BRPI0512681A - derivados de uréia cìclica de amino, preparação destes e emprego farmacêutico destes como inibidores de cinase - Google Patents

derivados de uréia cìclica de amino, preparação destes e emprego farmacêutico destes como inibidores de cinase

Info

Publication number
BRPI0512681A
BRPI0512681A BRPI0512681-9A BRPI0512681A BRPI0512681A BR PI0512681 A BRPI0512681 A BR PI0512681A BR PI0512681 A BRPI0512681 A BR PI0512681A BR PI0512681 A BRPI0512681 A BR PI0512681A
Authority
BR
Brazil
Prior art keywords
alkyl
heteroaryl
alkynyl
cycloalkyl
alkenyl
Prior art date
Application number
BRPI0512681-9A
Other languages
English (en)
Inventor
Hartmut Strobel
Sven Ruf
Dominique Lesuisse
Conception Nemecek
Youssef El-Ahmad
Stefan Guessregen
Anne Lebrum
Kurt Ritter
Didier Benard
Augustin Hittinger
Herve Bouchard
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34931289&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0512681(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BRPI0512681A publication Critical patent/BRPI0512681A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

DERIVADOS DE URéIA CìCLICA DE AMINO, PREPARAçãO DESTES E EMPREGO FARMACêUTICO DESTES COMO INIBIDORES DE CINASE A invenção refere-se a produtos de fórmula (I): em que p = 0,1 e 2; A = arila, heteroarila, carbociclo ou heterociclo; X = ligação única; -N(R)-; - NH-alk-; alquileno; -O-; -S(O)n-: -N(R6)-C(O)-; -NH-CO-alk-; -N(R6)-C(O)- N(R6<39>)-; .-N(R6)-C(S)-N(R6<39>)-; -N(R6)-C(O)O-; -N(R6)-SO2-; -N(R6)-SO2-N(R6<39>)-; -C(O)-N(R6)-; -SO2-NR6-; e -C(O)O-; L1 = ligação única, alquileno, alquenileno, alquinileno, cicloalquileno, fenileno, heteroarileno; todos opcionalmente substituídos: R1 = hidrogênio, alquila, alquenila, alquinila ou cicloalquila, arila, heteroarila, arilalquila, heteroarilalquila; -SO2R9, -C(O)R9; -C(O)OR9, -C(O)NR10R11, -C(S)NR10R11, -SO2NR10R11; R2 = hidrogênio, alquila, alquenila, alquinila, cicloalquila, ou R1 e R2 com N, ou NR1R2 com L1 podem formar heterociclo saturado ou insaturado possivelmente contendo O, N, S; R3 = hidrogênio; halogênio; alquila, alquenila, alquinila, cicloalquila, alcóxi, alquilenodióxi, heterociclo, arila e heteroarila, todos opcionalmente substituídos; S(O)n-alquila, amino, alquilamino, dialquilamino, com dialquilamino opcionalmente formando com N um ciclo, todos opcionalmente substituídos; R4, R4<39> e R4'' = hidrogênio, halogênio, alquila, alquenila, alquinila, cicloalquila, arila, heteroarila, oxo; com dois dentre R4, R4' e R4'' possivelmente formando com C um anel possivelmente contendo O, N ou S; L2 = ligação única, alquileno,alquenileno, alquinileno, cicloalquileno, -O-, -NR7-, -C(O)-, SO2; Y = N-heterociclo possivelmente contendo O, N ou S; R5 = hidrogênio, halogênio, alquila, alquenila, alquinila, cicloalquila, arila, arilalquila, heteroarila, heteroarilalquila; todos estes radicais sendo opcionalmente substituídos, estes produtos sendo em todas formas isoméricas e os sais, como produtos medicinais.
BRPI0512681-9A 2004-07-27 2005-07-25 derivados de uréia cìclica de amino, preparação destes e emprego farmacêutico destes como inibidores de cinase BRPI0512681A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04291904A EP1621536A1 (en) 2004-07-27 2004-07-27 Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
PCT/EP2005/008720 WO2006010641A2 (en) 2004-07-27 2005-07-25 Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0512681A true BRPI0512681A (pt) 2008-04-01

Family

ID=34931289

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512681-9A BRPI0512681A (pt) 2004-07-27 2005-07-25 derivados de uréia cìclica de amino, preparação destes e emprego farmacêutico destes como inibidores de cinase

Country Status (20)

