BRPI0511295A - 2-quinolil-oxazóis substituìdos úteis como inibidores de pde4 - Google Patents

2-quinolil-oxazóis substituìdos úteis como inibidores de pde4

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Publication number
BRPI0511295A
BRPI0511295A BRPI0511295-8A BRPI0511295A BRPI0511295A BR PI0511295 A BRPI0511295 A BR PI0511295A BR PI0511295 A BRPI0511295 A BR PI0511295A BR PI0511295 A BRPI0511295 A BR PI0511295A
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BR
Brazil
Prior art keywords
alkyl
cycloalkyl
pde4 inhibitors
quinolyl
hydroxyalkyl
Prior art date
Application number
BRPI0511295-8A
Other languages
English (en)
Inventor
Rongze Kuang
David Blythin
Neng-Yang Shih
Ho-Jane Shue
Xiao Chen
Jianhua Cao
Danlin Gu
Ying Huang
John N Schwerdt
Pauline C Ting
Shing-Chun Wong
Li Xiao
Original Assignee
Schering Corp
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Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BRPI0511295A publication Critical patent/BRPI0511295A/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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  • Chemical & Material Sciences (AREA)
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  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

2-QUINOLIL-OXAZóIS SUBSTITUìDOS úTEIS COMO INIBIDORES DE PDE4. A invenção refere-se a compostos da fórmula em que é uma heteroarila de 5 membros; X é S ou O; R¬ 1¬ é H, alquila, cicloalquila, cicloalquilalquila-, -CH~ 2~F, -CHF~ 2~, -CF~ 3~, -C(O)alquila ou -C(O)NR¬ 18¬R¬ 19¬; R¬ 3¬ e R¬ 4¬ H, alquila, hidroxialquila ou -C(O)Oalquila; R¬ 5 e R¬ 6¬ são H, alquila, hidroxialquila, alcoxialquila, mercaptoalquila, -CH~ 2~F, -CHF~ 2~, -CF~ 3~, -C(O)OH ou -C(O)Oalquila; R¬ 7¬ é H, alquila, alquenila, hidroxialquila, cicloalquila, alcoxialquila, aminoalquila, (R¬ 17¬-fenil)alquila ou -CH~ 2~-C(O)-O-alquila; e R¬ 8¬ compreende alquila, heteroarila, fenila ou cicloalquila, ou heterocicloalquila, todos opcionalmente substituídos, ou uma amida substituída por cicloalquila ou hetero-cicloalquila; ou R¬ 7¬ e R¬ 8¬ e o nitrogênio ao qual eles estão ligados conjuntamente formam um anel opcionalmente substituído; e as variáveis restantes são tais como definidas na especificação. Também são reivindicadas as composições farmacêuticas, o emprego dos compostos tais como inibidores de PDE4, e combinações com outros ativos.
BRPI0511295-8A 2004-05-18 2005-05-16 2-quinolil-oxazóis substituìdos úteis como inibidores de pde4 BRPI0511295A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57226604P 2004-05-18 2004-05-18
PCT/US2005/017134 WO2005116009A1 (en) 2004-05-18 2005-05-16 Substituted 2-quinolyl-oxazoles useful as pde4 inhibitors

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BRPI0511295A true BRPI0511295A (pt) 2007-12-04

