BRPI0514435A - isolamento seqüêncial de proteìnas e esquemas de purificação através de cromatografia por afinidade - Google Patents

isolamento seqüêncial de proteìnas e esquemas de purificação através de cromatografia por afinidade

Info

Publication number
BRPI0514435A
BRPI0514435A BRPI0514435-3A BRPI0514435A BRPI0514435A BR PI0514435 A BRPI0514435 A BR PI0514435A BR PI0514435 A BRPI0514435 A BR PI0514435A BR PI0514435 A BRPI0514435 A BR PI0514435A
Authority
BR
Brazil
Prior art keywords
proteins
affinity chromatography
ligand
biological sample
purification
Prior art date
Application number
BRPI0514435-3A
Other languages
English (en)
Inventor
Steven James Burton
Baldev Baines
John Curling
Timothy Keith Hayes
Dwun-Hou Chen
Christopher Bryant
David John Hammond
Original Assignee
Prometic Biosciences Ltd
American Nat Red Cross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prometic Biosciences Ltd, American Nat Red Cross filed Critical Prometic Biosciences Ltd
Publication of BRPI0514435A publication Critical patent/BRPI0514435A/pt
Publication of BRPI0514435B1 publication Critical patent/BRPI0514435B1/pt
Publication of BRPI0514435B8 publication Critical patent/BRPI0514435B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

ISOLAMENTO SEQüENCIAL DE PROTEìNAS E ESQUEMAS DE PURIFICAçãO ATRAVéS DE CROMATOGRAFIA POR AFINIDADE A invenção revela métodos para o isolamento e purificação seqüencial de proteínas e purificação a partir de uma amostra biológica através de cromatografia por afinidade. A cromatografia por afinidade é conduzida usando ligantes ou complexos de ligante-suporte que se ligam seletivamente e especificamente a proteínas na amostra biológica. Os ligantes ou os complexos de ligante-suporte foram colocados em contato seqüencialmente em uma ordem pré-determinada com a amostra biológica para permitir que cada ligante ou complexo ligante-suporte se ligue seqüencialmente a uma proteína da amostra biológica.
BRPI0514435A 2004-08-20 2005-08-19 isolamento sequêncial de proteínas e esquemas de purificação através de cromatografia por afinidade BRPI0514435B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60286804P 2004-08-20 2004-08-20
PCT/US2005/029739 WO2006023831A2 (en) 2004-08-20 2005-08-19 Sequential protein isolation and purification schemes by affinity chromatography

Publications (3)

Publication Number Publication Date
BRPI0514435A true BRPI0514435A (pt) 2008-06-10
BRPI0514435B1 BRPI0514435B1 (pt) 2019-08-13
BRPI0514435B8 BRPI0514435B8 (pt) 2021-05-25

Family

ID=35968252

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514435A BRPI0514435B8 (pt) 2004-08-20 2005-08-19 isolamento sequêncial de proteínas e esquemas de purificação através de cromatografia por afinidade

Country Status (15)

