BRPI0511295A - 2-quinolil-oxazóis substituìdos úteis como inibidores de pde4 - Google Patents

2-quinolil-oxazóis substituìdos úteis como inibidores de pde4

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Publication number
BRPI0511295A
BRPI0511295A BRPI0511295-8A BRPI0511295A BRPI0511295A BR PI0511295 A BRPI0511295 A BR PI0511295A BR PI0511295 A BRPI0511295 A BR PI0511295A BR PI0511295 A BRPI0511295 A BR PI0511295A
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BR
Brazil
Prior art keywords
alkyl
cycloalkyl
pde4 inhibitors
quinolyl
hydroxyalkyl
Prior art date
Application number
BRPI0511295-8A
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English (en)
Inventor
Rongze Kuang
David Blythin
Neng-Yang Shih
Ho-Jane Shue
Xiao Chen
Jianhua Cao
Danlin Gu
Ying Huang
John N Schwerdt
Pauline C Ting
Shing-Chun Wong
Li Xiao
Original Assignee
Schering Corp
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Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BRPI0511295A publication Critical patent/BRPI0511295A/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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  • Chemical & Material Sciences (AREA)
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  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

2-QUINOLIL-OXAZóIS SUBSTITUìDOS úTEIS COMO INIBIDORES DE PDE4. A invenção refere-se a compostos da fórmula em que é uma heteroarila de 5 membros; X é S ou O; R¬ 1¬ é H, alquila, cicloalquila, cicloalquilalquila-, -CH~ 2~F, -CHF~ 2~, -CF~ 3~, -C(O)alquila ou -C(O)NR¬ 18¬R¬ 19¬; R¬ 3¬ e R¬ 4¬ H, alquila, hidroxialquila ou -C(O)Oalquila; R¬ 5 e R¬ 6¬ são H, alquila, hidroxialquila, alcoxialquila, mercaptoalquila, -CH~ 2~F, -CHF~ 2~, -CF~ 3~, -C(O)OH ou -C(O)Oalquila; R¬ 7¬ é H, alquila, alquenila, hidroxialquila, cicloalquila, alcoxialquila, aminoalquila, (R¬ 17¬-fenil)alquila ou -CH~ 2~-C(O)-O-alquila; e R¬ 8¬ compreende alquila, heteroarila, fenila ou cicloalquila, ou heterocicloalquila, todos opcionalmente substituídos, ou uma amida substituída por cicloalquila ou hetero-cicloalquila; ou R¬ 7¬ e R¬ 8¬ e o nitrogênio ao qual eles estão ligados conjuntamente formam um anel opcionalmente substituído; e as variáveis restantes são tais como definidas na especificação. Também são reivindicadas as composições farmacêuticas, o emprego dos compostos tais como inibidores de PDE4, e combinações com outros ativos.
BRPI0511295-8A 2004-05-18 2005-05-16 2-quinolil-oxazóis substituìdos úteis como inibidores de pde4 BRPI0511295A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57226604P 2004-05-18 2004-05-18
PCT/US2005/017134 WO2005116009A1 (en) 2004-05-18 2005-05-16 Substituted 2-quinolyl-oxazoles useful as pde4 inhibitors

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BRPI0511295A true BRPI0511295A (pt) 2007-12-04

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US (1) US7511062B2 (pt)
EP (1) EP1758883B1 (pt)
JP (1) JP4584990B2 (pt)
KR (1) KR100907354B1 (pt)
CN (1) CN1984901B (pt)
AR (1) AR055192A1 (pt)
AT (1) ATE531705T1 (pt)
AU (1) AU2005247906B2 (pt)
BR (1) BRPI0511295A (pt)
CA (1) CA2565599C (pt)
EC (1) ECSP067013A (pt)
IL (1) IL179280A (pt)
MX (1) MXPA06013414A (pt)
NO (1) NO20065830L (pt)
NZ (1) NZ551017A (pt)
PE (1) PE20060241A1 (pt)
RU (1) RU2417993C9 (pt)
TW (1) TWI286475B (pt)
WO (1) WO2005116009A1 (pt)
ZA (1) ZA200609277B (pt)

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