BRPI0511533A - derivados indazol e indolona e seu uso como medicamento - Google Patents
derivados indazol e indolona e seu uso como medicamentoInfo
- Publication number
- BRPI0511533A BRPI0511533A BRPI0511533-7A BRPI0511533A BRPI0511533A BR PI0511533 A BRPI0511533 A BR PI0511533A BR PI0511533 A BRPI0511533 A BR PI0511533A BR PI0511533 A BRPI0511533 A BR PI0511533A
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- disorder
- sexual
- sexual dysfunction
- compounds
- Prior art date
Links
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title abstract 2
- 150000005624 indolones Chemical class 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 206010024419 Libido decreased Diseases 0.000 abstract 4
- 208000006262 Psychological Sexual Dysfunctions Diseases 0.000 abstract 4
- 208000017020 hypoactive sexual desire disease Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- 206010002652 Anorgasmia Diseases 0.000 abstract 2
- 208000021663 Female sexual arousal disease Diseases 0.000 abstract 2
- 206010057671 Female sexual dysfunction Diseases 0.000 abstract 2
- 206010057672 Male sexual dysfunction Diseases 0.000 abstract 2
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical class NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 1
- 229940052760 dopamine agonists Drugs 0.000 abstract 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
- 208000014840 female orgasmic disease Diseases 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 201000004197 inhibited female orgasm Diseases 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 206010036596 premature ejaculation Diseases 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS INDAZOL E INDOLONA E SEU USO COMO MEDICAMENTO A presente invenção proporciona compostos de fórmula (1), os quais são uma classe de agonistas de dopamina, mais particularmente uma classe de agonistas seletivos para D3 sobre D2. Esses compostos são de utilidade no tratamento e/ou prevenção da disfunção sexual, por exemplo, disfunção sexual feminina (FSD), particularmente, distúrbio de excitação sexual feminino (FSAD), distúrbio do desejo sexual hipoativo (HSDD; falta de interesse por sexo), distúrbio orgástico feminino (FOD, incapacidade de atingir orgasmo), e disfunção sexual masculina, particularmente, disfunção erétil masculina (MED) A disfunção sexual masculina como aqui indicado, significa a inclusão de distúrbios ejaculatórios, tais como ejaculação precoce, anorgasmia (incapacidade de atingir o orgasmo), ou distúrbios do desejo, tais como distúrbio do desejo sexual hipoativo (HSDD), falta de interesse por sexo) Esses compostos são úteis também no tratamento de distúrbios neuropsiquiátricos e distúrbios neurodegenerativos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0411810A GB0411810D0 (en) | 2004-05-26 | 2004-05-26 | New indazole and indolone derivatives and their use as pharmaceuticals |
| GB0415455A GB0415455D0 (en) | 2004-07-09 | 2004-07-09 | New indazole and indolone derivatives and their use as pharmaceuticals |
| PCT/IB2005/001513 WO2005116027A2 (en) | 2004-05-26 | 2005-05-17 | Indazole and indolone derivatives and their use as pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0511533A true BRPI0511533A (pt) | 2008-01-02 |
Family
ID=35219654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0511533-7A BRPI0511533A (pt) | 2004-05-26 | 2005-05-17 | derivados indazol e indolona e seu uso como medicamento |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1753763B1 (pt) |
| JP (2) | JP4093588B2 (pt) |
| AP (1) | AP2006003823A0 (pt) |
| AR (1) | AR049191A1 (pt) |
| AT (1) | ATE404560T1 (pt) |
| AU (1) | AU2005247696A1 (pt) |
| BR (1) | BRPI0511533A (pt) |
| CA (1) | CA2568050A1 (pt) |
| CR (1) | CR8772A (pt) |
| DE (1) | DE602005008954D1 (pt) |
| EA (1) | EA200601985A1 (pt) |
| EC (1) | ECSP067024A (pt) |
| ES (1) | ES2308492T3 (pt) |
| GT (1) | GT200500118A (pt) |
| IL (1) | IL179365A0 (pt) |
| MA (1) | MA28606B1 (pt) |
| MX (1) | MXPA06013759A (pt) |
| NL (1) | NL1029128C2 (pt) |
| NO (1) | NO20065328L (pt) |
| PA (1) | PA8635001A1 (pt) |
| PE (1) | PE20060289A1 (pt) |
