BRPI0511793B8 - proteínas quiméricas isoladas de lumazina sintase modificada - Google Patents

proteínas quiméricas isoladas de lumazina sintase modificada

Info

Publication number
BRPI0511793B8
BRPI0511793B8 BRPI0511793A BRPI0511793A BRPI0511793B8 BR PI0511793 B8 BRPI0511793 B8 BR PI0511793B8 BR PI0511793 A BRPI0511793 A BR PI0511793A BR PI0511793 A BRPI0511793 A BR PI0511793A BR PI0511793 B8 BRPI0511793 B8 BR PI0511793B8
Authority
BR
Brazil
Prior art keywords
chimeric proteins
vaccines
antibodies
nucleotide sequences
lumazine synthase
Prior art date
Application number
BRPI0511793A
Other languages
English (en)
Inventor
Fernando A Goldbaum
Original Assignee
Goldgene Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goldgene Llc filed Critical Goldgene Llc
Publication of BRPI0511793A publication Critical patent/BRPI0511793A/pt
Publication of BRPI0511793B1 publication Critical patent/BRPI0511793B1/pt
Publication of BRPI0511793B8 publication Critical patent/BRPI0511793B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01009—Riboflavin synthase (2.5.1.9)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

proteínas quiméricas isoladas de lumazina sintase modificada. a presente invenção refere-se a proteínas quiméricas isoladas incluindo até dez cópias de peptídeos, polipeptídeos ou domínios de proteína inseridas no termina amino de brucella spp. à enzima lumazina sintase. a seqüências de nucleotídeos que codificam as proteínas quiméricas. a vetores, plasmídeos e células transformadas utilizados para a expressão de proteínas. a anticorpos monoclonais e policlonais induzidos pelas proteínas quiméricas. a hibridomas que produzem os anticorpos monoclonais. a vacinas e compostos farmacêuticos incluindo as proteínas quiméricas, seqüências de nucleotídeos e anticorpos. a um método para induzir uma resposta imune em organismos superiores incluindo a administração de quantidade efetivas das vacinas e compostos farmacêuticos. a biossensores incluindo as proteínas quiméricas. a conjugados de proteína formados pelas proteínas quiméricas e um ligante ligados por meio de ligações covalentes e não covalentes. aos usos das proteínas quiméricas, seqüências de nucleotídeos, vetores, plasmídeos, células transformadas, anticorpos, hibridomas, conjugados, biossensores, vacinas e compostos farmacêuticos. à estrutura quaternária das proteínas quiméricas.
BRPI0511793A 2004-06-03 2005-06-03 proteínas quiméricas isoladas de lumazina sintase modificada BRPI0511793B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ARP04-01-01923 2004-06-03
ARP040101923A AR044603A1 (es) 2004-06-03 2004-06-03 Proteinas quimericas aisladas de lumazina sintetasa modificada para la presentacion multiple de moleculas y sus aplicaciones
PCT/US2005/019289 WO2005121330A2 (en) 2004-06-03 2005-06-03 Isolated chimeric proteins of modified lumazine synthase

Publications (3)

Publication Number Publication Date
BRPI0511793A BRPI0511793A (pt) 2008-01-15
BRPI0511793B1 BRPI0511793B1 (pt) 2018-10-23
BRPI0511793B8 true BRPI0511793B8 (pt) 2021-05-25

Family

ID=35503729

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511793A BRPI0511793B8 (pt) 2004-06-03 2005-06-03 proteínas quiméricas isoladas de lumazina sintase modificada

Country Status (10)

Country Link
US (1) US8685670B2 (pt)
EP (1) EP1776456B1 (pt)
CN (1) CN101133163B (pt)
AR (1) AR044603A1 (pt)
BR (1) BRPI0511793B8 (pt)
CA (1) CA2569401C (pt)
DK (1) DK1776456T3 (pt)
ES (1) ES2413159T3 (pt)
MX (1) MXPA06013984A (pt)
WO (1) WO2005121330A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105555293B (zh) * 2013-05-27 2021-08-03 英母拓公司 布鲁氏菌属2,4-二氧四氢蝶啶合酶和AB5毒素β亚基的嵌合体
WO2017066484A2 (en) * 2015-10-13 2017-04-20 Carter Daniel C Nsp10 self-assembling fusion proteins for vaccines, therapeutics, diagnostics and other nanomaterial applications
WO2017178945A1 (en) * 2016-04-11 2017-10-19 Biogénesis Bagó Uruguay S.A. Universal vaccine for viral diseases
CN106636138A (zh) * 2017-01-12 2017-05-10 李增魁 一种针对羊种3型布鲁氏菌感染的dna疫苗及其制备方法
CN112996819B (zh) * 2018-08-16 2025-11-04 纪念斯隆-凯特琳癌症中心 细胞分选系统及使用方法
EP4004018A1 (en) 2019-07-24 2022-06-01 GlaxoSmithKline Biologicals SA Modified human cytomegalovirus proteins
CN110922488A (zh) * 2019-11-08 2020-03-27 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 一种含EB病毒gp350的自组装纳米颗粒及制备方法和应用
CN111217918B (zh) * 2020-03-04 2020-11-10 中山大学 一种基于2,4-二氧四氢喋啶合酶的新型冠状病毒s蛋白双区域亚单位纳米疫苗
WO2021245611A1 (en) 2020-06-05 2021-12-09 Glaxosmithkline Biologicals Sa Modified betacoronavirus spike proteins
CN114621352B (zh) * 2020-12-10 2024-01-23 中国科学院大连化学物理研究所 硅融合蛋白及制备和应用
CN112458054B (zh) * 2020-12-25 2023-03-31 上海纳米技术及应用国家工程研究中心有限公司 一种快速扩增体外nk细胞的方法
WO2022216919A1 (en) * 2021-04-07 2022-10-13 Cornell University A multiplex assay for the diagnosis of brucella canis infection
US20250101067A1 (en) 2022-01-28 2025-03-27 Glaxosmithkline Biologicals Sa Modified human cytomegalovirus proteins

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4258029A (en) 1979-04-23 1981-03-24 Connaught Laboratories Limited Synthetic adjuvants for stimulation of antigenic responses
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
MXPA01005389A (es) 1998-11-30 2003-03-27 Cytos Biotechnology Ag Presentacion molecular ordenada de antigenos, metodos de preparacion y uso.
US20040014158A1 (en) * 1999-03-08 2004-01-22 Adelbert Bacher Protein conjugates, methods, vectors, proteins and DNA for producing them, their use, and medicaments and vaccines containing a certain quantity of said protein conjugates
DE19910102B4 (de) 1999-03-08 2006-06-01 Fischer, Markus, Dr.rer.nat. Proteinkonjugate, Verfahren, Vektoren, Proteine und DNA zu deren Herstellung, deren Verwendung, sowie Arzneimittel und Impfstoffe mit einem Gehalt derselben
GB9929151D0 (en) 1999-12-09 2000-02-02 Univ Cambridge Tech Peptide and polypeptide display
EP1278542A2 (en) 2000-05-05 2003-01-29 Cytos Biotechnology AG Molecular antigen arrays and vaccines
AU2003300831A1 (en) * 2002-12-11 2004-06-30 Hawaii Biotech, Inc. Recombinant vaccine against flavivirus infection

Also Published As

Publication number Publication date
US20090087435A1 (en) 2009-04-02
EP1776456A4 (en) 2008-06-18
WO2005121330A3 (en) 2007-11-01
US8685670B2 (en) 2014-04-01
DK1776456T3 (da) 2013-05-27
MXPA06013984A (es) 2007-03-01
ES2413159T3 (es) 2013-07-15
CN101133163A (zh) 2008-02-27
EP1776456A2 (en) 2007-04-25
CN101133163B (zh) 2013-04-24
BRPI0511793A (pt) 2008-01-15
CA2569401C (en) 2017-03-07
EP1776456B1 (en) 2013-02-20
CA2569401A1 (en) 2005-12-22
AR044603A1 (es) 2005-09-21
WO2005121330A2 (en) 2005-12-22
BRPI0511793B1 (pt) 2018-10-23

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

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Ipc: C12N 9/10 (2006.01), C12N 15/54 (2006.01), A61K 38

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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