BRPI0509182A - co-cristais de gossipol e uso dos mesmos - Google Patents

co-cristais de gossipol e uso dos mesmos

Info

Publication number
BRPI0509182A
BRPI0509182A BRPI0509182-9A BRPI0509182A BRPI0509182A BR PI0509182 A BRPI0509182 A BR PI0509182A BR PI0509182 A BRPI0509182 A BR PI0509182A BR PI0509182 A BRPI0509182 A BR PI0509182A
Authority
BR
Brazil
Prior art keywords
crystals
gossypol
relates
carboxylic acid
acid
Prior art date
Application number
BRPI0509182-9A
Other languages
English (en)
Inventor
Shaomeng Wang
Dajon Yang
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Publication of BRPI0509182A publication Critical patent/BRPI0509182A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

CO-CRISTAIS DE GOSSIPOT E USO DOS MESMOS Esta invenção se refere a composições compreendendo co-cristais de (-)- gossipol com um ácido carboxílico de C~ 1-8~ ou um ácido sulfânico de C~ 1-8~ que são úteis como inibidores das proteínas da família Bcl-2. A invenção também se refere ao uso de co-cristais de (-)-gossipol com um ácido carboxílico de C~ 1-8~ ou um ácido sulfónico de C~ 1-8~ para induzir apoptose em células e para sensibilizar células à indução de morte celular apoptótica.
BRPI0509182-9A 2004-03-25 2005-03-24 co-cristais de gossipol e uso dos mesmos BRPI0509182A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55624904P 2004-03-25 2004-03-25
PCT/US2005/009673 WO2005094804A1 (en) 2004-03-25 2005-03-24 Gossypol co-crystals and the use thereof

Publications (1)

Publication Number Publication Date
BRPI0509182A true BRPI0509182A (pt) 2007-09-18

Family

ID=35063489

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509182-9A BRPI0509182A (pt) 2004-03-25 2005-03-24 co-cristais de gossipol e uso dos mesmos

Country Status (15)

Country Link
US (3) US7342046B2 (pt)
EP (1) EP1732529A4 (pt)
JP (1) JP2007530568A (pt)
KR (2) KR100906843B1 (pt)
CN (1) CN1960719B (pt)
AU (2) AU2005228998B2 (pt)
BR (1) BRPI0509182A (pt)
CA (1) CA2561303C (pt)
EA (1) EA011218B1 (pt)
IL (1) IL178286A0 (pt)
MX (1) MXPA06010938A (pt)
NO (1) NO20064829L (pt)
SG (1) SG151299A1 (pt)
WO (1) WO2005094804A1 (pt)
ZA (1) ZA200607956B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
IL163846A0 (en) 2002-03-01 2005-12-18 Univ South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
IL165383A0 (en) 2002-06-21 2006-01-15 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
EP1610778A4 (en) * 2003-01-17 2006-05-31 Threshold Pharmaceuticals Inc TREATMENT OF BENIGNER PROSTATE HYPERPLASIA
CA2561303C (en) * 2004-03-25 2011-01-18 The Regents Of The University Of Michigan Gossypol co-crystals and the use thereof
WO2008150506A1 (en) * 2007-05-31 2008-12-11 Ascenta Therapeutics, Inc. Pulsatile dosing of gossypol for treatment of disease
TW200918099A (en) 2007-09-14 2009-05-01 Nitto Denko Corp Drug carriers
EP2197273B1 (en) * 2007-10-01 2014-09-24 Ascenta Therapeutics, Inc. Process for preparing r-gossypol l-phenylalaninol dienamine
US20090098118A1 (en) * 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
KR101657603B1 (ko) 2007-12-28 2016-09-19 가부시키가이샤 브리지스톤 히드록시아릴 관능화 중합체
WO2010019914A2 (en) * 2008-08-14 2010-02-18 The Uab Research Foundation Anti-arrhythmia agents, methods of their use, methods for their identification, and kits thereofre
US8765888B2 (en) 2009-06-30 2014-07-01 Bridgestone Corporation Polymers functionalized with hydroxyl group-containing diphenylethylene
KR101728184B1 (ko) * 2009-07-01 2017-04-18 가부시키가이샤 브리지스톤 자유 라디칼 개시 중합에 의한 히드록시아릴-관능화된 혼성중합체의 제조 방법
CN101810577B (zh) * 2010-05-06 2011-09-07 山东大学 治疗肿瘤的棉酚静脉注射脂肪乳剂
CN103038204B (zh) 2010-05-31 2015-03-04 株式会社普利司通 含羟基的甲基苯乙烯和引入其的聚合物
KR101408370B1 (ko) * 2012-06-26 2014-06-18 주식회사지씨비 아리피프라졸-유기산 공결정을 함유하는 제제 및 이의 제조 방법
KR101579371B1 (ko) * 2014-02-27 2015-12-22 국립암센터 고시폴 및 펜포르민을 유효성분으로 함유하는 암 치료용 약제학적 조성물
EP3417853B1 (en) 2016-02-18 2024-06-05 Industry-Academic Cooperation Foundation Yonsei University Pharmaceutical composition for treatment of stomach cancer containing gossypol, phenformin and irinotecan
US11123314B2 (en) 2017-02-22 2021-09-21 National Cancer Center Pharmaceutical composition for preventing and treating pancreatic cancer, containing gossypol and phenformin as active ingredients
EP3613417A4 (en) * 2017-04-22 2021-06-09 Caidong Qin Method for inhibiting cellular glycolysis process and application thereof
KR102259892B1 (ko) * 2019-08-05 2021-06-04 주식회사 하임바이오 식물유래 폴리페놀염의 대량 제조 방법