| SV (1) | SV2005002128A (pt) |
| TW (1) | TW200607500A (pt) |
| UY (1) | UY28918A1 (pt) |
| WO (1) | WO2005116027A2 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2860B1 (en) | 2009-05-07 | 2015-03-15 | ايلي ليلي اند كومباني | Phenylendazolyl compounds |
| CA2860453C (en) * | 2011-01-24 | 2020-04-28 | Inceptum Research & Therapeutics, Inc. | Compositions comprising a prostaglandin for treating neuropsychiatric conditions |
| CA2965741C (en) | 2014-11-03 | 2022-05-17 | Iomet Pharma Ltd | Pharmaceutical compound |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0641202A1 (en) * | 1992-05-18 | 1995-03-08 | Smithkline Beecham Plc | Use of indolone derivatives for the treatment of memory disorders, sexual dysfunction and parkinson's disease |
| WO1998035942A1 (en) * | 1997-02-18 | 1998-08-20 | American Home Products Corporation | 4-aminoethoxyindazole derivatives |
| GB0130219D0 (en) * | 2001-12-18 | 2002-02-06 | Pfizer Ltd | Compounds for the treatment of sexual dysfunction |
| RS51442B (sr) * | 2002-12-10 | 2011-04-30 | Pfizer Inc. | Derivati morfolina koji se upotrebljavaju kao agonisti dopamina u tretmanu i.a. seksualne disfunkcije |
-
2005
- 2005-05-17 AU AU2005247696A patent/AU2005247696A1/en not_active Abandoned
- 2005-05-17 EP EP05742759A patent/EP1753763B1/en not_active Expired - Lifetime
- 2005-05-17 DE DE602005008954T patent/DE602005008954D1/de not_active Expired - Fee Related
- 2005-05-17 CA CA002568050A patent/CA2568050A1/en not_active Abandoned
- 2005-05-17 JP JP2007514182A patent/JP4093588B2/ja not_active Expired - Fee Related
- 2005-05-17 BR BRPI0511533-7A patent/BRPI0511533A/pt not_active IP Right Cessation
- 2005-05-17 AP AP2006003823A patent/AP2006003823A0/xx unknown
- 2005-05-17 ES ES05742759T patent/ES2308492T3/es not_active Expired - Lifetime
- 2005-05-17 WO PCT/IB2005/001513 patent/WO2005116027A2/en not_active Ceased
- 2005-05-17 EA EA200601985A patent/EA200601985A1/ru unknown
- 2005-05-17 MX MXPA06013759A patent/MXPA06013759A/es unknown
- 2005-05-17 AT AT05742759T patent/ATE404560T1/de not_active IP Right Cessation
- 2005-05-20 GT GT200500118A patent/GT200500118A/es unknown
- 2005-05-23 PE PE2005000570A patent/PE20060289A1/es not_active Application Discontinuation
- 2005-05-24 AR ARP050102145A patent/AR049191A1/es unknown
- 2005-05-24 UY UY28918A patent/UY28918A1/es not_active Application Discontinuation
- 2005-05-25 NL NL1029128A patent/NL1029128C2/nl not_active IP Right Cessation
- 2005-05-25 TW TW094117076A patent/TW200607500A/zh unknown
- 2005-05-26 PA PA20058635001A patent/PA8635001A1/es unknown
- 2005-05-26 SV SV2005002128A patent/SV2005002128A/es not_active Application Discontinuation
-
2006
- 2006-11-16 IL IL179365A patent/IL179365A0/en unknown
- 2006-11-20 NO NO20065328A patent/NO20065328L/no unknown
- 2006-11-24 EC EC2006007024A patent/ECSP067024A/es unknown
- 2006-11-24 MA MA29487A patent/MA28606B1/fr unknown
- 2006-11-24 CR CR8772A patent/CR8772A/es unknown
-
2007
- 2007-12-11 JP JP2007320093A patent/JP2008074874A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL1029128C2 (nl) | 2006-06-14 |
| DE602005008954D1 (de) | 2008-09-25 |
| PE20060289A1 (es) | 2006-04-22 |
| CA2568050A1 (en) | 2005-12-08 |
| WO2005116027A2 (en) | 2005-12-08 |
| EP1753763B1 (en) | 2008-08-13 |
| AU2005247696A1 (en) | 2005-12-08 |
| UY28918A1 (es) | 2005-12-30 |
| PA8635001A1 (es) | 2006-05-16 |
| JP2008500329A (ja) | 2008-01-10 |
| JP2008074874A (ja) | 2008-04-03 |
| ECSP067024A (es) | 2006-12-29 |
| AP2006003823A0 (en) | 2006-12-31 |
| WO2005116027A3 (en) | 2006-04-13 |
| TW200607500A (en) | 2006-03-01 |
| JP4093588B2 (ja) | 2008-06-04 |
| NL1029128A1 (nl) | 2005-11-30 |
| CR8772A (es) | 2006-12-13 |
| IL179365A0 (en) | 2007-03-08 |
| MA28606B1 (fr) | 2007-05-02 |
| EP1753763A2 (en) | 2007-02-21 |
| ES2308492T3 (es) | 2008-12-01 |
| GT200500118A (es) | 2006-01-10 |
| EA200601985A1 (ru) | 2007-04-27 |
| SV2005002128A (es) | 2005-12-13 |
| AR049191A1 (es) | 2006-07-05 |
| MXPA06013759A (es) | 2007-02-08 |
| ATE404560T1 (de) | 2008-08-15 |
| NO20065328L (no) | 2006-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |