BRPI0514644A - composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna - Google Patents

composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna

Info

Publication number
BRPI0514644A
BRPI0514644A BRPI0514644-5A BRPI0514644A BRPI0514644A BR PI0514644 A BRPI0514644 A BR PI0514644A BR PI0514644 A BRPI0514644 A BR PI0514644A BR PI0514644 A BRPI0514644 A BR PI0514644A
Authority
BR
Brazil
Prior art keywords
rna
compound
phosphoramidite
ribonucleic acid
different
Prior art date
Application number
BRPI0514644-5A
Other languages
English (en)
Inventor
Tadaaki Ohgi
Kouichi Ishiyama
Yutaka Masutomi
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of BRPI0514644A publication Critical patent/BRPI0514644A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

COMPOSTO FOSFORAMIDITA, COMPOSTO áCIDO RIBONUCLéICO, E MéTODO PARA PRODUZIR OLIGO-RNA A presente invenção é refere-se um composto fosforamidita novo e útil para a síntese de oligo-RNA Um composto fosforamidita representado pela seguinte fórmula geral (1), em que: Bx representa uma nucleobase que pode ter um grupo protetor; e R¬ ¬ é um substituinte representado pela seguinte fórmula geral em que: R¬ ¬ , R¬ ¬ e R¬ ¬ são iguais ou diferentes e cada um representa hidrogênio ou alcóxi; e R¬ [¬ e R¬ 2b¬ são iguais ou diferentes e cada um representa alquila, ou R¬ [¬ e R¬ 2b¬ tomados juntos com o átomo de nitrogênio adjacente podem formar um grupo amino cíclico saturado de 5 a 6 membros, o grupo amino cíclico tendo opcionalmente um átomo de oxigênio ou de enxofre como um membro componente do anel, além do átomo de nitrogênio adjacente; e WG¬ ¬ e WG¬ ¬ são iguais ou diferentes e cada um representa um grupo captador de elétrons.
BRPI0514644-5A 2004-08-26 2005-08-25 composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna BRPI0514644A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2004246185 2004-08-26
JP2005110817 2005-04-07
JP2005193313 2005-07-01
PCT/JP2005/015420 WO2006022323A1 (ja) 2004-08-26 2005-08-25 ホスホロアミダイト化合物及びオリゴｒｎａの製法

Publications (1)

Publication Number Publication Date
BRPI0514644A true BRPI0514644A (pt) 2008-06-17

Family

ID=35967530

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514644-5A BRPI0514644A (pt) 2004-08-26 2005-08-25 composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna

Country Status (12)

Country Link
US (1) US8691970B2 (pt)
EP (1) EP1795536B1 (pt)
JP (1) JP5157168B2 (pt)
KR (1) KR101281836B1 (pt)
CN (1) CN101048423B (pt)
AT (1) ATE556085T1 (pt)
AU (1) AU2005275801B2 (pt)
BR (1) BRPI0514644A (pt)
CA (1) CA2577922C (pt)
ES (1) ES2386709T3 (pt)
MX (1) MX2007002245A (pt)
WO (1) WO2006022323A1 (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8158775B2 (en) * 2006-02-27 2012-04-17 Nippon Shinyaku Co., Ltd. Method for detaching protecting group on nucleic acid
US20090312534A1 (en) * 2006-02-27 2009-12-17 Nippon Shinyaku Co., Ltd. Method for removal of nucleic acid-protecting group
CN101522701B (zh) * 2006-08-02 2012-05-23 日本新药株式会社 核酸保护基的导入方法
JP2008174524A (ja) * 2007-01-22 2008-07-31 Nippon Shinyaku Co Ltd リボ核酸化合物の製造方法
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
EP2451461A4 (en) 2009-07-06 2013-05-29 Ontorii Inc NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
CN102574888A (zh) * 2009-09-16 2012-07-11 株式会社启拉坚 用于rna及其衍生物的合成的新型保护基
WO2011108682A1 (ja) * 2010-03-05 2011-09-09 国立大学法人 東京大学 リボヌクレオシドホスホロチオエートの製造方法
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
EP2647644B1 (en) * 2010-11-30 2020-09-09 Wave Life Sciences Japan, Inc. 2'-o-modified rna
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
JP5554881B2 (ja) 2011-08-25 2014-07-23 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
CN112007045B (zh) 2012-07-13 2026-01-06 波涛生命科学有限公司 手性控制
DK2872485T3 (da) 2012-07-13 2021-03-08 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
JP6246121B2 (ja) 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
EP3044228B1 (en) * 2013-09-14 2021-04-07 Chemgenes Corporation Highly efficient synthesis of long rna using reverse direction approach
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인
CN104211741B (zh) * 2014-09-05 2017-05-31 河南师范大学 一种氘代核苷亚磷酰胺单体的合成方法
WO2017111137A1 (ja) 2015-12-22 2017-06-29 味の素株式会社 オリゴヌクレオチドの製造方法
JP7280248B2 (ja) * 2018-04-24 2023-05-23 住友化学株式会社 アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法
US12173028B2 (en) 2018-09-07 2024-12-24 Sumitomo Chemical Company, Limited Method for producing glycoside compound
KR20220079832A (ko) 2019-10-11 2022-06-14 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
JP7452549B2 (ja) * 2019-10-18 2024-03-19 富士フイルム和光純薬株式会社 ホスホロアミダイト活性化剤
JP7606972B2 (ja) 2019-10-23 2024-12-26 住友化学株式会社 配糖体化合物、アミダイト化合物、およびこれら化合物を用いたポリヌクレオチドの製造方法
CN115003680B (zh) * 2020-01-29 2025-01-28 住友化学株式会社 制备核酸寡聚物的方法
KR20220133878A (ko) 2020-01-29 2022-10-05 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
CN115335387A (zh) 2020-03-27 2022-11-11 住友化学株式会社 核酸寡聚物的制造方法
EP4137500B1 (en) 2020-04-14 2026-03-11 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer
US20230192755A1 (en) 2020-04-14 2023-06-22 Sumitomo Chemical Company, Limited Composition containing nucleic acid oligomer
WO2022009959A1 (ja) 2020-07-09 2022-01-13 住友化学株式会社 核酸オリゴマーの製造方法
CN116209668A (zh) * 2020-09-24 2023-06-02 住友化学株式会社 核酸寡聚物的制造方法
US20240300993A1 (en) 2021-07-06 2024-09-12 Sumitomo Chemical Company, Limited Composition containing nucleic acid oligomer
KR20240082343A (ko) 2021-09-28 2024-06-10 스미또모 가가꾸 가부시끼가이샤 정제 디클로로아세트산의 제조 방법
WO2023149563A1 (ja) 2022-02-04 2023-08-10 日東電工株式会社 オリゴヌクレオチドを製造する方法
WO2023149564A1 (ja) 2022-02-04 2023-08-10 日東電工株式会社 オリゴヌクレオチドを製造する方法
KR20240162536A (ko) 2022-03-23 2024-11-15 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
CN119403816A (zh) 2022-07-22 2025-02-07 住友化学株式会社 寡核苷酸的制造方法
JPWO2024024873A1 (pt) 2022-07-28 2024-02-01
CN115010769B (zh) * 2022-08-04 2022-11-15 上海百力格生物技术有限公司 固相亚磷酰胺三酯法合成长链rna核酸的方法
WO2024089953A1 (ja) 2022-10-27 2024-05-02 住友化学株式会社 オリゴヌクレオチドの製造方法
EP4644404A1 (en) 2022-12-26 2025-11-05 Sumitomo Chemical Company, Limited Oligonucleotide production method
CN119264195B (zh) * 2024-12-12 2025-04-08 天津奥瑞芙生物医药有限公司 一种亚磷酰胺单体的纯化方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3956500A (en) 1973-04-03 1976-05-11 Union Carbide Corporation Carbamate pesticidal compositions
US4629814A (en) 1985-08-27 1986-12-16 Rohm And Haas Company Process for preparing bis-bromoalkyl ethers
US4925856A (en) 1987-07-28 1990-05-15 Sri International Aldoxime-substituted imidazolium derivatives useful in the treatment of poisoning by phosphorus-containing chemicals
JP2794461B2 (ja) 1989-08-17 1998-09-03 有機合成薬品工業株式会社 ホスホアミダイト化合物及びそれを用いたオリゴリボヌクレオチドの固相合成法
GB9126355D0 (en) * 1991-12-11 1992-02-12 Ici Plc Production of hydrofluorocarbons
US5637776A (en) 1992-12-10 1997-06-10 Imperial Chemical Industries Plc Production of hydrofluorocarbons
AR037328A1 (es) * 2001-10-23 2004-11-03 Dow Agrosciences Llc Compuesto de [7-bencil-2,6-dioxo-1,5-dioxonan-3-il]-4-metoxipiridin-2-carboxamida, composicion que lo comprende y metodo que lo utiliza

Also Published As

Publication number Publication date
ATE556085T1 (de) 2012-05-15
CN101048423B (zh) 2011-06-08
ES2386709T3 (es) 2012-08-27
CN101048423A (zh) 2007-10-03
KR101281836B1 (ko) 2013-07-03
KR20070054688A (ko) 2007-05-29
US20070282097A1 (en) 2007-12-06
EP1795536A4 (en) 2009-04-08
AU2005275801A1 (en) 2006-03-02
MX2007002245A (es) 2007-04-20
AU2005275801A2 (en) 2006-03-02
EP1795536B1 (en) 2012-05-02
AU2005275801B2 (en) 2012-05-10
JPWO2006022323A1 (ja) 2008-05-08
WO2006022323A1 (ja) 2006-03-02
JP5157168B2 (ja) 2013-03-06
US8691970B2 (en) 2014-04-08
CA2577922A1 (en) 2006-03-02
EP1795536A1 (en) 2007-06-13
CA2577922C (en) 2013-06-25

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]