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3364242A (en) 1963-07-05 1968-01-16 Swift & Co Separation of gossypol from cottonseed oil
US3347885A (en) 1966-01-03 1967-10-17 Anderson Clayton & Co Inc Cottonseed oil direct extraction method
US3647791A (en) 1967-09-19 1972-03-07 Ciba Geigy Corp 2 3 4 4a 5 6-hexahydro - 1h - pyrazino (1 2-a) quinolines and pharmaceutical compositions containing same
DE1917341C3 (de) 1969-04-03 1973-10-18 Wsesojusnyj Nautschno-Issledowatelskij Institut Schirow, Leningrad (Sowjetunion) Verfahren zur Gewinnung von Baum wollsaatol
SU322042A1 (ru) 1969-07-15 1976-02-15 Ордена Трудового Красного Знамени Институт Химии Растительных Веществ Ан Узбекской Сср Способ очистки госсипола
NL7303876A (pt) 1972-03-30 1973-10-02
US4297341A (en) 1980-05-09 1981-10-27 University Of Illinois Foundation Spermicidal composition
SU1351915A1 (ru) 1982-06-16 1987-11-15 Институт Биоорганической Химии Ан Узсср Способ получени госсипола из антранилата госсипола
US4747979A (en) 1984-07-02 1988-05-31 The Dow Chemical Company Removal of toxins from cottonseed
US4806568A (en) 1985-09-12 1989-02-21 Research Corporation Gossypol derivatives
US5260327A (en) 1985-10-02 1993-11-09 Sloan-Kettering Institute For Cancer Research Methods for inhibiting the proliferation of brain and hepatic metastases by using lonidamine
JPH01132542A (ja) 1987-11-19 1989-05-25 Toomen:Kk ゴッシポールラセミ体の光学分割法
CN1017705B (zh) 1987-12-26 1992-08-05 中国医学科学院药物研究所 制备光学活性棉酚的方法
CH676360A5 (en) 1988-12-28 1991-01-15 Inst Bioorg Khim Nauk Uzbexkoi Purificn. of antiviral gossypol cpd. - by recrystallisation from ether with hexane
US5059717A (en) 1989-01-05 1991-10-22 Ibragimov Bakhtiyar T Method for purification of 2,2'-di(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-naphthaldehyde)
US5759837A (en) 1989-01-17 1998-06-02 John Hopkins University Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
CN1044455A (zh) 1989-01-25 1990-08-08 乌兹别克苏维埃共和国科学院生物有机化学研究所 2，2，-二(1，6，7-三羟基-3-甲基-5-异丙基-8-萘甲醛)的纯化方法
US5026726A (en) 1989-12-11 1991-06-25 The University Of New Mexico Gossylic iminolactones and gossylic lactones and their anti-viral activities
US5385936A (en) * 1990-07-12 1995-01-31 The United States Of America As Represented By The Secretary Of The Department Of The Health And Human Services Gossypol acetic acid for the treatment of cancer
US5277909A (en) 1990-08-24 1994-01-11 The United States Of America, As Represented By The Secretary Of Agriculture Method for removal of gossypol from cottonseed meal by the use of urea in a borate containing buffer
US5077441A (en) 1990-10-05 1991-12-31 The United States Of America As Represented By The Secretary Of Agriculture Selective gossypol abatement process from oil extraction of cottonseed
US5112637A (en) 1990-11-05 1992-05-12 The United States Of America As Represented By The Secretary Of Agriculture Extraction of gossypol from cottonseed
RU2067111C1 (ru) 1992-06-16 1996-09-27 Узбекский научно-исследовательский институт химической технологии катализа им.А.Султанова Способ получения госсипола из сырого черного хлопкового масла
ES2183815T3 (es) 1992-07-24 2003-04-01 Univ Johns Hopkins Quimioterapia para el cancer.
HUT71799A (en) 1993-03-01 1996-02-28 Merck Sharp & Dohme Pyrrolo-pyridine derivatives, pharmaceutical compositions containing the same, process for producing them
CN1094392A (zh) 1993-04-20 1994-11-02 徐世江 碱液提取棉酚法
EP0775118B1 (en) 1994-08-05 2003-06-04 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
US6094217A (en) * 1994-10-27 2000-07-25 Fuji Photo Film Co., Ltd. Automatic regenerating method for film image
US5780675A (en) 1995-04-28 1998-07-14 The University Of New Mexico Deoxygossylic compounds
US5688950A (en) 1996-04-23 1997-11-18 Neurogen Corporation Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands
DE69719555T2 (de) * 1996-08-31 2003-09-25 Toyo Denso K.K., Tokio/Tokyo Zündspulenvorrichtung für Verbrennungsmotor
JPH1132542A (ja) 1997-07-23 1999-02-09 Iseki & Co Ltd コンバインの刈取前処理装置
KR20010031501A (ko) 1997-10-31 2001-04-16 추후제출 5-알파 환원효소 활성을 조절하는 방법 및 조성물
US6696484B2 (en) * 1997-10-31 2004-02-24 University Of Chicago Office Of Technology And Intellectual Property Method and compositions for regulation of 5-alpha reductase activity
US6113397A (en) * 1999-02-10 2000-09-05 General Instrument Corporation Coaxial connectors mounted back-to-back on backplane
WO2002041828A2 (en) 2000-11-17 2002-05-30 Dajun Yang Houttuyninum compositions and methods for inhibiting the activity of erbb-2 based thereon
JP2005502579A (ja) * 2000-12-15 2005-01-27 ワックヴォム リミテッド 新生血管形成に関連する状態を処置するための方法および組成物
ATE474568T1 (de) * 2001-05-30 2010-08-15 Univ Michigan Synergistische kombination von (-) -gossypol mit docetaxel oder paclitaxel zur behandlung von krebs.
US7432304B2 (en) * 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
CA2450370A1 (en) 2001-06-11 2002-12-19 Jody Mesaros Accelerators for increasing the rate of formation of free radicals and reactive oxygen species
US20030119894A1 (en) 2001-07-20 2003-06-26 Gemin X Biotechnologies Inc. Methods for treatment of cancer or neoplastic disease and for inhibiting growth of cancer cells and neoplastic cells
CN1229321C (zh) 2001-09-06 2005-11-30 新疆科赛生物工程有限公司 用二苯胺棉酚生产棉酚的方法
PL1653943T6 (pl) 2003-06-25 2009-02-27 The Burnham Inst La Jolla Pochodne katecholu do leczenia raka
CA2561303C (en) * 2004-03-25 2011-01-18 The Regents Of The University Of Michigan Gossypol co-crystals and the use thereof

Also Published As

Publication number Publication date
KR20080097496A (ko) 2008-11-05
SG151299A1 (en) 2009-04-30
AU2009200387A1 (en) 2009-02-19
AU2005228998A1 (en) 2005-10-13
ZA200607956B (en) 2008-02-27
CN1960719A (zh) 2007-05-09
MXPA06010938A (es) 2007-01-25
IL178286A0 (en) 2007-03-08
US7432300B2 (en) 2008-10-07
AU2005228998B2 (en) 2008-11-06
EA200601562A1 (ru) 2007-02-27
NO20064829L (no) 2006-12-20
KR20070026473A (ko) 2007-03-08
WO2005094804A1 (en) 2005-10-13
CA2561303A1 (en) 2005-10-13
KR100906843B1 (ko) 2009-07-08
CN1960719B (zh) 2011-12-07
US7342046B2 (en) 2008-03-11
EP1732529A4 (en) 2009-02-25
US20070293585A1 (en) 2007-12-20
EA011218B1 (ru) 2009-02-27
JP2007530568A (ja) 2007-11-01
US20090082445A1 (en) 2009-03-26
US20050234135A1 (en) 2005-10-20
CA2561303C (en) 2011-01-18
EP1732529A1 (en) 2006-12-20

Similar Documents

Publication Publication Date Title
BRPI0810522B8 (pt) compostos miméticos diazo bicíclicos de smac, composição farmacêutica e kit compreendendo ditos compostos e uso dos mesmos para o tratamento de câncer
NO20064829L (no) Gossypol-co-krystaller og anvendelse derav
BRPI0819714A8 (pt) Formulações de proteína e métodos de produção das mesmas
ECSP11011297A (es) Proteinas ligadoras il-17
CL2011000230A1 (es) Anticuerpo monoclonal humano aislado que se une al inhibidor de la via del factor tisular (tfpi); composicion farmaceutica que lo comprende; uso para tratar deficiencias adquiridas o geneticas de la coagulacion, o para acortar el tiempo de sangrado.
BR112012031071A2 (pt) 8-proteínas de ligação à il-1
BRPI0514504A (pt) pequenas moléculas inibidoras de membros da famìlia bcl-2 anti-apoptóticos e os usos das mesmas
CL2011000301A1 (es) Compuestos derivados de purina con actividad inmunomoduladora; composición farmacéutica que los comprende; y uso de ellos en el tratamiento de enfermedades alérgicas, rinitis alérgica, asma, enfermedades infecciosas y cáncer.
ECSP109917A (es) Nuevos derivados de ácido azabifenilaminobenzoico
CL2013002811A1 (es) Anticuerpo monoclonal aislado que se une a un epitopo del inhibidor de la ruta del factor tisular humano; molecula de acido nucleico que lo codifica; composicion farmaceutica que lo comprende; y su uso para tratar deficiencias o defectos geneticos o adquiridos en la coagulacion.
UY33802A (es) Composiciones inmunógenas que comprenden un antígeno relacionado con M72 y que tienen una fuerza iónica baja
Kwon et al. Meroterpenoid-rich fraction of an ethanolic extract from Sargassum serratifolium alleviates obesity and non-alcoholic fatty liver disease in high fat-fed C57BL/6J mice
ECSP088758A (es) Métodos para reducir la aglomeración de proteína
BRPI0816784A8 (pt) Fatores neuro-endócrinos para o tratamento de doenças degenerativas
NI201000079A (es) Algunos derivados de 2-pirazinona y su uso como inhibidores de elastasa de los neutrófilos.
BR112015008708A2 (pt) composição para clivagem de dna alvo compreendendo um rna guia específico para o dna alvo e ácido nucleico que codifica proteína cas ou proteína cas e uso da mesma
BR112013018399A2 (pt) anticorpos anti-il1rap e seus usos para tratamento humano
BR112012019881A2 (pt) proteínas de domínio estrutural baseadas na fibronectina que ligam-se à il-23
CO6640289A2 (es) Composiciones de anticuerpos anti-factor de crecimiento nervioso (ngf)
BRPI0506883A (pt) miméticos de smac conformacionalmente comprimidos e seus usos
MX2008006589A (es) Composiciones de edulcorante natural de mesa, de alta potencia, con perfil temporal y/o de sabor mejorado, metodos para su formulacion, y usos
BR112012006252A2 (pt) "formas cristalinas de abt-263 e solvatos para o uso no tratamento de doenças relacionadas á proteína bcl-2".
BR112014018728A8 (pt) Compostos de purinonas como inibidores de quinase
CL2017003218A1 (es) Anticuerpos monoclonales optimizados contra el inhibidor de la vía del factor tisular (tfpi)
BRPI0908887B8 (pt) composição farmacêutica líquida, recipiente farmacêutico, e, métodos para preparar e para fabricar uma composição farmacêutica

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 14A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2507 DE 22-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.