Country Link
US (1) US7759379B2 (pt)
EP (2) EP1621536A1 (pt)
JP (1) JP2008508228A (pt)
KR (1) KR20070038529A (pt)
CN (1) CN101031559A (pt)
AR (1) AR050269A1 (pt)
AT (1) ATE498618T1 (pt)
AU (1) AU2005266460A1 (pt)
BR (1) BRPI0512681A (pt)
CA (1) CA2571323A1 (pt)
DE (1) DE602005026395D1 (pt)
EA (1) EA011088B1 (pt)
IL (1) IL180286A0 (pt)
MA (1) MA28732B1 (pt)
MX (1) MX2007001024A (pt)
NO (1) NO20071067L (pt)
PE (1) PE20060383A1 (pt)
TW (1) TW200616973A (pt)
UY (1) UY29039A1 (pt)
WO (1) WO2006010641A2 (pt)

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US7354933B2 (en) * 2003-01-31 2008-04-08 Aventis Pharma Sa Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621535A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
FR2896504B1 (fr) 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
FR2896503B1 (fr) * 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
EP2656842B1 (en) 2006-03-27 2016-08-10 The Regents of The University of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
CA2678577A1 (en) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
US8575156B2 (en) * 2007-07-26 2013-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) * 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
EP2252598A2 (en) * 2008-02-11 2010-11-24 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8598160B2 (en) * 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CA2718264A1 (en) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
TW201004945A (en) 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291373B1 (en) * 2008-05-01 2013-09-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
NZ588954A (en) 2008-05-01 2012-08-31 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN104327062A (zh) 2008-07-25 2015-02-04 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2393807B1 (en) 2009-02-04 2013-08-14 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
GEP20156309B (en) * 2009-04-30 2015-07-10 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN102869775A (zh) 2009-09-30 2013-01-09 哈佛大学校长及研究员协会 通过调节自噬抑制基因产物调节自噬的方法
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
EA201300522A1 (ru) 2010-11-02 2013-11-29 Бёрингер Ингельхайм Интернациональ Гмбх Фармацевтические комбинации для лечения метаболических нарушений
ES2836424T3 (es) 2012-09-26 2021-06-25 Aragon Pharmaceuticals Inc Antiandrógenos para tratar el cáncer de próstata no metastásico y resistente a la castración
MX387238B (es) * 2014-09-29 2025-03-18 Chemocentryx Inc Procesos e compuestos intermedios en la preparación de antagonistas de c5ar.
US11292782B2 (en) 2018-11-30 2022-04-05 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
WO2021057696A1 (zh) * 2019-09-27 2021-04-01 隆泰申医药科技(南京)有限公司 一种杂芳基类化合物及其应用
WO2022206583A1 (zh) * 2021-03-29 2022-10-06 浙江大学 吲唑类化合物及其制备方法和应用

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FR2850652B1 (fr) * 2003-01-31 2008-05-30 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
US7354933B2 (en) * 2003-01-31 2008-04-08 Aventis Pharma Sa Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
US7256208B2 (en) 2003-11-13 2007-08-14 Bristol-Myers Squibb Company Monocyclic N-Aryl hydantoin modulators of androgen receptor function
EP1621535A1 (en) 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621539A1 (en) 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

Also Published As

Publication number Publication date
WO2006010641A3 (en) 2006-10-26
PE20060383A1 (es) 2006-06-06
AU2005266460A1 (en) 2006-02-02
CN101031559A (zh) 2007-09-05
TW200616973A (en) 2006-06-01
EP1773808A2 (en) 2007-04-18
MX2007001024A (es) 2007-04-16
MA28732B1 (fr) 2007-07-02
NO20071067L (no) 2007-04-26
IL180286A0 (en) 2007-07-04
ATE498618T1 (de) 2011-03-15
EP1773808B1 (en) 2011-02-16
CA2571323A1 (en) 2006-01-02
US20080004300A1 (en) 2008-01-03
US7759379B2 (en) 2010-07-20
WO2006010641A2 (en) 2006-02-02
UY29039A1 (es) 2006-02-24
AR050269A1 (es) 2006-10-11
JP2008508228A (ja) 2008-03-21
EA011088B1 (ru) 2008-12-30
EP1621536A1 (en) 2006-02-01
KR20070038529A (ko) 2007-04-10
EA200700141A1 (ru) 2007-08-31
DE602005026395D1 (de) 2011-03-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.