Country Link
US (1) US8198407B1 (pt)
EP (1) EP1786273B1 (pt)
JP (1) JP4970260B2 (pt)
CN (1) CN101035439B (pt)
AU (1) AU2005277190B2 (pt)
BR (1) BRPI0514435B8 (pt)
CA (1) CA2576963C (pt)
DK (1) DK1786273T3 (pt)
ES (1) ES2710025T3 (pt)
MX (1) MX2007002085A (pt)
MY (1) MY147996A (pt)
PL (1) PL1786273T3 (pt)
PT (1) PT1786273T (pt)
TW (1) TWI392685B (pt)
WO (1) WO2006023831A2 (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100553636C (zh) 2000-08-04 2009-10-28 Dmi生物科学公司 二酮基哌嗪和包含它们的组合物的使用方法
EP2517718B1 (en) 2003-05-15 2016-03-02 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
AU2011250839B2 (en) * 2007-08-17 2012-07-12 Csl Behring Gmbh Methods for purification of alpha-1-antitrypsin and apolipoprotein A-1
CA2694854C (en) 2007-08-17 2016-09-27 Csl Behring Gmbh Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i
CN101396650B (zh) * 2007-09-26 2010-12-22 中国科学院大连化学物理研究所 一种固定钛离子亲和色谱材料及其制备和应用
CN102015094B (zh) * 2008-04-22 2016-11-09 通用电气医疗集团生物工艺研发股份公司 层析介质
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
FR2942233B1 (fr) * 2009-02-19 2015-03-13 Lfb Biotechnologies Moyens pour la purification d'une proteine du plasma sanguin, et procedes pour sa mise en oeuvre
BR112012004054B1 (pt) * 2009-10-01 2021-09-08 F. Hoffmann-La Roche Ag Método para produzir um anticorpo anti-her2
JP2012050386A (ja) * 2010-09-01 2012-03-15 Kaneka Corp ２種類以上の多孔質充填剤を充填するカラム
WO2012036140A1 (ja) * 2010-09-14 2012-03-22 株式会社カネカ クリングル配列を有する蛋白質またはペプチドを精製または除去するアフィニティ担体、及びそれを用いた精製方法、除去方法
JP5836577B2 (ja) * 2010-09-14 2015-12-24 株式会社カネカ クリングル配列を有する蛋白質またはペプチドを精製または除去するアフィニティ担体の製造方法、その精製方法、除去方法
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
EA028343B1 (ru) 2011-10-10 2017-11-30 Ампио Фармасьютикалз, Инк. Лечение дегенеративного заболевания сустава
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
EP2771007B1 (en) 2011-10-28 2018-04-04 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
EP2871968B1 (en) * 2012-07-11 2016-06-15 Coöperatie AVEBE U.A. Potato protein isolates
CN103351431A (zh) * 2012-11-13 2013-10-16 蔡胜和 一种凝血八因子及其变异体纯化方法
SG11201505715RA (en) * 2013-02-01 2015-08-28 Ampio Pharmaceuticals Inc Methods for producing diketopiperazines and compositions containing diketopiperazines
BR112015020469A2 (pt) 2013-03-15 2020-01-28 Ampio Pharmaceuticals Inc Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo
WO2014186874A1 (en) 2013-05-23 2014-11-27 Yyz Pharmatech, Inc. Methods and compositions for enzyme linked immuno and hybridization mass spectrometric assay
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma
US20160347789A1 (en) * 2014-02-04 2016-12-01 Basf Se Method for purification of antibodies, antibody fragments or engineered variants thereof using specific anthraquinone dye-ligand structures
FR3018450B1 (fr) * 2014-03-11 2016-04-15 Lab Francais Du Fractionnement Procede de preparation de proteines plasmatiques humaines
US20170044210A1 (en) * 2014-04-30 2017-02-16 Novo Nordisk A/S Methods for the purification of proteins using caprylic acid
RU2736513C2 (ru) 2014-08-18 2020-11-17 Ампио Фармасьютикалз, Инк. Лечение патологических состояний суставов
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES
WO2017078947A1 (en) * 2015-10-21 2017-05-11 Cambryn Biologics, Llc Processes for purifying proteins from plasma
CN105504131B (zh) * 2016-01-26 2018-07-17 重庆希尔康血液净化器材研发有限公司 用于血液净化清除β2-微球蛋白的树脂的制备方法
EP3205665A1 (en) * 2016-02-11 2017-08-16 Octapharma AG Method of separating factor viii from blood products
EP3810563A4 (en) * 2018-06-22 2022-03-23 Somalogic, Inc. IMPROVED PROTEOMIC MULTIPLEX TESTS
WO2021087404A1 (en) * 2019-10-30 2021-05-06 Future Fields Cellular Agriculture and Research LTD. Method for producing recombinant proteins in insects

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE392038B (sv) 1971-09-08 1977-03-14 Kabi Ab Forfarande for isolering av antitrombin ur blod eller blodprodukter
US4137307A (en) 1973-11-15 1979-01-30 The Green Cross Corporation Process for preparing haptoglobin aqueous solution using strong anion exchanger
US4061735A (en) 1973-11-15 1977-12-06 The Green Cross Corporation Haptoglobin in aqueous solution and process for preparing the same
US4011067A (en) 1974-01-30 1977-03-08 Minnesota Mining And Manufacturing Company Filter medium layered between supporting layers
US3943245A (en) * 1974-02-14 1976-03-09 Armour Pharmaceutical Company Purification of plasminogen
CA1064396A (en) 1975-02-18 1979-10-16 Myer L. Coval Fractional precipitation of gamma globulin with polyethylene glycol
JPS52125609A (en) 1976-04-09 1977-10-21 Green Cross Corp:The Purification of agglutination factor viii
JPS56106594A (en) 1980-01-25 1981-08-24 Green Cross Corp:The Stabilizing method of plasminogen
JPS5716824A (en) 1980-07-03 1982-01-28 Green Cross Corp:The Plasminogen pharmaceutical and stabilizing method thereof
US4371520A (en) 1981-10-28 1983-02-01 The Green Cross Corporation Process for preparing immunoglobulin suitable for intravenous injection
JPS5967228A (ja) 1982-10-07 1984-04-16 Green Cross Corp:The 寒冷不溶性グロブリンの凍結乾燥方法
JPS63108000A (ja) 1986-05-15 1988-05-12 Green Cross Corp:The 第８因子の精製方法
US5187155A (en) * 1989-06-23 1993-02-16 Board Of Regents, The University Of Texas System Anticoagulant peptides
US5138034A (en) 1989-07-12 1992-08-11 The Green Cross Corporation Method of fractionating plasma proteins
US5576220A (en) 1993-02-19 1996-11-19 Arris Pharmaceutical Corporation Thin film HPMP matrix systems and methods for constructing and displaying ligands
JP3128398B2 (ja) 1993-10-13 2001-01-29 三洋電機株式会社 部品装着装置における部品認識用照明装置
US6117996A (en) 1995-09-20 2000-09-12 Novo Nordisk A/S Triazine based ligands and use thereof
ATE211486T1 (de) * 1995-09-22 2002-01-15 Zlb Bioplasma Ag Verfahren zur gewinnung von immunglobulinen aus fraktionen, die bei der fraktionierung von menschlichem blutplasma entstehen
AT403764B (de) * 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
US6037457A (en) * 1997-01-31 2000-03-14 The University Of North Carolina At Chapel Hill Method for recombinant fibrinogen production
US5985836A (en) * 1998-07-31 1999-11-16 Bayer Corporation Alpha-1 proteinase inhibitor binding peptides
US6214221B1 (en) 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
ATE342112T1 (de) 1999-02-22 2006-11-15 Ncsrt Inc Reinigung von biologischen substanzen

