BRPI0512970A - prodrogas de inibidores da hiv protease - Google Patents

prodrogas de inibidores da hiv protease

Info

Publication number
BRPI0512970A
BRPI0512970A BRPI0512970-2A BRPI0512970A BRPI0512970A BR PI0512970 A BRPI0512970 A BR PI0512970A BR PI0512970 A BRPI0512970 A BR PI0512970A BR PI0512970 A BRPI0512970 A BR PI0512970A
Authority
BR
Brazil
Prior art keywords
hiv protease
protease inhibitor
inhibitor prodrugs
disclosed
prodrugs
Prior art date
Application number
BRPI0512970-2A
Other languages
English (en)
Inventor
David A Degoey
William J Flosi
David J Grampovnik
Larry L Klein
Dale J Kempf
Xiu C Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BRPI0512970A publication Critical patent/BRPI0512970A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PRODROGAS DE INIBIDORES DA HIV PROTEASE Um composto da fórmula, ou é revelado como uma prodroga de um inibidor da HIV protease - Métodos e composições de inibir a atividade da HIV protease e de tratar infecção por são também revelados.
BRPI0512970-2A 2004-07-06 2005-06-29 prodrogas de inibidores da hiv protease BRPI0512970A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58571004P 2004-07-06 2004-07-06
PCT/US2005/023047 WO2006014282A2 (en) 2004-07-06 2005-06-29 Prodrugs of hiv protease inhibitors

Publications (1)

Publication Number Publication Date
BRPI0512970A true BRPI0512970A (pt) 2008-04-22

Family

ID=35063063

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512970-2A BRPI0512970A (pt) 2004-07-06 2005-06-29 prodrogas de inibidores da hiv protease

Country Status (15)

Country Link
US (2) US7718633B2 (pt)
EP (2) EP1773850B1 (pt)
JP (2) JP5142714B2 (pt)
KR (1) KR101229431B1 (pt)
CN (1) CN101023090B (pt)
AU (1) AU2005270124B2 (pt)
BR (1) BRPI0512970A (pt)
CA (1) CA2571726C (pt)
ES (1) ES2402552T3 (pt)
IL (1) IL180433A (pt)
MX (1) MXPA06015108A (pt)
NZ (2) NZ552276A (pt)
TW (1) TWI365876B (pt)
WO (1) WO2006014282A2 (pt)
ZA (1) ZA200700101B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1773850B1 (en) * 2004-07-06 2013-01-30 Abbott Laboratories Prodrugs of hiv protease inhibitors
KR101477822B1 (ko) 2006-07-07 2015-01-02 길리애드 사이언시즈, 인코포레이티드 치료제의 약동학 특성의 모듈레이터
PT3150586T (pt) * 2007-02-23 2020-03-31 Gilead Sciences Inc Moduladores de propriedades farmacocinéticas de agentes terapêuticos
MX2009013565A (es) * 2007-06-12 2010-06-02 Concert Pharmaceuticals Inc Derivados de azapeptidos.
FI20070574A0 (fi) * 2007-07-30 2007-07-30 Kuopion Yliopisto Vesiliukoinen propofolin etylideenifosfaatti-aihiolääke
AU2009249069A1 (en) 2008-05-20 2009-11-26 Neurogesx, Inc. Carbonate prodrugs and methods of using the same
JP5757864B2 (ja) 2008-05-20 2015-08-05 ニューロジェシックス， インコーポレイテッド 水溶性アセトアミノフェン類似体
MY158809A (en) * 2010-09-22 2016-11-15 Craun Res Sdn Bhd Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same
WO2012048204A2 (en) * 2010-10-08 2012-04-12 Virginia Commonwealth University Prodrugs utilizing a transporter directed uptake mechanism
WO2012075117A2 (en) * 2010-12-01 2012-06-07 Ablitech, Inc. Small molecule-polymer conjugates and methods of making same
ES2739536T3 (es) 2014-10-21 2020-01-31 Abbvie Inc Profármacos de carbidopa y L-dopa y su uso para tratar la enfermedad de Parkinson
US20190224220A1 (en) * 2016-04-20 2019-07-25 Abbvie Inc. Carbidopa and L-Dopa Prodrugs and Methods of Use
UY37592A (es) 2017-02-06 2018-08-31 Gilead Sciences Inc Compuestos inhibidores del vih
TWI829205B (zh) 2018-07-30 2024-01-11 美商基利科學股份有限公司 抗hiv化合物
TW202031265A (zh) 2018-11-15 2020-09-01 美商艾伯維有限公司 用於皮下投藥之醫藥調配物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696270A (en) * 1989-05-23 1997-12-09 Abbott Laboratories Intermediate for making retroviral protease inhibiting compounds
CA2055685A1 (en) 1990-11-19 1992-05-20 Samuel L. Graham Hiv protease inhibitors having polyether substituents
NO310238B1 (no) 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
JPH09503497A (ja) * 1993-09-10 1997-04-08 ナルヘックス リミテッド 極性置換炭化水素
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
ZA9710071B (en) 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US20030100088A1 (en) 2001-07-13 2003-05-29 Sigler Gerald F. Protease inhibitor conjugates and antibodies useful in immunoassay
US7205413B2 (en) * 2002-05-03 2007-04-17 Transform Pharmaceuticals, Inc. Solvates and polymorphs of ritonavir and methods of making and using the same
EP1773850B1 (en) 2004-07-06 2013-01-30 Abbott Laboratories Prodrugs of hiv protease inhibitors

Also Published As

Publication number Publication date
CA2571726C (en) 2013-05-21
TWI365876B (en) 2012-06-11
IL180433A0 (en) 2007-06-03
EP1773850A2 (en) 2007-04-18
HK1104558A1 (en) 2008-01-18
US20100286032A1 (en) 2010-11-11
EP2336138A3 (en) 2011-11-16
NZ552276A (en) 2011-03-31
KR20070029244A (ko) 2007-03-13
IL180433A (en) 2013-07-31
JP5142714B2 (ja) 2013-02-13
NZ590128A (en) 2012-08-31
CN101023090A (zh) 2007-08-22
ES2402552T3 (es) 2013-05-06
US7718633B2 (en) 2010-05-18
AU2005270124A1 (en) 2006-02-09
WO2006014282A3 (en) 2006-05-11
US8426388B2 (en) 2013-04-23
KR101229431B1 (ko) 2013-02-04
JP2013040178A (ja) 2013-02-28
JP2008505898A (ja) 2008-02-28
CN101023090B (zh) 2013-03-27
EP2336138A2 (en) 2011-06-22
US20070270383A1 (en) 2007-11-22
WO2006014282A2 (en) 2006-02-09
ZA200700101B (en) 2009-10-28
AU2005270124B2 (en) 2011-09-08
MXPA06015108A (es) 2007-03-26
TW200613289A (en) 2006-05-01
CA2571726A1 (en) 2006-02-09
EP1773850B1 (en) 2013-01-30

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: ABBVIE INC. (US)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL