NO20071067L - Nye cykliske ureaderivater, fremstilling derav og farmasoytisk anvendelse derav som kinaseinhibitorer. - Google Patents

Nye cykliske ureaderivater, fremstilling derav og farmasoytisk anvendelse derav som kinaseinhibitorer.

Info

Publication number
NO20071067L
NO20071067L NO20071067A NO20071067A NO20071067L NO 20071067 L NO20071067 L NO 20071067L NO 20071067 A NO20071067 A NO 20071067A NO 20071067 A NO20071067 A NO 20071067A NO 20071067 L NO20071067 L NO 20071067L
Authority
NO
Norway
Prior art keywords
alkyl
heteroaryl
alkynyl
cycloalkyl
alkenyl
Prior art date
Application number
NO20071067A
Other languages
English (en)
Inventor
Augustin Hittinger
Herve Bouchard
Hartmut Strobel
Youssef El-Ahmad
Conception Nemecek
Sven Ruf
Kurt Ritter
Dominique Lesuisse
Stefan Guessregen
Anne Lebrun
Didier Benard
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34931289&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20071067(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of NO20071067L publication Critical patent/NO20071067L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Oppfinnelsen vedrører produkter av formel (I): hvori: p= 0, 1 og 2; A = aryl, heteroaryl, karbosykel eller heterosykel; X = enkeltbinding, -N(R6)-, NH-alk-, alkylen, -O-, -C(O)-, -S(O)N-, -N(R6)- C(O)-, -NH-CO-alk-, -N(R6)-C(O)-N(R6')-, -N(R6)-C(S)-N(R6')-, N(R6)- C(O)O-, -N(R6)-SO2-, -N(R6)-SO2-N(R6')-, -C(O)-N(R6)-, -SO2-NR6- og - C(O)O-; L1 = enkeltbinding, alkylen, alkenylen, alkynylen, sykloalkylen, fenylen, heteroarylen, alle valgfritt substituert; R1 = hydrogen, alkyl, alkenyl, alkynyl eller sykloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl; -SO2R9, -C(O)R9; - (O)OR9, -C(O)NR10R11, C(S)NR10R11, -SO2NR10R11; R2 = hydrogen, alkyl, alkenyl, alkynyl, sykloalkyl, enten kan R1 og R2 med N eller NRlR2 med Ll danne en mettet eller umettet heterosyklus som kan inneholde O, N, S; R3 = hydrogen, halogen, alkyl, alkenyl, alkynyl, sykloalkyl, alkoksy, alkylendioksy, heterosyklus, aryl og heteroaryl, alle valgfritt substituert; S(O)nalkyl, amino, alkylamino, dialkylamino, med dialkylamino som valgfritt med N danner en syklus, alle valgfritt substituert; R4, R4' og R4" = hydrogen, halogen, alkyl, alkenyl, alkynyl, sykloalkyl, aryl, heteroaryl, okso; med to fra blant R4, R4' og R4" som muligens sammen med C danner en ring som muligens inneholder O, N eller S; L2 = enkeltbinding, alkylen, alkenylen, alkynylen, sykloalkylen, -O-, -NR17-, C(O)-, SO2; Y = N-heterosyklus muligens inneholdende O, N eller S; R5 = hydrogen, halogen, alkyl, alkenyl, alkynyl, sykloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl; idet alle disse radikaler eventuelt er valgtfritt substituert, idet disse produkter foreligger i alle de isomere former og saltene som medisinalprodukter.
NO20071067A 2004-07-27 2007-02-26 Nye cykliske ureaderivater, fremstilling derav og farmasoytisk anvendelse derav som kinaseinhibitorer. NO20071067L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04291904A EP1621536A1 (en) 2004-07-27 2004-07-27 Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
PCT/EP2005/008720 WO2006010641A2 (en) 2004-07-27 2005-07-25 Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20071067L true NO20071067L (no) 2007-04-26

Family

ID=34931289

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071067A NO20071067L (no) 2004-07-27 2007-02-26 Nye cykliske ureaderivater, fremstilling derav og farmasoytisk anvendelse derav som kinaseinhibitorer.