Also Published As

Publication number Publication date
BRPI0514435B1 (pt) 2019-08-13
BRPI0514435B8 (pt) 2021-05-25
ES2710025T3 (es) 2019-04-22
WO2006023831A3 (en) 2006-06-08
MX2007002085A (es) 2007-07-19
CA2576963A1 (en) 2006-03-02
EP1786273A4 (en) 2010-05-26
MY147996A (en) 2013-02-28
DK1786273T3 (en) 2019-02-18
CN101035439B (zh) 2013-02-06
TW200621798A (en) 2006-07-01
PT1786273T (pt) 2019-02-19
JP4970260B2 (ja) 2012-07-04
CA2576963C (en) 2015-02-17
EP1786273B1 (en) 2018-11-14
US8198407B1 (en) 2012-06-12
AU2005277190A1 (en) 2006-03-02
EP1786273A2 (en) 2007-05-23
PL1786273T3 (pl) 2019-05-31
JP2008510724A (ja) 2008-04-10
CN101035439A (zh) 2007-09-12
AU2005277190B2 (en) 2011-03-03
TWI392685B (zh) 2013-04-11
WO2006023831A2 (en) 2006-03-02

Similar Documents

Publication Publication Date Title
BRPI0514435A (pt) isolamento seqüêncial de proteìnas e esquemas de purificação através de cromatografia por afinidade
BRPI0518994A2 (pt) anticorpos ou polipeptÍdeos que se ligam a br3, seus usos e formulaÇÕes lÍquidas
EA200801621A1 (ru) Антитела, направленные на her-3, и их применение
CR9576A (es) METODOS PARA PURIFICAR PROTEINAS QUE CONTIENE LA REGION Fc
BRPI0413495A (pt) reagentes de peptìdeos especìficos para prìons e seus usos
EA201100694A1 (ru) Антитело к cd38 человека и его применение
MA31092B1 (fr) Anticorps humains contre le delta-like ligand 4 humain.
EA200600037A1 (ru) Композиции и способы увеличения минерализации костей
DK1629011T3 (da) Humane anti-humane-DC3-bindingsmolekyler
DE60226486D1 (de) Selbstanordnende moleküle
DK1742966T3 (da) Antistoffer og molekyler afledt deraf som binder til STEAP-1 proteiner
UY28453A1 (es) Anticuerpos dirigidos a c-met.-
DE60127958D1 (de) Mikroarrays für durchführen von proteomanalyse
EA201070553A1 (ru) Антитела к гепцидину и варианты их применения
PL378566A1 (pl) Ligandy dla białek wiążących TGF-beta i ich zastosowania
TW200626614A (en) Human monoclonal antibodies to influenza M2 protein and methods of making and using same
BRPI0820885B8 (pt) "anticorpo ou fraguimento do mesmo, célula de hibridoma, polinucleotídeo, polipeptídeo compreendendoum domínio de cadeia pesada ou leve de anticorpo, método para detecção de gravidez em um animal bovino, kit e método de purificação de um antígeno principal associado à gravidez (pag)".
WO2007090630A3 (en) Peptide aptamer for neutralizing the binding of platelet antigene specific antibodies and diagnostic and therapeutic applications containing the same
BR112013023978A2 (pt) "polipeptídeo com afinidade por proteínas de choque térmico e seu uso em diagnóstico de doença infecciosa, produção de resposta imune e tratamento 5 de câncer, bem como ácido nucleico, composição e método de fracionamento de substância para pesquisa ou análise clínica de amostra biológica".
BR112018074620A2 (pt) método para a detecção de um anticorpo de igm específico para um flavivírus em uma amostra
ATE542831T1 (de) Neue antigene und antikörper, die mit adenokarzinomen des pankreasgangs assoziiert sind
ATE420365T1 (de) Präparierung von sphären für diagnostische tests
NO20081794L (no) Fremgangsmate for kvantitativ bestemmelse av poloxamere
ATE547161T1 (de) Verfahren zur quantitativen bestimmung von poloxameren
MX2007013108A (es) Reactivos que enlazan ccx-ckr2.

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/08/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/08/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/08/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF