BRPI0514644A - composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna - Google Patents

composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna

Info

Publication number
BRPI0514644A
BRPI0514644A BRPI0514644-5A BRPI0514644A BRPI0514644A BR PI0514644 A BRPI0514644 A BR PI0514644A BR PI0514644 A BRPI0514644 A BR PI0514644A BR PI0514644 A BRPI0514644 A BR PI0514644A
Authority
BR
Brazil
Prior art keywords
rna
compound
phosphoramidite
ribonucleic acid
different
Prior art date
Application number
BRPI0514644-5A
Other languages
English (en)
Inventor
Tadaaki Ohgi
Kouichi Ishiyama
Yutaka Masutomi
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of BRPI0514644A publication Critical patent/BRPI0514644A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

COMPOSTO FOSFORAMIDITA, COMPOSTO áCIDO RIBONUCLéICO, E MéTODO PARA PRODUZIR OLIGO-RNA A presente invenção é refere-se um composto fosforamidita novo e útil para a síntese de oligo-RNA Um composto fosforamidita representado pela seguinte fórmula geral (1), em que: Bx representa uma nucleobase que pode ter um grupo protetor; e R¬ ¬ é um substituinte representado pela seguinte fórmula geral em que: R¬ ¬ , R¬ ¬ e R¬ ¬ são iguais ou diferentes e cada um representa hidrogênio ou alcóxi; e R¬ [¬ e R¬ 2b¬ são iguais ou diferentes e cada um representa alquila, ou R¬ [¬ e R¬ 2b¬ tomados juntos com o átomo de nitrogênio adjacente podem formar um grupo amino cíclico saturado de 5 a 6 membros, o grupo amino cíclico tendo opcionalmente um átomo de oxigênio ou de enxofre como um membro componente do anel, além do átomo de nitrogênio adjacente; e WG¬ ¬ e WG¬ ¬ são iguais ou diferentes e cada um representa um grupo captador de elétrons.
BRPI0514644-5A 2004-08-26 2005-08-25 composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna BRPI0514644A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2004246185 2004-08-26
JP2005110817 2005-04-07
JP2005193313 2005-07-01
PCT/JP2005/015420 WO2006022323A1 (ja) 2004-08-26 2005-08-25 ホスホロアミダイト化合物及びオリゴｒｎａの製法

Publications (1)

Publication Number Publication Date
BRPI0514644A true BRPI0514644A (pt) 2008-06-17

Family

ID=35967530

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514644-5A BRPI0514644A (pt) 2004-08-26 2005-08-25 composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna

Country Status (12)

Country Link
US (1) US8691970B2 (pt)
EP (1) EP1795536B1 (pt)
JP (1) JP5157168B2 (pt)
KR (1) KR101281836B1 (pt)
CN (1) CN101048423B (pt)
AT (1) ATE556085T1 (pt)
AU (1) AU2005275801B2 (pt)
BR (1) BRPI0514644A (pt)
CA (1) CA2577922C (pt)
ES (1) ES2386709T3 (pt)
MX (1) MX2007002245A (pt)
WO (1) WO2006022323A1 (pt)

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JP2008174524A (ja) * 2007-01-22 2008-07-31 Nippon Shinyaku Co Ltd リボ核酸化合物の製造方法
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RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
ES2586683T3 (es) * 2009-09-16 2016-10-18 Wave Life Sciences Japan, Inc. Grupo protector novedoso para sintetizar ARN y derivados del mismo
JP5847700B2 (ja) * 2010-03-05 2016-01-27 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ リボヌクレオシドホスホロチオエートの製造方法
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
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CN103796657B (zh) 2011-07-19 2017-07-11 波涛生命科学有限公司 合成官能化核酸的方法
MX370398B (es) * 2011-08-25 2019-12-11 Bonac Corp Compuesto de glicosido, metodo para producir tioeter, eter, metodo para producir eter, metodo para producir un compuesto de glicosido, metodo para producir acido nucleico.
KR102213609B1 (ko) 2012-07-13 2021-02-08 웨이브 라이프 사이언시스 리미티드 키랄 제어
PL2872485T3 (pl) 2012-07-13 2021-05-31 Wave Life Sciences Ltd. Asymetryczna grupa pomocnicza
CA2879066C (en) 2012-07-13 2019-08-13 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
JP6571663B2 (ja) * 2013-09-14 2019-09-04 ケムジーンズ コーポレーション 逆方向アプローチを使用した長いｒｎａの非常に効果的な合成
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
BR112016016400A2 (pt) 2014-01-16 2017-10-03 Wave Life Sciences Ltd Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos
CN104211741B (zh) * 2014-09-05 2017-05-31 河南师范大学 一种氘代核苷亚磷酰胺单体的合成方法
WO2017111137A1 (ja) 2015-12-22 2017-06-29 味の素株式会社 オリゴヌクレオチドの製造方法
KR102670605B1 (ko) * 2018-04-24 2024-05-29 스미또모 가가꾸 가부시끼가이샤 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법
US12173028B2 (en) 2018-09-07 2024-12-24 Sumitomo Chemical Company, Limited Method for producing glycoside compound
JP7640461B2 (ja) 2019-10-11 2025-03-05 住友化学株式会社 核酸オリゴマーの製造方法
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JP7667788B2 (ja) * 2020-01-29 2025-04-23 住友化学株式会社 核酸オリゴマーの製造方法
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CN115867559A (zh) * 2020-07-09 2023-03-28 住友化学株式会社 核酸寡聚物的制造方法
KR20230074205A (ko) 2020-09-24 2023-05-26 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
EP4368627A4 (en) 2021-07-06 2025-10-08 Sumitomo Chemical Co COMPOSITION CONTAINING A NUCLEIC ACID OLIGOMER
CN117980285A (zh) 2021-09-28 2024-05-03 住友化学株式会社 纯化二氯乙酸的制造方法
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Also Published As

Publication number Publication date
JP5157168B2 (ja) 2013-03-06
EP1795536A1 (en) 2007-06-13
ATE556085T1 (de) 2012-05-15
ES2386709T3 (es) 2012-08-27
JPWO2006022323A1 (ja) 2008-05-08
CA2577922C (en) 2013-06-25
AU2005275801A2 (en) 2006-03-02
AU2005275801B2 (en) 2012-05-10
EP1795536A4 (en) 2009-04-08
CN101048423B (zh) 2011-06-08
EP1795536B1 (en) 2012-05-02
US8691970B2 (en) 2014-04-08
CN101048423A (zh) 2007-10-03
WO2006022323A1 (ja) 2006-03-02
KR20070054688A (ko) 2007-05-29
CA2577922A1 (en) 2006-03-02
KR101281836B1 (ko) 2013-07-03
US20070282097A1 (en) 2007-12-06
AU2005275801A1 (en) 2006-03-02
MX2007002245A (es) 2007-04-20

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]