Country Status (20)

Country Link
US (1) US7759379B2 (no)
EP (2) EP1621536A1 (no)
JP (1) JP2008508228A (no)
KR (1) KR20070038529A (no)
CN (1) CN101031559A (no)
AR (1) AR050269A1 (no)
AT (1) ATE498618T1 (no)
AU (1) AU2005266460A1 (no)
BR (1) BRPI0512681A (no)
CA (1) CA2571323A1 (no)
DE (1) DE602005026395D1 (no)
EA (1) EA011088B1 (no)
IL (1) IL180286A0 (no)
MA (1) MA28732B1 (no)
MX (1) MX2007001024A (no)
NO (1) NO20071067L (no)
PE (1) PE20060383A1 (no)
TW (1) TW200616973A (no)
UY (1) UY29039A1 (no)
WO (1) WO2006010641A2 (no)

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US7354933B2 (en) * 2003-01-31 2008-04-08 Aventis Pharma Sa Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621535A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
FR2896504B1 (fr) * 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
FR2896503B1 (fr) * 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
ES2689292T3 (es) 2006-03-27 2018-11-13 The Regents Of The University Of California Modulador del receptor de andrógenos para el tratamiento del cáncer de próstata y enfermedades asociadas con el receptor de andrógenos
EP2125750B1 (en) * 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8329897B2 (en) * 2007-07-26 2012-12-11 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
EP2252601B1 (en) * 2008-01-24 2012-12-19 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2714532A1 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
EP2254872A2 (en) * 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EP2274287B1 (en) * 2008-03-18 2016-03-09 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
CA2722427A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291373B1 (en) * 2008-05-01 2013-09-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001058A1 (es) 2008-05-01 2010-09-10 Vitae Pharmaceuticals Inc Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras.
JP5777030B2 (ja) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
RU2539979C2 (ru) 2008-07-25 2015-01-27 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
US20100331320A1 (en) * 2009-04-30 2010-12-30 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
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KR20120082906A (ko) 2009-09-30 2012-07-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 자가포식현상-향상 유전자 생성물의 조절을 통한 자가포식현상의 조절 방법
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
BR112013010021A2 (pt) 2010-11-02 2019-09-24 Boehringer Ingelheim Int combinações farmacêuticas para o tratamento de distúrbios metabólicos.
CN115737643A (zh) 2012-09-26 2023-03-07 阿拉贡药品公司 用于治疗非转移性去势抵抗性前列腺癌的抗雄激素
EP3682879B1 (en) * 2014-09-29 2022-08-03 ChemoCentryx, Inc. Processes and intermediates in the preparation of c5ar antagonists
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WO2021057696A1 (zh) * 2019-09-27 2021-04-01 隆泰申医药科技(南京)有限公司 一种杂芳基类化合物及其应用
WO2022206583A1 (zh) * 2021-03-29 2022-10-06 浙江大学 吲唑类化合物及其制备方法和应用

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EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

Also Published As

Publication number Publication date
UY29039A1 (es) 2006-02-24
BRPI0512681A (pt) 2008-04-01
US20080004300A1 (en) 2008-01-03
EP1773808B1 (en) 2011-02-16
DE602005026395D1 (de) 2011-03-31
AU2005266460A1 (en) 2006-02-02
CA2571323A1 (en) 2006-01-02
EP1621536A1 (en) 2006-02-01
ATE498618T1 (de) 2011-03-15
EA011088B1 (ru) 2008-12-30
WO2006010641A2 (en) 2006-02-02
CN101031559A (zh) 2007-09-05
EP1773808A2 (en) 2007-04-18
US7759379B2 (en) 2010-07-20
EA200700141A1 (ru) 2007-08-31
PE20060383A1 (es) 2006-06-06
KR20070038529A (ko) 2007-04-10
MX2007001024A (es) 2007-04-16
TW200616973A (en) 2006-06-01
IL180286A0 (en) 2007-07-04
AR050269A1 (es) 2006-10-11
JP2008508228A (ja) 2008-03-21
WO2006010641A3 (en) 2006-10-26
MA28732B1 (fr) 2007-07-02

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