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US (1) US7511062B2 (pt)
EP (1) EP1758883B1 (pt)
JP (1) JP4584990B2 (pt)
KR (1) KR100907354B1 (pt)
CN (1) CN1984901B (pt)
AR (1) AR055192A1 (pt)
AT (1) ATE531705T1 (pt)
AU (1) AU2005247906B2 (pt)
BR (1) BRPI0511295A (pt)
CA (1) CA2565599C (pt)
EC (1) ECSP067013A (pt)
IL (1) IL179280A (pt)
MX (1) MXPA06013414A (pt)
NO (1) NO20065830L (pt)
NZ (1) NZ551017A (pt)
PE (1) PE20060241A1 (pt)
RU (1) RU2417993C9 (pt)
TW (1) TWI286475B (pt)
WO (1) WO2005116009A1 (pt)
ZA (1) ZA200609277B (pt)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8145182B2 (en) * 2004-05-07 2012-03-27 Interdigital Technology Corporation Supporting emergency calls on a wireless local area network
KR101122359B1 (ko) 2004-05-07 2012-03-23 인터디지탈 테크날러지 코포레이션 무선 근거리 통신망의 긴급 호 지원
US8682279B2 (en) * 2004-05-07 2014-03-25 Interdigital Technology Corporation Supporting emergency calls on a wireless local area network
MX2007012084A (es) * 2005-03-30 2007-11-21 Schering Corp Medicamentos y metodos que combinan un anticolinergico, un corticosteroide y un agonista beta de accion prolongada.
SG170767A1 (en) * 2005-12-23 2011-05-30 Zealand Pharma As Modified lysine-mimetic compounds
BRPI0707091B8 (pt) * 2006-03-10 2018-02-14 Nissan Chemical Ind Ltd composto de isoxalina e benzaldoxima substituído ou um sal do mesmo; pesticida, agroquímico, endo- ou ecto-parasiticidapara mamíferos ou pássaros, inseticida e acaricida contendo como um ou mais ingredientes ativos selecionados a partir do composto de isoxalina substituído e o sal do mesmo
EA200802058A1 (ru) * 2006-05-09 2009-06-30 Пфайзер Продактс Инк. Производные циклоалкиламинокислот и их фармацевтические композиции
EP2038279A2 (en) * 2006-06-06 2009-03-25 Avigen, Inc. Substituted pyrazolo [1,5- alpha] pyridine compounds and their methods of use
KR20090109527A (ko) * 2006-07-07 2009-10-20 칼립시스, 인코포레이티드 Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제
US8138205B2 (en) * 2006-07-07 2012-03-20 Kalypsys, Inc. Heteroarylalkoxy-substituted quinolone inhibitors of PDE4
KR20090026217A (ko) 2006-07-11 2009-03-11 쉐링 코포레이션 치환된 5-옥사졸-2-일-퀴놀린 화합물의 크시나포에이트 염
ITMI20061581A1 (it) * 2006-08-04 2008-02-05 Univ Bari Ligandi del recettore beta-3 adrenergico e loro uso in terapia
WO2008021235A2 (en) * 2006-08-14 2008-02-21 Schering Corporation Process and intermediates for the synthesis of 2-(quinolin-5-yl)-4,5 disubstituted-azole derivatives
EP2069337A1 (en) * 2006-08-14 2009-06-17 Schering Corporation Salts of 5 - ( l ( s ) -amino - 2 - hydroxyethyl ) -n- ý ( 2, 4 -difluorophenyl) -methyl¨- 2 - ý 8 -methoxy - 2 - (trifluoromethyl) - 5 - quinoline¨- 4 - oxazolecarboxamide
CA2663500A1 (en) 2006-09-15 2008-03-20 Schering Corporation Spiro-condensed azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabolism
CA2663504A1 (en) 2006-09-15 2008-03-20 Schering Corporation Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism
US20080070892A1 (en) * 2006-09-15 2008-03-20 Harris Joel M Treating pain, diabetes, and disorders of lipid metabolism
WO2008045564A2 (en) * 2006-10-12 2008-04-17 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
JP2008260691A (ja) * 2007-04-10 2008-10-30 Bayer Cropscience Ag 殺虫性アリールイソオキサゾリン誘導体
JP4986927B2 (ja) * 2007-05-14 2012-07-25 大塚製薬株式会社 医薬
US20110171195A1 (en) * 2007-06-15 2011-07-14 Duke University Methods and compositions for treating urinary tract infections using agents that mimic or elevate cyclic amp
US20110003780A1 (en) * 2007-07-10 2011-01-06 Schering Corporation Hydrogen chloride salt of a substituted 5-oxazol-2-yl-quinoline compound and a process for the production thereof
CA2692781A1 (en) * 2007-07-10 2009-01-15 Schering Corporation Process for the production of substituted 5-quinolyl-oxazoles and pharmaceutically acceptable salts thereof
GB2451629A (en) * 2007-08-06 2009-02-11 Univ Sheffield 1-(Azolylcarbonyl)-2-(hydroxymethyl)pyrrolidine derivatives for use as catalysts for asymmetric reduction of imines & reductive amination of ketones
BRPI0820701A2 (pt) 2007-12-11 2015-06-16 Cytopathfinder Inc Composto de carboxamida e seu uso como agonistas do receptor de quimiocina
