BRPI0514644A - composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna - Google Patents

composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna

Info

Publication number
BRPI0514644A
BRPI0514644A BRPI0514644-5A BRPI0514644A BRPI0514644A BR PI0514644 A BRPI0514644 A BR PI0514644A BR PI0514644 A BRPI0514644 A BR PI0514644A BR PI0514644 A BRPI0514644 A BR PI0514644A
Authority
BR
Brazil
Prior art keywords
rna
compound
phosphoramidite
ribonucleic acid
different
Prior art date
Application number
BRPI0514644-5A
Other languages
English (en)
Inventor
Tadaaki Ohgi
Kouichi Ishiyama
Yutaka Masutomi
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of BRPI0514644A publication Critical patent/BRPI0514644A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

COMPOSTO FOSFORAMIDITA, COMPOSTO áCIDO RIBONUCLéICO, E MéTODO PARA PRODUZIR OLIGO-RNA A presente invenção é refere-se um composto fosforamidita novo e útil para a síntese de oligo-RNA Um composto fosforamidita representado pela seguinte fórmula geral (1), em que: Bx representa uma nucleobase que pode ter um grupo protetor; e R¬ ¬ é um substituinte representado pela seguinte fórmula geral em que: R¬ ¬ , R¬ ¬ e R¬ ¬ são iguais ou diferentes e cada um representa hidrogênio ou alcóxi; e R¬ [¬ e R¬ 2b¬ são iguais ou diferentes e cada um representa alquila, ou R¬ [¬ e R¬ 2b¬ tomados juntos com o átomo de nitrogênio adjacente podem formar um grupo amino cíclico saturado de 5 a 6 membros, o grupo amino cíclico tendo opcionalmente um átomo de oxigênio ou de enxofre como um membro componente do anel, além do átomo de nitrogênio adjacente; e WG¬ ¬ e WG¬ ¬ são iguais ou diferentes e cada um representa um grupo captador de elétrons.
BRPI0514644-5A 2004-08-26 2005-08-25 composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna BRPI0514644A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2004246185 2004-08-26
JP2005110817 2005-04-07
JP2005193313 2005-07-01
PCT/JP2005/015420 WO2006022323A1 (ja) 2004-08-26 2005-08-25 ホスホロアミダイト化合物及びオリゴｒｎａの製法

Publications (1)

Publication Number Publication Date
BRPI0514644A true BRPI0514644A (pt) 2008-06-17

Family

ID=35967530

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514644-5A BRPI0514644A (pt) 2004-08-26 2005-08-25 composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna

Country Status (12)

Country Link
US (1) US8691970B2 (pt)
EP (1) EP1795536B1 (pt)
JP (1) JP5157168B2 (pt)
KR (1) KR101281836B1 (pt)
CN (1) CN101048423B (pt)
AT (1) ATE556085T1 (pt)
AU (1) AU2005275801B2 (pt)
BR (1) BRPI0514644A (pt)
CA (1) CA2577922C (pt)
ES (1) ES2386709T3 (pt)
MX (1) MX2007002245A (pt)
WO (1) WO2006022323A1 (pt)

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RU2572826C2 (ru) 2008-12-02 2016-01-20 Чиралджен, Лтд. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
CA2767253A1 (en) 2009-07-06 2011-01-13 Ontorii, Inc. Novel nucleic acid prodrugs and methods of use thereof
EP2479182B8 (en) * 2009-09-16 2016-07-13 Wave Life Sciences Japan, Inc. Novel protecting group for synthesizing rna and derivative thereof
US8859755B2 (en) 2010-03-05 2014-10-14 Chiralgen, Ltd. Method for preparing ribonucleoside phosphorothioate
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
JP6093924B2 (ja) * 2010-11-30 2017-03-15 株式会社Wave Life Sciences Japan ２’−ｏ−修飾ｒｎａ
AU2012284265B2 (en) 2011-07-19 2017-08-17 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
WO2013027843A1 (ja) * 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
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JP6571663B2 (ja) * 2013-09-14 2019-09-04 ケムジーンズ コーポレーション 逆方向アプローチを使用した長いｒｎａの非常に効果的な合成
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
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JPWO2017111137A1 (ja) 2015-12-22 2018-10-18 味の素株式会社 オリゴヌクレオチドの製造方法
KR102670605B1 (ko) 2018-04-24 2024-05-29 스미또모 가가꾸 가부시끼가이샤 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법
JP7423533B2 (ja) 2018-09-07 2024-01-29 住友化学株式会社 配糖体化合物の製造方法
US12509483B2 (en) 2019-10-11 2025-12-30 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomers
EP4047004B1 (en) * 2019-10-18 2024-03-06 FUJIFILM Wako Pure Chemical Corporation Phosphoramidite activator
EP4049996B1 (en) 2019-10-23 2026-01-07 Sumitomo Chemical Company, Limited Glycoside compound, amidite compound, and production method for polynucleotide using said compounds
US20230312635A1 (en) 2020-01-29 2023-10-05 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer
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CN115362163B (zh) 2020-04-14 2025-04-11 住友化学株式会社 核酸寡聚物的制造方法
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KR20240028416A (ko) 2021-07-06 2024-03-05 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머를 함유하는 조성물
KR20240082343A (ko) 2021-09-28 2024-06-10 스미또모 가가꾸 가부시끼가이샤 정제 디클로로아세트산의 제조 방법
US20250145656A1 (en) 2022-02-04 2025-05-08 Nitto Denko Corporation Method for producing oligonucleotides
EP4474387A4 (en) 2022-02-04 2025-09-24 Nitto Denko Corp PROCESS FOR PRODUCING OLIGONUCLEOTIDE
KR20240162536A (ko) 2022-03-23 2024-11-15 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
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Also Published As

Publication number Publication date
JPWO2006022323A1 (ja) 2008-05-08
WO2006022323A1 (ja) 2006-03-02
US20070282097A1 (en) 2007-12-06
AU2005275801A1 (en) 2006-03-02
KR101281836B1 (ko) 2013-07-03
CN101048423A (zh) 2007-10-03
CA2577922C (en) 2013-06-25
EP1795536A1 (en) 2007-06-13
KR20070054688A (ko) 2007-05-29
JP5157168B2 (ja) 2013-03-06
EP1795536A4 (en) 2009-04-08
CN101048423B (zh) 2011-06-08
ATE556085T1 (de) 2012-05-15
AU2005275801B2 (en) 2012-05-10
ES2386709T3 (es) 2012-08-27
CA2577922A1 (en) 2006-03-02
EP1795536B1 (en) 2012-05-02
MX2007002245A (es) 2007-04-20
AU2005275801A2 (en) 2006-03-02
US8691970B2 (en) 2014-04-08

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]