BRPI0512359A - dicetopiperazinas substituìdas como antagonistas da oxitocina - Google Patents
dicetopiperazinas substituìdas como antagonistas da oxitocinaInfo
- Publication number
- BRPI0512359A BRPI0512359A BRPI0512359-3A BRPI0512359A BRPI0512359A BR PI0512359 A BRPI0512359 A BR PI0512359A BR PI0512359 A BRPI0512359 A BR PI0512359A BR PI0512359 A BRPI0512359 A BR PI0512359A
- Authority
- BR
- Brazil
- Prior art keywords
- oxytocin antagonists
- methyl
- antagonists
- substituted diketopiperazines
- oxytocin
- Prior art date
Links
- 239000003336 oxytocin antagonist Substances 0.000 title abstract 2
- 229940121361 oxytocin antagonists Drugs 0.000 title abstract 2
- -1 2-indanyl Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DICETOPIPERAZINAS SUBSTITUìDAS COMO ANTAGONISTAS DA OXITOCINA. Compostos de fórmula (IA) onde R~ 1~ é 2-indanila, R~ 2~ é 1-metilpropila, R~ 3~ é 1-metil-indazol-5-ila, R~ 4~ representa metila e R~ 5~ representa hidrogênio ou metila, e seus derivados farmaceuticamente aceitáveis são descritas, como o são processos para a preparação deles, composições contendo eles e uso deles em medicina, particularmente uso deles como antagonistas da oxitocina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0414092.7A GB0414092D0 (en) | 2004-06-23 | 2004-06-23 | Novel compounds |
| PCT/EP2005/006761 WO2006000400A1 (en) | 2004-06-23 | 2005-06-21 | Substituted diketopiperazines as oxytocin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0512359A true BRPI0512359A (pt) | 2008-03-04 |
Family
ID=32800052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0512359-3A BRPI0512359A (pt) | 2004-06-23 | 2005-06-21 | dicetopiperazinas substituìdas como antagonistas da oxitocina |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20070208031A1 (pt) |
| EP (1) | EP1758893A1 (pt) |
| JP (1) | JP2008503535A (pt) |
| CN (1) | CN1989130A (pt) |
| AR (1) | AR049651A1 (pt) |
| AU (1) | AU2005256471A1 (pt) |
| BR (1) | BRPI0512359A (pt) |
| CA (1) | CA2571529A1 (pt) |
| GB (1) | GB0414092D0 (pt) |
| IL (1) | IL179912A0 (pt) |
| MA (1) | MA28698B1 (pt) |
| MX (1) | MXPA06014544A (pt) |
| NO (1) | NO20070157L (pt) |
| PE (1) | PE20060533A1 (pt) |
| RU (1) | RU2007102272A (pt) |
| TW (1) | TW200616635A (pt) |
| WO (1) | WO2006000400A1 (pt) |
| ZA (1) | ZA200610121B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2641806B1 (fr) * | 1989-01-16 | 1992-05-07 | Diffusion Rech Tech Financ | Procede de stabilisation d'une aire de terrain meuble |
| GB0130677D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| GB0314738D0 (en) * | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| GB0414100D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414093D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| CA2695384A1 (en) * | 2007-07-31 | 2009-02-05 | Burnham Institute For Medical Research | Bi-dentate compounds as kinase inhibitors |
| US20100038143A1 (en) * | 2008-08-14 | 2010-02-18 | George Alexander Burnett | Drill cuttings treatment systems |
| JP2013509391A (ja) | 2009-10-30 | 2013-03-14 | グラクソ グループ リミテッド | （３ｒ，６ｒ）−３−（２，３−ジヒドロ−１ｈ−インデン−２−イル）−１−［（１ｒ）−１−（２，６−ジメチル−３−ピリジニル）−２−（４−モルホリニル）−２−オキソエチル］−６−［（１ｓ）−１−メチルプロピル］−２，５−ピペラジンジオンの新規結晶性形態 |
| CN109305969B (zh) * | 2017-07-27 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 哌嗪-2,5-二酮类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130677D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| GB0414100D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
-
2004
- 2004-06-23 GB GBGB0414092.7A patent/GB0414092D0/en not_active Ceased
-
2005
- 2005-06-21 AR ARP050102538A patent/AR049651A1/es unknown
- 2005-06-21 EP EP05755377A patent/EP1758893A1/en not_active Withdrawn
- 2005-06-21 BR BRPI0512359-3A patent/BRPI0512359A/pt not_active IP Right Cessation
- 2005-06-21 CA CA002571529A patent/CA2571529A1/en not_active Abandoned
- 2005-06-21 MX MXPA06014544A patent/MXPA06014544A/es not_active Application Discontinuation