PL2098526T3 (pl) * 2008-02-22 2014-06-30 Neurotune Ag Bicykliczne związki zawierające azot aktywne w stanach przewlekłego bólu
AR074318A1 (es) * 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
TWI396689B (zh) * 2008-11-14 2013-05-21 Amgen Inc 作為磷酸二酯酶１０抑制劑之吡衍生物
JP5476895B2 (ja) 2008-12-17 2014-04-23 セントラル硝子株式会社 ヒドロキシル基置換生成物の製造方法
WO2010080864A1 (en) 2009-01-12 2010-07-15 Array Biopharma Inc. Piperidine-containing compounds and use thereof
US8796297B2 (en) 2009-06-30 2014-08-05 Abbvie Inc. 4-substituted-2-amino-pyrimidine derivatives
SG10201405568UA (en) * 2009-09-08 2014-11-27 Hoffmann La Roche 4-substituted pyridin-3-yl-carboxamide compounds and methods of use
US8435976B2 (en) * 2009-09-08 2013-05-07 F. Hoffmann-La Roche 4-substituted pyridin-3-yl-carboxamide compounds and methods of use
KR101483215B1 (ko) 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
SG185515A1 (en) 2010-05-13 2012-12-28 Amgen Inc Nitrogen heterocyclic compounds useful as pde10 inhibitors
JP5709101B2 (ja) * 2010-09-01 2015-04-30 東レ・ファインケミカル株式会社 ヒドロキシプロリン誘導体の製造法
US9238643B2 (en) 2010-09-06 2016-01-19 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Amide compounds
WO2012072512A1 (en) 2010-11-29 2012-06-07 Glaxo Group Limited N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists
CN102408433B (zh) * 2011-10-20 2014-04-09 天津药物研究院 含嘧啶的肟类化合物、其制备方法和用途
US8530461B2 (en) * 2011-12-29 2013-09-10 Boehringer Ingelheim International Gmbh Azetidine derivatives
KR20150003849A (ko) 2012-04-24 2015-01-09 추가이 세이야쿠 가부시키가이샤 퀴나졸린디온 유도체
US9695118B2 (en) * 2012-04-24 2017-07-04 Chugai Seiyaku Kabushiki Kaisha Benzamide derivative
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
EP3587406B1 (en) * 2013-03-13 2021-01-27 Forma Therapeutics, Inc. 2-hydroxy-1-{4-[(4-phenylphenyl)carbonyl]piperazin-1-yl}ethan-1-one derivatives and related compounds as fatty acid synthase (fasn) inhibitors for the treatment of cancer
WO2014151959A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
US9944644B2 (en) 2013-03-14 2018-04-17 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles their preparation and use
EP3495357B1 (en) 2013-03-14 2021-05-05 The Trustees of Columbia University in the City of New York 4-phenylpiperidines, their preparation and use
US9637450B2 (en) 2013-03-14 2017-05-02 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, their preparation and use
KR20160073413A (ko) 2013-10-23 2016-06-24 추가이 세이야쿠 가부시키가이샤 퀴나졸리논 및 이소퀴놀리논 유도체
CN105085428B (zh) * 2014-04-25 2019-03-22 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
BR112016025356B1 (pt) 2014-04-30 2023-04-18 The Trustees Of Columbia University In The City Of New York Compostos de 4-fenilpiperidinas substituídas, composições e seus usos
GB201415569D0 (en) 2014-09-03 2014-10-15 C4X Discovery Ltd Therapeutic Compounds
JP2018016544A (ja) * 2014-12-03 2018-02-01 持田製薬株式会社 新規ジアザビシクロ［２．２．２］オクタン誘導体
CN104829492A (zh) * 2015-05-06 2015-08-12 河北工业大学 一种反式N-Boc-1,3-环丁二胺的制备方法
CN106279138B (zh) * 2015-12-29 2019-03-01 广东东阳光药业有限公司 芳杂环类衍生物及其在药物中的应用
GB201601703D0 (en) 2016-01-29 2016-03-16 C4X Discovery Ltd Therapeutic compounds
EP3720436A4 (en) 2017-12-06 2021-06-02 Lin Bioscience, Pty Ltd. TUBULIN INHIBITORS
CN111741944B (zh) * 2018-02-01 2025-01-03 悉尼大学 抗癌化合物
KR102682705B1 (ko) * 2018-07-04 2024-07-05 고려대학교 세종산학협력단 옥사졸로퀴놀리논 유도체를 유효성분으로 포함하는 우울증 및 스트레스 관련 질환의 예방 또는 치료용 약학 조성물
CA3106385A1 (en) * 2018-09-13 2020-03-19 Kissei Pharmaceutical Co., Ltd. Imidazopyridinone compound
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
CN113382633A (zh) 2018-10-29 2021-09-10 福马治疗股份有限公司 (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式
CN112079791A (zh) * 2020-08-21 2020-12-15 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） 单环β-内酰胺类抗生素侧链酸及其酯、其制备方法和应用
US20240316015A1 (en) 2021-01-21 2024-09-26 Natural Medicine Institute Of Zhejiang Yangshengtang Co., Ltd. Composition and method for treating tumors
CN119053602A (zh) * 2022-01-28 2024-11-29 柏奥艾奇实验室公司 Nlrp3炎性体的n-氧化物抑制剂
TWI907890B (zh) * 2022-12-14 2025-12-11 國立成功大學 化合物及其合成方法與應用
US12509459B2 (en) 2024-03-26 2025-12-30 BioAge Labs, Inc. Inhibitors of NLRP3 inflammasome

