511084 A BR PI0511084A BR PI0511084 A BRPI0511084 A BR PI0511084A
Authority
BR
Brazil
Prior art keywords
perfusion system
integral configuration
electrophysiology
reverse cell
cell integral
Prior art date
Application number
BRPI0511084-0A
Other languages
English (en)
Inventor
Dmytro Vasylyovich Vasylyev
Thomas L Merrill
Mark Robert Bowlby
Anton Federkiewicz
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0511084A publication Critical patent/BRPI0511084A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

SISTEMA DE PERFUSãO E APARELHO PARA REGISTROS DE ELETROFISIOLOGIA AUTOMATIZADOS DE MULTICANAL UTILIZANDO CONFIGURAçãO DE CéLULA INTEGRAL áS AVESSAS. Esta invenção refere-se a um sistema e método para medições de eletrofisiologiade alto rendimento para estudar o efeito de diversos produtos químicos sobre os canais de transferência de tons. Uma ou mais configurações de eletrofisiologiasão estabelecidas, cada uma compreendendo uma célula vedada uma pipeta. As pipetas são afixadas a um acessório de pipeta. O acessório de pipeta e a placa compreendendo uma ou mais cavidades são movidos relativamente de modo que cada célula esteja dentro de uma cavidade. Propriedades elétricas das células são medidas.
BRPI0511084-0A 2004-05-12 2005-05-12 sistema de perfusão e aparelho para registros de eletrofisiologia automatizados de multicanal utilizando configuração de célula integral ás avessas BRPI0511084A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/843,322 US7465558B2 (en) 2004-05-12 2004-05-12 Perfusion system and apparatus for automated multi-channel patch-clamp recordings utilizing inside-out whole-cell configuration
PCT/US2005/016590 WO2005113740A2 (en) 2004-05-12 2005-05-12 Perfusion system and apparatus for automated multi-channel patch-clamp recordings utilizing inside-out whole-cell configuration

Publications (1)

Publication Number Publication Date
BRPI0511084A true BRPI0511084A (pt) 2007-12-26

Family

ID=35309852

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511084-0A BRPI0511084A (pt) 2004-05-12 2005-05-12 sistema de perfusão e aparelho para registros de eletrofisiologia automatizados de multicanal utilizando configuração de célula integral ás avessas

Country Status (9)

Country Link
US (1) US7465558B2 (pt)
EP (1) EP1745119A2 (pt)
JP (1) JP2008500516A (pt)
CN (1) CN101124332A (pt)
AU (1) AU2005245854A1 (pt)
BR (1) BRPI0511084A (pt)
CA (1) CA2564360A1 (pt)
MX (1) MXPA06012907A (pt)
WO (1) WO2005113740A2 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007060796A1 (de) * 2007-12-14 2009-06-18 Wolfgang Barth Halterung für eine Mikropipette
JP2012507565A (ja) * 2008-10-30 2012-03-29 グオ・ペイシュエン Ｄｎａのシークエンシング及び他の用途のための、膜に組み込まれたウイルスｄｎａパッケージングモータタンパク質コネクタバイオセンサ
US8329009B2 (en) * 2010-04-09 2012-12-11 Molecular Devices, Llc High throughput screening of ion channels
USD675171S1 (en) 2010-12-16 2013-01-29 Tecella Llc Multi-electrode holder
DK2710109T3 (en) * 2011-05-19 2018-01-22 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Univ Tuebingen Method and use of a device for automated positioning of a microsystem for manipulating a spherical micro object
US9031700B2 (en) 2011-10-11 2015-05-12 Intermolecular, Inc. Facilities manifold with proximity sensor
US9082608B2 (en) 2012-12-03 2015-07-14 Intermolecular, Inc. Pneumatic clamping mechanism for cells with adjustable height
KR101702745B1 (ko) * 2014-11-13 2017-02-03 인제대학교 산학협력단 단일세포 분리장치 및 방법
CN106033069B (zh) * 2015-03-10 2019-05-28 中国科学院生物物理研究所 单个囊泡融合和回收及其与钙离子通道耦合的膜片钳检测装置
CN114540192A (zh) * 2015-08-26 2022-05-27 仿真股份有限公司 灌注歧管组件
EP3321689A1 (de) * 2016-11-09 2018-05-16 Siemens Healthcare Diagnostics Products GmbH Pipettiersystem zum pipettieren von flüssigkeiten in einem automatischen analysegerät
US12203953B2 (en) 2020-07-29 2025-01-21 Siemens Healthcare Diagnostics Inc. Helix wash station that augments the fluid dynamics associated with clinical chemistry and immunoassay probe cleaning
CN113406316B (zh) * 2021-06-17 2023-08-08 重庆医科大学附属儿童医院 一种电生理膜片钳灌流装置
GB2609944B (en) * 2021-08-18 2024-06-05 Agm Medical System for assessing cell viability, cell membrane piercing and selecting a cell for microinjection
CN114317218A (zh) * 2022-01-10 2022-04-12 武汉维他智联科技有限公司 一种细胞精准挑选装置
CN117517633B (zh) * 2023-11-10 2024-12-10 南开大学 基于囊泡破裂过程检测的机器人化内面朝外膜片钳技术

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0788600T3 (da) * 1994-10-28 2002-08-05 Sophion Bioscience As Patch-clamp-apparat og -teknik med høj gennemgang og lave fluidvolumenkrav
WO1997017426A1 (en) * 1995-11-08 1997-05-15 Trustees Of Boston University Cellular physiology workstations for automated data acquisition and perfusion control
NZ337814A (en) * 1997-05-01 2001-04-27 Neurosearch As Patch clamp apparatus with means for automatically connecting electrode to a cell
US20030139336A1 (en) * 2000-03-21 2003-07-24 Norwood James Henry Interface patch clamping
MXPA03000160A (es) * 2000-07-07 2003-09-22 Bristol Myers Squibb Co Configuracion de electrofisiologia adecuada para separacion por exclusion de alta produccion de compuestos para el descubrimiento de farmacos.
AU2003205132A1 (en) * 2002-02-12 2003-09-04 Celectricon AB Systems and methods for rapidly changing the solution environment around sensors

Also Published As

Publication number Publication date
JP2008500516A (ja) 2008-01-10
EP1745119A2 (en) 2007-01-24
AU2005245854A1 (en) 2005-12-01
CA2564360A1 (en) 2005-12-01
WO2005113740A2 (en) 2005-12-01
WO2005113740A3 (en) 2007-11-08
US20050255446A1 (en) 2005-11-17
CN101124332A (zh) 2008-02-13
MXPA06012907A (es) 2007-01-26
US7465558B2 (en) 2008-12-16

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]