BRPI0514504A - pequenas moléculas inibidoras de membros da famìlia bcl-2 anti-apoptóticos e os usos das mesmas - Google Patents

pequenas moléculas inibidoras de membros da famìlia bcl-2 anti-apoptóticos e os usos das mesmas

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Publication number
BRPI0514504A
BRPI0514504A BRPI0514504-0A BRPI0514504A BRPI0514504A BR PI0514504 A BRPI0514504 A BR PI0514504A BR PI0514504 A BRPI0514504 A BR PI0514504A BR PI0514504 A BRPI0514504 A BR PI0514504A
Authority
BR
Brazil
Prior art keywords
family members
apoptotic bcl
inhibitory molecules
small inhibitory
bcl
Prior art date
Application number
BRPI0514504-0A
Other languages
English (en)
Inventor
Shaomeng Wang
Guoping Wang
Guozhi Tang
Renxiao Wang
Zaneta Nikolovska-Coleska
Dajon Wang
Liang Xu
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Publication of BRPI0514504A publication Critical patent/BRPI0514504A/pt

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    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/38—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. nitrodiphenyl ethers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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Abstract

PEQUENAS MOLéCULAS INIBIDORAS DE MEMBROS DA FAMìLIA BCL-2 ANTI-APOPTóTICOS E OS USOS DAS MESMAS A invenção refere-se a pequenas moléculas que funcionam como inibidores de proteínas membros da família Bcl-2 (por exemplo, Bcl-2 e Bcl-xL). A invenção também se refere a estes compostos para indução de morte celular apoptótica e sensibilização de células para indução de morte celular apoptótica.
BRPI0514504-0A 2004-08-20 2005-08-22 pequenas moléculas inibidoras de membros da famìlia bcl-2 anti-apoptóticos e os usos das mesmas BRPI0514504A (pt)

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US11/209,998 US8557812B2 (en) 2004-08-20 2005-08-22 Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof

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