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199802385T2 (xx) * 1996-05-20 1999-04-21 Darwin Discovery Limited TNF inhibit�rleri ve FDE-IV inhibit�rleri olarak kinolin karboksamidler.
WO1997044322A1 (en) * 1996-05-20 1997-11-27 Darwin Discovery Limited Quinoline sulfonamides as tnf inhibitors and as pde-iv inhibitors
DE69723863T2 (de) * 1996-11-06 2004-04-15 Darwin Discovery Ltd., Slough Chinoline und deren therapeutische verwendung
US6069151A (en) * 1996-11-06 2000-05-30 Darwin Discovery, Ltd. Quinolines and their therapeutic use
NZ505362A (en) * 1997-12-22 2004-12-24 Upjohn Co 4-hydroxyquinoline-3-carboxamides and -hydrazides useful as antiviral agents
EP1165542B1 (en) 1999-03-29 2003-08-20 Neurogen Corporation 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
US6569885B1 (en) * 1999-12-23 2003-05-27 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
GB0003254D0 (en) * 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
EP1310494B1 (en) * 2000-08-11 2012-01-25 Nippon Chemiphar Co., Ltd. PPAR (delta) ACTIVATORS
WO2002076957A1 (en) * 2001-03-23 2002-10-03 Nippon Chemiphar Co.,Ltd. Activator for peroxisome proliferator-activated receptor
DE10227269A1 (de) 2002-06-19 2004-01-08 Merck Patent Gmbh Thiazolderivate
KR20090026217A (ko) * 2006-07-11 2009-03-11 쉐링 코포레이션 치환된 5-옥사졸-2-일-퀴놀린 화합물의 크시나포에이트 염

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