- 2005-06-21 TW TW094120516A patent/TW200616635A/zh unknown
- 2005-06-21 WO PCT/EP2005/006761 patent/WO2006000400A1/en not_active Ceased
- 2005-06-21 JP JP2007517198A patent/JP2008503535A/ja active Pending
- 2005-06-21 CN CNA200580024634XA patent/CN1989130A/zh active Pending
- 2005-06-21 RU RU2007102272/04A patent/RU2007102272A/ru not_active Application Discontinuation
- 2005-06-21 US US11/630,097 patent/US20070208031A1/en not_active Abandoned
- 2005-06-21 AU AU2005256471A patent/AU2005256471A1/en not_active Abandoned
- 2005-06-22 PE PE2005000713A patent/PE20060533A1/es not_active Application Discontinuation
-
2006
- 2006-12-04 ZA ZA200610121A patent/ZA200610121B/xx unknown
- 2006-12-07 IL IL179912A patent/IL179912A0/en unknown
- 2006-12-29 MA MA29584A patent/MA28698B1/fr unknown
-
2007
- 2007-01-09 NO NO20070157A patent/NO20070157L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR049651A1 (es) | 2006-08-23 |
| NO20070157L (no) | 2007-01-23 |
| ZA200610121B (en) | 2008-08-27 |
| MA28698B1 (fr) | 2007-06-01 |
| US20070208031A1 (en) | 2007-09-06 |
| TW200616635A (en) | 2006-06-01 |
| CA2571529A1 (en) | 2006-01-05 |
| EP1758893A1 (en) | 2007-03-07 |
| RU2007102272A (ru) | 2008-07-27 |
| MXPA06014544A (es) | 2007-03-12 |
| PE20060533A1 (es) | 2006-09-03 |
| CN1989130A (zh) | 2007-06-27 |
| GB0414092D0 (en) | 2004-07-28 |
| IL179912A0 (en) | 2007-05-15 |
| JP2008503535A (ja) | 2008-02-07 |
| WO2006000400A1 (en) | 2006-01-05 |
| AU2005256471A1 (en) | 2006-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY130803A (en) | New quinuclidine amide derivatives | |
| CY1109719T1 (el) | Σκευασμα 1-[(3-υδροξυ-αδαμαντ-1-υλαμινο)-ακετυλο]-πυρρολιδινο-2-(s)-καρβονιτριλιου τροποποιημενης απελευθερωσης | |
| ECSP056194A (es) | Derivados de pirazolo-quinazolina, procedimiento para su preparacion y su uso como inhibidores de quinasa | |
| NO20091893L (no) | Nye 1,4-benzotiepin-1,1-dioksidderivater som er substituert med benzylgrupper, fremgangsmater for fremstilling av medisiner inneholdende forbindelsene og anvendelse derav. | |
| UY27807A1 (es) | Nuevos derivados de piridazin-3(2h)-ona | |
| ATE327977T1 (de) | Tetrahydrochinolin-derivate als crth2 antagonisten | |
| NO20023037L (no) | Nye piperidin- og piperazinderivater | |
| NO20060001L (no) | Nye P2X7-reseptorantagonister og deres anvendelse | |
| MY139302A (en) | Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof | |
| BRPI0413427A (pt) | derivados de piridilpirrol ativos como inibidores da cinase | |
| NO20044826L (no) | Pyrrolidinderivater | |
| BR0213562A (pt) | Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna | |
| MX2007010072A (es) | Derivados de piperidina antibacterianos. | |
| BR0108437A (pt) | Piridinil-imidazóis | |
| NO20070224L (no) | 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav | |
| BRPI0821004A8 (pt) | Composto derivado de aminopirazol, composição farmacêutica que o contem e uso deste | |
| NO20062504L (no) | Sammensetninger og doseringsformer for forbedret absorpsjon | |
| TR200200795T2 (tr) | 5-HT1B antagonistleri olarak piperazin türevleri | |
| MXPA06000302A (es) | Derivados de pirazolil-indol activos como inhibidores de cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden. | |
| MX2009013501A (es) | Compuestos piperidinicos y sus usos. | |
| UY29087A1 (es) | Derivados de adamantilo, composiciones farmaceuticas que los contienen, procesos para su preparacion y uso terapeutico | |
| NO20061839L (no) | Benzimidazolderivater, sammensetninger inneholdende dem, fremstilling derav, og anvendelse derav | |
| BRPI0713132B8 (pt) | compostos derivados de cinamoil-piperazina, método de preparação dos referidos compostos, composições farmacêuticas, seus usos como antagonistas de par-i e produtos | |
| BRPI0413094A (pt) | derivados de quinolina e seu uso em terapia | |
| BRPI0512376A (pt) | piperazinodionas como antagonistas de receptor oxitocina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |