BRPI0511770A - métodos e composições para a inibição da expressão de genes - Google Patents

métodos e composições para a inibição da expressão de genes

Info

Publication number
BRPI0511770A
BRPI0511770A BRPI0511770-4A BRPI0511770A BRPI0511770A BR PI0511770 A BRPI0511770 A BR PI0511770A BR PI0511770 A BRPI0511770 A BR PI0511770A BR PI0511770 A BRPI0511770 A BR PI0511770A
Authority
BR
Brazil
Prior art keywords
compositions
methods
gene expression
inhibiting gene
present
Prior art date
Application number
BRPI0511770-4A
Other languages
English (en)
Inventor
Gholamreza Sheikhnehjad
Mina Patel Sooch
Neal Goodwin
David Olso
Original Assignee
Pronai Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pronai Therapeutics Inc filed Critical Pronai Therapeutics Inc
Publication of BRPI0511770A publication Critical patent/BRPI0511770A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

MéTODOS E COMPOSIçõES PARA A INIBIçãO DE EXPRESSãO DE GENES A invenção presente se refere a métodos e composições para a inibição de expressão de genes. Em particular, a presente invenção provê terapias baseadas em oligonucleotídeos para a inibição de oncogenes envolvidos em cânceres.
BRPI0511770-4A 2004-06-01 2005-06-01 métodos e composições para a inibição da expressão de genes BRPI0511770A (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US10/858,145 US7498315B2 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,013 US20060135455A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,146 US20060229267A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,164 US7524827B2 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,341 US20050287667A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US10/858,094 US20080152700A1 (en) 2004-06-01 2004-06-01 Methods and compositions for the inhibition of gene expression
US61197404P 2004-09-22 2004-09-22
US63721204P 2004-12-17 2004-12-17
PCT/US2005/018993 WO2005118824A2 (en) 2004-06-01 2005-06-01 Methods and compositions for the inhibition of gene expression

Publications (1)

Publication Number Publication Date
BRPI0511770A true BRPI0511770A (pt) 2008-01-08

Family

ID=35463455

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511770-4A BRPI0511770A (pt) 2004-06-01 2005-06-01 métodos e composições para a inibição da expressão de genes

Country Status (10)

Country Link
US (6) US7498315B2 (pt)
EP (2) EP2141173B1 (pt)
JP (3) JP4906717B2 (pt)
CN (1) CN101014608B (pt)
AU (1) AU2005250453B2 (pt)
BR (1) BRPI0511770A (pt)
CA (1) CA2569183A1 (pt)
ES (1) ES2402532T3 (pt)
PL (1) PL2141173T3 (pt)
WO (1) WO2005118824A2 (pt)

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Also Published As

Publication number Publication date
ES2402532T3 (es) 2013-05-06
EP1773859A4 (en) 2008-03-26
HK1107098A1 (en) 2008-03-28
JP2012085642A (ja) 2012-05-10
WO2005118824A3 (en) 2006-11-09
AU2005250453A1 (en) 2005-12-15
EP2141173A1 (en) 2010-01-06
CA2569183A1 (en) 2005-12-15
PL2141173T3 (pl) 2013-08-30
US20080152700A1 (en) 2008-06-26
JP4906717B2 (ja) 2012-03-28
US7498315B2 (en) 2009-03-03
JP5922913B2 (ja) 2016-05-24
US20060198828A1 (en) 2006-09-07
JP2015133967A (ja) 2015-07-27
WO2005118824A2 (en) 2005-12-15
WO2005118824A8 (en) 2007-01-25
US7524827B2 (en) 2009-04-28
US20060229267A1 (en) 2006-10-12
US20060073596A1 (en) 2006-04-06
CN101014608A (zh) 2007-08-08
EP1773859A2 (en) 2007-04-18
JP2008500838A (ja) 2008-01-17
WO2005118824A9 (en) 2006-06-15
CN101014608B (zh) 2011-07-06
US20060135455A1 (en) 2006-06-22
EP2141173B1 (en) 2013-01-02
US20050287667A1 (en) 2005-12-29
AU2005250453B2 (en) 2012-02-23

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.